WP_ANGIOGENESIS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 AKT1 RAC-alpha serine/threonine-protein kinase [1] -1.02[2] -1.27[3] -2.06[4] -1.63[5] -1.81[6] -1.36[7]
2 HIF1A Hypoxia-inducible factor 1-alpha [8] -1.26[9] -1.60[10] -0.52[11] 0.71[12] 0.88[13] -1.92[14]
3 VEGFA Vascular endothelial growth factor A [15] 0.12[16] 1.44[17] 0.33[18] -1.14[19] -0.64[20] -0.34[21]
4 MAPK1 Mitogen-activated protein kinase 1 [22] 0.61[23] 0.73[24] 0.84[25] 0.27[26] -0.29[27] 0.66[28]
5 TIMP3 Metalloproteinase inhibitor 3 [29] -0.33[30] -0.52[31] 0.76[32] -5.76[33] -5.03[34] 0.77[35]
6 PTK2 Focal adhesion kinase 1 [36] -0.37[37] 0.10[38] 0.77[39] 0.36[40] -0.64[41] -0.36[42]
7 MAPK14 Mitogen-activated protein kinase 14 [43] 0.37[44] 0.42[45] 0.29[46] 0.10[47] -0.63[48] 0.17[49]
8 TIMP2 Metalloproteinase inhibitor 2 [50] 1.12[51] -1.24[52] -2.77[53] 1.50[54] 2.01[55] -1.27[56]
9 ARNT Aryl hydrocarbon receptor nuclear translocator [57] -0.68[58] -0.91[59] 0.25[60] -0.22[61] -0.65[62] 0.42[63]
10 SMAD1 Mothers against decapentaplegic homolog 1 [64] -2.15[65] -1.91[66] -1.33[67] -2.31[68] -1.96[69] -0.49[70]
11 FGF2 Fibroblast growth factor 2 [71] -7.79[72] -7.55[73] -3.11[74] -0.65[75] 0.73[76] -2.78[77]
12 SRC Proto-oncogene tyrosine-protein kinase Src [78] 1.92[79] 1.89[80] 1.18[81] 0.82[82] -0.21[83] -1.97[84]
13 PLCG1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 2.39[85] 1.99[86] 1.61[87] 1.24[88] 0.53[89] -0.78[90]
14 PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform -1.48[91] 0.14[92] 0.61[93] -0.45[94] -0.45[95] 0.80[96]
15 CREBBP CREB-binding protein [97] 1.80[98] 1.00[99] 1.89[100] 1.17[101] 0.98[102] 2.12[103]
16 FGFR2 Fibroblast growth factor receptor 2 [104] -3.61[105] -2.42[106] 1.81[107] -0.13[108] -5.17[109] 2.30[110]
17 MMP9 Matrix metalloproteinase-9 [111] -3.82[112] -4.89[113] -7.00[114] -3.01[115] -5.78[116] -1.26[117]
18 PDGFB Platelet-derived growth factor subunit B [118] 1.95[119] 1.80[120] -0.72[121] -1.52[122] -2.15[123] -0.75[124]
19 PDGFRA Platelet-derived growth factor receptor alpha [125] -4.72[126] -5.72[127] 2.20[128] -1.06[129] 3.41[130] 4.20[131]
20 KDR Vascular endothelial growth factor receptor 2 [132] -6.73[133] -8.40[134] -7.41[135] -3.32[136] 2.94[137] 5.18[138]
21 NOS3 Nitric oxide synthase, endothelial [139] 3.67[140] 0.75[141] 0.51[142] -1.53[143] -0.39[144] 1.65[145]
22 FLT1 Vascular endothelial growth factor receptor 1 [146] -2.61[147] -2.26[148] -2.41[149] -1.87[150] -3.01[151] 4.98[152]
23 TEK Angiopoietin-1 receptor [153] -5.65[154] -7.18[155] -5.86[156] 2.73[157] 0.14[158] 4.31[159]
24 ANGPT1 Angiopoietin-1 [160] -0.81[161] [162] 6.39[163] 8.83[164] 4.18[165] 5.56[166]
[1]
ref_hepatocyte AKT1
Mean 37.6
Standard deviation 15
Values 19 32 31 55 50
[2]
HepG2 AKT1
Mean 87.8
Standard deviation 2.3
Values 86 89
[3]
HepG2.C3A AKT1
Mean 66.6
Standard deviation 2.4
Values 68 65
[4]
HuH.7 AKT1
Mean 30.2
Standard deviation 6.6
Values 35 23 33
[5]
SNU475 AKT1
Mean 66.6
Standard deviation 14
Values 57 76
[6]
THLE AKT1
Mean 75.8
Standard deviation 6.1
Values 72 80
[7]
liver AKT1
Mean 45.1
Standard deviation 25
Values 79 48 34 20
[8]
ref_hepatocyte HIF1A
Mean 26.5
Standard deviation 22
Values 30 5.8 8.1 27 61
[9]
HepG2 HIF1A
Mean 52.5
Standard deviation 22
Values 68 37
[10]
HepG2.C3A HIF1A
Mean 37.2
Standard deviation 10
Values 44 30
[11]
HuH.7 HIF1A
Mean 62
Standard deviation 17
Values 49 55 81
[12]
SNU475 HIF1A
Mean 237
Standard deviation 65
Values 1.9e+02 2.8e+02
[13]
THLE HIF1A
Mean 346
Standard deviation 60
Values 3.9e+02 3e+02
[14]
liver HIF1A
Mean 21.5
Standard deviation 8.5
Values 31 25 12 18
[15]
ref_hepatocyte VEGFA
Mean 15.4
Standard deviation 8.3
Values 12 25 22 12 5.2
[16]
HepG2 VEGFA
Mean 78.9
Standard deviation 39
Values 51 1.1e+02
[17]
HepG2.C3A VEGFA
Mean 178
Standard deviation 91
Values 1.1e+02 2.4e+02
[18]
HuH.7 VEGFA
Mean 64.6
Standard deviation 7.4
Values 73 62 59
[19]
SNU475 VEGFA
Mean 38.2
Standard deviation 17
Values 50 26
[20]
THLE VEGFA
Mean 70.1
Standard deviation 17
Values 82 58
[21]
liver VEGFA
Mean 37.5
Standard deviation 27
Values 48 70 18 14
[22]
ref_hepatocyte MAPK1
Mean 10.7
Standard deviation 3.7
Values 13 7.4 6.1 14 13
[23]
HepG2 MAPK1
Mean 77.6
Standard deviation 22
Values 93 62
[24]
HepG2.C3A MAPK1
Mean 76.1
Standard deviation 7.2
Values 81 71
[25]
HuH.7 MAPK1
Mean 64.8
Standard deviation 7.4
Values 61 60 73
[26]
SNU475 MAPK1
Mean 71.1
Standard deviation 8
Values 65 77
[27]
THLE MAPK1
Mean 62.4
Standard deviation 14
Values 53 72
[28]
liver MAPK1
Mean 52.3
Standard deviation 14
Values 61 68 39 41
[29]
ref_hepatocyte TIMP3
Mean 9.2
Standard deviation 12
Values 3.2 3.7 4.4 31 3.4
[30]
HepG2 TIMP3
Mean 34.8
Standard deviation 4.7
Values 38 31
[31]
HepG2.C3A TIMP3
Mean 27.4
Standard deviation 11
Values 20 35
[32]
HuH.7 TIMP3
Mean 52.4
Standard deviation 5.6
Values 48 59 51
[33]
SNU475 TIMP3
Mean 0.933
Standard deviation 0.86
Values 1.5 0.32
[34]
THLE TIMP3
Mean 2
Standard deviation 0.15
Values 2.1 1.9
[35]
liver TIMP3
Mean 48.3
Standard deviation 17
Values 41 30 68 54
[36]
ref_hepatocyte PTK2
Mean 8.92
Standard deviation 4.8
Values 11 3.9 4.1 15 11
[37]
HepG2 PTK2
Mean 32.8
Standard deviation 5.2
Values 36 29
[38]
HepG2.C3A PTK2
Mean 40.9
Standard deviation 2.3
Values 39 43
[39]
HuH.7 PTK2
Mean 51.1
Standard deviation 2.8
Values 48 52 53
[40]
SNU475 PTK2
Mean 63.1
Standard deviation 3.5
Values 61 66
[41]
THLE PTK2
Mean 40.6
Standard deviation 3.7
Values 38 43
[42]
liver PTK2
Mean 21.5
Standard deviation 4.9
Values 24 27 19 16
[43]
ref_hepatocyte MAPK14
Mean 8.71
Standard deviation 2
Values 7.2 8.3 7.5 12 8.5
[44]
HepG2 MAPK14
Mean 53.4
Standard deviation 8.7
Values 60 47
[45]
HepG2.C3A MAPK14
Mean 49.9
Standard deviation 0.11
Values 50 50
[46]
HuH.7 MAPK14
Mean 35.7
Standard deviation 1.3
Values 34 36 37
[47]
SNU475 MAPK14
Mean 51.3
Standard deviation 0.4
Values 51 52
[48]
THLE MAPK14
Mean 40
Standard deviation 3.6
Values 37 43
[49]
liver MAPK14
Mean 30.1
Standard deviation 8.3
Values 37 38 24 22
[50]
ref_hepatocyte TIMP2
Mean 7.86
Standard deviation 14
Values 1.4 1.6 1.6 34 1
[51]
HepG2 TIMP2
Mean 80.9
Standard deviation 4.5
Values 78 84
[52]
HepG2.C3A TIMP2
Mean 14.2
Standard deviation 2
Values 13 16
[53]
HuH.7 TIMP2
Mean 3.88
Standard deviation 2.3
Values 2 6.5 3.2
[54]
SNU475 TIMP2
Mean 123
Standard deviation 31
Values 1e+02 1.4e+02
[55]
THLE TIMP2
Mean 225
Standard deviation 43
Values 1.9e+02 2.6e+02
[56]
liver TIMP2
Mean 10.1
Standard deviation 3.4
Values 7.3 7.7 15 11
[57]
ref_hepatocyte ARNT
Mean 5.93
Standard deviation 1.4
Values 4.1 6.5 4.8 7.7 6.5
[58]
HepG2 ARNT
Mean 17.5
Standard deviation 1.2
Values 18 17
[59]
HepG2.C3A ARNT
Mean 13.5
Standard deviation 3
Values 11 16
[60]
HuH.7 ARNT
Mean 23.6
Standard deviation 6.3
Values 19 31 22
[61]
SNU475 ARNT
Mean 28.1
Standard deviation 0.55
Values 28 28
[62]
THLE ARNT
Mean 26.8
Standard deviation 1.6
Values 26 28
[63]
liver ARNT
Mean 24.4
Standard deviation 4.2
Values 23 19 29 26
[64]
ref_hepatocyte SMAD1
Mean 5.73
Standard deviation 2
Values 6.7 7.5 7 2.8 4.6
[65]
HepG2 SMAD1
Mean 6.12
Standard deviation 1.6
Values 7.2 5
[66]
HepG2.C3A SMAD1
Mean 6.51
Standard deviation 0.83
Values 7.1 5.9
[67]
HuH.7 SMAD1
Mean 7.65
Standard deviation 2.8
Values 5.8 11 6.3
[68]
SNU475 SMAD1
Mean 6.35
Standard deviation 0.026
Values 6.3 6.4
[69]
THLE SMAD1
Mean 10.5
Standard deviation 1.5
Values 9.5 12
[70]
liver SMAD1
Mean 12.6
Standard deviation 5.3
Values 11 7.6 20 12
[71]
ref_hepatocyte FGF2
Mean 4.04
Standard deviation 6.5
Values 3.7 0.73 0.37 0.052 15
[72]
HepG2 FGF2
Mean 0.0866
Standard deviation 0.08
Values 0.03 0.14
[73]
HepG2.C3A FGF2
Mean 0.092
Standard deviation 0.0064
Values 0.097 0.087
[74]
HuH.7 FGF2
Mean 1.57
Standard deviation 0.89
Values 1.1 2.6 0.98
[75]
SNU475 FGF2
Mean 14.2
Standard deviation 1.3
Values 15 13
[76]
THLE FGF2
Mean 47.5
Standard deviation 0.66
Values 48 47
[77]
liver FGF2
Mean 1.81
Standard deviation 0.66
Values 2 2.5 1.9 0.9
[78]
ref_hepatocyte SRC
Mean 3.67
Standard deviation 3.6
Values 2.2 1.2 0.77 9.6 4.7
[79]
HepG2 SRC
Mean 66
Standard deviation 21
Values 51 81
[80]
HepG2.C3A SRC
Mean 58.1
Standard deviation 18
Values 45 71
[81]
HuH.7 SRC
Mean 27.9
Standard deviation 2
Values 26 29 28
[82]
SNU475 SRC
Mean 35.6
Standard deviation 3.5
Values 33 38
[83]
THLE SRC
Mean 22.5
Standard deviation 2.7
Values 21 24
[84]
liver SRC
Mean 2.9
Standard deviation 1
Values 3.2 2.5 4.1 1.7
[85]
ref_hepatocyte PLCG1
Mean 3.54
Standard deviation 4.5
Values 1.7 1.2 0.91 11 2.4
[86]
HepG2 PLCG1
Mean 87.8
Standard deviation 4.3
Values 85 91
[87]
HepG2.C3A PLCG1
Mean 60.1
Standard deviation 10
Values 53 67
[88]
HuH.7 PLCG1
Mean 36.2
Standard deviation 5.9
Values 39 30 40
[89]
SNU475 PLCG1
Mean 45.9
Standard deviation 1.9
Values 45 47
[90]
THLE PLCG1
Mean 36.2
Standard deviation 0.92
Values 36 37
[91]
liver PLCG1
Mean 6.36
Standard deviation 4.9
Values 12 8.9 2.3 2.2
[92]
ref_hepatocyte PIK3CA
Mean 1.87
Standard deviation 0.73
Values 2.3 0.94 1.2 2.3 2.6
[93]
HepG2 PIK3CA
Mean 3.17
Standard deviation 1.6
Values 4.3 2.1
[94]
HepG2.C3A PIK3CA
Mean 8.78
Standard deviation 1.1
Values 9.6 8
[95]
HuH.7 PIK3CA
Mean 9.59
Standard deviation 2.4
Values 7 12 10
[96]
SNU475 PIK3CA
Mean 7.49
Standard deviation 0.93
Values 6.8 8.1
[97]
THLE PIK3CA
Mean 9.67
Standard deviation 0.66
Values 10 9.2
[98]
liver PIK3CA
Mean 9.99
Standard deviation 4.7
Values 13 15 6.1 6
[99]
ref_hepatocyte CREBBP
Mean 1.78
Standard deviation 0.69
Values 2.6 1.9 1.9 1.8 0.72
[100]
HepG2 CREBBP
Mean 29.3
Standard deviation 2.8
Values 31 27
[101]
HepG2.C3A CREBBP
Mean 15.2
Standard deviation 1
Values 14 16
[102]
HuH.7 CREBBP
Mean 22.2
Standard deviation 7.2
Values 14 24 28
[103]
SNU475 CREBBP
Mean 22.1
Standard deviation 0.2
Values 22 22
[104]
THLE CREBBP
Mean 24.9
Standard deviation 7.3
Values 20 30
[105]
liver CREBBP
Mean 23.8
Standard deviation 6
Values 28 21 30 17
[106]
ref_hepatocyte FGFR2
Mean 1.34
Standard deviation 1.4
Values 0.084 3.2 2.4 0.47 0.46
[107]
HepG2 FGFR2
Mean 0.519
Standard deviation 0.3
Values 0.73 0.3
[108]
HepG2.C3A FGFR2
Mean 1.07
Standard deviation 0.3
Values 1.3 0.86
[109]
HuH.7 FGFR2
Mean 15.7
Standard deviation 0.71
Values 16 15 16
[110]
SNU475 FGFR2
Mean 6.74
Standard deviation 6.4
Values 2.2 11
[111]
THLE FGFR2
Mean 0.263
Standard deviation 0.0039
Values 0.27 0.26
[112]
liver FGFR2
Mean 20.4
Standard deviation 8
Values 32 19 18 13
[113]
ref_hepatocyte MMP9
Mean 0.779
Standard deviation 1.6
Values 3.7 0.033 0.06 0.1 0.049
[114]
HepG2 MMP9
Mean 0.261
Standard deviation 0.18
Values 0.13 0.39
[115]
HepG2.C3A MMP9
Mean 0.112
Standard deviation 0.0078
Values 0.12 0.11
[116]
HuH.7 MMP9
Mean 0.0205
Standard deviation 0.012
Values 0.0094 0.019 0.033
[117]
SNU475 MMP9
Mean 0.53
Standard deviation 0.7
Values 1 0.037
[118]
THLE MMP9
Mean 0.101
Standard deviation 0.076
Values 0.047 0.15
[119]
liver MMP9
Mean 1
Standard deviation 0.93
Values 2.4 0.73 0.33 0.59
[120]
ref_hepatocyte PDGFB
Mean 0.738
Standard deviation 0.56
Values 1.3 0.54 0.23 0.25 1.4
[121]
HepG2 PDGFB
Mean 13.6
Standard deviation 5.2
Values 9.9 17
[122]
HepG2.C3A PDGFB
Mean 11
Standard deviation 4.6
Values 7.7 14
[123]
HuH.7 PDGFB
Mean 1.5
Standard deviation 0.44
Values 1.5 2 1.1
[124]
SNU475 PDGFB
Mean 1.42
Standard deviation 0.33
Values 1.2 1.7
[125]
THLE PDGFB
Mean 1.18
Standard deviation 0.022
Values 1.2 1.2
[126]
liver PDGFB
Mean 1.36
Standard deviation 0.68
Values 1.4 2 0.4 1.7
[127]
ref_hepatocyte PDGFRA
Mean 0.51
Standard deviation 0.67
Values 1.5 0.11 0.93 0 0.018
[128]
HepG2 PDGFRA
Mean 0.0916
Standard deviation 0.016
Values 0.1 0.08
[129]
HepG2.C3A PDGFRA
Mean 0.0414
Standard deviation 0.017
Values 0.054 0.029
[130]
HuH.7 PDGFRA
Mean 7.89
Standard deviation 0.88
Values 6.9 8.5 8.3
[131]
SNU475 PDGFRA
Mean 1.35
Standard deviation 1.4
Values 2.3 0.38
[132]
THLE PDGFRA
Mean 38.6
Standard deviation 7.6
Values 33 44
[133]
liver PDGFRA
Mean 28.9
Standard deviation 13
Values 43 35 23 15
[134]
ref_hepatocyte KDR
Mean 0.384
Standard deviation 0.38
Values 0.38 0.98 0.47 0.021 0.075
[135]
HepG2 KDR
Mean 0.0172
Standard deviation 2.3e-05
Values 0.017 0.017
[136]
HepG2.C3A KDR
Mean 0.00486
Standard deviation 0.0069
Values 0 0.0097
[137]
HuH.7 KDR
Mean 0.00761
Standard deviation 0.0083
Values 0 0.0064 0.016
[138]
SNU475 KDR
Mean 0.211
Standard deviation 0.25
Values 0.39 0.037
[139]
THLE KDR
Mean 20.9
Standard deviation 3.6
Values 18 23
[140]
liver KDR
Mean 42.9
Standard deviation 25
Values 33 76 17 45
[141]
ref_hepatocyte NOS3
Mean 0.251
Standard deviation 0.22
Values 0.014 0.18 0.12 0.58 0.37
[142]
HepG2 NOS3
Mean 15.1
Standard deviation 1.3
Values 16 14
[143]
HepG2.C3A NOS3
Mean 1.81
Standard deviation 0.061
Values 1.9 1.8
[144]
HuH.7 NOS3
Mean 1.2
Standard deviation 0.2
Values 1.2 1 1.4
[145]
SNU475 NOS3
Mean 0.48
Standard deviation 0.28
Values 0.28 0.68
[146]
THLE NOS3
Mean 1.36
Standard deviation 0.21
Values 1.5 1.2
[147]
liver NOS3
Mean 2.44
Standard deviation 1.3
Values 4.3 2.3 1.5 1.6
[148]
ref_hepatocyte FLT1
Mean 0.232
Standard deviation 0.18
Values 0.38 0.37 0.33 0 0.085
[149]
HepG2 FLT1
Mean 0.18
Standard deviation 0.0053
Values 0.18 0.18
[150]
HepG2.C3A FLT1
Mean 0.206
Standard deviation 0.072
Values 0.26 0.16
[151]
HuH.7 FLT1
Mean 0.146
Standard deviation 0.035
Values 0.12 0.19 0.13
[152]
SNU475 FLT1
Mean 0.348
Standard deviation 0.21
Values 0.5 0.2
[153]
THLE FLT1
Mean 0.204
Standard deviation 0.02
Values 0.19 0.22
[154]
liver FLT1
Mean 22.6
Standard deviation 10
Values 22 37 14 17
[155]
ref_hepatocyte TEK
Mean 0.182
Standard deviation 0.14
Values 0.32 0.25 0.26 0 0.075
[156]
HepG2 TEK
Mean 0.0172
Standard deviation 0.024
Values 0 0.034
[157]
HepG2.C3A TEK
Mean 0.00536
Standard deviation 0.0076
Values 0.011 0
[158]
HuH.7 TEK
Mean 0.0105
Standard deviation 0.0096
Values 0.019 0.013 0
[159]
SNU475 TEK
Mean 6.66
Standard deviation 0.4
Values 6.4 6.9
[160]
THLE TEK
Mean 1.42
Standard deviation 0.52
Values 1.1 1.8
[161]
liver TEK
Mean 11.1
Standard deviation 5.3
Values 12 18 6.5 7.4
[162]
ref_hepatocyte ANGPT1
Mean 0.0114
Standard deviation 0.025
Values 0 0.057 0 0 0
[163]
HepG2 ANGPT1
Mean 0.0308
Standard deviation 0.011
Values 0.039 0.023
[164]
HepG2.C3A ANGPT1
Mean 0
Standard deviation 0
Values 0 0
[165]
HuH.7 ANGPT1
Mean 3.22
Standard deviation 0.24
Values 3 3.5 3.2
[166]
SNU475 ANGPT1
Mean 28.5
Standard deviation 5.2
Values 32 25
[167]
THLE ANGPT1
Mean 1.46
Standard deviation 0.3
Values 1.7 1.3
[168]
liver ANGPT1
Mean 1.66
Standard deviation 0.92
Values 0.9 2.7 0.85 2.2