REACTOME_PI_3K_CASCADE_FGFR3 Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 PTPN11 Tyrosine-protein phosphatase non-receptor type 11 [1] -0.63[2] -0.32[3] -0.58[4] -0.06[5] 0.29[6] -0.16[7]
2 GRB2 Growth factor receptor-bound protein 2 [8] 0.12[9] -0.16[10] -0.26[11] -0.40[12] -0.76[13] -1.12[14]
3 FGFR3 Fibroblast growth factor receptor 3 [15] 1.65[16] 1.45[17] 1.56[18] -4.25[19] -3.17[20] -0.97[21]
4 PIK3R1 Phosphatidylinositol 3-kinase regulatory subunit alpha [22] -1.55[23] -1.55[24] -0.67[25] 1.11[26] 0.34[27] 1.58[28]
5 FGF2 Fibroblast growth factor 2 [29] -7.76[30] -7.63[31] -3.69[32] -0.02[33] 1.29[34] -3.09[35]
6 PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform -1.45[36] 0.06[37] 0.03[38] 0.18[39] 0.10[40] 0.49[41]
7 FRS2 Fibroblast growth factor receptor substrate 2 [42] 0.21[43] 1.19[44] 1.47[45] 1.95[46] 1.30[47] 1.92[48]
8 GAB1 GRB2-associated-binding protein 1 [49] 0.23[50] 1.20[51] 1.10[52] 0.98[53] 0.57[54] 1.45[55]
9 FGF5 Fibroblast growth factor 5 [56] -2.06[57] -0.86[58] -1.16[59] 0.53[60] -0.06[61] 1.71[62]
10 FGF1 Fibroblast growth factor 1 [63] -3.84[64] -3.17[65] -7.85[66] -0.37[67] 0.94[68] -1.38[69]
11 FGF8 Fibroblast growth factor 8 [70] -4.40[71] -4.17[72] 0.10[73] -2.87[74] [75] 1.27[76]
12 FGF18 Fibroblast growth factor 18 [77] 0.71[78] -3.53[79] -1.58[80] -0.34[81] -0.02[82] -0.84[83]
13 FGF9 Fibroblast growth factor 9 [84] 1.18[85] -2.59[86] [87] 1.83[88] -3.56[89] -1.32[90]
14 FGF16 Fibroblast growth factor 16 [91] [92] [93] [94] [95] [96] [97]
15 FGF4 Fibroblast growth factor 4 [98] [99] [100] [101] [102] [103] [104]
16 FGF17 Fibroblast growth factor 17 [105] [106] [107] [108] [109] [110] [111]
17 FGF20 Fibroblast growth factor 20 [112] [113] [114] [115] [116] [117] [118]
18 FGF23 Fibroblast growth factor 23 [119] [120] [121] [122] [123] [124] [125]
[1]
ref_hepatocyte PTPN11
Mean 22.2
Standard deviation 20
Values 33 53 10 7.5 7.4
[2]
HepG2 PTPN11
Mean 66.7
Standard deviation 12
Values 58 76
[3]
HepG2.C3A PTPN11
Mean 80.2
Standard deviation 17
Values 68 92
[4]
HuH.7 PTPN11
Mean 74.5
Standard deviation 12
Values 86 77 61
[5]
SNU475 PTPN11
Mean 75.4
Standard deviation 0.72
Values 75 76
[6]
THLE PTPN11
Mean 131
Standard deviation 5.1
Values 1.3e+02 1.3e+02
[7]
liver PTPN11
Mean 75.4
Standard deviation 18
Values 60 99 62 80
[8]
ref_hepatocyte GRB2
Mean 20.7
Standard deviation 5.5
Values 27 26 20 14 17
[9]
HepG2 GRB2
Mean 104
Standard deviation 4.7
Values 1e+02 1.1e+02
[10]
HepG2.C3A GRB2
Mean 83.1
Standard deviation 0.44
Values 83 83
[11]
HuH.7 GRB2
Mean 86.7
Standard deviation 7.6
Values 89 78 93
[12]
SNU475 GRB2
Mean 55.7
Standard deviation 1.4
Values 55 57
[13]
THLE GRB2
Mean 58.8
Standard deviation 3.7
Values 56 61
[14]
liver GRB2
Mean 36.1
Standard deviation 16
Values 50 22 50 22
[15]
ref_hepatocyte FGFR3
Mean 7.46
Standard deviation 9.2
Values 23 2.7 0.18 4.6 6.4
[16]
HepG2 FGFR3
Mean 109
Standard deviation 1.1
Values 1.1e+02 1.1e+02
[17]
HepG2.C3A FGFR3
Mean 91.5
Standard deviation 12
Values 1e+02 83
[18]
HuH.7 FGFR3
Mean 110
Standard deviation 12
Values 1.2e+02 97 1.2e+02
[19]
SNU475 FGFR3
Mean 1.4
Standard deviation 0.25
Values 1.6 1.2
[20]
THLE FGFR3
Mean 3.99
Standard deviation 0.31
Values 3.8 4.2
[21]
liver FGFR3
Mean 14.5
Standard deviation 8.7
Values 9.3 18 5.8 25
[22]
ref_hepatocyte PIK3R1
Mean 7.45
Standard deviation 3.9
Values 4.1 7.4 4.2 8.1 14
[23]
HepG2 PIK3R1
Mean 11.9
Standard deviation 3
Values 9.8 14
[24]
HepG2.C3A PIK3R1
Mean 11.5
Standard deviation 2.6
Values 9.6 13
[25]
HuH.7 PIK3R1
Mean 23.4
Standard deviation 8.6
Values 23 32 15
[26]
SNU475 PIK3R1
Mean 57.3
Standard deviation 32
Values 80 35
[27]
THLE PIK3R1
Mean 45.5
Standard deviation 1.5
Values 44 47
[28]
liver PIK3R1
Mean 84.8
Standard deviation 47
Values 64 1e+02 32 1.4e+02
[29]
ref_hepatocyte FGF2
Mean 4.04
Standard deviation 6.5
Values 0.052 15 3.7 0.37 0.73
[30]
HepG2 FGF2
Mean 0.0866
Standard deviation 0.08
Values 0.14 0.03
[31]
HepG2.C3A FGF2
Mean 0.092
Standard deviation 0.0064
Values 0.087 0.097
[32]
HuH.7 FGF2
Mean 1.57
Standard deviation 0.89
Values 0.98 2.6 1.1
[33]
SNU475 FGF2
Mean 14.2
Standard deviation 1.3
Values 13 15
[34]
THLE FGF2
Mean 47.5
Standard deviation 0.66
Values 48 47
[35]
liver FGF2
Mean 1.81
Standard deviation 0.66
Values 1.9 2.5 0.9 2
[36]
ref_hepatocyte PIK3CA
Mean 1.87
Standard deviation 0.73
Values 2.3 2.6 2.3 1.2 0.94
[37]
HepG2 PIK3CA
Mean 3.17
Standard deviation 1.6
Values 2.1 4.3
[38]
HepG2.C3A PIK3CA
Mean 8.78
Standard deviation 1.1
Values 8 9.6
[39]
HuH.7 PIK3CA
Mean 9.59
Standard deviation 2.4
Values 10 12 7
[40]
SNU475 PIK3CA
Mean 7.49
Standard deviation 0.93
Values 8.1 6.8
[41]
THLE PIK3CA
Mean 9.67
Standard deviation 0.66
Values 10 9.2
[42]
liver PIK3CA
Mean 9.99
Standard deviation 4.7
Values 6.1 15 6 13
[43]
ref_hepatocyte FRS2
Mean 1.15
Standard deviation 0.48
Values 1.3 1.9 0.69 0.74 1.2
[44]
HepG2 FRS2
Mean 6.18
Standard deviation 3
Values 4 8.3
[45]
HepG2.C3A FRS2
Mean 11.7
Standard deviation 4
Values 8.9 15
[46]
HuH.7 FRS2
Mean 15.9
Standard deviation 4.9
Values 16 21 11
[47]
SNU475 FRS2
Mean 15.7
Standard deviation 0.35
Values 16 15
[48]
THLE FRS2
Mean 13.6
Standard deviation 0.96
Values 14 13
[49]
liver FRS2
Mean 16.5
Standard deviation 3.3
Values 18 20 13 15
[50]
ref_hepatocyte GAB1
Mean 0.787
Standard deviation 0.67
Values 2 0.61 0.33 0.38 0.66
[51]
HepG2 GAB1
Mean 4.28
Standard deviation 2.2
Values 2.8 5.8
[52]
HepG2.C3A GAB1
Mean 8.12
Standard deviation 2.3
Values 6.5 9.8
[53]
HuH.7 GAB1
Mean 8.48
Standard deviation 1.4
Values 10 8.1 7.3
[54]
SNU475 GAB1
Mean 5.52
Standard deviation 1.6
Values 6.6 4.4
[55]
THLE GAB1
Mean 5.62
Standard deviation 0.39
Values 5.9 5.3
[56]
liver GAB1
Mean 8.2
Standard deviation 2.5
Values 7.1 10 5.3 10
[57]
ref_hepatocyte FGF5
Mean 0.241
Standard deviation 0.27
Values 0.042 0.036 0.09 0.64 0.4
[58]
HepG2 FGF5
Mean 0.268
Standard deviation 0.022
Values 0.25 0.28
[59]
HepG2.C3A FGF5
Mean 0.596
Standard deviation 0.024
Values 0.61 0.58
[60]
HuH.7 FGF5
Mean 0.543
Standard deviation 0.15
Values 0.62 0.65 0.37
[61]
SNU475 FGF5
Mean 1.24
Standard deviation 0.35
Values 0.99 1.5
[62]
THLE FGF5
Mean 1.11
Standard deviation 0.17
Values 0.99 1.2
[63]
liver FGF5
Mean 3.01
Standard deviation 1.5
Values 2.3 4.5 1.2 4.1
[64]
ref_hepatocyte FGF1
Mean 0.126
Standard deviation 0.27
Values 0 0.6 0 0 0.024
[65]
HepG2 FGF1
Mean 0.0408
Standard deviation 0.04
Values 0.069 0.013
[66]
HepG2.C3A FGF1
Mean 0.0628
Standard deviation 0.048
Values 0.029 0.097
[67]
HuH.7 FGF1
Mean 0.00273
Standard deviation 0.0047
Values 0.0082 0 0
[68]
SNU475 FGF1
Mean 0.346
Standard deviation 0.077
Values 0.29 0.4
[69]
THLE FGF1
Mean 1.16
Standard deviation 0.44
Values 0.85 1.5
[70]
liver FGF1
Mean 0.184
Standard deviation 0.042
Values 0.14 0.21 0.15 0.23
[71]
ref_hepatocyte FGF8
Mean 0.0195
Standard deviation 0.044
Values 0 0 0 0 0.098
[72]
HepG2 FGF8
Mean 0.00429
Standard deviation 0.0061
Values 0 0.0086
[73]
HepG2.C3A FGF8
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[74]
HuH.7 FGF8
Mean 0.105
Standard deviation 0.073
Values 0.19 0.051 0.075
[75]
SNU475 FGF8
Mean 0.00949
Standard deviation 0.0063
Values 0.014 0.0051
[76]
THLE FGF8
Mean 0
Standard deviation 0
Values 0 0
[77]
liver FGF8
Mean 0.18
Standard deviation 0.14
Values 0.047 0.34 0.077 0.25
[78]
ref_hepatocyte FGF18
Mean 0.0138
Standard deviation 0.031
Values 0 0 0 0.069 0
[79]
HepG2 FGF18
Mean 0.105
Standard deviation 0.039
Values 0.13 0.077
[80]
HepG2.C3A FGF18
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[81]
HuH.7 FGF18
Mean 0.0232
Standard deviation 0.02
Values 0 0.032 0.037
[82]
SNU475 FGF18
Mean 0.0388
Standard deviation 0.0024
Values 0.037 0.041
[83]
THLE FGF18
Mean 0.0657
Standard deviation 0.033
Values 0.089 0.043
[84]
liver FGF18
Mean 0.0294
Standard deviation 0.0072
Values 0.024 0.029 0.026 0.04
[85]
ref_hepatocyte FGF9
Mean 0.0065
Standard deviation 0.015
Values 0 0 0 0 0.033
[86]
HepG2 FGF9
Mean 0.0687
Standard deviation 9.1e-05
Values 0.069 0.069
[87]
HepG2.C3A FGF9
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[88]
HuH.7 FGF9
Mean 0
Standard deviation 0
Values 0 0 0
[89]
SNU475 FGF9
Mean 0.0822
Standard deviation 0.08
Values 0.14 0.025
[90]
THLE FGF9
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[91]
liver FGF9
Mean 0.00993
Standard deviation 0.02
Values 0 0 0 0.04
[92]
ref_hepatocyte FGF16
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[93]
HepG2 FGF16
Mean 0
Standard deviation 0
Values 0 0
[94]
HepG2.C3A FGF16
Mean 0
Standard deviation 0
Values 0 0
[95]
HuH.7 FGF16
Mean 0
Standard deviation 0
Values 0 0 0
[96]
SNU475 FGF16
Mean 0
Standard deviation 0
Values 0 0
[97]
THLE FGF16
Mean 0
Standard deviation 0
Values 0 0
[98]
liver FGF16
Mean 0.0118
Standard deviation 0.024
Values 0.047 0 0 0
[99]
ref_hepatocyte FGF4
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[100]
HepG2 FGF4
Mean 0
Standard deviation 0
Values 0 0
[101]
HepG2.C3A FGF4
Mean 0
Standard deviation 0
Values 0 0
[102]
HuH.7 FGF4
Mean 0
Standard deviation 0
Values 0 0 0
[103]
SNU475 FGF4
Mean 0.00253
Standard deviation 0.0036
Values 0 0.0051
[104]
THLE FGF4
Mean 0
Standard deviation 0
Values 0 0
[105]
liver FGF4
Mean 0
Standard deviation 0
Values 0 0 0 0
[106]
ref_hepatocyte FGF17
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[107]
HepG2 FGF17
Mean 0.398
Standard deviation 0.15
Values 0.5 0.29
[108]
HepG2.C3A FGF17
Mean 1.23
Standard deviation 1.1
Values 2 0.46
[109]
HuH.7 FGF17
Mean 0.183
Standard deviation 0.2
Values 0.074 0.41 0.066
[110]
SNU475 FGF17
Mean 0.00232
Standard deviation 0.0033
Values 0.0046 0
[111]
THLE FGF17
Mean 0.0228
Standard deviation 0.0096
Values 0.03 0.016
[112]
liver FGF17
Mean 0.00588
Standard deviation 0.012
Values 0.024 0 0 0
[113]
ref_hepatocyte FGF20
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[114]
HepG2 FGF20
Mean 0.0115
Standard deviation 0.016
Values 0.023 0
[115]
HepG2.C3A FGF20
Mean 0
Standard deviation 0
Values 0 0
[116]
HuH.7 FGF20
Mean 0
Standard deviation 0
Values 0 0 0
[117]
SNU475 FGF20
Mean 0.00485
Standard deviation 0.0003
Values 0.0046 0.0051
[118]
THLE FGF20
Mean 0.00562
Standard deviation 0.00042
Values 0.0059 0.0053
[119]
liver FGF20
Mean 0.0118
Standard deviation 0.024
Values 0.047 0 0 0
[120]
ref_hepatocyte FGF23
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[121]
HepG2 FGF23
Mean 0
Standard deviation 0
Values 0 0
[122]
HepG2.C3A FGF23
Mean 0
Standard deviation 0
Values 0 0
[123]
HuH.7 FGF23
Mean 0.00312
Standard deviation 0.0054
Values 0 0 0.0094
[124]
SNU475 FGF23
Mean 0
Standard deviation 0
Values 0 0
[125]
THLE FGF23
Mean 0
Standard deviation 0
Values 0 0
[126]
liver FGF23
Mean 0.68
Standard deviation 0.31
Values 0.59 0.67 1.1 0.36