WP_4HYDROXYTAMOXIFEN_DEXAMETHASONE_AND_RETINOIC_ACIDS_REGULATION_OF_P27_EXPRESSION Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 EIF4EBP1 Eukaryotic translation initiation factor 4E-binding protein 1 [1] -1.11[2] -1.58[3] -1.16[4] -3.12[5] -1.90[6] -1.68[7]
2 AKT1 RAC-alpha serine/threonine-protein kinase [8] -0.04[9] -0.42[10] -1.69[11] 0.13[12] -0.18[13] -0.33[14]
3 MAP2K3 Dual specificity mitogen-activated protein kinase kinase 3 [15] -1.34[16] -1.19[17] -2.48[18] -1.64[19] -2.11[20] -1.52[21]
4 MKNK2 MAP kinase-interacting serine/threonine-protein kinase 2 [22] 0.07[23] -0.61[24] -0.68[25] -0.98[26] -0.32[27] -1.06[28]
5 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 [29] -1.05[30] -1.53[31] -1.13[32] -0.36[33] -0.18[34] -1.28[35]
6 MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 [36] -0.06[37] -0.54[38] 0.14[39] -0.66[40] -0.50[41] -1.79[42]
7 RAF1 RAF proto-oncogene serine/threonine-protein kinase [43] -0.18[44] 0.07[45] 1.15[46] 0.00[47] 0.53[48] 1.01[49]
8 EIF4E Eukaryotic translation initiation factor 4E [50] 0.02[51] 0.70[52] -0.13[53] -0.09[54] 0.61[55] 0.09[56]
9 MAP3K11 Mitogen-activated protein kinase kinase kinase 11 [57] 0.97[58] 0.76[59] 0.20[60] 0.33[61] -0.14[62] 0.37[63]
10 MAPK1 Mitogen-activated protein kinase 1 [64] 1.59[65] 1.58[66] 1.22[67] 2.03[68] 1.35[69] 1.69[70]
11 PRKAA1 5'-AMP-activated protein kinase catalytic subunit alpha-1 [71] -0.20[72] 0.93[73] 2.26[74] 1.65[75] 1.59[76] 1.98[77]
12 MAPK3 Mitogen-activated protein kinase 3 [78] 1.73[79] 1.63[80] 1.48[81] 0.61[82] 0.30[83] -1.12[84]
13 MKNK1 MAP kinase-interacting serine/threonine-protein kinase 1 [85] 0.25[86] -0.27[87] 0.05[88] 0.53[89] -0.20[90] 0.62[91]
14 MTOR Serine/threonine-protein kinase mTOR [92] 2.41[93] 3.28[94] 2.66[95] 2.87[96] 2.61[97] 3.37[98]
15 PBK Lymphokine-activated killer T-cell-originated protein kinase [99] 1.42[100] 2.42[101] 1.70[102] 2.05[103] 2.33[104] -1.77[105]
16 TSC1 Hamartin [106] 1.77[107] 2.28[108] 2.24[109] 2.24[110] 2.12[111] 2.67[112]
17 MAP2K6 Dual specificity mitogen-activated protein kinase kinase 6 [113] 0.17[114] -3.19[115] 1.47[116] 1.19[117] -3.17[118] -1.70[119]
18 MAP3K5 Mitogen-activated protein kinase kinase kinase 5 [120] -4.42[121] -7.49[122] -1.79[123] -1.68[124] 2.38[125] 2.97[126]
[1]
ref_hepatocyte EIF4EBP1
Mean 48.7
Standard deviation 38
Values 90 20 87 11 35
[2]
HepG2 EIF4EBP1
Mean 54.1
Standard deviation 26
Values 36 72
[3]
HepG2.C3A EIF4EBP1
Mean 38.6
Standard deviation 15
Values 28 49
[4]
HuH.7 EIF4EBP1
Mean 56.5
Standard deviation 22
Values 73 32 64
[5]
SNU475 EIF4EBP1
Mean 9.08
Standard deviation 1.3
Values 10 8.2
[6]
THLE EIF4EBP1
Mean 29.8
Standard deviation 5
Values 33 26
[7]
liver EIF4EBP1
Mean 22.9
Standard deviation 28
Values 4.4 3.1 62 22
[8]
ref_hepatocyte AKT1
Mean 37.6
Standard deviation 15
Values 19 32 31 55 50
[9]
HepG2 AKT1
Mean 87.8
Standard deviation 2.3
Values 86 89
[10]
HepG2.C3A AKT1
Mean 66.6
Standard deviation 2.4
Values 68 65
[11]
HuH.7 AKT1
Mean 30.2
Standard deviation 6.6
Values 35 23 33
[12]
SNU475 AKT1
Mean 66.6
Standard deviation 14
Values 57 76
[13]
THLE AKT1
Mean 75.8
Standard deviation 6.1
Values 72 80
[14]
liver AKT1
Mean 45.1
Standard deviation 25
Values 79 48 34 20
[15]
ref_hepatocyte MAP2K3
Mean 32.7
Standard deviation 39
Values 1e+02 17 16 11 17
[16]
HepG2 MAP2K3
Mean 31
Standard deviation 5.7
Values 35 27
[17]
HepG2.C3A MAP2K3
Mean 34
Standard deviation 1.9
Values 33 35
[18]
HuH.7 MAP2K3
Mean 15.2
Standard deviation 4.8
Values 18 9.6 18
[19]
SNU475 MAP2K3
Mean 16.9
Standard deviation 1.1
Values 18 16
[20]
THLE MAP2K3
Mean 17.3
Standard deviation 3
Values 15 19
[21]
liver MAP2K3
Mean 17.2
Standard deviation 13
Values 7.1 4.9 30 26
[22]
ref_hepatocyte MKNK2
Mean 28.3
Standard deviation 24
Values 66 26 33 7.9 8.5
[23]
HepG2 MKNK2
Mean 71.5
Standard deviation 19
Values 58 85
[24]
HepG2.C3A MKNK2
Mean 44
Standard deviation 12
Values 36 52
[25]
HuH.7 MKNK2
Mean 45.9
Standard deviation 9.7
Values 39 57 42
[26]
SNU475 MKNK2
Mean 23.2
Standard deviation 4.1
Values 20 26
[27]
THLE MKNK2
Mean 51.9
Standard deviation 8.4
Values 58 46
[28]
liver MKNK2
Mean 20.4
Standard deviation 5.4
Values 24 16 26 16
[29]
ref_hepatocyte MAP2K1
Mean 28.1
Standard deviation 8.6
Values 32 27 15 27 39
[30]
HepG2 MAP2K1
Mean 32.6
Standard deviation 3.7
Values 30 35
[31]
HepG2.C3A MAP2K1
Mean 23.1
Standard deviation 0.39
Values 23 23
[32]
HuH.7 MAP2K1
Mean 33.2
Standard deviation 6.4
Values 40 27 33
[33]
SNU475 MAP2K1
Mean 35.5
Standard deviation 5.2
Values 39 32
[34]
THLE MAP2K1
Mean 56.5
Standard deviation 3.6
Values 54 59
[35]
liver MAP2K1
Mean 17.5
Standard deviation 8
Values 12 11 28 18
[36]
ref_hepatocyte MAP2K2
Mean 27.7
Standard deviation 8.5
Values 28 26 42 22 20
[37]
HepG2 MAP2K2
Mean 63.6
Standard deviation 21
Values 48 79
[38]
HepG2.C3A MAP2K2
Mean 45.2
Standard deviation 14
Values 36 55
[39]
HuH.7 MAP2K2
Mean 79.3
Standard deviation 9.5
Values 69 82 87
[40]
SNU475 MAP2K2
Mean 28.4
Standard deviation 0.16
Values 28 28
[41]
THLE MAP2K2
Mean 44.5
Standard deviation 0.75
Values 44 45
[42]
liver MAP2K2
Mean 12.1
Standard deviation 3
Values 11 11 17 9.8
[43]
ref_hepatocyte RAF1
Mean 15.5
Standard deviation 5.7
Values 20 17 20 6 14
[44]
HepG2 RAF1
Mean 32.7
Standard deviation 5.2
Values 36 29
[45]
HepG2.C3A RAF1
Mean 38.6
Standard deviation 2.8
Values 37 41
[46]
HuH.7 RAF1
Mean 89
Standard deviation 4.2
Values 89 93 85
[47]
SNU475 RAF1
Mean 25
Standard deviation 4.6
Values 28 22
[48]
THLE RAF1
Mean 50.9
Standard deviation 5.2
Values 47 55
[49]
liver RAF1
Mean 47
Standard deviation 3.6
Values 46 42 51 49
[50]
ref_hepatocyte EIF4E
Mean 15
Standard deviation 8.3
Values 13 10 7.1 17 28
[51]
HepG2 EIF4E
Mean 36.5
Standard deviation 7.8
Values 42 31
[52]
HepG2.C3A EIF4E
Mean 57.7
Standard deviation 21
Values 72 43
[53]
HuH.7 EIF4E
Mean 35.6
Standard deviation 9.2
Values 41 25 41
[54]
SNU475 EIF4E
Mean 22.8
Standard deviation 0.41
Values 22 23
[55]
THLE EIF4E
Mean 52.1
Standard deviation 2.8
Values 50 54
[56]
liver EIF4E
Mean 24
Standard deviation 12
Values 12 16 33 36
[57]
ref_hepatocyte MAP3K11
Mean 10.8
Standard deviation 3.8
Values 6.1 12 13 16 7.7
[58]
HepG2 MAP3K11
Mean 50.5
Standard deviation 6.9
Values 55 46
[59]
HepG2.C3A MAP3K11
Mean 43.3
Standard deviation 11
Values 35 51
[60]
HuH.7 MAP3K11
Mean 32
Standard deviation 5.2
Values 30 28 38
[61]
SNU475 MAP3K11
Mean 21.9
Standard deviation 1.7
Values 21 23
[62]
THLE MAP3K11
Mean 22.3
Standard deviation 1.7
Values 21 23
[63]
liver MAP3K11
Mean 21
Standard deviation 5.1
Values 26 19 24 15
[64]
ref_hepatocyte MAPK1
Mean 10.7
Standard deviation 3.7
Values 13 7.4 6.1 14 13
[65]
HepG2 MAPK1
Mean 77.6
Standard deviation 22
Values 93 62
[66]
HepG2.C3A MAPK1
Mean 76.1
Standard deviation 7.2
Values 81 71
[67]
HuH.7 MAPK1
Mean 64.8
Standard deviation 7.4
Values 61 60 73
[68]
SNU475 MAPK1
Mean 71.1
Standard deviation 8
Values 65 77
[69]
THLE MAPK1
Mean 62.4
Standard deviation 14
Values 53 72
[70]
liver MAPK1
Mean 52.3
Standard deviation 14
Values 61 68 39 41
[71]
ref_hepatocyte PRKAA1
Mean 8.04
Standard deviation 3.4
Values 6.1 14 7.2 5.4 7.6
[72]
HepG2 PRKAA1
Mean 16.8
Standard deviation 2.1
Values 18 15
[73]
HepG2.C3A PRKAA1
Mean 36.3
Standard deviation 5.5
Values 40 32
[74]
HuH.7 PRKAA1
Mean 99.5
Standard deviation 14
Values 84 1e+02 1.1e+02
[75]
SNU475 PRKAA1
Mean 40.7
Standard deviation 4.8
Values 37 44
[76]
THLE PRKAA1
Mean 55.1
Standard deviation 6.9
Values 60 50
[77]
liver PRKAA1
Mean 47.6
Standard deviation 7.3
Values 47 58 40 45
[78]
ref_hepatocyte MAPK3
Mean 4.16
Standard deviation 1.3
Values 3.6 3.3 6 5.1 2.8
[79]
HepG2 MAPK3
Mean 33.1
Standard deviation 5.2
Values 29 37
[80]
HepG2.C3A MAPK3
Mean 30.4
Standard deviation 12
Values 22 39
[81]
HuH.7 MAPK3
Mean 30
Standard deviation 4.8
Values 32 25 34
[82]
SNU475 MAPK3
Mean 10.2
Standard deviation 2.4
Values 8.5 12
[83]
THLE MAPK3
Mean 11.6
Standard deviation 1.1
Values 11 12
[84]
liver MAPK3
Mean 2.87
Standard deviation 2.4
Values 0.82 0.81 5 4.8
[85]
ref_hepatocyte MKNK1
Mean 3.72
Standard deviation 0.64
Values 3.9 3.4 3.7 3 4.7
[86]
HepG2 MKNK1
Mean 10.6
Standard deviation 2.1
Values 12 9.1
[87]
HepG2.C3A MKNK1
Mean 7.29
Standard deviation 0.2
Values 7.2 7.4
[88]
HuH.7 MKNK1
Mean 10
Standard deviation 0.97
Values 11 8.9 10
[89]
SNU475 MKNK1
Mean 8.68
Standard deviation 2.1
Values 7.2 10
[90]
THLE MKNK1
Mean 7.38
Standard deviation 0.36
Values 7.6 7.1
[91]
liver MKNK1
Mean 8.59
Standard deviation 2.1
Values 7.3 6.3 11 10
[92]
ref_hepatocyte MTOR
Mean 3.34
Standard deviation 0.62
Values 4.3 3.2 3.5 2.6 3.1
[93]
HepG2 MTOR
Mean 42.7
Standard deviation 6.3
Values 47 38
[94]
HepG2.C3A MTOR
Mean 76.8
Standard deviation 17
Values 65 89
[95]
HuH.7 MTOR
Mean 54.5
Standard deviation 17
Values 41 50 73
[96]
SNU475 MTOR
Mean 39.4
Standard deviation 0.66
Values 40 39
[97]
THLE MTOR
Mean 46.6
Standard deviation 4.9
Values 43 50
[98]
liver MTOR
Mean 51.8
Standard deviation 18
Values 62 72 34 39
[99]
ref_hepatocyte PBK
Mean 2.12
Standard deviation 2.3
Values 0.14 0.18 1.6 3.1 5.6
[100]
HepG2 PBK
Mean 13.6
Standard deviation 6.4
Values 18 9.1
[101]
HepG2.C3A PBK
Mean 27
Standard deviation 20
Values 41 13
[102]
HuH.7 PBK
Mean 17.8
Standard deviation 8.3
Values 25 8.6 20
[103]
SNU475 PBK
Mean 14.2
Standard deviation 0.31
Values 14 14
[104]
THLE PBK
Mean 24.3
Standard deviation 2.3
Values 26 23
[105]
liver PBK
Mean 0.939
Standard deviation 1
Values 0 0.76 0.61 2.4
[106]
ref_hepatocyte TSC1
Mean 1.81
Standard deviation 0.96
Values 2.1 1.1 0.7 3.1 2.1
[107]
HepG2 TSC1
Mean 14.8
Standard deviation 1.6
Values 16 14
[108]
HepG2.C3A TSC1
Mean 20.9
Standard deviation 3.3
Values 19 23
[109]
HuH.7 TSC1
Mean 22.2
Standard deviation 4.3
Values 18 26 22
[110]
SNU475 TSC1
Mean 13.9
Standard deviation 2.8
Values 12 16
[111]
THLE TSC1
Mean 18
Standard deviation 3.2
Values 16 20
[112]
liver TSC1
Mean 17.4
Standard deviation 1.8
Values 17 20 17 16
[113]
ref_hepatocyte MAP2K6
Mean 1.65
Standard deviation 2.1
Values 0.17 1.1 0.98 5.3 0.69
[114]
HepG2 MAP2K6
Mean 4.46
Standard deviation 1.8
Values 5.7 3.2
[115]
HepG2.C3A MAP2K6
Mean 0.428
Standard deviation 0.00091
Values 0.43 0.43
[116]
HuH.7 MAP2K6
Mean 11.9
Standard deviation 2.1
Values 13 9.5 13
[117]
SNU475 MAP2K6
Mean 6.1
Standard deviation 1.1
Values 5.4 6.8
[118]
THLE MAP2K6
Mean 0.418
Standard deviation 0.064
Values 0.37 0.46
[119]
liver MAP2K6
Mean 0.764
Standard deviation 0.64
Values 0.79 0.61 1.6 0.051
[120]
ref_hepatocyte MAP3K5
Mean 1.19
Standard deviation 0.96
Values 0.68 2.2 2.2 0 0.9
[121]
HepG2 MAP3K5
Mean 0.133
Standard deviation 0.055
Values 0.094 0.17
[122]
HepG2.C3A MAP3K5
Mean 0.0156
Standard deviation 0.0083
Values 0.021 0.0097
[123]
HuH.7 MAP3K5
Mean 0.888
Standard deviation 0.21
Values 0.67 0.92 1.1
[124]
SNU475 MAP3K5
Mean 0.598
Standard deviation 0.29
Values 0.81 0.39
[125]
THLE MAP3K5
Mean 14.1
Standard deviation 0.49
Values 14 14
[126]
liver MAP3K5
Mean 14
Standard deviation 6.9
Values 20 20 7.3 8.7