REACTOME_PI3K_EVENTS_IN_ERBB2_SIGNALING Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 GRB2 Growth factor receptor-bound protein 2 [1] -0.02[2] -0.50[3] -0.42[4] -0.32[5] -0.18[6] -1.42[7]
2 ERBB3 Receptor tyrosine-protein kinase erbB-3 [8] 0.79[9] 1.85[10] 0.85[11] -6.74[12] -6.27[13] 0.59[14]
3 PIK3R1 Phosphatidylinositol 3-kinase regulatory subunit alpha [15] -1.68[16] -1.89[17] -0.84[18] 1.19[19] 0.92[20] 1.28[21]
4 ERBB2 Receptor tyrosine-protein kinase erbB-2 [22] 1.16[23] -0.34[24] 0.79[25] 0.38[26] 0.21[27] -1.57[28]
5 EGFR Epidermal growth factor receptor [29] -1.91[30] -2.60[31] 0.23[32] -0.44[33] 0.40[34] 0.93[35]
6 PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform -1.59[36] -0.28[37] -0.13[38] 0.26[39] 0.68[40] 0.19[41]
7 HBEGF Proheparin-binding EGF-like growth factor [42] -2.20[43] -3.33[44] -4.44[45] -0.57[46] -0.66[47] -4.15[48]
8 NRG1 Pro-neuregulin-1, membrane-bound isoform [49] -0.88[50] -7.34[51] -4.49[52] 1.18[53] -6.07[54] -0.95[55]
9 BTC Probetacellulin [56] -9.35[57] -10.07[58] -5.89[59] -3.75[60] -3.55[61] -4.64[62]
10 GAB1 GRB2-associated-binding protein 1 [63] 0.09[64] 0.86[65] 0.94[66] 1.06[67] 1.15[68] 1.15[69]
11 NRG4 Pro-neuregulin-4, membrane-bound isoform [70] -5.30[71] -2.75[72] -2.85[73] -0.59[74] -2.56[75] -2.66[76]
12 EREG Proepiregulin [77] 0.54[78] 0.15[79] -4.31[80] -2.44[81] 3.03[82] -3.20[83]
13 EGF Pro-epidermal growth factor [84] 0.76[85] 2.22[86] 5.79[87] 8.15[88] 5.80[89] -0.14[90]
14 NRG3 Pro-neuregulin-3, membrane-bound isoform [91] [92] [93] [94] [95] [96] [97]
15 ERBB4 Receptor tyrosine-protein kinase erbB-4 [98] [99] [100] [101] [102] [103] [104]
16 NRG2 Pro-neuregulin-2, membrane-bound isoform [105] [106] [107] [108] [109] [110] [111]
[1]
ref_hepatocyte GRB2
Mean 20.7
Standard deviation 5.5
Values 27 26 20 14 17
[2]
HepG2 GRB2
Mean 104
Standard deviation 4.7
Values 1e+02 1.1e+02
[3]
HepG2.C3A GRB2
Mean 83.1
Standard deviation 0.44
Values 83 83
[4]
HuH.7 GRB2
Mean 86.7
Standard deviation 7.6
Values 89 78 93
[5]
SNU475 GRB2
Mean 55.7
Standard deviation 1.4
Values 55 57
[6]
THLE GRB2
Mean 58.8
Standard deviation 3.7
Values 56 61
[7]
liver GRB2
Mean 36.1
Standard deviation 16
Values 50 22 50 22
[8]
ref_hepatocyte ERBB3
Mean 8.22
Standard deviation 4
Values 12 3.8 4.1 11 10
[9]
HepG2 ERBB3
Mean 72.9
Standard deviation 2.6
Values 75 71
[10]
HepG2.C3A ERBB3
Mean 169
Standard deviation 42
Values 2e+02 1.4e+02
[11]
HuH.7 ERBB3
Mean 83.4
Standard deviation 7.8
Values 92 80 78
[12]
SNU475 ERBB3
Mean 0.258
Standard deviation 0.12
Values 0.18 0.34
[13]
THLE ERBB3
Mean 0.344
Standard deviation 0.05
Values 0.38 0.31
[14]
liver ERBB3
Mean 57.8
Standard deviation 20
Values 44 71 39 79
[15]
ref_hepatocyte PIK3R1
Mean 7.45
Standard deviation 3.9
Values 4.1 7.4 4.2 8.1 14
[16]
HepG2 PIK3R1
Mean 11.9
Standard deviation 3
Values 9.8 14
[17]
HepG2.C3A PIK3R1
Mean 11.5
Standard deviation 2.6
Values 9.6 13
[18]
HuH.7 PIK3R1
Mean 23.4
Standard deviation 8.6
Values 23 32 15
[19]
SNU475 PIK3R1
Mean 57.3
Standard deviation 32
Values 80 35
[20]
THLE PIK3R1
Mean 45.5
Standard deviation 1.5
Values 44 47
[21]
liver PIK3R1
Mean 84.8
Standard deviation 47
Values 64 1e+02 32 1.4e+02
[22]
ref_hepatocyte ERBB2
Mean 6.44
Standard deviation 3.8
Values 13 3.9 4.7 3.7 7.1
[23]
HepG2 ERBB2
Mean 73.6
Standard deviation 10
Values 66 81
[24]
HepG2.C3A ERBB2
Mean 29
Standard deviation 6.9
Values 34 24
[25]
HuH.7 ERBB2
Mean 62.5
Standard deviation 7.1
Values 69 55 63
[26]
SNU475 ERBB2
Mean 28.2
Standard deviation 8.4
Values 34 22
[27]
THLE ERBB2
Mean 24.1
Standard deviation 2.7
Values 22 26
[28]
liver ERBB2
Mean 10.2
Standard deviation 3.4
Values 7.9 8.1 9.6 15
[29]
ref_hepatocyte EGFR
Mean 5.53
Standard deviation 4.2
Values 0.94 8.5 11 3.5 3.5
[30]
HepG2 EGFR
Mean 7.53
Standard deviation 0.89
Values 6.9 8.2
[31]
HepG2.C3A EGFR
Mean 5.18
Standard deviation 0.67
Values 5.7 4.7
[32]
HuH.7 EGFR
Mean 36.6
Standard deviation 25
Values 32 63 15
[33]
SNU475 EGFR
Mean 13.7
Standard deviation 0.74
Values 13 14
[34]
THLE EGFR
Mean 23.6
Standard deviation 4.4
Values 20 27
[35]
liver EGFR
Mean 49.4
Standard deviation 14
Values 39 69 47 42
[36]
ref_hepatocyte PIK3CA
Mean 1.87
Standard deviation 0.73
Values 2.3 2.6 2.3 1.2 0.94
[37]
HepG2 PIK3CA
Mean 3.17
Standard deviation 1.6
Values 2.1 4.3
[38]
HepG2.C3A PIK3CA
Mean 8.78
Standard deviation 1.1
Values 8 9.6
[39]
HuH.7 PIK3CA
Mean 9.59
Standard deviation 2.4
Values 10 12 7
[40]
SNU475 PIK3CA
Mean 7.49
Standard deviation 0.93
Values 8.1 6.8
[41]
THLE PIK3CA
Mean 9.67
Standard deviation 0.66
Values 10 9.2
[42]
liver PIK3CA
Mean 9.99
Standard deviation 4.7
Values 6.1 15 6 13
[43]
ref_hepatocyte HBEGF
Mean 1.81
Standard deviation 1.5
Values 1 3.1 3.8 0.78 0.34
[44]
HepG2 HBEGF
Mean 2.02
Standard deviation 0.16
Values 2.1 1.9
[45]
HepG2.C3A HBEGF
Mean 1.02
Standard deviation 0.3
Values 1.2 0.82
[46]
HuH.7 HBEGF
Mean 0.469
Standard deviation 0.044
Values 0.52 0.43 0.46
[47]
SNU475 HBEGF
Mean 4.11
Standard deviation 0.34
Values 3.9 4.4
[48]
THLE HBEGF
Mean 3.71
Standard deviation 0.17
Values 3.8 3.6
[49]
liver HBEGF
Mean 0.478
Standard deviation 0.29
Values 0.89 0.27 0.28 0.46
[50]
ref_hepatocyte NRG1
Mean 1.2
Standard deviation 1
Values 0 1 2.8 1.5 0.74
[51]
HepG2 NRG1
Mean 3.35
Standard deviation 2.7
Values 1.4 5.3
[52]
HepG2.C3A NRG1
Mean 0.0424
Standard deviation 0.046
Values 0.0097 0.075
[53]
HuH.7 NRG1
Mean 0.302
Standard deviation 0.17
Values 0.16 0.49 0.25
[54]
SNU475 NRG1
Mean 9.16
Standard deviation 3.3
Values 12 6.8
[55]
THLE NRG1
Mean 0.0576
Standard deviation 0.031
Values 0.035 0.08
[56]
liver NRG1
Mean 2.92
Standard deviation 2.1
Values 1.2 5.5 3.6 1.2
[57]
ref_hepatocyte BTC
Mean 0.915
Standard deviation 1.9
Values 0 4.4 0.079 0 0.12
[58]
HepG2 BTC
Mean 0.00716
Standard deviation 0.002
Values 0.0057 0.0086
[59]
HepG2.C3A BTC
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[60]
HuH.7 BTC
Mean 0.087
Standard deviation 0.09
Values 0.066 0.19 0.0094
[61]
SNU475 BTC
Mean 0.229
Standard deviation 0.03
Values 0.25 0.21
[62]
THLE BTC
Mean 0.251
Standard deviation 0.13
Values 0.34 0.16
[63]
liver BTC
Mean 0.172
Standard deviation 0.058
Values 0.21 0.23 0.1 0.15
[64]
ref_hepatocyte GAB1
Mean 0.787
Standard deviation 0.67
Values 2 0.61 0.33 0.38 0.66
[65]
HepG2 GAB1
Mean 4.28
Standard deviation 2.2
Values 2.8 5.8
[66]
HepG2.C3A GAB1
Mean 8.12
Standard deviation 2.3
Values 6.5 9.8
[67]
HuH.7 GAB1
Mean 8.48
Standard deviation 1.4
Values 10 8.1 7.3
[68]
SNU475 GAB1
Mean 5.52
Standard deviation 1.6
Values 6.6 4.4
[69]
THLE GAB1
Mean 5.62
Standard deviation 0.39
Values 5.9 5.3
[70]
liver GAB1
Mean 8.2
Standard deviation 2.5
Values 7.1 10 5.3 10
[71]
ref_hepatocyte NRG4
Mean 0.631
Standard deviation 0.35
Values 0 0.75 0.81 0.78 0.81
[72]
HepG2 NRG4
Mean 0.0816
Standard deviation 0.03
Values 0.1 0.06
[73]
HepG2.C3A NRG4
Mean 0.534
Standard deviation 0.042
Values 0.56 0.5
[74]
HuH.7 NRG4
Mean 0.494
Standard deviation 0.053
Values 0.43 0.51 0.53
[75]
SNU475 NRG4
Mean 1.41
Standard deviation 0.46
Values 1.7 1.1
[76]
THLE NRG4
Mean 0.345
Standard deviation 0.16
Values 0.46 0.23
[77]
liver NRG4
Mean 0.468
Standard deviation 0.12
Values 0.45 0.41 0.64 0.37
[78]
ref_hepatocyte EREG
Mean 0.24
Standard deviation 0.13
Values 0.3 0.18 0.15 0.13 0.45
[79]
HepG2 EREG
Mean 1.79
Standard deviation 1.2
Values 2.6 0.95
[80]
HepG2.C3A EREG
Mean 1.51
Standard deviation 1
Values 0.81 2.2
[81]
HuH.7 EREG
Mean 0.068
Standard deviation 0.032
Values 0.033 0.096 0.075
[82]
SNU475 EREG
Mean 0.149
Standard deviation 0.12
Values 0.065 0.23
[83]
THLE EREG
Mean 6.34
Standard deviation 2.2
Values 7.9 4.8
[84]
liver EREG
Mean 0.123
Standard deviation 0.11
Values 0 0.13 0.26 0.11
[85]
ref_hepatocyte EGF
Mean 0.00415
Standard deviation 0.0093
Values 0 0.021 0 0 0
[86]
HepG2 EGF
Mean 0.0358
Standard deviation 0.014
Values 0.046 0.026
[87]
HepG2.C3A EGF
Mean 0.11
Standard deviation 0.087
Values 0.049 0.17
[88]
HuH.7 EGF
Mean 1.29
Standard deviation 0.44
Values 0.97 1.8 1.1
[89]
SNU475 EGF
Mean 3.97
Standard deviation 0.5
Values 4.3 3.6
[90]
THLE EGF
Mean 0.743
Standard deviation 0.02
Values 0.76 0.73
[91]
liver EGF
Mean 0.0176
Standard deviation 0.027
Values 0 0.057 0 0.013
[92]
ref_hepatocyte NRG3
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[93]
HepG2 NRG3
Mean 0
Standard deviation 0
Values 0 0
[94]
HepG2.C3A NRG3
Mean 0
Standard deviation 0
Values 0 0
[95]
HuH.7 NRG3
Mean 0.376
Standard deviation 0.32
Values 0.18 0.75 0.2
[96]
SNU475 NRG3
Mean 0
Standard deviation 0
Values 0 0
[97]
THLE NRG3
Mean 0
Standard deviation 0
Values 0 0
[98]
liver NRG3
Mean 0.222
Standard deviation 0.073
Values 0.28 0.2 0.13 0.28
[99]
ref_hepatocyte ERBB4
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[100]
HepG2 ERBB4
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[101]
HepG2.C3A ERBB4
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[102]
HuH.7 ERBB4
Mean 0.136
Standard deviation 0.15
Values 0.098 0.3 0.0094
[103]
SNU475 ERBB4
Mean 0.0217
Standard deviation 0.0021
Values 0.023 0.02
[104]
THLE ERBB4
Mean 0.0662
Standard deviation 0.027
Values 0.047 0.085
[105]
liver ERBB4
Mean 0.308
Standard deviation 0.33
Values 0.14 0.29 0.026 0.78
[106]
ref_hepatocyte NRG2
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[107]
HepG2 NRG2
Mean 0.0236
Standard deviation 0.015
Values 0.034 0.013
[108]
HepG2.C3A NRG2
Mean 0
Standard deviation 0
Values 0 0
[109]
HuH.7 NRG2
Mean 0
Standard deviation 0
Values 0 0 0
[110]
SNU475 NRG2
Mean 0.181
Standard deviation 0.12
Values 0.093 0.27
[111]
THLE NRG2
Mean 0.79
Standard deviation 0.23
Values 0.63 0.95
[112]
liver NRG2
Mean 0.0321
Standard deviation 0.024
Values 0.047 0.029 0 0.053