WP_APOPTOSIS_MODULATION_AND_SIGNALING | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | HSPA1A | Heat shock 70 kDa protein 1A | [1] | -5.27[2] | -4.91[3] | -5.94[4] | -4.27[5] | -5.92[6] | -5.07[7] |
2 | NFKBIA | NF-kappa-B inhibitor alpha | [8] | -0.74[9] | -2.51[10] | -2.81[11] | -2.86[12] | -1.18[13] | -0.46[14] |
3 | CAPNS1 | Calpain small subunit 1 | [15] | -0.24[16] | -0.47[17] | -0.54[18] | -0.13[19] | -0.32[20] | -1.78[21] |
4 | BNIP3 | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 | [22] | 0.30[23] | 1.75[24] | 1.63[25] | -0.26[26] | -0.39[27] | 0.88[28] |
5 | MCL1 | Induced myeloid leukemia cell differentiation protein Mcl-1 | [29] | 0.16[30] | 0.14[31] | 0.40[32] | 0.81[33] | 1.10[34] | 0.76[35] |
6 | JUN | Transcription factor AP-1 | [36] | -0.18[37] | -1.69[38] | -1.35[39] | -1.04[40] | -0.68[41] | -1.13[42] |
7 | FOS | Proto-oncogene c-Fos | [43] | -5.70[44] | -4.41[45] | -5.00[46] | -5.51[47] | -4.65[48] | -0.63[49] |
8 | AIFM1 | Apoptosis-inducing factor 1, mitochondrial | [50] | -0.86[51] | -1.17[52] | 0.03[53] | -0.92[54] | -1.49[55] | 0.51[56] |
9 | CASP4 | Caspase-4 | [57] | -0.98[58] | -1.32[59] | -0.64[60] | -0.69[61] | -0.92[62] | -1.60[63] |
10 | TNFRSF1A | Tumor necrosis factor receptor superfamily member 1A | [64] | -0.16[65] | -0.59[66] | -0.22[67] | 1.03[68] | 1.00[69] | 0.75[70] |
11 | BCL2L1 | Bcl-2-like protein 1 | [71] | 2.45[72] | 1.87[73] | 2.90[74] | 0.04[75] | 0.23[76] | -0.14[77] |
12 | PTRH2 | Peptidyl-tRNA hydrolase 2, mitochondrial | [78] | -1.30[79] | -1.02[80] | -1.51[81] | -2.95[82] | -2.10[83] | -1.52[84] |
13 | PEA15 | Astrocytic phosphoprotein PEA-15 | [85] | -0.14[86] | -1.38[87] | -1.80[88] | 2.01[89] | 1.64[90] | -1.22[91] |
14 | BAX | Apoptosis regulator BAX | [92] | 0.64[93] | -0.13[94] | -0.51[95] | -0.94[96] | -0.77[97] | -3.28[98] |
15 | BOK | Bcl-2-related ovarian killer protein | [99] | 0.19[100] | 0.64[101] | -2.79[102] | -1.24[103] | -1.82[104] | 0.99[105] |
16 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | [106] | 1.73[107] | 1.15[108] | 0.20[109] | 1.46[110] | 1.62[111] | -0.01[112] |
17 | TNFSF10 | Tumor necrosis factor ligand superfamily member 10 | [113] | -4.16[114] | -2.53[115] | 0.17[116] | -1.81[117] | -5.27[118] | -0.72[119] |
18 | TOLLIP | Toll-interacting protein | [120] | 0.04[121] | -0.04[122] | 0.03[123] | -0.37[124] | -1.42[125] | 1.82[126] |
19 | BAD | Bcl2-associated agonist of cell death | [127] | -1.36[128] | -1.20[129] | -2.07[130] | -0.41[131] | -0.21[132] | -0.75[133] |
20 | CFLAR | CASP8 and FADD-like apoptosis regulator | [134] | -0.08[135] | 0.70[136] | 0.33[137] | 0.12[138] | 0.07[139] | 2.24[140] |
21 | DIABLO | Diablo homolog, mitochondrial | [141] | 0.16[142] | 0.45[143] | 0.22[144] | 0.33[145] | -0.12[146] | -0.06[147] |
22 | IL1R1 | Interleukin-1 receptor type 1 | [148] | -0.26[149] | -0.59[150] | -1.16[151] | -0.16[152] | 2.30[153] | 1.45[154] |
23 | DAXX | Death domain-associated protein 6 | [155] | 0.48[156] | 0.36[157] | 0.04[158] | 0.81[159] | 0.48[160] | -0.29[161] |
24 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | [162] | -2.81[163] | -1.75[164] | -4.07[165] | -2.46[166] | 1.10[167] | -1.40[168] |
25 | BAG3 | BAG family molecular chaperone regulator 3 | [169] | -0.41[170] | -0.37[171] | -1.21[172] | 0.49[173] | 0.63[174] | -1.06[175] |
26 | TNFRSF10 | Tumor necrosis factor receptor superfamily member 10B | [176] | 2.30[177] | 2.20[178] | 2.08[179] | 0.33[180] | 1.73[181] | 0.71[182] |
27 | CYCS | Cytochrome c | [183] | 1.64[184] | 1.87[185] | 2.02[186] | 1.99[187] | 2.19[188] | 1.99[189] |
28 | CASP3 | Caspase-3 | [190] | 0.44[191] | 1.15[192] | -1.32[193] | -0.24[194] | 0.55[195] | -0.13[196] |
29 | ENDOG | Endonuclease G, mitochondrial | [197] | -2.37[198] | -2.08[199] | -2.71[200] | -3.17[201] | -3.24[202] | -2.38[203] |
30 | BID | BH3-interacting domain death agonist | [204] | 0.04[205] | 0.17[206] | -0.13[207] | 0.37[208] | -0.37[209] | 0.85[210] |
31 | MYD88 | Myeloid differentiation primary response protein MyD88 | [211] | 0.12[212] | 0.21[213] | -0.28[214] | -0.38[215] | -0.29[216] | 1.47[217] |
32 | CRADD | Death domain-containing protein CRADD | [218] | -1.83[219] | -0.49[220] | -2.84[221] | -1.93[222] | -2.79[223] | -0.16[224] |
33 | DFFA | DNA fragmentation factor subunit alpha | [225] | 0.08[226] | 0.45[227] | 0.21[228] | 0.39[229] | 0.22[230] | 0.40[231] |
34 | FAS | Tumor necrosis factor receptor superfamily member 6 | [232] | -1.29[233] | -0.48[234] | -8.42[235] | -1.08[236] | -0.77[237] | -1.05[238] |
35 | CASP7 | Caspase-7 | [239] | 0.00[240] | -0.33[241] | 0.18[242] | -0.24[243] | -0.24[244] | 0.19[245] |
36 | BIRC2 | Baculoviral IAP repeat-containing protein 2 | [246] | 0.55[247] | 1.54[248] | 0.56[249] | 1.08[250] | 1.66[251] | 1.40[252] |
37 | AIFM2 | Apoptosis-inducing factor 2 | [253] | 2.57[254] | 2.01[255] | -1.78[256] | 0.90[257] | 0.54[258] | 0.43[259] |
38 | FADD | FAS-associated death domain protein | [260] | 0.35[261] | -0.33[262] | 0.47[263] | 2.59[264] | 0.20[265] | -1.10[266] |
39 | CASP8 | Caspase-8 | [267] | 0.33[268] | 0.93[269] | 0.18[270] | 0.58[271] | -0.37[272] | -0.75[273] |
40 | CASP6 | Caspase-6 | [274] | -0.96[275] | -0.72[276] | -0.28[277] | -0.29[278] | -0.82[279] | -0.21[280] |
41 | TNFRSF10 | Tumor necrosis factor receptor superfamily member 10A | [281] | -1.13[282] | -1.57[283] | -1.47[284] | -2.36[285] | -2.82[286] | -1.04[287] |
42 | BIRC5 | Baculoviral IAP repeat-containing protein 5 | [288] | 1.89[289] | 2.36[290] | 2.40[291] | 1.34[292] | 1.96[293] | -1.64[294] |
43 | MAPK8 | Mitogen-activated protein kinase 8 | [295] | -1.13[296] | 0.31[297] | -0.75[298] | -0.24[299] | -0.59[300] | 0.16[301] |
44 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | [302] | 0.98[303] | 0.69[304] | 0.55[305] | 0.41[306] | 1.12[307] | 1.12[308] |
45 | HTRA2 | Serine protease HTRA2, mitochondrial | [309] | 0.35[310] | 1.30[311] | -0.08[312] | 0.49[313] | -0.05[314] | -0.18[315] |
46 | BAK1 | Bcl-2 homologous antagonist/killer | [316] | 1.20[317] | 0.77[318] | 0.82[319] | 1.85[320] | 1.12[321] | -1.12[322] |
47 | BCL2A1 | Bcl-2-related protein A1 | [323] | -4.46[324] | -6.26[325] | -10.58[326] | -8.60[327] | -5.26[328] | -4.22[329] |
48 | TNFRSF10 | Tumor necrosis factor receptor superfamily member 10D | [330] | 2.06[331] | 2.13[332] | 2.76[333] | 1.08[334] | 0.03[335] | 0.69[336] |
49 | TRADD | Tumor necrosis factor receptor type 1-associated DEATH domain protein | 0.05[337] | -0.08[338] | -1.17[339] | -0.32[340] | -0.68[341] | 0.09[342] | |
50 | TP53 | Cellular tumor antigen p53 | [343] | 1.95[344] | 1.54[345] | 2.37[346] | 1.95[347] | 1.41[348] | 0.63[349] |
51 | IL1R2 | Interleukin-1 receptor type 2 | [350] | -2.12[351] | -2.14[352] | -6.03[353] | -4.93[354] | -3.03[355] | -0.16[356] |
52 | BCL2L2 | Bcl-2-like protein 2 | [357] | 2.12[358] | 0.84[359] | 0.70[360] | 0.98[361] | 1.27[362] | 1.06[363] |
53 | RIPK1 | Receptor-interacting serine/threonine-protein kinase 1 | [364] | 0.60[365] | 0.79[366] | 0.55[367] | 1.74[368] | 1.05[369] | 2.16[370] |
54 | MAPK3 | Mitogen-activated protein kinase 3 | [371] | 2.16[372] | 2.23[373] | 2.35[374] | 1.08[375] | 0.90[376] | -0.37[377] |
55 | BBC3 | Bcl-2-binding component 3 | [378] | 1.05[379] | 0.96[380] | 0.54[381] | -2.14[382] | -1.59[383] | -3.66[384] |
56 | CASP1 | Caspase-1 | [385] | -2.72[386] | -6.09[387] | -4.49[388] | 0.74[389] | 0.69[390] | -0.06[391] |
57 | TNFRSF1B | Tumor necrosis factor receptor superfamily member 1B | [392] | -1.81[393] | -5.90[394] | -6.48[395] | -2.71[396] | -1.28[397] | 2.13[398] |
58 | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | [399] | 0.83[400] | 0.92[401] | 1.10[402] | 0.92[403] | 0.80[404] | 1.86[405] |
59 | BMF | Bcl-2-modifying factor | [406] | 1.13[407] | 1.53[408] | 2.66[409] | 4.29[410] | -1.27[411] | -0.12[412] |
60 | XIAP | E3 ubiquitin-protein ligase XIAP | [413] | 1.83[414] | 2.45[415] | 2.98[416] | 3.25[417] | 2.47[418] | 3.36[419] |
61 | CASP9 | Caspase-9 | [420] | 0.47[421] | 1.45[422] | 0.65[423] | 0.91[424] | 0.01[425] | 0.14[426] |
62 | BCL2L10 | Bcl-2-like protein 10 | [427] | -10.85[428] | -9.48[429] | -6.87[430] | -6.74[431] | -5.20[432] | -0.96[433] |
63 | PMAIP1 | Phorbol-12-myristate-13-acetate-induced protein 1 | [434] | 0.36[435] | -2.98[436] | 0.65[437] | 2.94[438] | 1.96[439] | -3.62[440] |
64 | MAP3K14 | Mitogen-activated protein kinase kinase kinase 14 | [441] | -0.09[442] | 0.40[443] | -0.69[444] | 2.73[445] | 1.51[446] | 1.55[447] |
65 | MADD | MAP kinase-activating death domain protein | [448] | 2.87[449] | 2.76[450] | 3.25[451] | 2.75[452] | 2.24[453] | 3.24[454] |
66 | CASP10 | Caspase-10 | [455] | 1.53[456] | 2.85[457] | 1.88[458] | 1.08[459] | 0.93[460] | 1.74[461] |
67 | BCL2L11 | Bcl-2-like protein 11 | [462] | 1.82[463] | 1.85[464] | 2.25[465] | 2.53[466] | 1.29[467] | 2.66[468] |
68 | CASP2 | Caspase-2 | [469] | 2.01[470] | 1.67[471] | 2.55[472] | 2.53[473] | 2.76[474] | 2.26[475] |
69 | APAF1 | Apoptotic protease-activating factor 1 | [476] | 1.97[477] | 2.42[478] | 2.75[479] | 3.29[480] | 2.18[481] | 2.16[482] |
70 | TRAF3 | TNF receptor-associated factor 3 | [483] | 3.20[484] | 2.64[485] | 2.33[486] | 3.49[487] | 3.69[488] | 2.60[489] |
71 | MAP3K5 | Mitogen-activated protein kinase kinase kinase 5 | [490] | -3.99[491] | -6.89[492] | -0.92[493] | -1.21[494] | 2.98[495] | 3.73[496] |
72 | BIK | Bcl-2-interacting killer | [497] | 0.78[498] | 0.88[499] | -3.27[500] | -1.83[501] | -2.77[502] | -2.05[503] |
73 | TRAF6 | TNF receptor-associated factor 6 | [504] | 1.40[505] | 1.32[506] | 1.96[507] | 2.32[508] | 1.57[509] | 3.58[510] |
74 | DFFB | DNA fragmentation factor subunit beta | [511] | 1.20[512] | 2.15[513] | 1.58[514] | 1.43[515] | 0.89[516] | 1.31[517] |
75 | NAIP | Baculoviral IAP repeat-containing protein 1 | [518] | 1.44[519] | 3.23[520] | 3.29[521] | 2.57[522] | 1.36[523] | 4.84[524] |
76 | TNFRSF10 | Tumor necrosis factor receptor superfamily member 10C | [525] | -1.71[526] | -0.78[527] | -2.28[528] | -2.66[529] | -3.50[530] | 1.08[531] |
77 | TNFRSF6B | Tumor necrosis factor receptor superfamily member 6B | [532] | -4.99[533] | -4.20[534] | -4.87[535] | -5.22[536] | -2.08[537] | -3.60[538] |
78 | CDKN2A | Cyclin-dependent kinase inhibitor 2A | [539] | 4.39[540] | 2.19[541] | 5.67[542] | 5.87[543] | 7.44[544] | -1.48[545] |
79 | TNFRSF25 | Tumor necrosis factor receptor superfamily member 25 | [546] | 1.19[547] | 2.33[548] | 0.61[549] | -0.26[550] | 1.49[551] | 1.46[552] |
80 | PRKD1 | Serine/threonine-protein kinase D1 | [553] | 2.23[554] | 2.16[555] | 4.62[556] | 5.30[557] | 5.07[558] | 3.82[559] |
81 | BLK | Tyrosine-protein kinase Blk | [560] | -3.22[561] | -2.86[562] | [563] | [564] | -2.18[565] | 2.86[566] |
82 | BCL2 | Apoptosis regulator Bcl-2 | [567] | -2.54[568] | 2.89[569] | -4.44[570] | 2.43[571] | 1.94[572] | 3.90[573] |
83 | PTPN13 | Tyrosine-protein phosphatase non-receptor type 13 | [574] | -2.92[575] | [576] | -3.47[577] | 7.22[578] | 6.50[579] | 5.33[580] |
84 | FASLG | Tumor necrosis factor ligand superfamily member 6 | [581] | -3.50[582] | -1.60[583] | -5.50[584] | [585] | [586] | 1.26[587] |
85 | SEPTIN4 | [588] | [589] | [590] | [591] | [592] | [593] | [594] | |
86 | HRK | Activator of apoptosis harakiri | [595] | [596] | [597] | [598] | [599] | [600] | [601] |
87 | MIR718 | [602] | [603] | [604] | [605] | [606] | [607] | [608] | |
88 | MIR7846 | [609] | [610] | [611] | [612] | [613] | [614] | [615] | |
89 | PIDD1 | p53-induced death domain-containing protein 1 | [616] | [617] | [618] | [619] | [620] | [621] | [622] |
90 | MIR3191 | [623] | [624] | [625] | [626] | [627] | [628] | [629] | |
91 | BIRC7 | Baculoviral IAP repeat-containing protein 7 | [630] | [631] | [632] | [633] | [634] | [635] | [636] |