WP_BENZOAPYRENE_METABOLISM Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 AKR1C1 Aldo-keto reductase family 1 member C1 [1] -0.14[2] -0.03[3] -2.06[4] -1.26[5] -2.83[6] -2.92[7]
2 EPHX1 Epoxide hydrolase 1 [8] -0.42[9] -1.48[10] -0.65[11] 0.41[12] 0.34[13] 0.36[14]
3 CYP3A4 Cytochrome P450 3A4 [15] -9.13[16] -8.82[17] -8.86[18] -14.92[19] -10.16[20] 2.04[21]
4 AKR1C3 Aldo-keto reductase family 1 member C3 [22] 0.35[23] 1.40[24] -3.56[25] 1.98[26] -1.87[27] -0.88[28]
5 AKR1C2 Aldo-keto reductase family 1 member C2 [29] 1.73[30] 0.11[31] -0.84[32] 1.09[33] -1.65[34] 0.15[35]
6 AKR1C4 Aldo-keto reductase family 1 member C4 [36] -6.45[37] -3.66[38] -2.57[39] -9.07[40] -11.34[41] 0.43[42]
7 AKR1A1 Alcohol dehydrogenase [NADP(+)] [43] 1.42[44] 2.02[45] 4.41[46] -0.97[47] 1.96[48] 0.99[49]
8 CYP1A1 Cytochrome P450 1A1 [50] -1.85[51] -3.01[52] 2.33[53] -3.89[54] -1.22[55] -4.48[56]
9 CYP1B1 Cytochrome P450 1B1 [57] -4.43[58] -3.44[59] 2.35[60] 3.10[61] 8.93[62] 2.33[63]
[1]
ref_hepatocyte AKR1C1
Mean 1e+03
Standard deviation 4.3e+02
Values 9.2e+02 3.2e+02 1e+03 1.4e+03 1.3e+03
[2]
HepG2 AKR1C1
Mean 329
Standard deviation 2.6e+02
Values 1.5e+02 5.1e+02
[3]
HepG2.C3A AKR1C1
Mean 233
Standard deviation 65
Values 1.9e+02 2.8e+02
[4]
HuH.7 AKR1C1
Mean 17.1
Standard deviation 16
Values 8.5 35 7.8
[5]
SNU475 AKR1C1
Mean 254
Standard deviation 82
Values 3.1e+02 2e+02
[6]
THLE AKR1C1
Mean 10.3
Standard deviation 0.06
Values 10 10
[7]
liver AKR1C1
Mean 75.6
Standard deviation 54
Values 21 67 63 1.5e+02
[8]
ref_hepatocyte EPHX1
Mean 300
Standard deviation 3.6e+02
Values 48 6.7e+02 7.2e+02 43 21
[9]
HepG2 EPHX1
Mean 80.5
Standard deviation 9
Values 74 87
[10]
HepG2.C3A EPHX1
Mean 25.6
Standard deviation 6.3
Values 21 30
[11]
HuH.7 EPHX1
Mean 13.6
Standard deviation 1.2
Values 12 14 14
[12]
SNU475 EPHX1
Mean 243
Standard deviation 68
Values 2e+02 2.9e+02
[13]
THLE EPHX1
Mean 27.8
Standard deviation 0.14
Values 28 28
[14]
liver EPHX1
Mean 220
Standard deviation 1.4e+02
Values 61 3.1e+02 1.4e+02 3.7e+02
[15]
ref_hepatocyte CYP3A4
Mean 259
Standard deviation 4.1e+02
Values 11 9.6e+02 3.2e+02 0.24 11
[16]
HepG2 CYP3A4
Mean 0.167
Standard deviation 0.098
Values 0.24 0.097
[17]
HepG2.C3A CYP3A4
Mean 0.136
Standard deviation 0.096
Values 0.2 0.068
[18]
HuH.7 CYP3A4
Mean 0.0397
Standard deviation 0.029
Values 0.047 0.064 0.0082
[19]
SNU475 CYP3A4
Mean 0.00507
Standard deviation 0.0072
Values 0.01 0
[20]
THLE CYP3A4
Mean 0.0166
Standard deviation 0.0067
Values 0.012 0.021
[21]
liver CYP3A4
Mean 610
Standard deviation 5.3e+02
Values 49 6.4e+02 4.3e+02 1.3e+03
[22]
ref_hepatocyte AKR1C3
Mean 242
Standard deviation 1.8e+02
Values 1.1e+02 1.2e+02 4.3e+02 99 4.4e+02
[23]
HepG2 AKR1C3
Mean 111
Standard deviation 53
Values 74 1.5e+02
[24]
HepG2.C3A AKR1C3
Mean 152
Standard deviation 34
Values 1.3e+02 1.8e+02
[25]
HuH.7 AKR1C3
Mean 1.46
Standard deviation 0.83
Values 0.84 2.4 1.1
[26]
SNU475 AKR1C3
Mean 580
Standard deviation 2.8e+02
Values 3.9e+02 7.8e+02
[27]
THLE AKR1C3
Mean 4.84
Standard deviation 0.00088
Values 4.8 4.8
[28]
liver AKR1C3
Mean 75.4
Standard deviation 53
Values 32 67 51 1.5e+02
[29]
ref_hepatocyte AKR1C2
Mean 167
Standard deviation 1.2e+02
Values 1.1e+02 40 2.3e+02 1.2e+02 3.4e+02
[30]
HepG2 AKR1C2
Mean 199
Standard deviation 1.3e+02
Values 1e+02 2.9e+02
[31]
HepG2.C3A AKR1C2
Mean 42.9
Standard deviation 7.5
Values 38 48
[32]
HuH.7 AKR1C2
Mean 6.67
Standard deviation 6.9
Values 2.5 15 3
[33]
SNU475 AKR1C2
Mean 215
Standard deviation 34
Values 1.9e+02 2.4e+02
[34]
THLE AKR1C2
Mean 3.9
Standard deviation 0.29
Values 4.1 3.7
[35]
liver AKR1C2
Mean 106
Standard deviation 92
Values 19 1.1e+02 64 2.3e+02
[36]
ref_hepatocyte AKR1C4
Mean 105
Standard deviation 1.4e+02
Values 1.7 2.8e+02 2.3e+02 0 3.6
[37]
HepG2 AKR1C4
Mean 0.432
Standard deviation 0.36
Values 0.18 0.69
[38]
HepG2.C3A AKR1C4
Mean 1.97
Standard deviation 0.48
Values 2.3 1.6
[39]
HuH.7 AKR1C4
Mean 1.26
Standard deviation 0.56
Values 1.2 1.9 0.75
[40]
SNU475 AKR1C4
Mean 0.118
Standard deviation 0.055
Values 0.16 0.079
[41]
THLE AKR1C4
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[42]
liver AKR1C4
Mean 80.8
Standard deviation 62
Values 30 66 56 1.7e+02
[43]
ref_hepatocyte AKR1A1
Mean 65.3
Standard deviation 51
Values 38 1.3e+02 1.1e+02 28 21
[44]
HepG2 AKR1A1
Mean 63
Standard deviation 1.5
Values 64 62
[45]
HepG2.C3A AKR1A1
Mean 63.2
Standard deviation 3.9
Values 60 66
[46]
HuH.7 AKR1A1
Mean 99.3
Standard deviation 17
Values 1.2e+02 83 99
[47]
SNU475 AKR1A1
Mean 20.3
Standard deviation 2.5
Values 19 22
[48]
THLE AKR1A1
Mean 18.6
Standard deviation 2
Values 17 20
[49]
liver AKR1A1
Mean 74.5
Standard deviation 42
Values 41 37 1.2e+02 1e+02
[50]
ref_hepatocyte CYP1A1
Mean 43.8
Standard deviation 36
Values 0.06 82 17 77 43
[51]
HepG2 CYP1A1
Mean 4.39
Standard deviation 2.6
Values 2.6 6.2
[52]
HepG2.C3A CYP1A1
Mean 1.3
Standard deviation 0.1
Values 1.2 1.4
[53]
HuH.7 CYP1A1
Mean 15.8
Standard deviation 1.4
Values 17 17 14
[54]
SNU475 CYP1A1
Mean 1.8
Standard deviation 1.8
Values 3.1 0.49
[55]
THLE CYP1A1
Mean 1.38
Standard deviation 0.04
Values 1.4 1.4
[56]
liver CYP1A1
Mean 1.12
Standard deviation 0.58
Values 1.8 0.47 1.2 0.92
[57]
ref_hepatocyte CYP1B1
Mean 2.62
Standard deviation 3.2
Values 0.92 1.4 2.7 0.024 8
[58]
HepG2 CYP1B1
Mean 0.0437
Standard deviation 0.019
Values 0.03 0.057
[59]
HepG2.C3A CYP1B1
Mean 0.0575
Standard deviation 0.04
Values 0.086 0.029
[60]
HuH.7 CYP1B1
Mean 0.95
Standard deviation 0.082
Values 0.95 1 0.87
[61]
SNU475 CYP1B1
Mean 13.6
Standard deviation 3.1
Values 11 16
[62]
THLE CYP1B1
Mean 93
Standard deviation 14
Values 1e+02 83
[63]
liver CYP1B1
Mean 7.5
Standard deviation 1.4
Values 6.2 7.4 6.9 9.5