WP_ANTIVIRAL_AND_ANTIINFLAMMATORY_EFFECTS_OF_NRF2_ON_SARSCOV2_PATHWA | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | GSTA2 | Glutathione S-transferase A2 | [1] | -6.61[2] | -8.90[3] | -4.24[4] | -10.22[5] | -11.82[6] | -2.46[7] |
2 | NFKBIA | NF-kappa-B inhibitor alpha | [8] | -0.92[9] | -2.51[10] | -2.62[11] | -4.29[12] | -0.47[13] | -0.17[14] |
3 | HMOX1 | Heme oxygenase 1 | [15] | -0.35[16] | -1.07[17] | -1.92[18] | -2.37[19] | -0.67[20] | -1.12[21] |
4 | NQO1 | NAD(P)H dehydrogenase [quinone] 1 | [22] | 2.88[23] | 2.77[24] | 2.66[25] | 3.32[26] | 1.42[27] | -4.27[28] |
5 | GCLC | Glutamate--cysteine ligase catalytic subunit | [29] | -0.23[30] | 0.34[31] | -0.61[32] | 0.17[33] | -0.60[34] | 1.38[35] |
6 | IKBKG | NF-kappa-B essential modulator | [36] | -0.76[37] | -0.40[38] | -2.38[39] | -1.62[40] | -0.90[41] | 0.36[42] |
7 | GCLM | Glutamate--cysteine ligase regulatory subunit | [43] | -0.84[44] | -1.40[45] | -0.67[46] | 0.07[47] | 0.19[48] | 0.13[49] |
8 | RELA | Transcription factor p65 | [50] | 0.26[51] | -0.03[52] | 0.37[53] | -0.83[54] | 1.02[55] | 0.09[56] |
9 | NFE2L2 | Nuclear factor erythroid 2-related factor 2 | [57] | 0.90[58] | 2.04[59] | 1.91[60] | -0.31[61] | 1.87[62] | 1.14[63] |
10 | KEAP1 | Kelch-like ECH-associated protein 1 | [64] | 0.34[65] | 0.45[66] | 0.45[67] | -1.59[68] | 1.34[69] | 1.52[70] |
11 | RXRA | Retinoic acid receptor RXR-alpha | [71] | 0.08[72] | 0.09[73] | 1.19[74] | -0.76[75] | 0.85[76] | 3.12[77] |
12 | CCL2 | C-C motif chemokine 2 | [78] | -13.26[79] | [80] | -12.21[81] | -4.89[82] | -0.79[83] | -2.72[84] |
13 | MMP1 | Interstitial collagenase | [85] | -5.03[86] | -8.60[87] | [88] | -2.53[89] | -1.04[90] | -11.16[91] |
14 | IRF3 | Interferon regulatory factor 3 | [92] | 0.43[93] | 0.81[94] | 1.80[95] | -0.42[96] | 1.11[97] | -0.21[98] |
15 | TMPRSS2 | Transmembrane protease serine 2 | [99] | -2.07[100] | -7.00[101] | -5.36[102] | -11.04[103] | -7.32[104] | 0.87[105] |
16 | MMP3 | Stromelysin-1 | [106] | -4.38[107] | -9.09[108] | -11.20[109] | -2.52[110] | -3.63[111] | -7.36[112] |
17 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | [113] | 0.80[114] | 0.69[115] | 0.74[116] | -1.02[117] | 1.83[118] | 1.42[119] |
18 | CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha | [120] | 1.03[121] | 2.46[122] | 2.69[123] | -0.12[124] | 2.63[125] | 2.48[126] |
19 | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | [127] | 0.65[128] | 0.92[129] | 1.29[130] | -0.52[131] | 1.52[132] | 2.15[133] |
20 | IL1B | Interleukin-1 beta | [134] | -8.57[135] | -8.22[136] | -3.64[137] | -4.37[138] | 3.17[139] | -4.23[140] |
21 | IL6 | Interleukin-6 | [141] | -8.31[142] | [143] | -4.23[144] | -1.63[145] | 2.83[146] | [147] |
22 | SLC7A11 | Cystine/glutamate transporter | [148] | 2.80[149] | 3.86[150] | 3.97[151] | 4.11[152] | 4.85[153] | -0.05[154] |
23 | ACE2 | Angiotensin-converting enzyme 2 | [155] | -0.18[156] | 1.37[157] | 0.66[158] | -7.79[159] | -5.25[160] | 0.89[161] |
24 | IL12A | Interleukin-12 subunit alpha | [162] | -1.27[163] | [164] | 0.69[165] | -2.32[166] | 1.42[167] | -2.21[168] |
25 | TNF | Tumor necrosis factor | [169] | 1.23[170] | -0.69[171] | -5.03[172] | -3.00[173] | -4.28[174] | -0.92[175] |
26 | NOX1 | NADPH oxidase 1 | [176] | 0.49[177] | -0.07[178] | 5.36[179] | -0.84[180] | 2.48[181] | 1.80[182] |
27 | PRKG2 | cGMP-dependent protein kinase 2 | [183] | 3.03[184] | [185] | [186] | 6.01[187] | 2.25[188] | 3.01[189] |
28 | GUCY1A2 | Guanylate cyclase soluble subunit alpha-2 | [190] | 1.38[191] | 2.69[192] | 8.64[193] | 9.45[194] | 5.94[195] | 11.54[196] |
29 | GUCY1B2 | Guanylate cyclase soluble subunit beta-2 | [197] | [198] | [199] | [200] | [201] | [202] | [203] |
30 | CXCL8 | Interleukin-8 | [204] | [205] | [206] | [207] | [208] | [209] | [210] |
31 | GUCY1A1 | [211] | [212] | [213] | [214] | [215] | [216] | [217] | |
32 | GUCY1B1 | [218] | [219] | [220] | [221] | [222] | [223] | [224] |