WP_APOPTOSIS | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | IGF2 | Insulin-like growth factor II | [1] | -3.05[2] | -0.93[3] | -3.49[4] | -13.12[5] | -11.40[6] | -6.82[7] |
2 | NFKBIA | NF-kappa-B inhibitor alpha | [8] | -1.13[9] | -2.91[10] | -3.07[11] | -3.22[12] | -1.51[13] | -0.94[14] |
3 | MCL1 | Induced myeloid leukemia cell differentiation protein Mcl-1 | [15] | -0.23[16] | -0.27[17] | 0.14[18] | 0.46[19] | 0.77[20] | 0.28[21] |
4 | JUN | Transcription factor AP-1 | [22] | -0.57[23] | -2.10[24] | -1.61[25] | -1.40[26] | -1.00[27] | -1.61[28] |
5 | AKT1 | RAC-alpha serine/threonine-protein kinase | [29] | 0.00[30] | -0.22[31] | -1.08[32] | 0.25[33] | 0.10[34] | -0.05[35] |
6 | CASP4 | Caspase-4 | [36] | -1.37[37] | -1.72[38] | -0.90[39] | -1.05[40] | -1.24[41] | -2.08[42] |
7 | TNFRSF1A | Tumor necrosis factor receptor superfamily member 1A | [43] | -0.55[44] | -1.00[45] | -0.48[46] | 0.67[47] | 0.68[48] | 0.28[49] |
8 | MYC | Myc proto-oncogene protein | [50] | 0.35[51] | 0.03[52] | -1.78[53] | -2.48[54] | -0.29[55] | -1.80[56] |
9 | BCL2L1 | Bcl-2-like protein 1 | [57] | 2.06[58] | 1.46[59] | 2.64[60] | -0.31[61] | -0.10[62] | -0.62[63] |
10 | BAX | Apoptosis regulator BAX | [64] | 0.25[65] | -0.53[66] | -0.77[67] | -1.30[68] | -1.09[69] | -3.76[70] |
11 | IKBKG | NF-kappa-B essential modulator | [71] | -0.97[72] | -0.81[73] | -2.84[74] | -0.54[75] | -1.93[76] | -0.41[77] |
12 | BOK | Bcl-2-related ovarian killer protein | [78] | -0.20[79] | 0.23[80] | -3.06[81] | -1.59[82] | -2.14[83] | 0.51[84] |
13 | TNFSF10 | Tumor necrosis factor ligand superfamily member 10 | [85] | -4.55[86] | -2.93[87] | -0.09[88] | -2.17[89] | -5.59[90] | -1.19[91] |
14 | IGF1 | Insulin-like growth factor I | [92] | -8.50[93] | -9.42[94] | -7.42[95] | -1.23[96] | -9.24[97] | 1.12[98] |
15 | BAD | Bcl2-associated agonist of cell death | [99] | -1.75[100] | -1.60[101] | -2.34[102] | -0.76[103] | -0.53[104] | -1.22[105] |
16 | CFLAR | CASP8 and FADD-like apoptosis regulator | [106] | -0.46[107] | 0.30[108] | 0.07[109] | -0.24[110] | -0.25[111] | 1.76[112] |
17 | DIABLO | Diablo homolog, mitochondrial | [113] | -0.23[114] | 0.05[115] | -0.04[116] | -0.03[117] | -0.44[118] | -0.53[119] |
18 | RELA | Transcription factor p65 | [120] | 0.05[121] | -0.43[122] | -0.08[123] | 0.25[124] | -0.02[125] | -0.68[126] |
19 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | [127] | -3.19[128] | -2.16[129] | -4.33[130] | -2.82[131] | 0.78[132] | -1.88[133] |
20 | TNFRSF10 | Tumor necrosis factor receptor superfamily member 10B | [134] | 1.91[135] | 1.80[136] | 1.82[137] | -0.03[138] | 1.41[139] | 0.23[140] |
21 | CYCS | Cytochrome c | [141] | 1.25[142] | 1.47[143] | 1.76[144] | 1.64[145] | 1.87[146] | 1.52[147] |
22 | NFKBIB | NF-kappa-B inhibitor beta | [148] | -1.24[149] | -1.40[150] | -0.85[151] | -1.51[152] | -1.34[153] | -1.53[154] |
23 | TNFRSF21 | Tumor necrosis factor receptor superfamily member 21 | [155] | 1.85[156] | -0.55[157] | -0.10[158] | 1.46[159] | 1.21[160] | -2.49[161] |
24 | CASP3 | Caspase-3 | [162] | 0.06[163] | 0.75[164] | -1.58[165] | -0.59[166] | 0.23[167] | -0.61[168] |
25 | BID | BH3-interacting domain death agonist | [169] | -0.35[170] | -0.23[171] | -0.39[172] | 0.02[173] | -0.70[174] | 0.37[175] |
26 | CRADD | Death domain-containing protein CRADD | [176] | -2.22[177] | -0.89[178] | -3.10[179] | -2.29[180] | -3.11[181] | -0.64[182] |
27 | IRF7 | Interferon regulatory factor 7 | [183] | -9.31[184] | -8.30[185] | -6.98[186] | -2.84[187] | -3.28[188] | 0.13[189] |
28 | DFFA | DNA fragmentation factor subunit alpha | [190] | -0.31[191] | 0.05[192] | -0.05[193] | 0.04[194] | -0.11[195] | -0.07[196] |
29 | FAS | Tumor necrosis factor receptor superfamily member 6 | [197] | -1.68[198] | -0.89[199] | -8.68[200] | -1.44[201] | -1.09[202] | -1.53[203] |
30 | CASP7 | Caspase-7 | [204] | -0.39[205] | -0.74[206] | -0.08[207] | -0.59[208] | -0.56[209] | -0.29[210] |
31 | BIRC2 | Baculoviral IAP repeat-containing protein 2 | [211] | 0.16[212] | 1.13[213] | 0.30[214] | 0.72[215] | 1.34[216] | 0.93[217] |
32 | IRF3 | Interferon regulatory factor 3 | [218] | 0.22[219] | 0.41[220] | 1.35[221] | 0.66[222] | 0.08[223] | -0.98[224] |
33 | FADD | FAS-associated death domain protein | [225] | -0.04[226] | -0.73[227] | 0.21[228] | 2.24[229] | -0.12[230] | -1.57[231] |
34 | IRF2 | Interferon regulatory factor 2 | [232] | -1.17[233] | -0.77[234] | -1.71[235] | -0.79[236] | -0.90[237] | -0.14[238] |
35 | CASP8 | Caspase-8 | [239] | -0.06[240] | 0.53[241] | -0.08[242] | 0.22[243] | -0.70[244] | -1.22[245] |
36 | CASP6 | Caspase-6 | [246] | -1.35[247] | -1.12[248] | -0.54[249] | -0.65[250] | -1.14[251] | -0.68[252] |
37 | TRAF1 | TNF receptor-associated factor 1 | [253] | -4.50[254] | -4.61[255] | -3.55[256] | -3.23[257] | -2.84[258] | -2.70[259] |
38 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [260] | -0.55[261] | -0.42[262] | 0.89[263] | 2.37[264] | 1.70[265] | 3.20[266] |
39 | BIRC5 | Baculoviral IAP repeat-containing protein 5 | [267] | 1.50[268] | 1.96[269] | 2.14[270] | 0.99[271] | 1.64[272] | -2.12[273] |
40 | MDM2 | E3 ubiquitin-protein ligase Mdm2 | [274] | 2.03[275] | 3.47[276] | 0.92[277] | 0.82[278] | 1.52[279] | 2.36[280] |
41 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | [281] | 0.59[282] | 0.28[283] | 0.29[284] | 0.06[285] | 0.79[286] | 0.65[287] |
42 | SCAF11 | Protein SCAF11 | [288] | 0.12[289] | 2.13[290] | 1.77[291] | 2.16[292] | 1.44[293] | 2.96[294] |
43 | IRF1 | Interferon regulatory factor 1 | [295] | -0.59[296] | -1.04[297] | -0.68[298] | 1.56[299] | 0.38[300] | 1.03[301] |
44 | BAK1 | Bcl-2 homologous antagonist/killer | [302] | 0.81[303] | 0.37[304] | 0.55[305] | 1.49[306] | 0.80[307] | -1.59[308] |
45 | TRADD | Tumor necrosis factor receptor type 1-associated DEATH domain protein | -0.34[309] | -0.49[310] | -1.44[311] | -0.68[312] | -1.00[313] | -0.39[314] | |
46 | TP53 | Cellular tumor antigen p53 | [315] | 1.56[316] | 1.14[317] | 2.11[318] | 1.60[319] | 1.09[320] | 0.16[321] |
47 | MAP2K4 | Dual specificity mitogen-activated protein kinase kinase 4 | [322] | 0.63[323] | 1.27[324] | 0.69[325] | 1.51[326] | 0.73[327] | 1.26[328] |
48 | TRAF2 | TNF receptor-associated factor 2 | [329] | 0.15[330] | 0.23[331] | 0.18[332] | 0.43[333] | 0.26[334] | -0.60[335] |
49 | BNIP3L | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like | [336] | 2.21[337] | 2.18[338] | 2.95[339] | 2.70[340] | 1.96[341] | 1.83[342] |
50 | BCL2L2 | Bcl-2-like protein 2 | [343] | 1.73[344] | 0.43[345] | 0.44[346] | 0.62[347] | 0.95[348] | 0.58[349] |
51 | RIPK1 | Receptor-interacting serine/threonine-protein kinase 1 | [350] | 0.21[351] | 0.39[352] | 0.28[353] | 1.38[354] | 0.73[355] | 1.68[356] |
52 | BBC3 | Bcl-2-binding component 3 | [357] | 0.66[358] | 0.56[359] | 0.27[360] | -2.50[361] | -1.92[362] | -4.14[363] |
53 | IRF6 | Interferon regulatory factor 6 | [364] | -6.10[365] | -6.45[366] | -7.15[367] | -3.14[368] | -3.17[369] | 1.92[370] |
54 | NFKBIE | NF-kappa-B inhibitor epsilon | [371] | -0.04[372] | 0.90[373] | -0.75[374] | -0.48[375] | -0.19[376] | -1.07[377] |
55 | CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha | [378] | 0.82[379] | 2.06[380] | 2.24[381] | 0.96[382] | 1.59[383] | 1.71[384] |
56 | CASP1 | Caspase-1 | [385] | -3.11[386] | -6.50[387] | -4.75[388] | 0.39[389] | 0.37[390] | -0.53[391] |
57 | TNFRSF1B | Tumor necrosis factor receptor superfamily member 1B | [392] | -2.20[393] | -6.30[394] | -6.75[395] | -3.07[396] | -1.60[397] | 1.66[398] |
58 | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | [399] | 0.44[400] | 0.52[401] | 0.84[402] | 0.56[403] | 0.48[404] | 1.38[405] |
59 | XIAP | E3 ubiquitin-protein ligase XIAP | [406] | 1.44[407] | 2.04[408] | 2.72[409] | 2.90[410] | 2.14[411] | 2.88[412] |
60 | CASP9 | Caspase-9 | [413] | 0.08[414] | 1.05[415] | 0.39[416] | 0.55[417] | -0.31[418] | -0.34[419] |
61 | PMAIP1 | Phorbol-12-myristate-13-acetate-induced protein 1 | [420] | -0.03[421] | -3.38[422] | 0.39[423] | 2.59[424] | 1.63[425] | -4.10[426] |
62 | CASP10 | Caspase-10 | [427] | 1.14[428] | 2.45[429] | 1.62[430] | 0.73[431] | 0.61[432] | 1.26[433] |
63 | BCL2L11 | Bcl-2-like protein 11 | [434] | 1.43[435] | 1.45[436] | 1.99[437] | 2.17[438] | 0.97[439] | 2.18[440] |
64 | CASP2 | Caspase-2 | [441] | 1.62[442] | 1.27[443] | 2.29[444] | 2.18[445] | 2.44[446] | 1.78[447] |
65 | HELLS | Lymphoid-specific helicase | [448] | 1.28[449] | 2.12[450] | 3.49[451] | 1.13[452] | 2.33[453] | -0.71[454] |
66 | APAF1 | Apoptotic protease-activating factor 1 | [455] | 1.58[456] | 2.02[457] | 2.49[458] | 2.93[459] | 1.86[460] | 1.69[461] |
67 | TRAF3 | TNF receptor-associated factor 3 | [462] | 2.81[463] | 2.24[464] | 2.07[465] | 3.13[466] | 3.37[467] | 2.12[468] |
68 | MAP3K1 | Mitogen-activated protein kinase kinase kinase 1 | [469] | 2.57[470] | 2.30[471] | 2.25[472] | 2.63[473] | 1.33[474] | 3.00[475] |
69 | IRF5 | Interferon regulatory factor 5 | [476] | 0.22[477] | 0.02[478] | -0.93[479] | 0.66[480] | -1.78[481] | 1.18[482] |
70 | IGF1R | Insulin-like growth factor 1 receptor | [483] | 4.66[484] | 3.99[485] | 2.88[486] | 4.78[487] | 4.15[488] | 2.29[489] |
71 | DFFB | DNA fragmentation factor subunit beta | [490] | 0.81[491] | 1.75[492] | 1.32[493] | 1.07[494] | 0.57[495] | 0.83[496] |
72 | PRF1 | Perforin-1 | [497] | 3.88[498] | -3.33[499] | -6.81[500] | -7.40[501] | -6.22[502] | 1.65[503] |
73 | IRF4 | Interferon regulatory factor 4 | [504] | -4.91[505] | -4.55[506] | -4.96[507] | -4.00[508] | -5.29[509] | 0.81[510] |
74 | CDKN2A | Cyclin-dependent kinase inhibitor 2A | [511] | 4.00[512] | 1.79[513] | 5.41[514] | 5.51[515] | 7.12[516] | -1.96[517] |
75 | GZMB | Granzyme B | [518] | -4.70[519] | [520] | [521] | [522] | [523] | -0.51[524] |
76 | TNFRSF25 | Tumor necrosis factor receptor superfamily member 25 | [525] | 0.80[526] | 1.93[527] | 0.35[528] | -0.62[529] | 1.17[530] | 0.98[531] |
77 | TP73 | Tumor protein p73 | [532] | 0.65[533] | 3.21[534] | 2.35[535] | 0.98[536] | 1.94[537] | 0.85[538] |
78 | TNF | Tumor necrosis factor | [539] | 1.02[540] | -1.10[541] | -5.48[542] | -1.92[543] | -5.31[544] | -1.69[545] |
79 | BCL2 | Apoptosis regulator Bcl-2 | [546] | -2.93[547] | 2.49[548] | -4.70[549] | 2.08[550] | 1.62[551] | 3.43[552] |
80 | TP63 | Tumor protein 63 | [553] | [554] | [555] | -1.92[556] | -1.07[557] | -4.82[558] | -1.28[559] |
81 | FASLG | Tumor necrosis factor ligand superfamily member 6 | [560] | -3.89[561] | -2.00[562] | -5.76[563] | [564] | [565] | 0.78[566] |
82 | LTA | Lymphotoxin-alpha | [567] | -3.46[568] | [569] | -2.80[570] | -0.55[571] | -2.98[572] | -1.64[573] |
83 | MAPK10 | Mitogen-activated protein kinase 10 | [574] | -1.56[575] | [576] | [577] | 9.21[578] | 4.78[579] | 7.44[580] |
84 | MIR3191 | [581] | [582] | [583] | [584] | [585] | [586] | [587] | |
85 | MIR7846 | [588] | [589] | [590] | [591] | [592] | [593] | [594] | |
86 | HRK | Activator of apoptosis harakiri | [595] | [596] | [597] | [598] | [599] | [600] | [601] |