WP_BENZENE_METABOLISM Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 CYP2E1 Cytochrome P450 2E1 [1] -12.05[2] -11.80[3] -8.16[4] -15.42[5] -10.11[6] 0.07[7]
2 EPHX1 Epoxide hydrolase 1 [8] -0.60[9] -1.68[10] -2.14[11] -0.17[12] 0.29[13] -0.47[14]
3 NQO1 NAD(P)H dehydrogenase [quinone] 1 [15] 5.19[16] 5.28[17] 5.28[18] 5.11[19] 5.02[20] -4.76[21]
4 GSTM1 Glutathione S-transferase Mu 1 [22] 0.12[23] -0.75[24] 5.79[25] 5.10[26] 0.44[27] 7.03[28]
5 DHDH Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase [29] 2.15[30] 4.08[31] 2.52[32] -0.75[33] 3.52[34] -3.99[35]
6 MPO Myeloperoxidase [36] -0.08[37] -0.06[38] [39] -4.96[40] [41] 2.05[42]
[1]
ref_hepatocyte CYP2E1
Mean 1.39e+03
Standard deviation 1.9e+03
Values 90 4.1e+03 2.7e+03 0 4.6
[2]
HepG2 CYP2E1
Mean 0.133
Standard deviation 0.1
Values 0.06 0.21
[3]
HepG2.C3A CYP2E1
Mean 0.107
Standard deviation 0.15
Values 0 0.21
[4]
HuH.7 CYP2E1
Mean 0.975
Standard deviation 0.29
Values 0.99 1.3 0.67
[5]
SNU475 CYP2E1
Mean 0.0289
Standard deviation 0.005
Values 0.025 0.032
[6]
THLE CYP2E1
Mean 0.0955
Standard deviation 0.082
Values 0.15 0.037
[7]
liver CYP2E1
Mean 1.49e+03
Standard deviation 8.2e+02
Values 6.9e+02 1e+03 2.6e+03 1.7e+03
[8]
ref_hepatocyte EPHX1
Mean 300
Standard deviation 3.6e+02
Values 48 6.7e+02 7.2e+02 43 21
[9]
HepG2 EPHX1
Mean 80.5
Standard deviation 9
Values 74 87
[10]
HepG2.C3A EPHX1
Mean 25.6
Standard deviation 6.3
Values 21 30
[11]
HuH.7 EPHX1
Mean 13.6
Standard deviation 1.2
Values 12 14 14
[12]
SNU475 EPHX1
Mean 243
Standard deviation 68
Values 2e+02 2.9e+02
[13]
THLE EPHX1
Mean 27.8
Standard deviation 0.14
Values 28 28
[14]
liver EPHX1
Mean 220
Standard deviation 1.4e+02
Values 61 3.1e+02 1.4e+02 3.7e+02
[15]
ref_hepatocyte NQO1
Mean 42.1
Standard deviation 85
Values 1.6 0.37 1.4 1.9e+02 13
[16]
HepG2 NQO1
Mean 625
Standard deviation 2.7e+02
Values 4.3e+02 8.1e+02
[17]
HepG2.C3A NQO1
Mean 447
Standard deviation 1.2e+02
Values 5.3e+02 3.6e+02
[18]
HuH.7 NQO1
Mean 329
Standard deviation 90
Values 4e+02 2.3e+02 3.5e+02
[19]
SNU475 NQO1
Mean 1.32e+03
Standard deviation 2.1e+02
Values 1.2e+03 1.5e+03
[20]
THLE NQO1
Mean 103
Standard deviation 3.8
Values 1.1e+02 1e+02
[21]
liver NQO1
Mean 1.58
Standard deviation 1.1
Values 0.97 1.8 0.49 3.1
[22]
ref_hepatocyte GSTM1
Mean 0.404
Standard deviation 0.25
Values 0 0.36 0.52 0.52 0.62
[23]
HepG2 GSTM1
Mean 0.18
Standard deviation 0.14
Values 0.28 0.08
[24]
HepG2.C3A GSTM1
Mean 0.0657
Standard deviation 0.017
Values 0.054 0.078
[25]
HuH.7 GSTM1
Mean 4.5
Standard deviation 1.1
Values 4.7 3.3 5.5
[26]
SNU475 GSTM1
Mean 12.6
Standard deviation 6.3
Values 8.2 17
[27]
THLE GSTM1
Mean 0.0417
Standard deviation 0.0088
Values 0.035 0.048
[28]
liver GSTM1
Mean 54
Standard deviation 35
Values 38 15 93 70
[29]
ref_hepatocyte DHDH
Mean 0.294
Standard deviation 0.37
Values 0 0.15 0 0.88 0.44
[30]
HepG2 DHDH
Mean 0.532
Standard deviation 0.33
Values 0.3 0.77
[31]
HepG2.C3A DHDH
Mean 1.37
Standard deviation 0.57
Values 0.97 1.8
[32]
HuH.7 DHDH
Mean 0.34
Standard deviation 0.11
Values 0.47 0.26 0.29
[33]
SNU475 DHDH
Mean 0.16
Standard deviation 0.011
Values 0.15 0.17
[34]
THLE DHDH
Mean 0.257
Standard deviation 0.055
Values 0.3 0.22
[35]
liver DHDH
Mean 0.0189
Standard deviation 0.013
Values 0.026 0 0.024 0.026
[36]
ref_hepatocyte MPO
Mean 0.0797
Standard deviation 0.18
Values 0 0.4 0 0 0
[37]
HepG2 MPO
Mean 0.0308
Standard deviation 0.037
Values 0.0043 0.057
[38]
HepG2.C3A MPO
Mean 0.0209
Standard deviation 0.016
Values 0.032 0.0097
[39]
HuH.7 MPO
Mean 0
Standard deviation 0
Values 0 0 0
[40]
SNU475 MPO
Mean 0.00232
Standard deviation 0.0033
Values 0 0.0046
[41]
THLE MPO
Mean 0
Standard deviation 0
Values 0 0
[42]
liver MPO
Mean 0.336
Standard deviation 0.21
Values 0.15 0.57 0.16 0.46