REACTOME_PKA_ACTIVATION_IN_GLUCAGON_SIGNALLING Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas 0.00[1] 0.05[2] -0.18[3] 0.22[4] -0.10[5] -1.39[6]
2 PRKAR1A cAMP-dependent protein kinase type I-alpha regulatory subunit [7] -0.35[8] -0.21[9] 0.04[10] -0.71[11] -0.38[12] 0.54[13]
3 PRKACA cAMP-dependent protein kinase catalytic subunit alpha [14] -0.59[15] -0.75[16] -0.64[17] -1.09[18] -0.06[19] -0.83[20]
4 PRKAR2A cAMP-dependent protein kinase type II-alpha regulatory subunit [21] -0.37[22] -0.68[23] 0.54[24] -0.91[25] -0.61[26] 0.09[27]
5 PRKAR1B cAMP-dependent protein kinase type I-beta regulatory subunit [28] 0.55[29] 0.01[30] -1.67[31] -4.72[32] -1.49[33] -0.22[34]
6 PRKACB cAMP-dependent protein kinase catalytic subunit beta [35] -1.26[36] -0.47[37] 0.93[38] 1.61[39] 0.91[40] 1.66[41]
7 ADCY9 Adenylate cyclase type 9 [42] 2.19[43] 1.39[44] 1.93[45] 0.33[46] 0.32[47] 2.36[48]
8 ADCY6 Adenylate cyclase type 6 [49] 1.62[50] 2.10[51] 2.17[52] 1.88[53] 2.99[54] 2.58[55]
9 ADCY1 Adenylate cyclase type 1 [56] -1.26[57] -3.12[58] -3.21[59] -2.73[60] -2.31[61] 4.94[62]
10 ADCY7 Adenylate cyclase type 7 [63] 3.09[64] 2.72[65] 1.79[66] 2.68[67] 2.60[68] 2.87[69]
11 PRKAR2B cAMP-dependent protein kinase type II-beta regulatory subunit [70] -2.77[71] -0.93[72] 3.47[73] 4.46[74] 3.42[75] 3.26[76]
12 ADCY3 Adenylate cyclase type 3 [77] 1.03[78] -0.20[79] 3.24[80] 4.11[81] 6.08[82] 3.46[83]
13 ADCY2 Adenylate cyclase type 2 [84] -5.81[85] -3.86[86] -5.01[87] -3.36[88] -4.04[89] -4.17[90]
14 ADCY5 Adenylate cyclase type 5 [91] -0.27[92] 0.74[93] 1.88[94] 0.03[95] 1.59[96] 6.32[97]
15 ADCY4 Adenylate cyclase type 4 [98] -0.34[99] -1.39[100] 1.36[101] [102] [103] 8.32[104]
16 ADCY8 Adenylate cyclase type 8 [105] [106] [107] [108] [109] [110] [111]
17 PRKACG cAMP-dependent protein kinase catalytic subunit gamma [112] [113] [114] [115] [116] [117] [118]
[1]
ref_hepatocyte GNAS
Mean 120
Standard deviation 56
Values 1.4e+02 60 61 1.7e+02 1.7e+02
[2]
HepG2 GNAS
Mean 357
Standard deviation 65
Values 4e+02 3.1e+02
[3]
HepG2.C3A GNAS
Mean 326
Standard deviation 53
Values 3.6e+02 2.9e+02
[4]
HuH.7 GNAS
Mean 246
Standard deviation 32
Values 2.5e+02 2.1e+02 2.7e+02
[5]
SNU475 GNAS
Mean 397
Standard deviation 89
Values 4.6e+02 3.3e+02
[6]
THLE GNAS
Mean 262
Standard deviation 20
Values 2.5e+02 2.8e+02
[7]
liver GNAS
Mean 67.5
Standard deviation 15
Values 84 54 76 56
[8]
ref_hepatocyte PRKAR1A
Mean 51.9
Standard deviation 38
Values 1.1e+02 62 30 19 35
[9]
HepG2 PRKAR1A
Mean 121
Standard deviation 21
Values 1.1e+02 1.4e+02
[10]
HepG2.C3A PRKAR1A
Mean 117
Standard deviation 14
Values 1.1e+02 1.3e+02
[11]
HuH.7 PRKAR1A
Mean 124
Standard deviation 6.6
Values 1.3e+02 1.3e+02 1.2e+02
[12]
SNU475 PRKAR1A
Mean 89.4
Standard deviation 19
Values 1e+02 76
[13]
THLE PRKAR1A
Mean 93.3
Standard deviation 15
Values 83 1e+02
[14]
liver PRKAR1A
Mean 111
Standard deviation 40
Values 89 1.4e+02 1.5e+02 66
[15]
ref_hepatocyte PRKACA
Mean 15.8
Standard deviation 8.3
Values 7.6 11 11 27 23
[16]
HepG2 PRKACA
Mean 31.2
Standard deviation 2.7
Values 29 33
[17]
HepG2.C3A PRKACA
Mean 24.6
Standard deviation 3.5
Values 27 22
[18]
HuH.7 PRKACA
Mean 23.6
Standard deviation 5.7
Values 27 17 27
[19]
SNU475 PRKACA
Mean 21
Standard deviation 3.3
Values 23 19
[20]
THLE PRKACA
Mean 35.4
Standard deviation 5.3
Values 32 39
[21]
liver PRKACA
Mean 13.1
Standard deviation 4.9
Values 18 8.8 16 8.9
[22]
ref_hepatocyte PRKAR2A
Mean 7.11
Standard deviation 7.6
Values 6.5 20 6.5 1.3 1.4
[23]
HepG2 PRKAR2A
Mean 16.3
Standard deviation 1.9
Values 15 18
[24]
HepG2.C3A PRKAR2A
Mean 11.6
Standard deviation 4.5
Values 8.4 15
[25]
HuH.7 PRKAR2A
Mean 24
Standard deviation 9.6
Values 34 24 14
[26]
SNU475 PRKAR2A
Mean 10.7
Standard deviation 0.56
Values 11 10
[27]
THLE PRKAR2A
Mean 10.9
Standard deviation 4
Values 8.1 14
[28]
liver PRKAR2A
Mean 11.2
Standard deviation 5.7
Values 5.5 18 7.5 14
[29]
ref_hepatocyte PRKAR1B
Mean 6.04
Standard deviation 3.4
Values 7.5 11 3.5 5.3 2.7
[30]
HepG2 PRKAR1B
Mean 26.2
Standard deviation 3.9
Values 23 29
[31]
HepG2.C3A PRKAR1B
Mean 15.9
Standard deviation 0.32
Values 16 16
[32]
HuH.7 PRKAR1B
Mean 4.42
Standard deviation 1.8
Values 5.2 2.4 5.7
[33]
SNU475 PRKAR1B
Mean 0.647
Standard deviation 0.21
Values 0.79 0.5
[34]
THLE PRKAR1B
Mean 5.04
Standard deviation 0.84
Values 4.4 5.6
[35]
liver PRKAR1B
Mean 7.61
Standard deviation 2.9
Values 11 4.6 9.2 5.8
[36]
ref_hepatocyte PRKACB
Mean 2.75
Standard deviation 1.3
Values 2.1 3.1 1.4 2.4 4.8
[37]
HepG2 PRKACB
Mean 3.41
Standard deviation 1.6
Values 2.3 4.6
[38]
HepG2.C3A PRKACB
Mean 5.2
Standard deviation 0.9
Values 4.6 5.8
[39]
HuH.7 PRKACB
Mean 12.2
Standard deviation 3.4
Values 11 16 9.5
[40]
SNU475 PRKACB
Mean 23.8
Standard deviation 4.4
Values 27 21
[41]
THLE PRKACB
Mean 12.1
Standard deviation 0.96
Values 13 11
[42]
liver PRKACB
Mean 12.8
Standard deviation 2
Values 12 14 14 10
[43]
ref_hepatocyte ADCY9
Mean 2.69
Standard deviation 0.67
Values 3.5 2.2 1.8 3 2.9
[44]
HepG2 ADCY9
Mean 36.5
Standard deviation 7.3
Values 42 31
[45]
HepG2.C3A ADCY9
Mean 18.5
Standard deviation 4.9
Values 22 15
[46]
HuH.7 ADCY9
Mean 23.8
Standard deviation 5.7
Values 28 26 17
[47]
SNU475 ADCY9
Mean 9.58
Standard deviation 2.4
Values 11 7.9
[48]
THLE ADCY9
Mean 7.83
Standard deviation 1.4
Values 6.8 8.8
[49]
liver ADCY9
Mean 20.3
Standard deviation 12
Values 11 26 9.7 34
[50]
ref_hepatocyte ADCY6
Mean 1.84
Standard deviation 0.33
Values 1.7 2.4 1.9 1.8 1.5
[51]
HepG2 ADCY6
Mean 16.9
Standard deviation 1.2
Values 16 18
[52]
HepG2.C3A ADCY6
Mean 20.7
Standard deviation 1.1
Values 21 20
[53]
HuH.7 ADCY6
Mean 19.3
Standard deviation 0.93
Values 18 20 20
[54]
SNU475 ADCY6
Mean 19.2
Standard deviation 5.6
Values 23 15
[55]
THLE ADCY6
Mean 34.3
Standard deviation 2.1
Values 36 33
[56]
liver ADCY6
Mean 16.3
Standard deviation 9.4
Values 10 21 6.9 27
[57]
ref_hepatocyte ADCY1
Mean 0.753
Standard deviation 0.8
Values 0.18 0.11 0.22 1.6 1.6
[58]
HepG2 ADCY1
Mean 0.932
Standard deviation 0.17
Values 1 0.82
[59]
HepG2.C3A ADCY1
Mean 0.227
Standard deviation 0.064
Values 0.27 0.18
[60]
HuH.7 ADCY1
Mean 0.189
Standard deviation 0.063
Values 0.18 0.26 0.13
[61]
SNU475 ADCY1
Mean 0.321
Standard deviation 0.11
Values 0.25 0.4
[62]
THLE ADCY1
Mean 0.355
Standard deviation 0.017
Values 0.34 0.37
[63]
liver ADCY1
Mean 34
Standard deviation 27
Values 8 57 14 57
[64]
ref_hepatocyte ADCY7
Mean 0.512
Standard deviation 0.32
Values 0.68 0.13 0.92 0.28 0.54
[65]
HepG2 ADCY7
Mean 12.9
Standard deviation 4.7
Values 16 9.6
[66]
HepG2.C3A ADCY7
Mean 8.84
Standard deviation 0.22
Values 8.7 9
[67]
HuH.7 ADCY7
Mean 4.11
Standard deviation 0.66
Values 4.9 3.6 3.9
[68]
SNU475 ADCY7
Mean 9.31
Standard deviation 2.3
Values 11 7.7
[69]
THLE ADCY7
Mean 7.26
Standard deviation 0.034
Values 7.3 7.2
[70]
liver ADCY7
Mean 5.51
Standard deviation 3.3
Values 2.4 7.3 3.2 9.2
[71]
ref_hepatocyte PRKAR2B
Mean 0.12
Standard deviation 0.14
Values 0 0 0.21 0.078 0.31
[72]
HepG2 PRKAR2B
Mean 0.0522
Standard deviation 0.0072
Values 0.057 0.047
[73]
HepG2.C3A PRKAR2B
Mean 0.165
Standard deviation 0.097
Values 0.23 0.097
[74]
HuH.7 PRKAR2B
Mean 3.07
Standard deviation 1.2
Values 3.8 1.7 3.7
[75]
SNU475 PRKAR2B
Mean 7.46
Standard deviation 0.031
Values 7.5 7.4
[76]
THLE PRKAR2B
Mean 2.99
Standard deviation 0.15
Values 2.9 3.1
[77]
liver PRKAR2B
Mean 1.69
Standard deviation 0.7
Values 1.6 2.7 1.4 1.1
[78]
ref_hepatocyte ADCY3
Mean 0.12
Standard deviation 0.15
Values 0 0.11 0.38 0 0.11
[79]
HepG2 ADCY3
Mean 0.726
Standard deviation 0.55
Values 1.1 0.33
[80]
HepG2.C3A ADCY3
Mean 0.273
Standard deviation 0.084
Values 0.21 0.33
[81]
HuH.7 ADCY3
Mean 2.63
Standard deviation 1.3
Values 3.5 1.1 3.3
[82]
SNU475 ADCY3
Mean 5.86
Standard deviation 0.44
Values 5.5 6.2
[83]
THLE ADCY3
Mean 19
Standard deviation 3
Values 17 21
[84]
liver ADCY3
Mean 1.94
Standard deviation 1.2
Values 1.1 2.4 0.82 3.5
[85]
ref_hepatocyte ADCY2
Mean 0.081
Standard deviation 0.073
Values 0.061 0.016 0.2 0.043 0.081
[86]
HepG2 ADCY2
Mean 0.00429
Standard deviation 0.0061
Values 0 0.0086
[87]
HepG2.C3A ADCY2
Mean 0.0146
Standard deviation 0.021
Values 0.029 0
[88]
HuH.7 ADCY2
Mean 0.00586
Standard deviation 0.0051
Values 0.0082 0 0.0094
[89]
SNU475 ADCY2
Mean 0.0224
Standard deviation 0.019
Values 0.0093 0.035
[90]
THLE ADCY2
Mean 0.0115
Standard deviation 0.0088
Values 0.018 0.0053
[91]
liver ADCY2
Mean 0.00662
Standard deviation 0.013
Values 0 0 0 0.026
[92]
ref_hepatocyte ADCY5
Mean 0.0321
Standard deviation 0.047
Values 0 0 0 0.1 0.057
[93]
HepG2 ADCY5
Mean 0.0787
Standard deviation 0.022
Values 0.063 0.094
[94]
HepG2.C3A ADCY5
Mean 0.14
Standard deviation 0.077
Values 0.19 0.086
[95]
HuH.7 ADCY5
Mean 0.274
Standard deviation 0.063
Values 0.21 0.29 0.33
[96]
SNU475 ADCY5
Mean 0.0925
Standard deviation 0.091
Values 0.028 0.16
[97]
THLE ADCY5
Mean 0.226
Standard deviation 0.12
Values 0.31 0.14
[98]
liver ADCY5
Mean 3.77
Standard deviation 2.2
Values 2.5 3.4 2.3 6.9
[99]
ref_hepatocyte ADCY4
Mean 0.00488
Standard deviation 0.011
Values 0 0 0 0 0.024
[100]
HepG2 ADCY4
Mean 0.0115
Standard deviation 0.016
Values 0.023 0
[101]
HepG2.C3A ADCY4
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[102]
HuH.7 ADCY4
Mean 0.0291
Standard deviation 0.017
Values 0.049 0.019 0.019
[103]
SNU475 ADCY4
Mean 0
Standard deviation 0
Values 0 0
[104]
THLE ADCY4
Mean 0
Standard deviation 0
Values 0 0
[105]
liver ADCY4
Mean 2.29
Standard deviation 1.7
Values 4.6 0.78 1.5 2.3
[106]
ref_hepatocyte ADCY8
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[107]
HepG2 ADCY8
Mean 0.00573
Standard deviation 0.0081
Values 0.011 0
[108]
HepG2.C3A ADCY8
Mean 0
Standard deviation 0
Values 0 0
[109]
HuH.7 ADCY8
Mean 0
Standard deviation 0
Values 0 0 0
[110]
SNU475 ADCY8
Mean 0.0198
Standard deviation 0.015
Values 0.0093 0.03
[111]
THLE ADCY8
Mean 0.0937
Standard deviation 0.035
Values 0.12 0.069
[112]
liver ADCY8
Mean 0.0332
Standard deviation 0.041
Values 0 0.014 0.026 0.093
[113]
ref_hepatocyte PRKACG
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[114]
HepG2 PRKACG
Mean 0.00214
Standard deviation 0.003
Values 0 0.0043
[115]
HepG2.C3A PRKACG
Mean 0
Standard deviation 0
Values 0 0
[116]
HuH.7 PRKACG
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[117]
SNU475 PRKACG
Mean 0
Standard deviation 0
Values 0 0
[118]
THLE PRKACG
Mean 0
Standard deviation 0
Values 0 0
[119]
liver PRKACG
Mean 0
Standard deviation 0
Values 0 0 0 0