REACTOME_PINK1_PRKN_MEDIATED_MITOPHAGY Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 UBB Polyubiquitin-B [1] -0.58[2] -0.78[3] -0.79[4] -0.98[5] -0.63[6] -0.14[7]
2 SQSTM1 Sequestosome-1 [8] -0.14[9] -1.19[10] -0.79[11] 0.63[12] 0.43[13] -0.06[14]
3 RPS27A Ubiquitin-40S ribosomal protein S27a [15] [16] [17] [18] [19] [20] [21]
4 UBC Polyubiquitin-C [22] -0.14[23] -0.03[24] -0.42[25] -0.13[26] -0.25[27] 0.31[28]
5 VDAC1 Voltage-dependent anion-selective channel protein 1 [29] 1.27[30] 0.89[31] 0.52[32] 0.95[33] 1.12[34] 0.80[35]
6 TOMM6 Mitochondrial import receptor subunit TOM6 homolog [36] 0.53[37] 1.00[38] 0.01[39] 0.27[40] -0.36[41] -0.80[42]
7 UBA52 Ubiquitin-60S ribosomal protein L40 [43] 2.30[44] 2.21[45] 3.09[46] 1.27[47] 1.98[48] 1.08[49]
8 TOMM5 Mitochondrial import receptor subunit TOM5 homolog [50] 0.56[51] 1.09[52] 1.27[53] -0.89[54] 0.01[55] -0.32[56]
9 TOMM7 Mitochondrial import receptor subunit TOM7 homolog [57] -0.56[58] 0.28[59] 1.54[60] -0.42[61] -0.40[62] -0.19[63]
10 TOMM22 Mitochondrial import receptor subunit TOM22 homolog [64] 0.49[65] 0.50[66] 0.75[67] -0.47[68] -0.26[69] 0.09[70]
11 TOMM20 Mitochondrial import receptor subunit TOM20 homolog [71] 2.30[72] 3.00[73] 3.25[74] 2.49[75] 1.81[76] 0.76[77]
12 PINK1 Serine/threonine-protein kinase PINK1, mitochondrial [78] 0.50[79] 1.29[80] -1.83[81] 0.77[82] 0.45[83] 2.17[84]
13 TOMM40 Mitochondrial import receptor subunit TOM40 homolog [85] 1.81[86] 1.60[87] 1.31[88] 1.23[89] 1.18[90] 0.33[91]
14 MAP1LC3B Microtubule-associated proteins 1A/1B light chain 3B [92] 2.34[93] 2.07[94] 0.68[95] 1.95[96] 2.46[97] 1.18[98]
15 MFN2 Mitofusin-2 [99] 2.31[100] 3.20[101] 1.96[102] 2.67[103] 2.52[104] 2.82[105]
16 MAP1LC3A Microtubule-associated proteins 1A/1B light chain 3A [106] -7.42[107] -8.87[108] -8.39[109] -1.44[110] 0.40[111] 0.80[112]
17 ATG5 Autophagy protein 5 [113] 1.40[114] 2.43[115] 1.93[116] 2.58[117] 2.22[118] 2.58[119]
18 MFN1 Mitofusin-1 [120] 1.77[121] 2.45[122] 2.20[123] 2.69[124] 2.55[125] 2.65[126]
19 ATG12 Ubiquitin-like protein ATG12 [127] 2.05[128] 2.95[129] 2.72[130] 3.26[131] 2.93[132] 3.17[133]
20 PRKN E3 ubiquitin-protein ligase parkin [134] [135] [136] [137] [138] [139] [140]
21 TOMM70 Mitochondrial import receptor subunit TOM70 [141] [142] [143] [144] [145] [146] [147]
22 MTERF3 Transcription termination factor 3, mitochondrial [148] [149] [150] [151] [152] [153] [154]
[1]
ref_hepatocyte UBB
Mean 764
Standard deviation 4.8e+02
Values 3.8e+02 3.5e+02 5.3e+02 1.2e+03 1.3e+03
[2]
HepG2 UBB
Mean 368
Standard deviation 39
Values 4e+02 3.4e+02
[3]
HepG2.C3A UBB
Mean 285
Standard deviation 14
Values 2.8e+02 3e+02
[4]
HuH.7 UBB
Mean 304
Standard deviation 40
Values 2.9e+02 2.7e+02 3.5e+02
[5]
SNU475 UBB
Mean 204
Standard deviation 3.3
Values 2.1e+02 2e+02
[6]
THLE UBB
Mean 315
Standard deviation 34
Values 2.9e+02 3.4e+02
[7]
liver UBB
Mean 296
Standard deviation 1.3e+02
Values 4.3e+02 2.1e+02 3.9e+02 1.5e+02
[8]
ref_hepatocyte SQSTM1
Mean 520
Standard deviation 6e+02
Values 2e+02 1.6e+03 4.7e+02 1.7e+02 1.9e+02
[9]
HepG2 SQSTM1
Mean 340
Standard deviation 1.6e+02
Values 4.5e+02 2.3e+02
[10]
HepG2.C3A SQSTM1
Mean 146
Standard deviation 39
Values 1.7e+02 1.2e+02
[11]
HuH.7 SQSTM1
Mean 205
Standard deviation 98
Values 1.5e+02 3.2e+02 1.5e+02
[12]
SNU475 SQSTM1
Mean 424
Standard deviation 77
Values 3.7e+02 4.8e+02
[13]
THLE SQSTM1
Mean 447
Standard deviation 1.3e+02
Values 3.6e+02 5.4e+02
[14]
liver SQSTM1
Mean 213
Standard deviation 1.3e+02
Values 2.6e+02 1.4e+02 3.7e+02 80
[15]
ref_hepatocyte RPS27A
Mean 499
Standard deviation 2.2e+02
Values 6.6e+02 6.1e+02 1.7e+02 6.8e+02 3.8e+02
[16]
HepG2 RPS27A
Missing
[17]
HepG2.C3A RPS27A
Missing
[18]
HuH.7 RPS27A
Missing
[19]
SNU475 RPS27A
Missing
[20]
THLE RPS27A
Missing
[21]
liver RPS27A
Missing
[22]
ref_hepatocyte UBC
Mean 480
Standard deviation 2.8e+02
Values 1.8e+02 3.5e+02 9.1e+02 5.8e+02 3.8e+02
[23]
HepG2 UBC
Mean 314
Standard deviation 38
Values 3.4e+02 2.9e+02
[24]
HepG2.C3A UBC
Mean 302
Standard deviation 41
Values 3.3e+02 2.7e+02
[25]
HuH.7 UBC
Mean 246
Standard deviation 64
Values 2.4e+02 3.1e+02 1.9e+02
[26]
SNU475 UBC
Mean 232
Standard deviation 63
Values 2.8e+02 1.9e+02
[27]
THLE UBC
Mean 257
Standard deviation 41
Values 2.3e+02 2.9e+02
[28]
liver UBC
Mean 254
Standard deviation 78
Values 2.2e+02 3.1e+02 3.3e+02 1.6e+02
[29]
ref_hepatocyte VDAC1
Mean 106
Standard deviation 53
Values 1.9e+02 1.2e+02 66 80 70
[30]
HepG2 VDAC1
Mean 184
Standard deviation 1.3
Values 1.8e+02 1.8e+02
[31]
HepG2.C3A VDAC1
Mean 126
Standard deviation 2.5
Values 1.2e+02 1.3e+02
[32]
HuH.7 VDAC1
Mean 104
Standard deviation 14
Values 1.1e+02 89 1.2e+02
[33]
SNU475 VDAC1
Mean 108
Standard deviation 1.4
Values 1.1e+02 1.1e+02
[34]
THLE VDAC1
Mean 146
Standard deviation 33
Values 1.2e+02 1.7e+02
[35]
liver VDAC1
Mean 79
Standard deviation 36
Values 94 62 1.2e+02 40
[36]
ref_hepatocyte TOMM6
Mean 66.3
Standard deviation 21
Values 38 53 77 72 91
[37]
HepG2 TOMM6
Mean 68.9
Standard deviation 20
Values 55 83
[38]
HepG2.C3A TOMM6
Mean 84.7
Standard deviation 39
Values 57 1.1e+02
[39]
HuH.7 TOMM6
Mean 45.8
Standard deviation 16
Values 45 31 62
[40]
SNU475 TOMM6
Mean 42.1
Standard deviation 3.8
Values 45 39
[41]
THLE TOMM6
Mean 32.7
Standard deviation 3.4
Values 30 35
[42]
liver TOMM6
Mean 16.2
Standard deviation 15
Values 29 3.8 29 2.5
[43]
ref_hepatocyte UBA52
Mean 57.3
Standard deviation 43
Values 14 23 49 1.2e+02 81
[44]
HepG2 UBA52
Mean 203
Standard deviation 20
Values 2.2e+02 1.9e+02
[45]
HepG2.C3A UBA52
Mean 169
Standard deviation 3.3
Values 1.7e+02 1.7e+02
[46]
HuH.7 UBA52
Mean 334
Standard deviation 46
Values 3.4e+02 2.8e+02 3.7e+02
[47]
SNU475 UBA52
Mean 72.9
Standard deviation 11
Values 65 81
[48]
THLE UBA52
Mean 144
Standard deviation 15
Values 1.3e+02 1.5e+02
[49]
liver UBA52
Mean 51.7
Standard deviation 26
Values 79 32 68 28
[50]
ref_hepatocyte TOMM5
Mean 57
Standard deviation 15
Values 79 55 56 59 37
[51]
HepG2 TOMM5
Mean 60.4
Standard deviation 8.3
Values 55 66
[52]
HepG2.C3A TOMM5
Mean 78
Standard deviation 44
Values 47 1.1e+02
[53]
HuH.7 TOMM5
Mean 94.1
Standard deviation 41
Values 99 51 1.3e+02
[54]
SNU475 TOMM5
Mean 16.2
Standard deviation 0.016
Values 16 16
[55]
THLE TOMM5
Mean 36.4
Standard deviation 4.6
Values 33 40
[56]
liver TOMM5
Mean 19.5
Standard deviation 18
Values 33 5.1 36 3.5
[57]
ref_hepatocyte TOMM7
Mean 52.6
Standard deviation 55
Values 7.3 13 18 1.1e+02 1.1e+02
[58]
HepG2 TOMM7
Mean 25.7
Standard deviation 2.1
Values 24 27
[59]
HepG2.C3A TOMM7
Mean 41
Standard deviation 1.7
Values 40 42
[60]
HuH.7 TOMM7
Mean 105
Standard deviation 26
Values 76 1.1e+02 1.3e+02
[61]
SNU475 TOMM7
Mean 20.8
Standard deviation 1.3
Values 22 20
[62]
THLE TOMM7
Mean 25.4
Standard deviation 3.7
Values 23 28
[63]
liver TOMM7
Mean 19.7
Standard deviation 18
Values 37 4.9 34 3.9
[64]
ref_hepatocyte TOMM22
Mean 41.5
Standard deviation 13
Values 52 52 47 29 27
[65]
HepG2 TOMM22
Mean 41.9
Standard deviation 2.7
Values 40 44
[66]
HepG2.C3A TOMM22
Mean 37.6
Standard deviation 6
Values 33 42
[67]
HuH.7 TOMM22
Mean 47.7
Standard deviation 14
Values 48 34 61
[68]
SNU475 TOMM22
Mean 15.8
Standard deviation 0.26
Values 16 16
[69]
THLE TOMM22
Mean 22.1
Standard deviation 5.5
Values 18 26
[70]
liver TOMM22
Mean 18.8
Standard deviation 11
Values 27 10 30 7.8
[71]
ref_hepatocyte TOMM20
Mean 38.9
Standard deviation 27
Values 83 47 18 24 23
[72]
HepG2 TOMM20
Mean 138
Standard deviation 13
Values 1.5e+02 1.3e+02
[73]
HepG2.C3A TOMM20
Mean 200
Standard deviation 86
Values 2.6e+02 1.4e+02
[74]
HuH.7 TOMM20
Mean 254
Standard deviation 20
Values 2.6e+02 2.7e+02 2.3e+02
[75]
SNU475 TOMM20
Mean 115
Standard deviation 4.1
Values 1.2e+02 1.1e+02
[76]
THLE TOMM20
Mean 86.7
Standard deviation 1.4
Values 86 88
[77]
liver TOMM20
Mean 28.1
Standard deviation 6.1
Values 36 29 24 23
[78]
ref_hepatocyte PINK1
Mean 28.5
Standard deviation 14
Values 12 23 24 48 35
[79]
HepG2 PINK1
Mean 29.1
Standard deviation 3.2
Values 31 27
[80]
HepG2.C3A PINK1
Mean 44.8
Standard deviation 19
Values 58 31
[81]
HuH.7 PINK1
Mean 5.5
Standard deviation 1.6
Values 4.7 7.3 4.5
[82]
SNU475 PINK1
Mean 25.6
Standard deviation 2.7
Values 28 24
[83]
THLE PINK1
Mean 24.8
Standard deviation 0.42
Values 25 24
[84]
liver PINK1
Mean 54.8
Standard deviation 20
Values 62 42 79 36
[85]
ref_hepatocyte TOMM40
Mean 27.2
Standard deviation 9.8
Values 20 34 40 25 17
[86]
HepG2 TOMM40
Mean 68.8
Standard deviation 5.8
Values 73 65
[87]
HepG2.C3A TOMM40
Mean 52.9
Standard deviation 2.8
Values 51 55
[88]
HuH.7 TOMM40
Mean 46.3
Standard deviation 18
Values 53 26 60
[89]
SNU475 TOMM40
Mean 33.8
Standard deviation 11
Values 26 41
[90]
THLE TOMM40
Mean 39.2
Standard deviation 3.9
Values 36 42
[91]
liver TOMM40
Mean 14.6
Standard deviation 6.1
Values 20 9.9 20 8.7
[92]
ref_hepatocyte MAP1LC3B
Mean 19.5
Standard deviation 7.6
Values 23 15 20 29 9.7
[93]
HepG2 MAP1LC3B
Mean 71.1
Standard deviation 18
Values 84 58
[94]
HepG2.C3A MAP1LC3B
Mean 52.5
Standard deviation 21
Values 67 38
[95]
HuH.7 MAP1LC3B
Mean 21.3
Standard deviation 4.6
Values 17 26 20
[96]
SNU475 MAP1LC3B
Mean 39.8
Standard deviation 6.3
Values 44 35
[97]
THLE MAP1LC3B
Mean 68.2
Standard deviation 2.8
Values 66 70
[98]
liver MAP1LC3B
Mean 18.9
Standard deviation 17
Values 32 4.6 35 4
[99]
ref_hepatocyte MFN2
Mean 18.6
Standard deviation 7
Values 13 31 18 14 17
[100]
HepG2 MFN2
Mean 66.5
Standard deviation 4.7
Values 63 70
[101]
HepG2.C3A MFN2
Mean 110
Standard deviation 8
Values 1.2e+02 1e+02
[102]
HuH.7 MFN2
Mean 49.4
Standard deviation 6
Values 55 43 50
[103]
SNU475 MFN2
Mean 62.6
Standard deviation 3.1
Values 65 60
[104]
THLE MFN2
Mean 67.9
Standard deviation 6.3
Values 63 72
[105]
liver MFN2
Mean 55.9
Standard deviation 20
Values 37 62 43 82
[106]
ref_hepatocyte MAP1LC3A
Mean 7.47
Standard deviation 7.7
Values 0.12 3.6 6.6 6.7 20
[107]
HepG2 MAP1LC3A
Mean 0.0315
Standard deviation 0.004
Values 0.029 0.034
[108]
HepG2.C3A MAP1LC3A
Mean 0.0102
Standard deviation 0.00071
Values 0.0097 0.011
[109]
HuH.7 MAP1LC3A
Mean 0.0152
Standard deviation 0.017
Values 0.033 0.013 0
[110]
SNU475 MAP1LC3A
Mean 1.45
Standard deviation 0.48
Values 1.8 1.1
[111]
THLE MAP1LC3A
Mean 6.29
Standard deviation 0.45
Values 6.6 6
[112]
liver MAP1LC3A
Mean 5.54
Standard deviation 6.3
Values 14 0.49 7.4 0.61
[113]
ref_hepatocyte ATG5
Mean 6.42
Standard deviation 2
Values 4.4 4.5 6.5 8.4 8.3
[114]
HepG2 ATG5
Mean 12.2
Standard deviation 4.5
Values 9 15
[115]
HepG2.C3A ATG5
Mean 22.1
Standard deviation 5.1
Values 18 26
[116]
HuH.7 ATG5
Mean 16.7
Standard deviation 1.4
Values 16 16 18
[117]
SNU475 ATG5
Mean 20.3
Standard deviation 1.9
Values 22 19
[118]
THLE ATG5
Mean 19
Standard deviation 0.43
Values 19 19
[119]
liver ATG5
Mean 16.3
Standard deviation 4.6
Values 20 15 20 11
[120]
ref_hepatocyte MFN1
Mean 5.75
Standard deviation 5.7
Values 5.2 16 3.4 2.1 2.3
[121]
HepG2 MFN1
Mean 14.1
Standard deviation 5
Values 11 18
[122]
HepG2.C3A MFN1
Mean 20.1
Standard deviation 2.9
Values 18 22
[123]
HuH.7 MFN1
Mean 18.1
Standard deviation 3.3
Values 21 15 18
[124]
SNU475 MFN1
Mean 19.6
Standard deviation 3.4
Values 22 17
[125]
THLE MFN1
Mean 21.3
Standard deviation 0.13
Values 21 21
[126]
liver MFN1
Mean 15.4
Standard deviation 6.2
Values 10 23 10 18
[127]
ref_hepatocyte ATG12
Mean 4.73
Standard deviation 0.81
Values 5.6 5.4 3.6 4.5 4.5
[128]
HepG2 ATG12
Mean 14.1
Standard deviation 2.6
Values 12 16
[129]
HepG2.C3A ATG12
Mean 23.3
Standard deviation 1.9
Values 22 25
[130]
HuH.7 ATG12
Mean 21.4
Standard deviation 1.1
Values 20 21 23
[131]
SNU475 ATG12
Mean 23.9
Standard deviation 3.1
Values 26 22
[132]
THLE ATG12
Mean 22.9
Standard deviation 1.3
Values 22 24
[133]
liver ATG12
Mean 18.2
Standard deviation 8
Values 25 11 25 12
[134]
ref_hepatocyte PRKN
Missing
[135]
HepG2 PRKN
Missing
[136]
HepG2.C3A PRKN
Missing
[137]
HuH.7 PRKN
Missing
[138]
SNU475 PRKN
Missing
[139]
THLE PRKN
Missing
[140]
liver PRKN
Missing
[141]
ref_hepatocyte TOMM70
Missing
[142]
HepG2 TOMM70
Missing
[143]
HepG2.C3A TOMM70
Missing
[144]
HuH.7 TOMM70
Missing
[145]
SNU475 TOMM70
Missing
[146]
THLE TOMM70
Missing
[147]
liver TOMM70
Missing
[148]
ref_hepatocyte MTERF3
Missing
[149]
HepG2 MTERF3
Missing
[150]
HepG2.C3A MTERF3
Missing
[151]
HuH.7 MTERF3
Missing
[152]
SNU475 MTERF3
Missing
[153]
THLE MTERF3
Missing
[154]
liver MTERF3
Missing