REACTOME_PI_3K_CASCADE_FGFR4 Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 PTPN11 Tyrosine-protein phosphatase non-receptor type 11 [1] -0.52[2] -0.32[3] -0.87[4] 0.28[5] 0.65[6] -0.11[7]
2 GRB2 Growth factor receptor-bound protein 2 [8] 0.23[9] -0.17[10] -0.55[11] -0.06[12] -0.41[13] -1.07[14]
3 FGFR4 Fibroblast growth factor receptor 4 [15] 0.99[16] 1.10[17] 1.18[18] -4.84[19] -5.24[20] -0.87[21]
4 KLB Beta-klotho [22] -0.37[23] -0.77[24] 0.18[25] -6.58[26] -7.48[27] 0.18[28]
5 PIK3R1 Phosphatidylinositol 3-kinase regulatory subunit alpha [29] -1.44[30] -1.55[31] -0.96[32] 1.46[33] 0.69[34] 1.64[35]
6 FGF2 Fibroblast growth factor 2 [36] -7.65[37] -7.63[38] -3.98[39] 0.32[40] 1.64[41] -3.03[42]
7 PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform -1.35[43] 0.06[44] -0.26[45] 0.52[46] 0.46[47] 0.55[48]
8 FRS2 Fibroblast growth factor receptor substrate 2 [49] 0.32[50] 1.18[51] 1.18[52] 2.29[53] 1.66[54] 1.98[55]
9 GAB1 GRB2-associated-binding protein 1 [56] 0.34[57] 1.19[58] 0.81[59] 1.32[60] 0.92[61] 1.51[62]
10 FGF1 Fibroblast growth factor 1 [63] -3.73[64] -3.17[65] -8.14[66] -0.02[67] 1.29[68] -1.32[69]
11 FGF19 Fibroblast growth factor 19 [70] -3.03[71] -2.11[72] 4.13[73] 0.22[74] -3.51[75] [76]
12 FGF8 Fibroblast growth factor 8 [77] -4.29[78] -4.18[79] -0.19[80] -2.53[81] [82] 1.33[83]
13 FGF18 Fibroblast growth factor 18 [84] 0.81[85] -3.54[86] -1.87[87] 0.01[88] 0.34[89] -0.78[90]
14 FGF9 Fibroblast growth factor 9 [91] 1.29[92] -2.60[93] [94] 2.17[95] -3.21[96] -1.26[97]
15 FGF20 Fibroblast growth factor 20 [98] [99] [100] [101] [102] [103] [104]
16 FGF23 Fibroblast growth factor 23 [105] [106] [107] [108] [109] [110] [111]
17 FGF17 Fibroblast growth factor 17 [112] [113] [114] [115] [116] [117] [118]
18 FGF4 Fibroblast growth factor 4 [119] [120] [121] [122] [123] [124] [125]
19 FGF16 Fibroblast growth factor 16 [126] [127] [128] [129] [130] [131] [132]
20 FGF6 Fibroblast growth factor 6 [133] [134] [135] [136] [137] [138] [139]
[1]
ref_hepatocyte PTPN11
Mean 22.2
Standard deviation 20
Values 33 53 10 7.5 7.4
[2]
HepG2 PTPN11
Mean 66.7
Standard deviation 12
Values 58 76
[3]
HepG2.C3A PTPN11
Mean 80.2
Standard deviation 17
Values 68 92
[4]
HuH.7 PTPN11
Mean 74.5
Standard deviation 12
Values 86 77 61
[5]
SNU475 PTPN11
Mean 75.4
Standard deviation 0.72
Values 75 76
[6]
THLE PTPN11
Mean 131
Standard deviation 5.1
Values 1.3e+02 1.3e+02
[7]
liver PTPN11
Mean 75.4
Standard deviation 18
Values 60 99 62 80
[8]
ref_hepatocyte GRB2
Mean 20.7
Standard deviation 5.5
Values 27 26 20 14 17
[9]
HepG2 GRB2
Mean 104
Standard deviation 4.7
Values 1e+02 1.1e+02
[10]
HepG2.C3A GRB2
Mean 83.1
Standard deviation 0.44
Values 83 83
[11]
HuH.7 GRB2
Mean 86.7
Standard deviation 7.6
Values 89 78 93
[12]
SNU475 GRB2
Mean 55.7
Standard deviation 1.4
Values 55 57
[13]
THLE GRB2
Mean 58.8
Standard deviation 3.7
Values 56 61
[14]
liver GRB2
Mean 36.1
Standard deviation 16
Values 50 22 50 22
[15]
ref_hepatocyte FGFR4
Mean 15.1
Standard deviation 12
Values 30 2.5 2.2 18 23
[16]
HepG2 FGFR4
Mean 129
Standard deviation 13
Values 1.2e+02 1.4e+02
[17]
HepG2.C3A FGFR4
Mean 146
Standard deviation 22
Values 1.6e+02 1.3e+02
[18]
HuH.7 FGFR4
Mean 209
Standard deviation 68
Values 2.4e+02 1.3e+02 2.5e+02
[19]
SNU475 FGFR4
Mean 1.47
Standard deviation 0.43
Values 1.2 1.8
[20]
THLE FGFR4
Mean 1.51
Standard deviation 0.45
Values 1.8 1.2
[21]
liver FGFR4
Mean 30.3
Standard deviation 10
Values 43 18 31 29
[22]
ref_hepatocyte KLB
Mean 9.92
Standard deviation 12
Values 30 1.9 0.71 6.7 9.9
[23]
HepG2 KLB
Mean 33.1
Standard deviation 23
Values 17 49
[24]
HepG2.C3A KLB
Mean 26.3
Standard deviation 0.12
Values 26 26
[25]
HuH.7 KLB
Mean 68.9
Standard deviation 30
Values 57 1e+02 46
[26]
SNU475 KLB
Mean 0.292
Standard deviation 0.04
Values 0.32 0.26
[27]
THLE KLB
Mean 0.21
Standard deviation 0.004
Values 0.21 0.21
[28]
liver KLB
Mean 41.2
Standard deviation 7.6
Values 52 37 40 36
[29]
ref_hepatocyte PIK3R1
Mean 7.45
Standard deviation 3.9
Values 4.1 7.4 4.2 8.1 14
[30]
HepG2 PIK3R1
Mean 11.9
Standard deviation 3
Values 9.8 14
[31]
HepG2.C3A PIK3R1
Mean 11.5
Standard deviation 2.6
Values 9.6 13
[32]
HuH.7 PIK3R1
Mean 23.4
Standard deviation 8.6
Values 23 32 15
[33]
SNU475 PIK3R1
Mean 57.3
Standard deviation 32
Values 80 35
[34]
THLE PIK3R1
Mean 45.5
Standard deviation 1.5
Values 44 47
[35]
liver PIK3R1
Mean 84.8
Standard deviation 47
Values 64 1e+02 32 1.4e+02
[36]
ref_hepatocyte FGF2
Mean 4.04
Standard deviation 6.5
Values 0.052 15 3.7 0.37 0.73
[37]
HepG2 FGF2
Mean 0.0866
Standard deviation 0.08
Values 0.14 0.03
[38]
HepG2.C3A FGF2
Mean 0.092
Standard deviation 0.0064
Values 0.087 0.097
[39]
HuH.7 FGF2
Mean 1.57
Standard deviation 0.89
Values 0.98 2.6 1.1
[40]
SNU475 FGF2
Mean 14.2
Standard deviation 1.3
Values 13 15
[41]
THLE FGF2
Mean 47.5
Standard deviation 0.66
Values 48 47
[42]
liver FGF2
Mean 1.81
Standard deviation 0.66
Values 1.9 2.5 0.9 2
[43]
ref_hepatocyte PIK3CA
Mean 1.87
Standard deviation 0.73
Values 2.3 2.6 2.3 1.2 0.94
[44]
HepG2 PIK3CA
Mean 3.17
Standard deviation 1.6
Values 2.1 4.3
[45]
HepG2.C3A PIK3CA
Mean 8.78
Standard deviation 1.1
Values 8 9.6
[46]
HuH.7 PIK3CA
Mean 9.59
Standard deviation 2.4
Values 10 12 7
[47]
SNU475 PIK3CA
Mean 7.49
Standard deviation 0.93
Values 8.1 6.8
[48]
THLE PIK3CA
Mean 9.67
Standard deviation 0.66
Values 10 9.2
[49]
liver PIK3CA
Mean 9.99
Standard deviation 4.7
Values 6.1 15 6 13
[50]
ref_hepatocyte FRS2
Mean 1.15
Standard deviation 0.48
Values 1.3 1.9 0.69 0.74 1.2
[51]
HepG2 FRS2
Mean 6.18
Standard deviation 3
Values 4 8.3
[52]
HepG2.C3A FRS2
Mean 11.7
Standard deviation 4
Values 8.9 15
[53]
HuH.7 FRS2
Mean 15.9
Standard deviation 4.9
Values 16 21 11
[54]
SNU475 FRS2
Mean 15.7
Standard deviation 0.35
Values 16 15
[55]
THLE FRS2
Mean 13.6
Standard deviation 0.96
Values 14 13
[56]
liver FRS2
Mean 16.5
Standard deviation 3.3
Values 18 20 13 15
[57]
ref_hepatocyte GAB1
Mean 0.787
Standard deviation 0.67
Values 2 0.61 0.33 0.38 0.66
[58]
HepG2 GAB1
Mean 4.28
Standard deviation 2.2
Values 2.8 5.8
[59]
HepG2.C3A GAB1
Mean 8.12
Standard deviation 2.3
Values 6.5 9.8
[60]
HuH.7 GAB1
Mean 8.48
Standard deviation 1.4
Values 10 8.1 7.3
[61]
SNU475 GAB1
Mean 5.52
Standard deviation 1.6
Values 6.6 4.4
[62]
THLE GAB1
Mean 5.62
Standard deviation 0.39
Values 5.9 5.3
[63]
liver GAB1
Mean 8.2
Standard deviation 2.5
Values 7.1 10 5.3 10
[64]
ref_hepatocyte FGF1
Mean 0.126
Standard deviation 0.27
Values 0 0.6 0 0 0.024
[65]
HepG2 FGF1
Mean 0.0408
Standard deviation 0.04
Values 0.069 0.013
[66]
HepG2.C3A FGF1
Mean 0.0628
Standard deviation 0.048
Values 0.029 0.097
[67]
HuH.7 FGF1
Mean 0.00273
Standard deviation 0.0047
Values 0.0082 0 0
[68]
SNU475 FGF1
Mean 0.346
Standard deviation 0.077
Values 0.29 0.4
[69]
THLE FGF1
Mean 1.16
Standard deviation 0.44
Values 0.85 1.5
[70]
liver FGF1
Mean 0.184
Standard deviation 0.042
Values 0.14 0.21 0.15 0.23
[71]
ref_hepatocyte FGF19
Mean 0.122
Standard deviation 0.27
Values 0 0 0.61 0 0
[72]
HepG2 FGF19
Mean 0.0644
Standard deviation 0.0062
Values 0.069 0.06
[73]
HepG2.C3A FGF19
Mean 0.128
Standard deviation 0.0016
Values 0.13 0.13
[74]
HuH.7 FGF19
Mean 13.1
Standard deviation 3.4
Values 11 17 12
[75]
SNU475 FGF19
Mean 0.397
Standard deviation 0.15
Values 0.51 0.29
[76]
THLE FGF19
Mean 0.0402
Standard deviation 0.027
Values 0.059 0.021
[77]
liver FGF19
Mean 0
Standard deviation 0
Values 0 0 0 0
[78]
ref_hepatocyte FGF8
Mean 0.0195
Standard deviation 0.044
Values 0 0 0 0 0.098
[79]
HepG2 FGF8
Mean 0.00429
Standard deviation 0.0061
Values 0 0.0086
[80]
HepG2.C3A FGF8
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[81]
HuH.7 FGF8
Mean 0.105
Standard deviation 0.073
Values 0.19 0.051 0.075
[82]
SNU475 FGF8
Mean 0.00949
Standard deviation 0.0063
Values 0.014 0.0051
[83]
THLE FGF8
Mean 0
Standard deviation 0
Values 0 0
[84]
liver FGF8
Mean 0.18
Standard deviation 0.14
Values 0.047 0.34 0.077 0.25
[85]
ref_hepatocyte FGF18
Mean 0.0138
Standard deviation 0.031
Values 0 0 0 0.069 0
[86]
HepG2 FGF18
Mean 0.105
Standard deviation 0.039
Values 0.13 0.077
[87]
HepG2.C3A FGF18
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[88]
HuH.7 FGF18
Mean 0.0232
Standard deviation 0.02
Values 0 0.032 0.037
[89]
SNU475 FGF18
Mean 0.0388
Standard deviation 0.0024
Values 0.037 0.041
[90]
THLE FGF18
Mean 0.0657
Standard deviation 0.033
Values 0.089 0.043
[91]
liver FGF18
Mean 0.0294
Standard deviation 0.0072
Values 0.024 0.029 0.026 0.04
[92]
ref_hepatocyte FGF9
Mean 0.0065
Standard deviation 0.015
Values 0 0 0 0 0.033
[93]
HepG2 FGF9
Mean 0.0687
Standard deviation 9.1e-05
Values 0.069 0.069
[94]
HepG2.C3A FGF9
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[95]
HuH.7 FGF9
Mean 0
Standard deviation 0
Values 0 0 0
[96]
SNU475 FGF9
Mean 0.0822
Standard deviation 0.08
Values 0.14 0.025
[97]
THLE FGF9
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[98]
liver FGF9
Mean 0.00993
Standard deviation 0.02
Values 0 0 0 0.04
[99]
ref_hepatocyte FGF20
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[100]
HepG2 FGF20
Mean 0.0115
Standard deviation 0.016
Values 0.023 0
[101]
HepG2.C3A FGF20
Mean 0
Standard deviation 0
Values 0 0
[102]
HuH.7 FGF20
Mean 0
Standard deviation 0
Values 0 0 0
[103]
SNU475 FGF20
Mean 0.00485
Standard deviation 0.0003
Values 0.0046 0.0051
[104]
THLE FGF20
Mean 0.00562
Standard deviation 0.00042
Values 0.0059 0.0053
[105]
liver FGF20
Mean 0.0118
Standard deviation 0.024
Values 0.047 0 0 0
[106]
ref_hepatocyte FGF23
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[107]
HepG2 FGF23
Mean 0
Standard deviation 0
Values 0 0
[108]
HepG2.C3A FGF23
Mean 0
Standard deviation 0
Values 0 0
[109]
HuH.7 FGF23
Mean 0.00312
Standard deviation 0.0054
Values 0 0 0.0094
[110]
SNU475 FGF23
Mean 0
Standard deviation 0
Values 0 0
[111]
THLE FGF23
Mean 0
Standard deviation 0
Values 0 0
[112]
liver FGF23
Mean 0.68
Standard deviation 0.31
Values 0.59 0.67 1.1 0.36
[113]
ref_hepatocyte FGF17
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[114]
HepG2 FGF17
Mean 0.398
Standard deviation 0.15
Values 0.5 0.29
[115]
HepG2.C3A FGF17
Mean 1.23
Standard deviation 1.1
Values 2 0.46
[116]
HuH.7 FGF17
Mean 0.183
Standard deviation 0.2
Values 0.074 0.41 0.066
[117]
SNU475 FGF17
Mean 0.00232
Standard deviation 0.0033
Values 0.0046 0
[118]
THLE FGF17
Mean 0.0228
Standard deviation 0.0096
Values 0.03 0.016
[119]
liver FGF17
Mean 0.00588
Standard deviation 0.012
Values 0.024 0 0 0
[120]
ref_hepatocyte FGF4
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[121]
HepG2 FGF4
Mean 0
Standard deviation 0
Values 0 0
[122]
HepG2.C3A FGF4
Mean 0
Standard deviation 0
Values 0 0
[123]
HuH.7 FGF4
Mean 0
Standard deviation 0
Values 0 0 0
[124]
SNU475 FGF4
Mean 0.00253
Standard deviation 0.0036
Values 0 0.0051
[125]
THLE FGF4
Mean 0
Standard deviation 0
Values 0 0
[126]
liver FGF4
Mean 0
Standard deviation 0
Values 0 0 0 0
[127]
ref_hepatocyte FGF16
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[128]
HepG2 FGF16
Mean 0
Standard deviation 0
Values 0 0
[129]
HepG2.C3A FGF16
Mean 0
Standard deviation 0
Values 0 0
[130]
HuH.7 FGF16
Mean 0
Standard deviation 0
Values 0 0 0
[131]
SNU475 FGF16
Mean 0
Standard deviation 0
Values 0 0
[132]
THLE FGF16
Mean 0
Standard deviation 0
Values 0 0
[133]
liver FGF16
Mean 0.0118
Standard deviation 0.024
Values 0.047 0 0 0
[134]
ref_hepatocyte FGF6
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[135]
HepG2 FGF6
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[136]
HepG2.C3A FGF6
Mean 0
Standard deviation 0
Values 0 0
[137]
HuH.7 FGF6
Mean 0
Standard deviation 0
Values 0 0 0
[138]
SNU475 FGF6
Mean 0
Standard deviation 0
Values 0 0
[139]
THLE FGF6
Mean 0
Standard deviation 0
Values 0 0
[140]
liver FGF6
Mean 0.00357
Standard deviation 0.0071
Values 0 0.014 0 0