WP_ALTERNATIVE_PATHWAY_OF_FETAL_ANDROGEN_SYNTHESIS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 CYB5A Cytochrome b5 [1] -1.70[2] -0.89[3] -0.71[4] -2.77[5] -0.64[6] -0.39[7]
2 HSD17B6 17-beta-hydroxysteroid dehydrogenase type 6 [8] -7.69[9] -7.17[10] -4.87[11] -3.17[12] -4.14[13] 0.01[14]
3 AKR1C2 Aldo-keto reductase family 1 member C2 [15] 1.92[16] 0.21[17] -1.06[18] 2.34[19] -0.90[20] -0.83[21]
4 AKR1C4 Aldo-keto reductase family 1 member C4 [22] -6.26[23] -3.56[24] -2.79[25] -7.82[26] -10.59[27] -0.54[28]
5 POR NADPH--cytochrome P450 reductase [29] 1.88[30] 2.79[31] 2.92[32] 1.07[33] 2.76[34] 1.70[35]
6 SRD5A2 3-oxo-5-alpha-steroid 4-dehydrogenase 2 [36] -5.89[37] -4.73[38] -3.45[39] -9.50[40] -6.75[41] 0.07[42]
7 STAR Steroidogenic acute regulatory protein, mitochondrial [43] 3.57[44] 3.32[45] 1.02[46] -0.30[47] 4.82[48] -3.16[49]
8 CYP11A1 Cholesterol side-chain cleavage enzyme, mitochondrial [50] 2.14[51] -0.03[52] [53] -0.41[54] 6.35[55] 0.81[56]
9 HSD17B3 Testosterone 17-beta-dehydrogenase 3 [57] -0.40[58] -0.10[59] 5.86[60] 2.78[61] -0.42[62] 1.22[63]
10 CYP17A1 Steroid 17-alpha-hydroxylase/17,20 lyase [64] 0.06[65] 4.45[66] 2.37[67] -2.89[68] -0.13[69] 1.98[70]
11 HSD3B2 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 [71] -0.78[72] [73] 3.66[74] [75] 3.33[76] 1.12[77]
12 MIR4651 [78] [79] [80] [81] [82] [83] [84]
[1]
ref_hepatocyte CYB5A
Mean 485
Standard deviation 5e+02
Values 86 1.2e+03 8.6e+02 1.7e+02 1.3e+02
[2]
HepG2 CYB5A
Mean 47.2
Standard deviation 8.3
Values 53 41
[3]
HepG2.C3A CYB5A
Mean 58.3
Standard deviation 3.9
Values 61 55
[4]
HuH.7 CYB5A
Mean 24.7
Standard deviation 6.7
Values 32 20 22
[5]
SNU475 CYB5A
Mean 18.2
Standard deviation 3.3
Values 16 21
[6]
THLE CYB5A
Mean 13.5
Standard deviation 0.22
Values 14 13
[7]
liver CYB5A
Mean 416
Standard deviation 2.9e+02
Values 92 2.7e+02 5.6e+02 7.4e+02
[8]
ref_hepatocyte HSD17B6
Mean 293
Standard deviation 4.4e+02
Values 25 1e+03 4e+02 0.55 12
[9]
HepG2 HSD17B6
Mean 0.448
Standard deviation 0.28
Values 0.25 0.65
[10]
HepG2.C3A HSD17B6
Mean 0.452
Standard deviation 0.2
Values 0.31 0.59
[11]
HuH.7 HSD17B6
Mean 0.833
Standard deviation 0.2
Values 1 0.8 0.65
[12]
SNU475 HSD17B6
Mean 8.3
Standard deviation 4.2
Values 5.3 11
[13]
THLE HSD17B6
Mean 0.727
Standard deviation 0.11
Values 0.8 0.65
[14]
liver HSD17B6
Mean 332
Standard deviation 93
Values 2.5e+02 2.6e+02 4.3e+02 3.9e+02
[15]
ref_hepatocyte AKR1C2
Mean 167
Standard deviation 1.2e+02
Values 1.1e+02 40 2.3e+02 1.2e+02 3.4e+02
[16]
HepG2 AKR1C2
Mean 199
Standard deviation 1.3e+02
Values 1e+02 2.9e+02
[17]
HepG2.C3A AKR1C2
Mean 42.9
Standard deviation 7.5
Values 38 48
[18]
HuH.7 AKR1C2
Mean 6.67
Standard deviation 6.9
Values 2.5 15 3
[19]
SNU475 AKR1C2
Mean 215
Standard deviation 34
Values 1.9e+02 2.4e+02
[20]
THLE AKR1C2
Mean 3.9
Standard deviation 0.29
Values 4.1 3.7
[21]
liver AKR1C2
Mean 106
Standard deviation 92
Values 19 1.1e+02 64 2.3e+02
[22]
ref_hepatocyte AKR1C4
Mean 105
Standard deviation 1.4e+02
Values 1.7 2.8e+02 2.3e+02 0 3.6
[23]
HepG2 AKR1C4
Mean 0.432
Standard deviation 0.36
Values 0.18 0.69
[24]
HepG2.C3A AKR1C4
Mean 1.97
Standard deviation 0.48
Values 2.3 1.6
[25]
HuH.7 AKR1C4
Mean 1.26
Standard deviation 0.56
Values 1.2 1.9 0.75
[26]
SNU475 AKR1C4
Mean 0.118
Standard deviation 0.055
Values 0.16 0.079
[27]
THLE AKR1C4
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[28]
liver AKR1C4
Mean 80.8
Standard deviation 62
Values 30 66 56 1.7e+02
[29]
ref_hepatocyte POR
Mean 97
Standard deviation 75
Values 26 1.3e+02 2.1e+02 90 32
[30]
HepG2 POR
Mean 113
Standard deviation 40
Values 85 1.4e+02
[31]
HepG2.C3A POR
Mean 150
Standard deviation 87
Values 88 2.1e+02
[32]
HuH.7 POR
Mean 61.3
Standard deviation 8.5
Values 56 71 57
[33]
SNU475 POR
Mean 52.1
Standard deviation 1.3
Values 53 51
[34]
THLE POR
Mean 28.6
Standard deviation 2.7
Values 27 31
[35]
liver POR
Mean 355
Standard deviation 1.6e+02
Values 2.3e+02 3.2e+02 2.7e+02 5.9e+02
[36]
ref_hepatocyte SRD5A2
Mean 6.56
Standard deviation 6.6
Values 1.5 17 5.8 0.19 8.5
[37]
HepG2 SRD5A2
Mean 0.0351
Standard deviation 0.031
Values 0.013 0.057
[38]
HepG2.C3A SRD5A2
Mean 0.055
Standard deviation 0.032
Values 0.032 0.078
[39]
HuH.7 SRD5A2
Mean 0.0502
Standard deviation 0.057
Values 0.019 0.12 0.016
[40]
SNU475 SRD5A2
Mean 0.00232
Standard deviation 0.0033
Values 0 0.0046
[41]
THLE SRD5A2
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[42]
liver SRD5A2
Mean 7.73
Standard deviation 6.8
Values 18 3.3 5.4 4.4
[43]
ref_hepatocyte STAR
Mean 1.18
Standard deviation 2
Values 0.17 0.33 0.13 4.8 0.5
[44]
HepG2 STAR
Mean 4.43
Standard deviation 2.3
Values 6 2.8
[45]
HepG2.C3A STAR
Mean 2.62
Standard deviation 0.42
Values 2.3 2.9
[46]
HuH.7 STAR
Mean 0.2
Standard deviation 0.04
Values 0.24 0.17 0.19
[47]
SNU475 STAR
Mean 0.245
Standard deviation 0.084
Values 0.3 0.19
[48]
THLE STAR
Mean 1.46
Standard deviation 0.0069
Values 1.5 1.5
[49]
liver STAR
Mean 0.149
Standard deviation 0.075
Values 0.2 0.23 0.094 0.077
[50]
ref_hepatocyte CYP11A1
Mean 0.602
Standard deviation 0.44
Values 0.44 1.3 0.59 0.18 0.47
[51]
HepG2 CYP11A1
Mean 0.843
Standard deviation 0.49
Values 0.49 1.2
[52]
HepG2.C3A CYP11A1
Mean 0.131
Standard deviation 0.049
Values 0.097 0.17
[53]
HuH.7 CYP11A1
Mean 0
Standard deviation 0
Values 0 0 0
[54]
SNU475 CYP11A1
Mean 0.115
Standard deviation 0.045
Values 0.15 0.083
[55]
THLE CYP11A1
Mean 2.14
Standard deviation 0.87
Values 2.8 1.5
[56]
liver CYP11A1
Mean 1.18
Standard deviation 0.65
Values 0.75 0.57 1.4 2
[57]
ref_hepatocyte HSD17B3
Mean 0.262
Standard deviation 0.31
Values 0 0.58 0.63 0 0.1
[58]
HepG2 HSD17B3
Mean 0.063
Standard deviation 0.032
Values 0.086 0.04
[59]
HepG2.C3A HSD17B3
Mean 0.0545
Standard deviation 0.047
Values 0.021 0.087
[60]
HuH.7 HSD17B3
Mean 1.27
Standard deviation 0.54
Values 1.6 1.5 0.65
[61]
SNU475 HSD17B3
Mean 0.46
Standard deviation 0.0054
Values 0.46 0.46
[62]
THLE HSD17B3
Mean 0.00858
Standard deviation 0.0046
Values 0.012 0.0053
[63]
liver HSD17B3
Mean 0.686
Standard deviation 0.23
Values 0.87 0.54 0.89 0.44
[64]
ref_hepatocyte CYP17A1
Mean 0.208
Standard deviation 0.25
Values 0.31 0.13 0.6 0 0
[65]
HepG2 CYP17A1
Mean 0.0687
Standard deviation 0.024
Values 0.051 0.086
[66]
HepG2.C3A CYP17A1
Mean 1.01
Standard deviation 0.19
Values 0.88 1.1
[67]
HuH.7 CYP17A1
Mean 0.0898
Standard deviation 0.047
Values 0.094 0.13 0.041
[68]
SNU475 CYP17A1
Mean 0.00717
Standard deviation 0.003
Values 0.0051 0.0093
[69]
THLE CYP17A1
Mean 0.00828
Standard deviation 0.0033
Values 0.0059 0.011
[70]
liver CYP17A1
Mean 0.926
Standard deviation 1.4
Values 0.5 0.057 2.9 0.21
[71]
ref_hepatocyte HSD3B2
Mean 0.031
Standard deviation 0.065
Values 0 0.15 0.0086 0 0
[72]
HepG2 HSD3B2
Mean 0.00573
Standard deviation 0.0081
Values 0 0.011
[73]
HepG2.C3A HSD3B2
Mean 0
Standard deviation 0
Values 0 0
[74]
HuH.7 HSD3B2
Mean 0.0327
Standard deviation 0.028
Values 0.0094 0.064 0.025
[75]
SNU475 HSD3B2
Mean 0
Standard deviation 0
Values 0 0
[76]
THLE HSD3B2
Mean 0.0136
Standard deviation 0.011
Values 0.0059 0.021
[77]
liver HSD3B2
Mean 0.0756
Standard deviation 0.044
Values 0.053 0.057 0.14 0.051
[78]
ref_hepatocyte MIR4651
Missing
[79]
HepG2 MIR4651
Mean 0.00214
Standard deviation 0.003
Values 0.0043 0
[80]
HepG2.C3A MIR4651
Mean 0.00972
Standard deviation 0.014
Values 0 0.019
[81]
HuH.7 MIR4651
Mean 0
Standard deviation 0
Values 0 0 0
[82]
SNU475 MIR4651
Mean 0
Standard deviation 0
Values 0 0
[83]
THLE MIR4651
Mean 0
Standard deviation 0
Values 0 0
[84]
liver MIR4651
Mean 0
Standard deviation 0
Values 0 0 0 0