WP_ATM_SIGNALING_PATHWAY | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | NFKBIA | NF-kappa-B inhibitor alpha | [1] | -1.22[2] | -3.26[3] | -3.41[4] | -3.53[5] | -2.10[6] | -0.95[7] |
2 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | [8] | -2.63[9] | -3.96[10] | -3.54[11] | -3.99[12] | -2.72[13] | -2.83[14] |
3 | JUN | Transcription factor AP-1 | [15] | -0.65[16] | -2.45[17] | -1.95[18] | -1.71[19] | -1.60[20] | -1.63[21] |
4 | CDKN1A | Cyclin-dependent kinase inhibitor 1 | [22] | 0.68[23] | -0.97[24] | -3.42[25] | -1.99[26] | 0.10[27] | -1.65[28] |
5 | IKBKG | NF-kappa-B essential modulator | [29] | -1.05[30] | -1.16[31] | -3.17[32] | -0.86[33] | -2.53[34] | -0.42[35] |
6 | BID | BH3-interacting domain death agonist | [36] | -0.43[37] | -0.58[38] | -0.73[39] | -0.30[40] | -1.29[41] | 0.36[42] |
7 | CDK2 | Cyclin-dependent kinase 2 | [43] | -0.58[44] | -0.66[45] | -0.06[46] | -0.03[47] | 0.11[48] | -2.00[49] |
8 | CRADD | Death domain-containing protein CRADD | [50] | -2.30[51] | -1.24[52] | -3.44[53] | -2.60[54] | -3.71[55] | -0.65[56] |
9 | CCNB1 | G2/mitotic-specific cyclin-B1 | [57] | 1.68[58] | 1.67[59] | 2.08[60] | 1.60[61] | 2.12[62] | -2.16[63] |
10 | ATF2 | Cyclic AMP-dependent transcription factor ATF-2 | [64] | 0.48[65] | 1.27[66] | 1.73[67] | 0.77[68] | 0.09[69] | 1.20[70] |
11 | TLK1 | Serine/threonine-protein kinase tousled-like 1 | [71] | -0.40[72] | 0.93[73] | 0.49[74] | 0.77[75] | -0.37[76] | 1.47[77] |
12 | MDM2 | E3 ubiquitin-protein ligase Mdm2 | [78] | 1.95[79] | 3.11[80] | 0.58[81] | 0.50[82] | 0.92[83] | 2.35[84] |
13 | NBN | Nibrin | [85] | -0.58[86] | 0.35[87] | 0.33[88] | 1.50[89] | 0.16[90] | 1.45[91] |
14 | CDK1 | Cyclin-dependent kinase 1 | [92] | 1.09[93] | 2.90[94] | 1.87[95] | 2.26[96] | 2.62[97] | -2.29[98] |
15 | CHEK2 | Serine/threonine-protein kinase Chk2 | [99] | -0.06[100] | 0.13[101] | 0.76[102] | -0.26[103] | -1.09[104] | -3.10[105] |
16 | TP53 | Cellular tumor antigen p53 | [106] | 1.47[107] | 0.78[108] | 1.78[109] | 1.28[110] | 0.49[111] | 0.14[112] |
17 | RAD51 | DNA repair protein RAD51 homolog 1 | [113] | -0.42[114] | -0.85[115] | -0.52[116] | -0.19[117] | -0.68[118] | -3.76[119] |
18 | MAPK9 | Mitogen-activated protein kinase 9 | [120] | 1.07[121] | 1.04[122] | 1.33[123] | 1.71[124] | 0.71[125] | 0.69[126] |
19 | SMC1A | Structural maintenance of chromosomes protein 1A | [127] | 1.94[128] | 1.55[129] | 2.79[130] | 3.01[131] | 3.39[132] | 2.63[133] |
20 | RIPK1 | Receptor-interacting serine/threonine-protein kinase 1 | [134] | 0.13[135] | 0.03[136] | -0.05[137] | 1.07[138] | 0.14[139] | 1.67[140] |
21 | ABL1 | Tyrosine-protein kinase ABL1 | [141] | 2.07[142] | 1.21[143] | 2.24[144] | 2.06[145] | 2.29[146] | 1.12[147] |
22 | RAD50 | DNA repair protein RAD50 | [148] | -0.01[149] | 1.87[150] | 1.25[151] | 1.26[152] | 1.29[153] | 2.39[154] |
23 | CCNE1 | G1/S-specific cyclin-E1 | [155] | 1.08[156] | 0.93[157] | -0.65[158] | -0.41[159] | -0.27[160] | -4.45[161] |
24 | CHEK1 | Serine/threonine-protein kinase Chk1 | [162] | 1.37[163] | 1.48[164] | 1.28[165] | 2.14[166] | 1.92[167] | -1.84[168] |
25 | CDC25A | M-phase inducer phosphatase 1 | [169] | 1.26[170] | 1.65[171] | 2.23[172] | 0.34[173] | 1.34[174] | -2.48[175] |
26 | MDC1 | Mediator of DNA damage checkpoint protein 1 | [176] | 2.33[177] | 2.48[178] | 3.05[179] | 2.88[180] | 2.35[181] | 1.63[182] |
27 | RAD9A | Cell cycle checkpoint control protein RAD9A | [183] | -0.09[184] | -0.06[185] | 1.98[186] | 2.32[187] | -0.31[188] | 0.01[189] |
28 | BRCA1 | Breast cancer type 1 susceptibility protein | [190] | 1.51[191] | 2.50[192] | 3.13[193] | 2.14[194] | 2.21[195] | 1.86[196] |
29 | CREB1 | Cyclic AMP-responsive element-binding protein 1 | [197] | 1.56[198] | 2.46[199] | 3.19[200] | 2.53[201] | 2.02[202] | 2.52[203] |
30 | CASP2 | Caspase-2 | [204] | 1.53[205] | 0.92[206] | 1.95[207] | 1.87[208] | 1.84[209] | 1.77[210] |
31 | TP53BP1 | TP53-binding protein 1 | [211] | 2.42[212] | 1.67[213] | 2.87[214] | 3.93[215] | 2.93[216] | 2.46[217] |
32 | FANCD2 | Fanconi anemia group D2 protein | [218] | 2.27[219] | 2.16[220] | 3.46[221] | 2.41[222] | 2.64[223] | 0.21[224] |
33 | ATM | Serine-protein kinase ATM | [225] | 2.87[226] | 4.22[227] | 4.18[228] | 4.15[229] | 3.17[230] | 5.17[231] |
34 | MDM4 | Protein Mdm4 | [232] | 1.48[233] | 2.24[234] | 2.90[235] | 2.29[236] | 1.71[237] | 4.74[238] |
35 | CDC25C | M-phase inducer phosphatase 3 | [239] | 1.77[240] | 2.67[241] | 2.93[242] | 1.92[243] | 2.31[244] | -1.23[245] |
36 | TP73 | Tumor protein p73 | [246] | 0.56[247] | 2.86[248] | 2.02[249] | 0.67[250] | 1.35[251] | 0.83[252] |
37 | AP3B2 | AP-3 complex subunit beta-2 | [253] | -1.00[254] | [255] | 0.21[256] | 2.59[257] | 3.93[258] | 1.99[259] |
38 | PIDD1 | p53-induced death domain-containing protein 1 | [260] | [261] | [262] | [263] | [264] | [265] | [266] |
39 | MRE11 | Double-strand break repair protein MRE11 | [267] | [268] | [269] | [270] | [271] | [272] | [273] |
40 | H2AX | [274] | [275] | [276] | [277] | [278] | [279] | [280] |