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Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | SOD1 | Superoxide dismutase [Cu-Zn] | [1] | -2.86[2] | -2.87[3] | -3.81[4] | -3.48[5] | -3.65[6] | -1.23[7] |
2 | RHOA | Transforming protein RhoA | [8] | -0.40[9] | -0.89[10] | -0.62[11] | -1.01[12] | -0.57[13] | -1.03[14] |
3 | CDC42 | Cell division control protein 42 homolog | [15] | -0.28[16] | 0.44[17] | -0.52[18] | -0.32[19] | -1.06[20] | -1.79[21] |
4 | MSN | Moesin | [22] | -7.54[23] | -9.84[24] | -8.49[25] | 1.21[26] | 0.20[27] | -0.99[28] |
5 | NFKBIA | NF-kappa-B inhibitor alpha | [29] | -0.51[30] | -2.30[31] | -2.63[32] | -3.31[33] | -1.44[34] | -0.85[35] |
6 | DDOST | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit | 1.26[36] | 2.20[37] | 1.36[38] | 0.61[39] | 0.66[40] | 0.25[41] | |
7 | RAC1 | Ras-related C3 botulinum toxin substrate 1 | [42] | 0.15[43] | -0.17[44] | 0.58[45] | 0.23[46] | 0.19[47] | -0.67[48] |
8 | JUN | Transcription factor AP-1 | [49] | 0.05[50] | -1.48[51] | -1.17[52] | -1.49[53] | -0.94[54] | -1.52[55] |
9 | AKT1 | RAC-alpha serine/threonine-protein kinase | [56] | 0.62[57] | 0.40[58] | -0.64[59] | 0.16[60] | 0.17[61] | 0.05[62] |
10 | STAT3 | Signal transducer and activator of transcription 3 | [63] | 1.09[64] | -0.40[65] | 0.39[66] | 0.45[67] | -0.29[68] | 2.70[69] |
11 | EZR | Ezrin | [70] | 1.51[71] | 0.15[72] | 0.96[73] | -0.12[74] | 1.09[75] | -0.09[76] |
12 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [77] | -0.39[78] | -0.71[79] | -0.08[80] | -0.33[81] | 0.16[82] | -0.90[83] |
13 | DIAPH1 | Protein diaphanous homolog 1 | [84] | 1.15[85] | 0.82[86] | 1.29[87] | 0.13[88] | 0.54[89] | 1.22[90] |
14 | HIF1A | Hypoxia-inducible factor 1-alpha | [91] | 0.39[92] | 0.06[93] | 0.91[94] | 2.50[95] | 2.86[96] | -0.51[97] |
15 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | [98] | 0.47[99] | -0.44[100] | 0.71[101] | 2.74[102] | 0.46[103] | 1.24[104] |
16 | SHC1 | SHC-transforming protein 1 | [105] | 1.71[106] | 1.93[107] | 2.05[108] | 2.86[109] | 2.33[110] | 1.07[111] |
17 | RELA | Transcription factor p65 | [112] | 0.68[113] | 0.18[114] | 0.36[115] | 0.16[116] | 0.05[117] | -0.59[118] |
18 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | [119] | 0.28[120] | -5.12[121] | -7.96[122] | -4.32[123] | -6.28[124] | 1.09[125] |
19 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | [126] | 0.48[127] | 0.89[128] | 2.21[129] | 0.03[130] | 0.87[131] | 1.39[132] |
20 | CYCS | Cytochrome c | [133] | 1.88[134] | 2.08[135] | 2.20[136] | 1.54[137] | 1.93[138] | 1.61[139] |
21 | CASP3 | Caspase-3 | [140] | 0.68[141] | 1.36[142] | -1.14[143] | -0.68[144] | 0.29[145] | -0.51[146] |
22 | MYD88 | Myeloid differentiation primary response protein MyD88 | [147] | 0.36[148] | 0.42[149] | -0.10[150] | -0.82[151] | -0.54[152] | 1.09[153] |
23 | MAPK1 | Mitogen-activated protein kinase 1 | [154] | 2.25[155] | 2.39[156] | 2.27[157] | 2.06[158] | 1.69[159] | 2.07[160] |
24 | CASP8 | Caspase-8 | [161] | 0.56[162] | 1.14[163] | 0.36[164] | 0.13[165] | -0.63[166] | -1.13[167] |
25 | MAPK14 | Mitogen-activated protein kinase 14 | [168] | 2.02[169] | 2.09[170] | 1.71[171] | 1.90[172] | 1.35[173] | 1.57[174] |
26 | LGALS3 | Galectin-3 | [175] | 1.78[176] | 2.55[177] | 1.73[178] | 1.28[179] | 0.32[180] | -1.72[181] |
27 | PRKCZ | Protein kinase C zeta type | [182] | 1.01[183] | 1.40[184] | -0.55[185] | -2.08[186] | -4.30[187] | -1.35[188] |
28 | ATF2 | Cyclic AMP-dependent transcription factor ATF-2 | [189] | 1.18[190] | 2.23[191] | 2.51[192] | 1.00[193] | 0.75[194] | 1.31[195] |
29 | MAPK8 | Mitogen-activated protein kinase 8 | [196] | -0.90[197] | 0.51[198] | -0.57[199] | -0.69[200] | -0.85[201] | -0.22[202] |
30 | ROCK1 | Rho-associated protein kinase 1 | [203] | -0.41[204] | 1.12[205] | 1.94[206] | 1.58[207] | 0.90[208] | 1.88[209] |
31 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | [210] | 1.21[211] | 0.89[212] | 0.73[213] | -0.03[214] | 0.86[215] | 0.74[216] |
32 | SMAD3 | Mothers against decapentaplegic homolog 3 | [217] | 2.47[218] | 1.87[219] | 2.15[220] | 2.01[221] | 2.87[222] | 0.50[223] |
33 | INSR | Insulin receptor | [224] | 1.00[225] | 1.66[226] | 3.14[227] | -2.87[228] | -0.29[229] | 4.30[230] |
34 | EGFR | Epidermal growth factor receptor | [231] | -0.15[232] | -0.52[233] | 2.41[234] | 0.65[235] | 1.25[236] | 2.94[237] |
35 | MAPK9 | Mitogen-activated protein kinase 9 | [238] | 1.77[239] | 2.00[240] | 2.11[241] | 1.93[242] | 1.37[243] | 0.80[244] |
36 | MAPK3 | Mitogen-activated protein kinase 3 | [245] | 2.39[246] | 2.44[247] | 2.53[248] | 0.64[249] | 0.64[250] | -0.75[251] |
37 | STAT5B | Signal transducer and activator of transcription 5B | [252] | 1.90[253] | 1.53[254] | 2.28[255] | 1.76[256] | 0.89[257] | 1.91[258] |
38 | CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha | [259] | 1.45[260] | 2.67[261] | 2.68[262] | 0.86[263] | 1.66[264] | 1.81[265] |
39 | SRC | Proto-oncogene tyrosine-protein kinase Src | [266] | 3.57[267] | 3.56[268] | 2.60[269] | 2.61[270] | 1.77[271] | -0.56[272] |
40 | PRKCD | Protein kinase C delta type | [273] | 1.64[274] | 1.89[275] | 1.42[276] | -0.29[277] | 0.85[278] | -0.78[279] |
41 | SP1 | Transcription factor Sp1 | [280] | 2.36[281] | 2.61[282] | 3.72[283] | 2.88[284] | 2.55[285] | 2.45[286] |
42 | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | [287] | 1.06[288] | 1.13[289] | 1.28[290] | 0.47[291] | 0.55[292] | 1.47[293] |
43 | MMP14 | Matrix metalloproteinase-14 | [294] | 1.60[295] | 1.02[296] | 3.06[297] | 0.93[298] | 5.45[299] | -0.22[300] |
44 | IRS1 | Insulin receptor substrate 1 | [301] | 2.63[302] | 2.08[303] | 3.56[304] | 1.92[305] | 1.48[306] | 2.41[307] |
45 | CASP9 | Caspase-9 | [308] | 0.70[309] | 1.66[310] | 0.83[311] | 0.46[312] | -0.24[313] | -0.25[314] |
46 | SMAD2 | Mothers against decapentaplegic homolog 2 | [315] | 2.56[316] | 2.83[317] | 2.37[318] | 2.60[319] | 2.77[320] | 2.86[321] |
47 | PRKCA | Protein kinase C alpha type | [322] | 3.38[323] | 3.43[324] | 3.83[325] | 2.36[326] | 2.70[327] | 2.21[328] |
48 | STAT5A | Signal transducer and activator of transcription 5A | [329] | -1.41[330] | -0.23[331] | -1.11[332] | -0.63[333] | 0.11[334] | 0.53[335] |
49 | TIRAP | Toll/interleukin-1 receptor domain-containing adapter protein | [336] | 0.41[337] | 0.38[338] | 0.53[339] | 0.49[340] | -0.70[341] | 0.56[342] |
50 | FOXO1 | Forkhead box protein O1 | [343] | 2.24[344] | 1.91[345] | 2.09[346] | 1.39[347] | 3.39[348] | 3.38[349] |
51 | NCF1 | Neutrophil cytosol factor 1 | [350] | -6.62[351] | -8.67[352] | [353] | [354] | -9.10[355] | -2.51[356] |
52 | FOXO4 | Forkhead box protein O4 | [357] | 1.27[358] | 1.67[359] | 1.55[360] | 0.38[361] | 0.57[362] | -0.40[363] |
53 | IRAK4 | Interleukin-1 receptor-associated kinase 4 | [364] | 0.80[365] | 2.17[366] | 2.49[367] | 1.63[368] | 1.37[369] | 2.07[370] |
54 | INHBB | Inhibin beta B chain | [371] | 3.70[372] | -2.96[373] | -4.87[374] | -2.20[375] | 3.78[376] | 0.58[377] |
55 | MMP9 | Matrix metalloproteinase-9 | [378] | -2.18[379] | -3.22[380] | -5.57[381] | -1.22[382] | -3.80[383] | 0.15[384] |
56 | JAK2 | Tyrosine-protein kinase JAK2 | [385] | 0.77[386] | 0.77[387] | 0.37[388] | 0.98[389] | 1.55[390] | 3.00[391] |
57 | MSR1 | Macrophage scavenger receptor types I and II | [392] | -8.63[393] | [394] | -2.81[395] | 0.87[396] | [397] | 3.11[398] |
58 | NOS2 | Nitric oxide synthase, inducible | [399] | 0.56[400] | [401] | -5.63[402] | -4.64[403] | -5.55[404] | -7.02[405] |
59 | AGER | Advanced glycosylation end product-specific receptor | [406] | -0.50[407] | 2.68[408] | 1.65[409] | 0.85[410] | 0.60[411] | 0.18[412] |
60 | PRKCB | Protein kinase C beta type | [413] | -6.27[414] | -5.07[415] | [416] | 2.70[417] | -2.63[418] | 3.83[419] |
61 | NOS3 | Nitric oxide synthase, endothelial | [420] | 5.31[421] | 2.42[422] | 1.93[423] | 0.27[424] | 1.59[425] | 3.06[426] |
62 | MMP7 | Matrilysin | [427] | 0.97[428] | -1.81[429] | [430] | 2.76[431] | -2.52[432] | 1.00[433] |
63 | MMP2 | 72 kDa type IV collagenase | [434] | 3.98[435] | -3.00[436] | -1.68[437] | 7.65[438] | 7.18[439] | 4.22[440] |
64 | PLA2G4A | Cytosolic phospholipase A2 | [441] | 0.81[442] | -1.74[443] | 6.42[444] | 3.72[445] | 7.46[446] | 4.64[447] |
65 | MMP13 | Collagenase 3 | [448] | [449] | [450] | [451] | [452] | [453] | [454] |
66 | INS | Insulin | [455] | [456] | [457] | [458] | [459] | [460] | [461] |