WP_BDNFTRKB_SIGNALING | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | RHEB | GTP-binding protein Rheb | [1] | -2.22[2] | -1.78[3] | -1.90[4] | -1.59[5] | -1.33[6] | -1.30[7] |
2 | EIF4EBP1 | Eukaryotic translation initiation factor 4E-binding protein 1 | [8] | -1.27[9] | -1.72[10] | -1.16[11] | -3.79[12] | -2.09[13] | -1.80[14] |
3 | AKT1 | RAC-alpha serine/threonine-protein kinase | [15] | -0.20[16] | -0.56[17] | -1.69[18] | -0.54[19] | -0.37[20] | -0.45[21] |
4 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [22] | -1.21[23] | -1.66[24] | -1.13[25] | -1.03[26] | -0.38[27] | -1.40[28] |
5 | GRB2 | Growth factor receptor-bound protein 2 | [29] | 0.92[30] | 0.63[31] | 0.70[32] | 0.06[33] | 0.13[34] | 0.09[35] |
6 | SHC1 | SHC-transforming protein 1 | [36] | 0.89[37] | 0.98[38] | 1.00[39] | 2.16[40] | 1.80[41] | 0.57[42] |
7 | NRAS | GTPase NRas | [43] | 0.35[44] | 0.66[45] | 1.02[46] | 0.51[47] | 0.23[48] | -0.46[49] |
8 | HRAS | GTPase HRas | [50] | -1.29[51] | -2.12[52] | -2.96[53] | -1.44[54] | -1.50[55] | -2.87[56] |
9 | MAPK1 | Mitogen-activated protein kinase 1 | [57] | 1.43[58] | 1.44[59] | 1.22[60] | 1.36[61] | 1.16[62] | 1.57[63] |
10 | KRAS | GTPase KRas | [64] | -0.79[65] | -0.94[66] | 0.61[67] | 0.31[68] | 0.12[69] | 0.47[70] |
11 | SOS1 | Son of sevenless homolog 1 | [71] | -0.38[72] | 1.02[73] | 0.48[74] | 0.35[75] | -0.26[76] | 0.33[77] |
12 | RPS6KA1 | Ribosomal protein S6 kinase alpha-1 | [78] | [79] | [80] | [81] | [82] | [83] | [84] |
13 | MKNK1 | MAP kinase-interacting serine/threonine-protein kinase 1 | [85] | 0.09[86] | -0.41[87] | 0.05[88] | -0.15[89] | -0.40[90] | 0.49[91] |
14 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 3.21[92] | 2.70[93] | 1.98[94] | 2.33[95] | 1.97[96] | 0.13[97] | |
15 | MTOR | Serine/threonine-protein kinase mTOR | [98] | 2.26[99] | 3.14[100] | 2.66[101] | 2.19[102] | 2.42[103] | 3.24[104] |
16 | TSC2 | Tuberin | [105] | 1.54[106] | 0.94[107] | 1.57[108] | 0.71[109] | 1.38[110] | 1.87[111] |
17 | RPS6KB1 | Ribosomal protein S6 kinase beta-1 | [112] | [113] | [114] | [115] | [116] | [117] | [118] |
18 | EEF2K | Eukaryotic elongation factor 2 kinase | [119] | 2.18[120] | 1.50[121] | 1.82[122] | 1.07[123] | 0.64[124] | 1.93[125] |
19 | TSC1 | Hamartin | [126] | 1.61[127] | 2.14[128] | 2.24[129] | 1.57[130] | 1.93[131] | 2.55[132] |
20 | CREB1 | Cyclic AMP-responsive element-binding protein 1 | [133] | 1.44[134] | 2.47[135] | 2.91[136] | 2.05[137] | 2.14[138] | 2.13[139] |
21 | GAB2 | GRB2-associated-binding protein 2 | [140] | 1.29[141] | 0.95[142] | 1.14[143] | 0.43[144] | 0.67[145] | 0.34[146] |
22 | BRAF | Serine/threonine-protein kinase B-raf | [147] | -0.03[148] | -0.43[149] | 1.55[150] | 0.25[151] | 0.09[152] | 1.65[153] |
23 | HOMER1 | Homer protein homolog 1 | [154] | 1.15[155] | 1.96[156] | 2.64[157] | 1.03[158] | 0.90[159] | -0.73[160] |
24 | GAB1 | GRB2-associated-binding protein 1 | [161] | 1.02[162] | 1.98[163] | 2.06[164] | 1.44[165] | 1.45[166] | 2.67[167] |
25 | ADCY1 | Adenylate cyclase type 1 | [168] | -1.11[169] | -3.11[170] | -3.36[171] | -2.60[172] | -2.47[173] | 4.78[174] |
26 | DLG4 | Disks large homolog 4 | [175] | 2.50[176] | 2.67[177] | 1.36[178] | 1.47[179] | 3.83[180] | 1.49[181] |
27 | ARC | Activity-regulated cytoskeleton-associated protein | [182] | -2.68[183] | -0.63[184] | -4.91[185] | -1.85[186] | 1.94[187] | -3.72[188] |
28 | PIK3CG | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | [189] | [190] | [191] | 0.85[192] | -3.89[193] | 3.89[194] | |
29 | BDNF | Brain-derived neurotrophic factor | [195] | -1.94[196] | -4.83[197] | -2.96[198] | 6.25[199] | 5.16[200] | 1.89[201] |
30 | TRPC6 | Short transient receptor potential channel 6 | [202] | -1.19[203] | 0.25[204] | 0.90[205] | 0.37[206] | -1.18[207] | 3.07[208] |
31 | GRIN1 | Glutamate receptor ionotropic, NMDA 1 | [209] | [210] | [211] | [212] | [213] | [214] | [215] |
32 | TRPC3 | Short transient receptor potential channel 3 | [216] | [217] | [218] | [219] | [220] | [221] | [222] |
33 | NTRK2 | BDNF/NT-3 growth factors receptor | [223] | [224] | [225] | [226] | [227] | [228] | [229] |