WP_AMPLIFICATION_AND_EXPANSION_OF_ONCOGENIC_PATHWAYS_AS_METASTATIC_TRAITS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 VEGFA Vascular endothelial growth factor A [1] -1.07[2] 0.43[3] -0.45[4] -1.07[5] -0.74[6] -0.63[7]
2 EPAS1 Endothelial PAS domain-containing protein 1 [8] 0.42[9] -0.20[10] -0.03[11] -2.08[12] 0.56[13] 0.51[14]
3 VHL von Hippel-Lindau disease tumor suppressor [15] -0.34[16] -0.06[17] 1.23[18] -0.67[19] -0.36[20] -0.44[21]
4 SRC Proto-oncogene tyrosine-protein kinase Src [22] 0.73[23] 0.88[24] 0.40[25] 0.89[26] -0.31[27] -2.27[28]
5 JAG1 Protein jagged-1 [29] 2.49[30] 1.24[31] 1.22[32] 0.00[33] -1.73[34] -0.37[35]
6 TNC Tenascin [36] -9.10[37] -8.58[38] -7.18[39] 2.87[40] 1.73[41] -1.37[42]
7 TCF7L2 Transcription factor 7-like 2 [43] -1.42[44] -0.49[45] 0.23[46] -0.82[47] -1.21[48] 0.31[49]
8 CXCR4 C-X-C chemokine receptor type 4 [50] -4.15[51] [52] -3.94[53] -7.07[54] -3.62[55] -1.48[56]
9 TCF7L1 Transcription factor 7-like 1 [57] -5.34[58] -3.37[59] -0.66[60] -3.33[61] -3.59[62] -1.12[63]
10 TCF7 Transcription factor 7 [64] 0.15[65] -1.03[66] -1.46[67] -1.35[68] -2.04[69] -1.78[70]
11 VCAM1 Vascular cell adhesion protein 1 [71] -9.31[72] [73] -5.39[74] -0.99[75] 2.02[76] 2.12[77]
12 CYTIP Cytohesin-interacting protein [78] -9.46[79] [80] -4.66[81] -4.46[82] -9.43[83] -0.66[84]
13 NOTCH1 Neurogenic locus notch homolog protein 1 [85] -0.39[86] -1.38[87] 0.47[88] 1.07[89] 1.05[90] 3.22[91]
14 POSTN Periostin [92] -6.06[93] -4.79[94] -3.36[95] 6.49[96] 4.14[97] 2.02[98]
15 PIK3CG Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [99] [100] [101] -0.17[102] -5.44[103] 2.68[104]
16 LEF1 Lymphoid enhancer-binding factor 1 [105] 0.36[106] -6.40[107] 2.04[108] -0.43[109] -2.51[110] -0.33[111]
17 WNT2 Protein Wnt-2 [112] [113] [114] -3.61[115] -0.58[116] -4.89[117] 4.81[118]
[1]
ref_hepatocyte VEGFA
Mean 15.4
Standard deviation 8.3
Values 12 25 22 12 5.2
[2]
HepG2 VEGFA
Mean 78.9
Standard deviation 39
Values 51 1.1e+02
[3]
HepG2.C3A VEGFA
Mean 178
Standard deviation 91
Values 1.1e+02 2.4e+02
[4]
HuH.7 VEGFA
Mean 64.6
Standard deviation 7.4
Values 73 62 59
[5]
SNU475 VEGFA
Mean 38.2
Standard deviation 17
Values 50 26
[6]
THLE VEGFA
Mean 70.1
Standard deviation 17
Values 82 58
[7]
liver VEGFA
Mean 37.5
Standard deviation 27
Values 48 70 18 14
[8]
ref_hepatocyte EPAS1
Mean 12.6
Standard deviation 4.8
Values 9.1 18 18 9.5 8.7
[9]
HepG2 EPAS1
Mean 182
Standard deviation 60
Values 1.4e+02 2.2e+02
[10]
HepG2.C3A EPAS1
Mean 93.9
Standard deviation 18
Values 81 1.1e+02
[11]
HuH.7 EPAS1
Mean 71
Standard deviation 9.1
Values 61 77 75
[12]
SNU475 EPAS1
Mean 15.6
Standard deviation 8.9
Values 22 9.3
[13]
THLE EPAS1
Mean 142
Standard deviation 5.8
Values 1.4e+02 1.5e+02
[14]
liver EPAS1
Mean 68.1
Standard deviation 34
Values 1.2e+02 69 49 38
[15]
ref_hepatocyte VHL
Mean 5.19
Standard deviation 2
Values 3.8 5.2 4.3 8.7 3.9
[16]
HepG2 VHL
Mean 44.2
Standard deviation 11
Values 37 52
[17]
HepG2.C3A VHL
Mean 42.7
Standard deviation 0.95
Values 42 43
[18]
HuH.7 VHL
Mean 70.1
Standard deviation 8.2
Values 73 61 76
[19]
SNU475 VHL
Mean 17.1
Standard deviation 0.32
Values 17 17
[20]
THLE VHL
Mean 30.8
Standard deviation 4
Values 28 34
[21]
liver VHL
Mean 14.5
Standard deviation 3.7
Values 19 16 9.9 13
[22]
ref_hepatocyte SRC
Mean 3.67
Standard deviation 3.6
Values 2.2 1.2 0.77 9.6 4.7
[23]
HepG2 SRC
Mean 66
Standard deviation 21
Values 51 81
[24]
HepG2.C3A SRC
Mean 58.1
Standard deviation 18
Values 45 71
[25]
HuH.7 SRC
Mean 27.9
Standard deviation 2
Values 26 29 28
[26]
SNU475 SRC
Mean 35.6
Standard deviation 3.5
Values 33 38
[27]
THLE SRC
Mean 22.5
Standard deviation 2.7
Values 21 24
[28]
liver SRC
Mean 2.9
Standard deviation 1
Values 3.2 2.5 4.1 1.7
[29]
ref_hepatocyte JAG1
Mean 2.61
Standard deviation 3.4
Values 1.7 0.21 0.3 8.4 2.4
[30]
HepG2 JAG1
Mean 158
Standard deviation 86
Values 97 2.2e+02
[31]
HepG2.C3A JAG1
Mean 52.9
Standard deviation 7.2
Values 48 58
[32]
HuH.7 JAG1
Mean 35.1
Standard deviation 12
Values 39 21 45
[33]
SNU475 JAG1
Mean 13.7
Standard deviation 0.39
Values 14 13
[34]
THLE JAG1
Mean 6
Standard deviation 0.4
Values 5.7 6.3
[35]
liver JAG1
Mean 7.68
Standard deviation 5.1
Values 15 8.6 4.1 3.5
[36]
ref_hepatocyte TNC
Mean 2.48
Standard deviation 3.4
Values 7.4 0.15 0.17 0 4.7
[37]
HepG2 TNC
Mean 0.0487
Standard deviation 0.045
Values 0.017 0.08
[38]
HepG2.C3A TNC
Mean 0.0555
Standard deviation 0.018
Values 0.043 0.068
[39]
HuH.7 TNC
Mean 0.0987
Standard deviation 0.059
Values 0.037 0.1 0.16
[40]
SNU475 TNC
Mean 95.1
Standard deviation 21
Values 1.1e+02 81
[41]
THLE TNC
Mean 62.8
Standard deviation 42
Values 33 92
[42]
liver TNC
Mean 3.65
Standard deviation 2.7
Values 6.2 5.5 0.28 2.6
[43]
ref_hepatocyte TCF7L2
Mean 2.36
Standard deviation 1.2
Values 4.4 2.5 1.9 1.7 1.3
[44]
HepG2 TCF7L2
Mean 9.52
Standard deviation 1.6
Values 8.4 11
[45]
HepG2.C3A TCF7L2
Mean 14.4
Standard deviation 3.4
Values 12 17
[46]
HuH.7 TCF7L2
Mean 15.9
Standard deviation 1.6
Values 15 16 18
[47]
SNU475 TCF7L2
Mean 7.02
Standard deviation 1.3
Values 6.1 7.9
[48]
THLE TCF7L2
Mean 7.78
Standard deviation 0.97
Values 7.1 8.5
[49]
liver TCF7L2
Mean 11.1
Standard deviation 8.5
Values 5 3.4 21 14
[50]
ref_hepatocyte CXCR4
Mean 2.08
Standard deviation 2.5
Values 1.9 6.2 2.1 0.14 0
[51]
HepG2 CXCR4
Mean 1.26
Standard deviation 0.15
Values 1.4 1.2
[52]
HepG2.C3A CXCR4
Mean 0
Standard deviation 0
Values 0 0
[53]
HuH.7 CXCR4
Mean 0.781
Standard deviation 0.18
Values 0.92 0.84 0.58
[54]
SNU475 CXCR4
Mean 0.0809
Standard deviation 0.11
Values 0.16 0.0046
[55]
THLE CXCR4
Mean 1.29
Standard deviation 0.58
Values 1.7 0.88
[56]
liver CXCR4
Mean 2.82
Standard deviation 1.4
Values 1.5 2 4.6 3.1
[57]
ref_hepatocyte TCF7L1
Mean 1.79
Standard deviation 1.6
Values 4.2 1.6 2.4 0.2 0.6
[58]
HepG2 TCF7L1
Mean 0.477
Standard deviation 0.1
Values 0.4 0.55
[59]
HepG2.C3A TCF7L1
Mean 1.48
Standard deviation 0.7
Values 0.99 2
[60]
HuH.7 TCF7L1
Mean 6.53
Standard deviation 0.65
Values 6.4 7.2 5.9
[61]
SNU475 TCF7L1
Mean 0.932
Standard deviation 0.52
Values 1.3 0.57
[62]
THLE TCF7L1
Mean 1.14
Standard deviation 0.018
Values 1.1 1.1
[63]
liver TCF7L1
Mean 3.12
Standard deviation 2.9
Values 1.1 1 7.2 3.2
[64]
ref_hepatocyte TCF7
Mean 1.74
Standard deviation 2
Values 0.54 1.5 0.79 5.2 0.67
[65]
HepG2 TCF7
Mean 20.8
Standard deviation 2.1
Values 19 22
[66]
HepG2.C3A TCF7
Mean 7.29
Standard deviation 0.88
Values 7.9 6.7
[67]
HuH.7 TCF7
Mean 3.64
Standard deviation 1.4
Values 3.7 2.2 5
[68]
SNU475 TCF7
Mean 3.57
Standard deviation 2
Values 5 2.2
[69]
THLE TCF7
Mean 3.23
Standard deviation 0.38
Values 3 3.5
[70]
liver TCF7
Mean 1.91
Standard deviation 0.66
Values 2.7 1.6 2.2 1.2
[71]
ref_hepatocyte VCAM1
Mean 1.05
Standard deviation 1.3
Values 0.35 2.3 2.7 0 0
[72]
HepG2 VCAM1
Mean 0.0179
Standard deviation 0.0071
Values 0.013 0.023
[73]
HepG2.C3A VCAM1
Mean 0
Standard deviation 0
Values 0 0
[74]
HuH.7 VCAM1
Mean 0.144
Standard deviation 0.19
Values 0 0.36 0.074
[75]
SNU475 VCAM1
Mean 2.78
Standard deviation 0.33
Values 3 2.5
[76]
THLE VCAM1
Mean 32.7
Standard deviation 7.1
Values 28 38
[77]
liver VCAM1
Mean 17.3
Standard deviation 13
Values 18 34 3.9 13
[78]
ref_hepatocyte CYTIP
Mean 0.747
Standard deviation 0.77
Values 0.8 1.8 1.1 0 0
[79]
HepG2 CYTIP
Mean 0.0115
Standard deviation 0.016
Values 0 0.023
[80]
HepG2.C3A CYTIP
Mean 0
Standard deviation 0
Values 0 0
[81]
HuH.7 CYTIP
Mean 0.17
Standard deviation 0.036
Values 0.15 0.21 0.15
[82]
SNU475 CYTIP
Mean 0.178
Standard deviation 0.18
Values 0.3 0.051
[83]
THLE CYTIP
Mean 0.00828
Standard deviation 0.0033
Values 0.0059 0.011
[84]
liver CYTIP
Mean 1.79
Standard deviation 0.45
Values 2.3 1.9 1.8 1.2
[85]
ref_hepatocyte NOTCH1
Mean 0.644
Standard deviation 0.25
Values 0.55 0.89 0.91 0.33 0.55
[86]
HepG2 NOTCH1
Mean 5.33
Standard deviation 3.7
Values 2.7 8
[87]
HepG2.C3A NOTCH1
Mean 2.12
Standard deviation 0.1
Values 2.2 2.1
[88]
HuH.7 NOTCH1
Mean 5.14
Standard deviation 1.4
Values 3.6 6.4 5.4
[89]
SNU475 NOTCH1
Mean 7.09
Standard deviation 0.64
Values 7.5 6.6
[90]
THLE NOTCH1
Mean 10.2
Standard deviation 2.2
Values 8.6 12
[91]
liver NOTCH1
Mean 22.8
Standard deviation 16
Values 41 31 10 8.8
[92]
ref_hepatocyte POSTN
Mean 0.0798
Standard deviation 0.1
Values 0 0.024 0.22 0 0.15
[93]
HepG2 POSTN
Mean 0.0129
Standard deviation 0.0061
Values 0.0086 0.017
[94]
HepG2.C3A POSTN
Mean 0.0248
Standard deviation 0.02
Values 0.011 0.039
[95]
HuH.7 POSTN
Mean 0.0446
Standard deviation 0.037
Values 0.0094 0.083 0.041
[96]
SNU475 POSTN
Mean 37.6
Standard deviation 2.7
Values 36 40
[97]
THLE POSTN
Mean 10.7
Standard deviation 6.2
Values 6.3 15
[98]
liver POSTN
Mean 1.23
Standard deviation 0.56
Values 0.64 1.2 1.1 2
[99]
ref_hepatocyte PIK3CG
Mean 0.0637
Standard deviation 0.13
Values 0 0.29 0.026 0 0
[100]
HepG2 PIK3CG
Mean 0
Standard deviation 0
Values 0 0
[101]
HepG2.C3A PIK3CG
Mean 0
Standard deviation 0
Values 0 0
[102]
HuH.7 PIK3CG
Mean 0
Standard deviation 0
Values 0 0 0
[103]
SNU475 PIK3CG
Mean 0.296
Standard deviation 0.1
Values 0.37 0.22
[104]
THLE PIK3CG
Mean 0.0112
Standard deviation 0.00084
Values 0.012 0.011
[105]
liver PIK3CG
Mean 1.55
Standard deviation 0.43
Values 1.6 1.9 0.94 1.7
[106]
ref_hepatocyte LEF1
Mean 0.0478
Standard deviation 0.085
Values 0.2 0 0.043 0 0
[107]
HepG2 LEF1
Mean 0.663
Standard deviation 0.44
Values 0.35 0.97
[108]
HepG2.C3A LEF1
Mean 0.00486
Standard deviation 0.0069
Values 0 0.0097
[109]
HuH.7 LEF1
Mean 1.13
Standard deviation 0.42
Values 0.77 1.6 1
[110]
SNU475 LEF1
Mean 0.186
Standard deviation 0.2
Values 0.33 0.042
[111]
THLE LEF1
Mean 0.0639
Standard deviation 0.015
Values 0.053 0.074
[112]
liver LEF1
Mean 0.144
Standard deviation 0.047
Values 0.13 0.13 0.21 0.1
[113]
ref_hepatocyte WNT2
Mean 0.0103
Standard deviation 0.023
Values 0 0 0.052 0 0
[114]
HepG2 WNT2
Mean 0
Standard deviation 0
Values 0 0
[115]
HepG2.C3A WNT2
Mean 0
Standard deviation 0
Values 0 0
[116]
HuH.7 WNT2
Mean 0.00487
Standard deviation 0.0043
Values 0 0.0064 0.0082
[117]
SNU475 WNT2
Mean 0.0363
Standard deviation 0.0011
Values 0.035 0.037
[118]
THLE WNT2
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[119]
liver WNT2
Mean 1.1
Standard deviation 0.37
Values 0.87 0.76 1.6 1.2