REACTOME_PI_3K_CASCADE_FGFR1 Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 PTPN11 Tyrosine-protein phosphatase non-receptor type 11 [1] -0.42[2] -0.01[3] -0.36[4] -0.48[5] 0.02[6] -0.25[7]
2 GRB2 Growth factor receptor-bound protein 2 [8] 0.33[9] 0.14[10] -0.04[11] -0.82[12] -1.03[13] -1.21[14]
3 PIK3R1 Phosphatidylinositol 3-kinase regulatory subunit alpha [15] -1.34[16] -1.24[17] -0.45[18] 0.70[19] 0.07[20] 1.49[21]
4 FGF2 Fibroblast growth factor 2 [22] -7.55[23] -7.32[24] -3.47[25] -0.44[26] 1.01[27] -3.17[28]
5 PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform -1.25[29] 0.37[30] 0.26[31] -0.24[32] -0.17[33] 0.41[34]
6 FRS2 Fibroblast growth factor receptor substrate 2 [35] 0.42[36] 1.49[37] 1.69[38] 1.53[39] 1.03[40] 1.83[41]
7 FGFR1 Fibroblast growth factor receptor 1 [42] 3.71[43] 2.00[44] 3.35[45] 3.69[46] 2.82[47] 0.15[48]
8 GAB1 GRB2-associated-binding protein 1 [49] 0.43[50] 1.50[51] 1.32[52] 0.56[53] 0.29[54] 1.37[55]
9 KL Klotho [56] -6.92[57] [58] [59] -2.76[60] -8.15[61] -1.26[62]
10 FGF5 Fibroblast growth factor 5 [63] -1.86[64] -0.56[65] -0.93[66] 0.11[67] -0.33[68] 1.63[69]
11 FGF1 Fibroblast growth factor 1 [70] -3.63[71] -2.86[72] -7.63[73] -0.78[74] 0.66[75] -1.47[76]
12 FGF8 Fibroblast growth factor 8 [77] -4.20[78] -3.87[79] 0.32[80] -3.29[81] [82] 1.19[83]
13 FGF9 Fibroblast growth factor 9 [84] 1.39[85] -2.29[86] [87] 1.41[88] -3.83[89] -1.41[90]
14 FGF20 Fibroblast growth factor 20 [91] [92] [93] [94] [95] [96] [97]
15 FGF23 Fibroblast growth factor 23 [98] [99] [100] [101] [102] [103] [104]
16 FGF3 Fibroblast growth factor 3 [105] [106] [107] [108] [109] [110] [111]
17 FGF17 Fibroblast growth factor 17 [112] [113] [114] [115] [116] [117] [118]
18 FGF10 Fibroblast growth factor 10 [119] [120] [121] [122] [123] [124] [125]
19 FGF22 Fibroblast growth factor 22 [126] [127] [128] [129] [130] [131] [132]
20 FGF4 Fibroblast growth factor 4 [133] [134] [135] [136] [137] [138] [139]
21 FGF6 Fibroblast growth factor 6 [140] [141] [142] [143] [144] [145] [146]
[1]
ref_hepatocyte PTPN11
Mean 22.2
Standard deviation 20
Values 33 53 10 7.5 7.4
[2]
HepG2 PTPN11
Mean 66.7
Standard deviation 12
Values 58 76
[3]
HepG2.C3A PTPN11
Mean 80.2
Standard deviation 17
Values 68 92
[4]
HuH.7 PTPN11
Mean 74.5
Standard deviation 12
Values 86 77 61
[5]
SNU475 PTPN11
Mean 75.4
Standard deviation 0.72
Values 75 76
[6]
THLE PTPN11
Mean 131
Standard deviation 5.1
Values 1.3e+02 1.3e+02
[7]
liver PTPN11
Mean 75.4
Standard deviation 18
Values 60 99 62 80
[8]
ref_hepatocyte GRB2
Mean 20.7
Standard deviation 5.5
Values 27 26 20 14 17
[9]
HepG2 GRB2
Mean 104
Standard deviation 4.7
Values 1e+02 1.1e+02
[10]
HepG2.C3A GRB2
Mean 83.1
Standard deviation 0.44
Values 83 83
[11]
HuH.7 GRB2
Mean 86.7
Standard deviation 7.6
Values 89 78 93
[12]
SNU475 GRB2
Mean 55.7
Standard deviation 1.4
Values 55 57
[13]
THLE GRB2
Mean 58.8
Standard deviation 3.7
Values 56 61
[14]
liver GRB2
Mean 36.1
Standard deviation 16
Values 50 22 50 22
[15]
ref_hepatocyte PIK3R1
Mean 7.45
Standard deviation 3.9
Values 4.1 7.4 4.2 8.1 14
[16]
HepG2 PIK3R1
Mean 11.9
Standard deviation 3
Values 9.8 14
[17]
HepG2.C3A PIK3R1
Mean 11.5
Standard deviation 2.6
Values 9.6 13
[18]
HuH.7 PIK3R1
Mean 23.4
Standard deviation 8.6
Values 23 32 15
[19]
SNU475 PIK3R1
Mean 57.3
Standard deviation 32
Values 80 35
[20]
THLE PIK3R1
Mean 45.5
Standard deviation 1.5
Values 44 47
[21]
liver PIK3R1
Mean 84.8
Standard deviation 47
Values 64 1e+02 32 1.4e+02
[22]
ref_hepatocyte FGF2
Mean 4.04
Standard deviation 6.5
Values 0.052 15 3.7 0.37 0.73
[23]
HepG2 FGF2
Mean 0.0866
Standard deviation 0.08
Values 0.14 0.03
[24]
HepG2.C3A FGF2
Mean 0.092
Standard deviation 0.0064
Values 0.087 0.097
[25]
HuH.7 FGF2
Mean 1.57
Standard deviation 0.89
Values 0.98 2.6 1.1
[26]
SNU475 FGF2
Mean 14.2
Standard deviation 1.3
Values 13 15
[27]
THLE FGF2
Mean 47.5
Standard deviation 0.66
Values 48 47
[28]
liver FGF2
Mean 1.81
Standard deviation 0.66
Values 1.9 2.5 0.9 2
[29]
ref_hepatocyte PIK3CA
Mean 1.87
Standard deviation 0.73
Values 2.3 2.6 2.3 1.2 0.94
[30]
HepG2 PIK3CA
Mean 3.17
Standard deviation 1.6
Values 2.1 4.3
[31]
HepG2.C3A PIK3CA
Mean 8.78
Standard deviation 1.1
Values 8 9.6
[32]
HuH.7 PIK3CA
Mean 9.59
Standard deviation 2.4
Values 10 12 7
[33]
SNU475 PIK3CA
Mean 7.49
Standard deviation 0.93
Values 8.1 6.8
[34]
THLE PIK3CA
Mean 9.67
Standard deviation 0.66
Values 10 9.2
[35]
liver PIK3CA
Mean 9.99
Standard deviation 4.7
Values 6.1 15 6 13
[36]
ref_hepatocyte FRS2
Mean 1.15
Standard deviation 0.48
Values 1.3 1.9 0.69 0.74 1.2
[37]
HepG2 FRS2
Mean 6.18
Standard deviation 3
Values 4 8.3
[38]
HepG2.C3A FRS2
Mean 11.7
Standard deviation 4
Values 8.9 15
[39]
HuH.7 FRS2
Mean 15.9
Standard deviation 4.9
Values 16 21 11
[40]
SNU475 FRS2
Mean 15.7
Standard deviation 0.35
Values 16 15
[41]
THLE FRS2
Mean 13.6
Standard deviation 0.96
Values 14 13
[42]
liver FRS2
Mean 16.5
Standard deviation 3.3
Values 18 20 13 15
[43]
ref_hepatocyte FGFR1
Mean 0.81
Standard deviation 0.63
Values 1.2 0.49 1.6 0.06 0.62
[44]
HepG2 FGFR1
Mean 42.7
Standard deviation 4
Values 40 46
[45]
HepG2.C3A FGFR1
Mean 11.8
Standard deviation 3.5
Values 9.3 14
[46]
HuH.7 FGFR1
Mean 35.6
Standard deviation 13
Values 43 20 43
[47]
SNU475 FGFR1
Mean 49.5
Standard deviation 1.4
Values 50 49
[48]
THLE FGFR1
Mean 33.4
Standard deviation 3.3
Values 36 31
[49]
liver FGFR1
Mean 3.64
Standard deviation 0.67
Values 3 4.2 3.2 4.3
[50]
ref_hepatocyte GAB1
Mean 0.787
Standard deviation 0.67
Values 2 0.61 0.33 0.38 0.66
[51]
HepG2 GAB1
Mean 4.28
Standard deviation 2.2
Values 2.8 5.8
[52]
HepG2.C3A GAB1
Mean 8.12
Standard deviation 2.3
Values 6.5 9.8
[53]
HuH.7 GAB1
Mean 8.48
Standard deviation 1.4
Values 10 8.1 7.3
[54]
SNU475 GAB1
Mean 5.52
Standard deviation 1.6
Values 6.6 4.4
[55]
THLE GAB1
Mean 5.62
Standard deviation 0.39
Values 5.9 5.3
[56]
liver GAB1
Mean 8.2
Standard deviation 2.5
Values 7.1 10 5.3 10
[57]
ref_hepatocyte KL
Mean 0.258
Standard deviation 0.29
Values 0 0 0.4 0.2 0.69
[58]
HepG2 KL
Mean 0.00858
Standard deviation 0.012
Values 0 0.017
[59]
HepG2.C3A KL
Mean 0
Standard deviation 0
Values 0 0
[60]
HuH.7 KL
Mean 0
Standard deviation 0
Values 0 0 0
[61]
SNU475 KL
Mean 0.181
Standard deviation 0.026
Values 0.2 0.16
[62]
THLE KL
Mean 0.00532
Standard deviation 0.0075
Values 0 0.011
[63]
liver KL
Mean 0.436
Standard deviation 0.32
Values 0.38 0.31 0.15 0.9
[64]
ref_hepatocyte FGF5
Mean 0.241
Standard deviation 0.27
Values 0.042 0.036 0.09 0.64 0.4
[65]
HepG2 FGF5
Mean 0.268
Standard deviation 0.022
Values 0.25 0.28
[66]
HepG2.C3A FGF5
Mean 0.596
Standard deviation 0.024
Values 0.61 0.58
[67]
HuH.7 FGF5
Mean 0.543
Standard deviation 0.15
Values 0.62 0.65 0.37
[68]
SNU475 FGF5
Mean 1.24
Standard deviation 0.35
Values 0.99 1.5
[69]
THLE FGF5
Mean 1.11
Standard deviation 0.17
Values 0.99 1.2
[70]
liver FGF5
Mean 3.01
Standard deviation 1.5
Values 2.3 4.5 1.2 4.1
[71]
ref_hepatocyte FGF1
Mean 0.126
Standard deviation 0.27
Values 0 0.6 0 0 0.024
[72]
HepG2 FGF1
Mean 0.0408
Standard deviation 0.04
Values 0.069 0.013
[73]
HepG2.C3A FGF1
Mean 0.0628
Standard deviation 0.048
Values 0.029 0.097
[74]
HuH.7 FGF1
Mean 0.00273
Standard deviation 0.0047
Values 0.0082 0 0
[75]
SNU475 FGF1
Mean 0.346
Standard deviation 0.077
Values 0.29 0.4
[76]
THLE FGF1
Mean 1.16
Standard deviation 0.44
Values 0.85 1.5
[77]
liver FGF1
Mean 0.184
Standard deviation 0.042
Values 0.14 0.21 0.15 0.23
[78]
ref_hepatocyte FGF8
Mean 0.0195
Standard deviation 0.044
Values 0 0 0 0 0.098
[79]
HepG2 FGF8
Mean 0.00429
Standard deviation 0.0061
Values 0 0.0086
[80]
HepG2.C3A FGF8
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[81]
HuH.7 FGF8
Mean 0.105
Standard deviation 0.073
Values 0.19 0.051 0.075
[82]
SNU475 FGF8
Mean 0.00949
Standard deviation 0.0063
Values 0.014 0.0051
[83]
THLE FGF8
Mean 0
Standard deviation 0
Values 0 0
[84]
liver FGF8
Mean 0.18
Standard deviation 0.14
Values 0.047 0.34 0.077 0.25
[85]
ref_hepatocyte FGF9
Mean 0.0065
Standard deviation 0.015
Values 0 0 0 0 0.033
[86]
HepG2 FGF9
Mean 0.0687
Standard deviation 9.1e-05
Values 0.069 0.069
[87]
HepG2.C3A FGF9
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[88]
HuH.7 FGF9
Mean 0
Standard deviation 0
Values 0 0 0
[89]
SNU475 FGF9
Mean 0.0822
Standard deviation 0.08
Values 0.14 0.025
[90]
THLE FGF9
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[91]
liver FGF9
Mean 0.00993
Standard deviation 0.02
Values 0 0 0 0.04
[92]
ref_hepatocyte FGF20
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[93]
HepG2 FGF20
Mean 0.0115
Standard deviation 0.016
Values 0.023 0
[94]
HepG2.C3A FGF20
Mean 0
Standard deviation 0
Values 0 0
[95]
HuH.7 FGF20
Mean 0
Standard deviation 0
Values 0 0 0
[96]
SNU475 FGF20
Mean 0.00485
Standard deviation 0.0003
Values 0.0046 0.0051
[97]
THLE FGF20
Mean 0.00562
Standard deviation 0.00042
Values 0.0059 0.0053
[98]
liver FGF20
Mean 0.0118
Standard deviation 0.024
Values 0.047 0 0 0
[99]
ref_hepatocyte FGF23
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[100]
HepG2 FGF23
Mean 0
Standard deviation 0
Values 0 0
[101]
HepG2.C3A FGF23
Mean 0
Standard deviation 0
Values 0 0
[102]
HuH.7 FGF23
Mean 0.00312
Standard deviation 0.0054
Values 0 0 0.0094
[103]
SNU475 FGF23
Mean 0
Standard deviation 0
Values 0 0
[104]
THLE FGF23
Mean 0
Standard deviation 0
Values 0 0
[105]
liver FGF23
Mean 0.68
Standard deviation 0.31
Values 0.59 0.67 1.1 0.36
[106]
ref_hepatocyte FGF3
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[107]
HepG2 FGF3
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[108]
HepG2.C3A FGF3
Mean 0
Standard deviation 0
Values 0 0
[109]
HuH.7 FGF3
Mean 0.00487
Standard deviation 0.0043
Values 0.0082 0.0064 0
[110]
SNU475 FGF3
Mean 0.00717
Standard deviation 0.003
Values 0.0093 0.0051
[111]
THLE FGF3
Mean 0
Standard deviation 0
Values 0 0
[112]
liver FGF3
Mean 0
Standard deviation 0
Values 0 0 0 0
[113]
ref_hepatocyte FGF17
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[114]
HepG2 FGF17
Mean 0.398
Standard deviation 0.15
Values 0.5 0.29
[115]
HepG2.C3A FGF17
Mean 1.23
Standard deviation 1.1
Values 2 0.46
[116]
HuH.7 FGF17
Mean 0.183
Standard deviation 0.2
Values 0.074 0.41 0.066
[117]
SNU475 FGF17
Mean 0.00232
Standard deviation 0.0033
Values 0.0046 0
[118]
THLE FGF17
Mean 0.0228
Standard deviation 0.0096
Values 0.03 0.016
[119]
liver FGF17
Mean 0.00588
Standard deviation 0.012
Values 0.024 0 0 0
[120]
ref_hepatocyte FGF10
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[121]
HepG2 FGF10
Mean 0
Standard deviation 0
Values 0 0
[122]
HepG2.C3A FGF10
Mean 0
Standard deviation 0
Values 0 0
[123]
HuH.7 FGF10
Mean 0
Standard deviation 0
Values 0 0 0
[124]
SNU475 FGF10
Mean 0
Standard deviation 0
Values 0 0
[125]
THLE FGF10
Mean 0
Standard deviation 0
Values 0 0
[126]
liver FGF10
Mean 0.0234
Standard deviation 0.038
Values 0 0.014 0 0.079
[127]
ref_hepatocyte FGF22
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[128]
HepG2 FGF22
Mean 0.01
Standard deviation 0.002
Values 0.011 0.0086
[129]
HepG2.C3A FGF22
Mean 0
Standard deviation 0
Values 0 0
[130]
HuH.7 FGF22
Mean 0.00625
Standard deviation 0.011
Values 0 0 0.019
[131]
SNU475 FGF22
Mean 0.00464
Standard deviation 0.0066
Values 0.0093 0
[132]
THLE FGF22
Mean 0
Standard deviation 0
Values 0 0
[133]
liver FGF22
Mean 0
Standard deviation 0
Values 0 0 0 0
[134]
ref_hepatocyte FGF4
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[135]
HepG2 FGF4
Mean 0
Standard deviation 0
Values 0 0
[136]
HepG2.C3A FGF4
Mean 0
Standard deviation 0
Values 0 0
[137]
HuH.7 FGF4
Mean 0
Standard deviation 0
Values 0 0 0
[138]
SNU475 FGF4
Mean 0.00253
Standard deviation 0.0036
Values 0 0.0051
[139]
THLE FGF4
Mean 0
Standard deviation 0
Values 0 0
[140]
liver FGF4
Mean 0
Standard deviation 0
Values 0 0 0 0
[141]
ref_hepatocyte FGF6
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[142]
HepG2 FGF6
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[143]
HepG2.C3A FGF6
Mean 0
Standard deviation 0
Values 0 0
[144]
HuH.7 FGF6
Mean 0
Standard deviation 0
Values 0 0 0
[145]
SNU475 FGF6
Mean 0
Standard deviation 0
Values 0 0
[146]
THLE FGF6
Mean 0
Standard deviation 0
Values 0 0
[147]
liver FGF6
Mean 0.00357
Standard deviation 0.0071
Values 0 0.014 0 0