REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 PRKAR1A cAMP-dependent protein kinase type I-alpha regulatory subunit [1] -0.31[2] -0.19[3] -0.34[4] -0.86[5] -0.76[6] -0.58[7]
2 CALM1 Calmodulin-1 [8] -0.31[9] -0.28[10] -0.12[11] 0.81[12] 0.29[13] 0.45[14]
3 PRKACA cAMP-dependent protein kinase catalytic subunit alpha [15] -0.55[16] -0.73[17] -1.03[18] -1.24[19] -0.45[20] -1.95[21]
4 PRKAR2A cAMP-dependent protein kinase type II-alpha regulatory subunit [22] -0.33[23] -0.66[24] 0.15[25] -1.06[26] -0.99[27] -1.02[28]
5 PRKAR1B cAMP-dependent protein kinase type I-beta regulatory subunit [29] 0.59[30] 0.03[31] -2.06[32] -4.87[33] -1.87[34] -1.34[35]
6 PRKACB cAMP-dependent protein kinase catalytic subunit beta [36] -1.22[37] -0.45[38] 0.54[39] 1.46[40] 0.53[41] 0.54[42]
7 ADCY9 Adenylate cyclase type 9 [43] 2.23[44] 1.41[45] 1.54[46] 0.19[47] -0.07[48] 1.25[49]
8 ADCY6 Adenylate cyclase type 6 [50] 1.67[51] 2.12[52] 1.78[53] 1.73[54] 2.61[55] 1.47[56]
9 CREB1 Cyclic AMP-responsive element-binding protein 1 [57] 1.34[58] 2.49[59] 2.68[60] 1.77[61] 1.92[62] 1.18[63]
10 ADCY1 Adenylate cyclase type 1 [64] -1.22[65] -3.10[66] -3.60[67] -2.88[68] -2.69[69] 3.83[70]
11 PRKX cAMP-dependent protein kinase catalytic subunit PRKX [71] -2.03[72] -2.27[73] 2.36[74] 0.48[75] 2.22[76] 0.28[77]
12 ADCY7 Adenylate cyclase type 7 [78] 3.13[79] 2.74[80] 1.40[81] 2.54[82] 2.22[83] 1.76[84]
13 PRKAR2B cAMP-dependent protein kinase type II-beta regulatory subunit [85] -2.72[86] -0.91[87] 3.08[88] 4.31[89] 3.03[90] 2.15[91]
14 ADCY3 Adenylate cyclase type 3 [92] 1.08[93] -0.18[94] 2.85[95] 3.97[96] 5.70[97] 2.35[98]
15 ADCY2 Adenylate cyclase type 2 [99] -5.77[100] -3.84[101] -5.40[102] -3.50[103] -4.42[104] -5.29[105]
16 NBEA Neurobeachin [106] 3.61[107] 3.28[108] 0.78[109] 1.17[110] 3.72[111] 3.65[112]
17 ADCY5 Adenylate cyclase type 5 [113] -0.23[114] 0.76[115] 1.49[116] -0.12[117] 1.21[118] 5.21[119]
18 ADCY4 Adenylate cyclase type 4 [120] -0.29[121] -1.37[122] 0.97[123] [124] [125] 7.20[126]
19 ADCY8 Adenylate cyclase type 8 [127] [128] [129] [130] [131] [132] [133]
20 PRKACG cAMP-dependent protein kinase catalytic subunit gamma [134] [135] [136] [137] [138] [139] [140]
[1]
ref_hepatocyte PRKAR1A
Mean 51.9
Standard deviation 38
Values 1.1e+02 62 30 19 35
[2]
HepG2 PRKAR1A
Mean 121
Standard deviation 21
Values 1.1e+02 1.4e+02
[3]
HepG2.C3A PRKAR1A
Mean 117
Standard deviation 14
Values 1.1e+02 1.3e+02
[4]
HuH.7 PRKAR1A
Mean 124
Standard deviation 6.6
Values 1.3e+02 1.3e+02 1.2e+02
[5]
SNU475 PRKAR1A
Mean 89.4
Standard deviation 19
Values 1e+02 76
[6]
THLE PRKAR1A
Mean 93.3
Standard deviation 15
Values 83 1e+02
[7]
liver PRKAR1A
Mean 111
Standard deviation 40
Values 89 1.4e+02 1.5e+02 66
[8]
ref_hepatocyte CALM1
Mean 29.2
Standard deviation 11
Values 17 40 21 28 40
[9]
HepG2 CALM1
Mean 67.9
Standard deviation 4.3
Values 65 71
[10]
HepG2.C3A CALM1
Mean 62
Standard deviation 16
Values 51 73
[11]
HuH.7 CALM1
Mean 81.9
Standard deviation 15
Values 90 64 92
[12]
SNU475 CALM1
Mean 160
Standard deviation 24
Values 1.8e+02 1.4e+02
[13]
THLE CALM1
Mean 109
Standard deviation 13
Values 1e+02 1.2e+02
[14]
liver CALM1
Mean 127
Standard deviation 70
Values 2.1e+02 80 1.7e+02 57
[15]
ref_hepatocyte PRKACA
Mean 15.8
Standard deviation 8.3
Values 7.6 11 11 27 23
[16]
HepG2 PRKACA
Mean 31.2
Standard deviation 2.7
Values 29 33
[17]
HepG2.C3A PRKACA
Mean 24.6
Standard deviation 3.5
Values 27 22
[18]
HuH.7 PRKACA
Mean 23.6
Standard deviation 5.7
Values 27 17 27
[19]
SNU475 PRKACA
Mean 21
Standard deviation 3.3
Values 23 19
[20]
THLE PRKACA
Mean 35.4
Standard deviation 5.3
Values 32 39
[21]
liver PRKACA
Mean 13.1
Standard deviation 4.9
Values 18 8.8 16 8.9
[22]
ref_hepatocyte PRKAR2A
Mean 7.11
Standard deviation 7.6
Values 6.5 20 6.5 1.3 1.4
[23]
HepG2 PRKAR2A
Mean 16.3
Standard deviation 1.9
Values 15 18
[24]
HepG2.C3A PRKAR2A
Mean 11.6
Standard deviation 4.5
Values 8.4 15
[25]
HuH.7 PRKAR2A
Mean 24
Standard deviation 9.6
Values 34 24 14
[26]
SNU475 PRKAR2A
Mean 10.7
Standard deviation 0.56
Values 11 10
[27]
THLE PRKAR2A
Mean 10.9
Standard deviation 4
Values 8.1 14
[28]
liver PRKAR2A
Mean 11.2
Standard deviation 5.7
Values 5.5 18 7.5 14
[29]
ref_hepatocyte PRKAR1B
Mean 6.04
Standard deviation 3.4
Values 7.5 11 3.5 5.3 2.7
[30]
HepG2 PRKAR1B
Mean 26.2
Standard deviation 3.9
Values 23 29
[31]
HepG2.C3A PRKAR1B
Mean 15.9
Standard deviation 0.32
Values 16 16
[32]
HuH.7 PRKAR1B
Mean 4.42
Standard deviation 1.8
Values 5.2 2.4 5.7
[33]
SNU475 PRKAR1B
Mean 0.647
Standard deviation 0.21
Values 0.79 0.5
[34]
THLE PRKAR1B
Mean 5.04
Standard deviation 0.84
Values 4.4 5.6
[35]
liver PRKAR1B
Mean 7.61
Standard deviation 2.9
Values 11 4.6 9.2 5.8
[36]
ref_hepatocyte PRKACB
Mean 2.75
Standard deviation 1.3
Values 2.1 3.1 1.4 2.4 4.8
[37]
HepG2 PRKACB
Mean 3.41
Standard deviation 1.6
Values 2.3 4.6
[38]
HepG2.C3A PRKACB
Mean 5.2
Standard deviation 0.9
Values 4.6 5.8
[39]
HuH.7 PRKACB
Mean 12.2
Standard deviation 3.4
Values 11 16 9.5
[40]
SNU475 PRKACB
Mean 23.8
Standard deviation 4.4
Values 27 21
[41]
THLE PRKACB
Mean 12.1
Standard deviation 0.96
Values 13 11
[42]
liver PRKACB
Mean 12.8
Standard deviation 2
Values 12 14 14 10
[43]
ref_hepatocyte ADCY9
Mean 2.69
Standard deviation 0.67
Values 3.5 2.2 1.8 3 2.9
[44]
HepG2 ADCY9
Mean 36.5
Standard deviation 7.3
Values 42 31
[45]
HepG2.C3A ADCY9
Mean 18.5
Standard deviation 4.9
Values 22 15
[46]
HuH.7 ADCY9
Mean 23.8
Standard deviation 5.7
Values 28 26 17
[47]
SNU475 ADCY9
Mean 9.58
Standard deviation 2.4
Values 11 7.9
[48]
THLE ADCY9
Mean 7.83
Standard deviation 1.4
Values 6.8 8.8
[49]
liver ADCY9
Mean 20.3
Standard deviation 12
Values 11 26 9.7 34
[50]
ref_hepatocyte ADCY6
Mean 1.84
Standard deviation 0.33
Values 1.7 2.4 1.9 1.8 1.5
[51]
HepG2 ADCY6
Mean 16.9
Standard deviation 1.2
Values 16 18
[52]
HepG2.C3A ADCY6
Mean 20.7
Standard deviation 1.1
Values 21 20
[53]
HuH.7 ADCY6
Mean 19.3
Standard deviation 0.93
Values 18 20 20
[54]
SNU475 ADCY6
Mean 19.2
Standard deviation 5.6
Values 23 15
[55]
THLE ADCY6
Mean 34.3
Standard deviation 2.1
Values 36 33
[56]
liver ADCY6
Mean 16.3
Standard deviation 9.4
Values 10 21 6.9 27
[57]
ref_hepatocyte CREB1
Mean 1.8
Standard deviation 1.2
Values 3.7 2.1 1.5 0.96 0.81
[58]
HepG2 CREB1
Mean 13.1
Standard deviation 2.8
Values 11 15
[59]
HepG2.C3A CREB1
Mean 26.1
Standard deviation 3.2
Values 24 28
[60]
HuH.7 CREB1
Mean 35.1
Standard deviation 4
Values 38 36 31
[61]
SNU475 CREB1
Mean 19.3
Standard deviation 0.081
Values 19 19
[62]
THLE CREB1
Mean 20.8
Standard deviation 2.1
Values 22 19
[63]
liver CREB1
Mean 13
Standard deviation 3.1
Values 12 16 9.3 15
[64]
ref_hepatocyte ADCY1
Mean 0.753
Standard deviation 0.8
Values 0.18 0.11 0.22 1.6 1.6
[65]
HepG2 ADCY1
Mean 0.932
Standard deviation 0.17
Values 1 0.82
[66]
HepG2.C3A ADCY1
Mean 0.227
Standard deviation 0.064
Values 0.27 0.18
[67]
HuH.7 ADCY1
Mean 0.189
Standard deviation 0.063
Values 0.18 0.26 0.13
[68]
SNU475 ADCY1
Mean 0.321
Standard deviation 0.11
Values 0.25 0.4
[69]
THLE ADCY1
Mean 0.355
Standard deviation 0.017
Values 0.34 0.37
[70]
liver ADCY1
Mean 34
Standard deviation 27
Values 8 57 14 57
[71]
ref_hepatocyte PRKX
Mean 0.643
Standard deviation 0.41
Values 0.54 1.3 0.75 0.22 0.41
[72]
HepG2 PRKX
Mean 0.454
Standard deviation 0.14
Values 0.56 0.35
[73]
HepG2.C3A PRKX
Mean 0.346
Standard deviation 0.034
Values 0.37 0.32
[74]
HuH.7 PRKX
Mean 10.1
Standard deviation 3.2
Values 13 6.7 11
[75]
SNU475 PRKX
Mean 2.81
Standard deviation 0.015
Values 2.8 2.8
[76]
THLE PRKX
Mean 9.15
Standard deviation 0.52
Values 8.8 9.5
[77]
liver PRKX
Mean 2.48
Standard deviation 1.2
Values 1.1 3.4 1.8 3.6
[78]
ref_hepatocyte ADCY7
Mean 0.512
Standard deviation 0.32
Values 0.68 0.13 0.92 0.28 0.54
[79]
HepG2 ADCY7
Mean 12.9
Standard deviation 4.7
Values 16 9.6
[80]
HepG2.C3A ADCY7
Mean 8.84
Standard deviation 0.22
Values 8.7 9
[81]
HuH.7 ADCY7
Mean 4.11
Standard deviation 0.66
Values 4.9 3.6 3.9
[82]
SNU475 ADCY7
Mean 9.31
Standard deviation 2.3
Values 11 7.7
[83]
THLE ADCY7
Mean 7.26
Standard deviation 0.034
Values 7.3 7.2
[84]
liver ADCY7
Mean 5.51
Standard deviation 3.3
Values 2.4 7.3 3.2 9.2
[85]
ref_hepatocyte PRKAR2B
Mean 0.12
Standard deviation 0.14
Values 0 0 0.21 0.078 0.31
[86]
HepG2 PRKAR2B
Mean 0.0522
Standard deviation 0.0072
Values 0.057 0.047
[87]
HepG2.C3A PRKAR2B
Mean 0.165
Standard deviation 0.097
Values 0.23 0.097
[88]
HuH.7 PRKAR2B
Mean 3.07
Standard deviation 1.2
Values 3.8 1.7 3.7
[89]
SNU475 PRKAR2B
Mean 7.46
Standard deviation 0.031
Values 7.5 7.4
[90]
THLE PRKAR2B
Mean 2.99
Standard deviation 0.15
Values 2.9 3.1
[91]
liver PRKAR2B
Mean 1.69
Standard deviation 0.7
Values 1.6 2.7 1.4 1.1
[92]
ref_hepatocyte ADCY3
Mean 0.12
Standard deviation 0.15
Values 0 0.11 0.38 0 0.11
[93]
HepG2 ADCY3
Mean 0.726
Standard deviation 0.55
Values 1.1 0.33
[94]
HepG2.C3A ADCY3
Mean 0.273
Standard deviation 0.084
Values 0.21 0.33
[95]
HuH.7 ADCY3
Mean 2.63
Standard deviation 1.3
Values 3.5 1.1 3.3
[96]
SNU475 ADCY3
Mean 5.86
Standard deviation 0.44
Values 5.5 6.2
[97]
THLE ADCY3
Mean 19
Standard deviation 3
Values 17 21
[98]
liver ADCY3
Mean 1.94
Standard deviation 1.2
Values 1.1 2.4 0.82 3.5
[99]
ref_hepatocyte ADCY2
Mean 0.081
Standard deviation 0.073
Values 0.061 0.016 0.2 0.043 0.081
[100]
HepG2 ADCY2
Mean 0.00429
Standard deviation 0.0061
Values 0 0.0086
[101]
HepG2.C3A ADCY2
Mean 0.0146
Standard deviation 0.021
Values 0.029 0
[102]
HuH.7 ADCY2
Mean 0.00586
Standard deviation 0.0051
Values 0.0082 0 0.0094
[103]
SNU475 ADCY2
Mean 0.0224
Standard deviation 0.019
Values 0.0093 0.035
[104]
THLE ADCY2
Mean 0.0115
Standard deviation 0.0088
Values 0.018 0.0053
[105]
liver ADCY2
Mean 0.00662
Standard deviation 0.013
Values 0 0 0 0.026
[106]
ref_hepatocyte NBEA
Mean 0.0721
Standard deviation 0.084
Values 0.22 0.052 0.06 0 0.033
[107]
HepG2 NBEA
Mean 2.53
Standard deviation 0.11
Values 2.6 2.5
[108]
HepG2.C3A NBEA
Mean 1.81
Standard deviation 0.35
Values 2.1 1.6
[109]
HuH.7 NBEA
Mean 0.377
Standard deviation 0.1
Values 0.3 0.49 0.35
[110]
SNU475 NBEA
Mean 0.508
Standard deviation 0.07
Values 0.46 0.56
[111]
THLE NBEA
Mean 2.9
Standard deviation 0.63
Values 3.3 2.5
[112]
liver NBEA
Mean 2.89
Standard deviation 2
Values 1.7 4.7 0.77 4.4
[113]
ref_hepatocyte ADCY5
Mean 0.0321
Standard deviation 0.047
Values 0 0 0 0.1 0.057
[114]
HepG2 ADCY5
Mean 0.0787
Standard deviation 0.022
Values 0.063 0.094
[115]
HepG2.C3A ADCY5
Mean 0.14
Standard deviation 0.077
Values 0.19 0.086
[116]
HuH.7 ADCY5
Mean 0.274
Standard deviation 0.063
Values 0.21 0.29 0.33
[117]
SNU475 ADCY5
Mean 0.0925
Standard deviation 0.091
Values 0.028 0.16
[118]
THLE ADCY5
Mean 0.226
Standard deviation 0.12
Values 0.31 0.14
[119]
liver ADCY5
Mean 3.77
Standard deviation 2.2
Values 2.5 3.4 2.3 6.9
[120]
ref_hepatocyte ADCY4
Mean 0.00488
Standard deviation 0.011
Values 0 0 0 0 0.024
[121]
HepG2 ADCY4
Mean 0.0115
Standard deviation 0.016
Values 0.023 0
[122]
HepG2.C3A ADCY4
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[123]
HuH.7 ADCY4
Mean 0.0291
Standard deviation 0.017
Values 0.049 0.019 0.019
[124]
SNU475 ADCY4
Mean 0
Standard deviation 0
Values 0 0
[125]
THLE ADCY4
Mean 0
Standard deviation 0
Values 0 0
[126]
liver ADCY4
Mean 2.29
Standard deviation 1.7
Values 4.6 0.78 1.5 2.3
[127]
ref_hepatocyte ADCY8
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[128]
HepG2 ADCY8
Mean 0.00573
Standard deviation 0.0081
Values 0.011 0
[129]
HepG2.C3A ADCY8
Mean 0
Standard deviation 0
Values 0 0
[130]
HuH.7 ADCY8
Mean 0
Standard deviation 0
Values 0 0 0
[131]
SNU475 ADCY8
Mean 0.0198
Standard deviation 0.015
Values 0.0093 0.03
[132]
THLE ADCY8
Mean 0.0937
Standard deviation 0.035
Values 0.12 0.069
[133]
liver ADCY8
Mean 0.0332
Standard deviation 0.041
Values 0 0.014 0.026 0.093
[134]
ref_hepatocyte PRKACG
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[135]
HepG2 PRKACG
Mean 0.00214
Standard deviation 0.003
Values 0 0.0043
[136]
HepG2.C3A PRKACG
Mean 0
Standard deviation 0
Values 0 0
[137]
HuH.7 PRKACG
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[138]
SNU475 PRKACG
Mean 0
Standard deviation 0
Values 0 0
[139]
THLE PRKACG
Mean 0
Standard deviation 0
Values 0 0
[140]
liver PRKACG
Mean 0
Standard deviation 0
Values 0 0 0 0