REACTOME_PLASMA_LIPOPROTEIN_CLEARANCE | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | APOC1 | Apolipoprotein C-I | [1] | -4.12[2] | -3.99[3] | -2.75[4] | -8.27[5] | -9.09[6] | -3.18[7] |
2 | APOA1 | Apolipoprotein A-I | [8] | -1.23[9] | -0.56[10] | -2.68[11] | -9.40[12] | -9.70[13] | -0.41[14] |
3 | APOE | Apolipoprotein E | [15] | -0.65[16] | -0.88[17] | -0.39[18] | -6.12[19] | -5.49[20] | -1.09[21] |
4 | APOC4 | Apolipoprotein C-IV | [22] | [23] | [24] | [25] | [26] | [27] | [28] |
5 | APOB | Apolipoprotein B-100 | [29] | 4.95[30] | 5.11[31] | 4.81[32] | -2.79[33] | -2.86[34] | 5.61[35] |
6 | CLTA | Clathrin light chain A | [36] | 1.13[37] | 0.34[38] | 0.97[39] | 2.19[40] | 2.43[41] | -2.52[42] |
7 | NPC2 | Epididymal secretory protein E1 | [43] | 1.69[44] | 1.89[45] | 0.71[46] | 2.78[47] | 3.17[48] | -1.53[49] |
8 | LSR | Lipolysis-stimulated lipoprotein receptor | [50] | 1.97[51] | 1.56[52] | 1.15[53] | -1.93[54] | 0.64[55] | -0.50[56] |
9 | HDLBP | Vigilin | [57] | 4.97[58] | 4.20[59] | 4.52[60] | 6.15[61] | 6.05[62] | 2.70[63] |
10 | LIPA | Lysosomal acid lipase/cholesteryl ester hydrolase | [64] | 2.32[65] | 1.72[66] | 1.17[67] | 2.74[68] | 3.00[69] | 0.47[70] |
11 | SCARB1 | Scavenger receptor class B member 1 | [71] | 3.96[72] | 2.98[73] | 3.19[74] | 3.73[75] | 2.42[76] | 1.35[77] |
12 | AP2M1 | AP-2 complex subunit mu | [78] | 3.22[79] | 2.42[80] | 2.44[81] | 5.63[82] | 6.01[83] | 0.58[84] |
13 | AP2S1 | AP-2 complex subunit sigma | [85] | 1.39[86] | 0.76[87] | 1.97[88] | 3.91[89] | 4.21[90] | -0.28[91] |
14 | LIPC | Hepatic triacylglycerol lipase | [92] | 0.82[93] | 0.33[94] | 2.84[95] | -4.73[96] | -5.42[97] | 0.43[98] |
15 | AMN | Protein amnionless | [99] | -0.39[100] | -0.16[101] | -0.76[102] | -5.69[103] | -6.10[104] | -3.13[105] |
16 | CLTC | Clathrin heavy chain 1 | [106] | 4.62[107] | 4.11[108] | 4.80[109] | 6.33[110] | 6.34[111] | 3.20[112] |
17 | NR1H3 | Oxysterols receptor LXR-alpha | [113] | 1.34[114] | 1.75[115] | 3.20[116] | 1.92[117] | 0.44[118] | 0.43[119] |
18 | LDLR | Low-density lipoprotein receptor | [120] | 3.20[121] | 3.43[122] | 4.95[123] | 3.75[124] | 4.82[125] | 1.97[126] |
19 | NR1H2 | Oxysterols receptor LXR-beta | [127] | 2.32[128] | 1.60[129] | 2.48[130] | 4.41[131] | 4.63[132] | 0.76[133] |
20 | AP2A1 | AP-2 complex subunit alpha-1 | [134] | 4.21[135] | 3.27[136] | 4.62[137] | 6.05[138] | 6.00[139] | 1.70[140] |
21 | PCSK9 | Proprotein convertase subtilisin/kexin type 9 | [141] | 0.05[142] | 4.53[143] | 6.40[144] | -1.33[145] | -1.89[146] | 2.00[147] |
22 | AP2B1 | AP-2 complex subunit beta | [148] | 5.25[149] | 4.37[150] | 6.61[151] | 7.21[152] | 6.93[153] | 1.68[154] |
23 | AP2A2 | AP-2 complex subunit alpha-2 | [155] | 4.27[156] | 3.50[157] | 4.15[158] | 5.50[159] | 5.01[160] | 1.41[161] |
24 | CES3 | Carboxylesterase 3 | [162] | 1.76[163] | 2.41[164] | 0.14[165] | 0.93[166] | 0.15[167] | 0.97[168] |
25 | LDLRAP1 | Low density lipoprotein receptor adapter protein 1 | [169] | 2.81[170] | 2.64[171] | 2.22[172] | 5.17[173] | 5.06[174] | 1.53[175] |
26 | NPC1 | Niemann-Pick C1 protein | [176] | 4.97[177] | 4.71[178] | 5.20[179] | 6.67[180] | 6.02[181] | 1.68[182] |
27 | SOAT1 | Sterol O-acyltransferase 1 | [183] | 4.02[184] | 3.96[185] | 5.26[186] | 7.56[187] | 7.04[188] | 2.40[189] |
28 | NCEH1 | Neutral cholesterol ester hydrolase 1 | [190] | 3.72[191] | 3.63[192] | 4.32[193] | 5.21[194] | 6.54[195] | -0.12[196] |
29 | VLDLR | Very low-density lipoprotein receptor | [197] | 4.60[198] | 3.35[199] | 4.27[200] | 7.06[201] | 4.93[202] | 0.38[203] |
30 | SOAT2 | Sterol O-acyltransferase 2 | [204] | 4.34[205] | 6.20[206] | 5.38[207] | -1.63[208] | -2.32[209] | -0.60[210] |
31 | MYLIP | E3 ubiquitin-protein ligase MYLIP | [211] | 5.00[212] | 4.13[213] | 5.58[214] | 6.70[215] | 6.12[216] | 2.77[217] |
32 | APOBR | Apolipoprotein B receptor | [218] | 1.28[219] | 0.51[220] | 2.30[221] | 0.52[222] | 1.51[223] | 1.63[224] |
33 | CUBN | Cubilin | [225] | 4.23[226] | 5.12[227] | 3.89[228] | 9.96[229] | 8.28[230] | 5.45[231] |