REACTOME_PI3K_EVENTS_IN_ERBB4_SIGNALING Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 PIK3R1 Phosphatidylinositol 3-kinase regulatory subunit alpha [1] 0.01[2] -0.11[3] 0.35[4] 0.44[5] 0.37[6] 0.69[7]
2 PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 0.10[8] 1.51[9] 1.05[10] -0.50[11] 0.13[12] -0.40[13]
3 HBEGF Proheparin-binding EGF-like growth factor [14] -0.50[15] -1.55[16] -3.26[17] -1.32[18] -1.21[19] -4.74[20]
4 NRG1 Pro-neuregulin-1, membrane-bound isoform [21] 0.82[22] -5.55[23] -3.30[24] 0.42[25] -6.62[26] -1.54[27]
5 BTC Probetacellulin [28] -7.66[29] -8.28[30] -4.70[31] -4.50[32] -4.10[33] -5.23[34]
6 NRG4 Pro-neuregulin-4, membrane-bound isoform [35] -3.61[36] -0.97[37] -1.66[38] -1.34[39] -3.11[40] -3.25[41]
7 EREG Proepiregulin [42] 2.24[43] 1.93[44] -3.13[45] -3.19[46] 2.48[47] -3.78[48]
8 NRG3 Pro-neuregulin-3, membrane-bound isoform [49] [50] [51] [52] [53] [54] [55]
9 ERBB4 Receptor tyrosine-protein kinase erbB-4 [56] [57] [58] [59] [60] [61] [62]
10 NRG2 Pro-neuregulin-2, membrane-bound isoform [63] [64] [65] [66] [67] [68] [69]
[1]
ref_hepatocyte PIK3R1
Mean 7.45
Standard deviation 3.9
Values 4.1 7.4 4.2 8.1 14
[2]
HepG2 PIK3R1
Mean 11.9
Standard deviation 3
Values 9.8 14
[3]
HepG2.C3A PIK3R1
Mean 11.5
Standard deviation 2.6
Values 9.6 13
[4]
HuH.7 PIK3R1
Mean 23.4
Standard deviation 8.6
Values 23 32 15
[5]
SNU475 PIK3R1
Mean 57.3
Standard deviation 32
Values 80 35
[6]
THLE PIK3R1
Mean 45.5
Standard deviation 1.5
Values 44 47
[7]
liver PIK3R1
Mean 84.8
Standard deviation 47
Values 64 1e+02 32 1.4e+02
[8]
ref_hepatocyte PIK3CA
Mean 1.87
Standard deviation 0.73
Values 2.3 2.6 2.3 1.2 0.94
[9]
HepG2 PIK3CA
Mean 3.17
Standard deviation 1.6
Values 2.1 4.3
[10]
HepG2.C3A PIK3CA
Mean 8.78
Standard deviation 1.1
Values 8 9.6
[11]
HuH.7 PIK3CA
Mean 9.59
Standard deviation 2.4
Values 10 12 7
[12]
SNU475 PIK3CA
Mean 7.49
Standard deviation 0.93
Values 8.1 6.8
[13]
THLE PIK3CA
Mean 9.67
Standard deviation 0.66
Values 10 9.2
[14]
liver PIK3CA
Mean 9.99
Standard deviation 4.7
Values 6.1 15 6 13
[15]
ref_hepatocyte HBEGF
Mean 1.81
Standard deviation 1.5
Values 1 3.1 3.8 0.78 0.34
[16]
HepG2 HBEGF
Mean 2.02
Standard deviation 0.16
Values 2.1 1.9
[17]
HepG2.C3A HBEGF
Mean 1.02
Standard deviation 0.3
Values 1.2 0.82
[18]
HuH.7 HBEGF
Mean 0.469
Standard deviation 0.044
Values 0.52 0.43 0.46
[19]
SNU475 HBEGF
Mean 4.11
Standard deviation 0.34
Values 3.9 4.4
[20]
THLE HBEGF
Mean 3.71
Standard deviation 0.17
Values 3.8 3.6
[21]
liver HBEGF
Mean 0.478
Standard deviation 0.29
Values 0.89 0.27 0.28 0.46
[22]
ref_hepatocyte NRG1
Mean 1.2
Standard deviation 1
Values 0 1 2.8 1.5 0.74
[23]
HepG2 NRG1
Mean 3.35
Standard deviation 2.7
Values 1.4 5.3
[24]
HepG2.C3A NRG1
Mean 0.0424
Standard deviation 0.046
Values 0.0097 0.075
[25]
HuH.7 NRG1
Mean 0.302
Standard deviation 0.17
Values 0.16 0.49 0.25
[26]
SNU475 NRG1
Mean 9.16
Standard deviation 3.3
Values 12 6.8
[27]
THLE NRG1
Mean 0.0576
Standard deviation 0.031
Values 0.035 0.08
[28]
liver NRG1
Mean 2.92
Standard deviation 2.1
Values 1.2 5.5 3.6 1.2
[29]
ref_hepatocyte BTC
Mean 0.915
Standard deviation 1.9
Values 0 4.4 0.079 0 0.12
[30]
HepG2 BTC
Mean 0.00716
Standard deviation 0.002
Values 0.0057 0.0086
[31]
HepG2.C3A BTC
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[32]
HuH.7 BTC
Mean 0.087
Standard deviation 0.09
Values 0.066 0.19 0.0094
[33]
SNU475 BTC
Mean 0.229
Standard deviation 0.03
Values 0.25 0.21
[34]
THLE BTC
Mean 0.251
Standard deviation 0.13
Values 0.34 0.16
[35]
liver BTC
Mean 0.172
Standard deviation 0.058
Values 0.21 0.23 0.1 0.15
[36]
ref_hepatocyte NRG4
Mean 0.631
Standard deviation 0.35
Values 0 0.75 0.81 0.78 0.81
[37]
HepG2 NRG4
Mean 0.0816
Standard deviation 0.03
Values 0.1 0.06
[38]
HepG2.C3A NRG4
Mean 0.534
Standard deviation 0.042
Values 0.56 0.5
[39]
HuH.7 NRG4
Mean 0.494
Standard deviation 0.053
Values 0.43 0.51 0.53
[40]
SNU475 NRG4
Mean 1.41
Standard deviation 0.46
Values 1.7 1.1
[41]
THLE NRG4
Mean 0.345
Standard deviation 0.16
Values 0.46 0.23
[42]
liver NRG4
Mean 0.468
Standard deviation 0.12
Values 0.45 0.41 0.64 0.37
[43]
ref_hepatocyte EREG
Mean 0.24
Standard deviation 0.13
Values 0.3 0.18 0.15 0.13 0.45
[44]
HepG2 EREG
Mean 1.79
Standard deviation 1.2
Values 2.6 0.95
[45]
HepG2.C3A EREG
Mean 1.51
Standard deviation 1
Values 0.81 2.2
[46]
HuH.7 EREG
Mean 0.068
Standard deviation 0.032
Values 0.033 0.096 0.075
[47]
SNU475 EREG
Mean 0.149
Standard deviation 0.12
Values 0.065 0.23
[48]
THLE EREG
Mean 6.34
Standard deviation 2.2
Values 7.9 4.8
[49]
liver EREG
Mean 0.123
Standard deviation 0.11
Values 0 0.13 0.26 0.11
[50]
ref_hepatocyte NRG3
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[51]
HepG2 NRG3
Mean 0
Standard deviation 0
Values 0 0
[52]
HepG2.C3A NRG3
Mean 0
Standard deviation 0
Values 0 0
[53]
HuH.7 NRG3
Mean 0.376
Standard deviation 0.32
Values 0.18 0.75 0.2
[54]
SNU475 NRG3
Mean 0
Standard deviation 0
Values 0 0
[55]
THLE NRG3
Mean 0
Standard deviation 0
Values 0 0
[56]
liver NRG3
Mean 0.222
Standard deviation 0.073
Values 0.28 0.2 0.13 0.28
[57]
ref_hepatocyte ERBB4
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[58]
HepG2 ERBB4
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[59]
HepG2.C3A ERBB4
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[60]
HuH.7 ERBB4
Mean 0.136
Standard deviation 0.15
Values 0.098 0.3 0.0094
[61]
SNU475 ERBB4
Mean 0.0217
Standard deviation 0.0021
Values 0.023 0.02
[62]
THLE ERBB4
Mean 0.0662
Standard deviation 0.027
Values 0.047 0.085
[63]
liver ERBB4
Mean 0.308
Standard deviation 0.33
Values 0.14 0.29 0.026 0.78
[64]
ref_hepatocyte NRG2
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[65]
HepG2 NRG2
Mean 0.0236
Standard deviation 0.015
Values 0.034 0.013
[66]
HepG2.C3A NRG2
Mean 0
Standard deviation 0
Values 0 0
[67]
HuH.7 NRG2
Mean 0
Standard deviation 0
Values 0 0 0
[68]
SNU475 NRG2
Mean 0.181
Standard deviation 0.12
Values 0.093 0.27
[69]
THLE NRG2
Mean 0.79
Standard deviation 0.23
Values 0.63 0.95
[70]
liver NRG2
Mean 0.0321
Standard deviation 0.024
Values 0.047 0.029 0 0.053