REACTOME_PI3K_AKT_ACTIVATION Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 RHOA Transforming protein RhoA [1] -0.41[2] -0.67[3] -0.93[4] -0.69[5] -0.59[6] -1.12[7]
2 PIK3R1 Phosphatidylinositol 3-kinase regulatory subunit alpha [8] 0.06[9] 0.41[10] 1.03[11] 2.60[12] 1.74[13] 3.21[14]
3 PIK3R2 Phosphatidylinositol 3-kinase regulatory subunit beta [15] 2.40[16] 2.87[17] 3.00[18] 1.24[19] 1.44[20] -0.08[21]
4 PIK3CB Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 1.74[22] 2.49[23] 2.17[24] 1.58[25] 1.38[26] 1.36[27]
5 IRS1 Insulin receptor substrate 1 [28] 2.62[29] 2.30[30] 3.25[31] 2.24[32] 1.46[33] 2.32[34]
6 IRS2 Insulin receptor substrate 2 [35] -5.12[36] [37] -2.51[38] -0.14[39] 3.34[40] 2.59[41]
7 PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 0.15[42] 2.03[43] 1.73[44] 1.66[45] 1.51[46] 2.12[47]
8 NTRK1 High affinity nerve growth factor receptor [48] [49] [50] [51] [52] [53] [54]
9 NGF Beta-nerve growth factor [55] [56] [57] [58] [59] [60] [61]
[1]
ref_hepatocyte RHOA
Mean 177
Standard deviation 1.2e+02
Values 2.2e+02 3.8e+02 1.4e+02 75 79
[2]
HepG2 RHOA
Mean 204
Standard deviation 38
Values 2.3e+02 1.8e+02
[3]
HepG2.C3A RHOA
Mean 129
Standard deviation 1.6
Values 1.3e+02 1.3e+02
[4]
HuH.7 RHOA
Mean 144
Standard deviation 23
Values 1.6e+02 1.2e+02 1.6e+02
[5]
SNU475 RHOA
Mean 139
Standard deviation 21
Values 1.5e+02 1.2e+02
[6]
THLE RHOA
Mean 214
Standard deviation 38
Values 1.9e+02 2.4e+02
[7]
liver RHOA
Mean 101
Standard deviation 59
Values 1.6e+02 54 1.4e+02 46
[8]
ref_hepatocyte PIK3R1
Mean 7.45
Standard deviation 3.9
Values 4.1 7.4 4.2 8.1 14
[9]
HepG2 PIK3R1
Mean 11.9
Standard deviation 3
Values 9.8 14
[10]
HepG2.C3A PIK3R1
Mean 11.5
Standard deviation 2.6
Values 9.6 13
[11]
HuH.7 PIK3R1
Mean 23.4
Standard deviation 8.6
Values 23 32 15
[12]
SNU475 PIK3R1
Mean 57.3
Standard deviation 32
Values 80 35
[13]
THLE PIK3R1
Mean 45.5
Standard deviation 1.5
Values 44 47
[14]
liver PIK3R1
Mean 84.8
Standard deviation 47
Values 64 1e+02 32 1.4e+02
[15]
ref_hepatocyte PIK3R2
Mean 5.25
Standard deviation 3.4
Values 11 3.2 3.1 4.9 3.8
[16]
HepG2 PIK3R2
Mean 42.5
Standard deviation 2.8
Values 44 41
[17]
HepG2.C3A PIK3R2
Mean 44.2
Standard deviation 13
Values 53 35
[18]
HuH.7 PIK3R2
Mean 64.7
Standard deviation 10
Values 75 55 64
[19]
SNU475 PIK3R2
Mean 15.7
Standard deviation 3.3
Values 18 13
[20]
THLE PIK3R2
Mean 26
Standard deviation 2.8
Values 24 28
[21]
liver PIK3R2
Mean 6.1
Standard deviation 1.7
Values 7.6 6 3.8 6.9
[22]
ref_hepatocyte PIK3CB
Mean 3.18
Standard deviation 1.5
Values 5.2 4.2 2.6 1.8 2.1
[23]
HepG2 PIK3CB
Mean 16.3
Standard deviation 2.1
Values 15 18
[24]
HepG2.C3A PIK3CB
Mean 20.6
Standard deviation 2.7
Values 23 19
[25]
HuH.7 PIK3CB
Mean 22.1
Standard deviation 2.1
Values 24 23 20
[26]
SNU475 PIK3CB
Mean 12.1
Standard deviation 2.7
Values 14 10
[27]
THLE PIK3CB
Mean 15.1
Standard deviation 0.94
Values 14 16
[28]
liver PIK3CB
Mean 10.1
Standard deviation 3.7
Values 6.4 15 7.9 11
[29]
ref_hepatocyte IRS1
Mean 3.05
Standard deviation 1.4
Values 4.3 1.5 2.7 2.1 4.7
[30]
HepG2 IRS1
Mean 28.7
Standard deviation 8.6
Values 35 23
[31]
HepG2.C3A IRS1
Mean 17.4
Standard deviation 6
Values 22 13
[32]
HuH.7 IRS1
Mean 44.8
Standard deviation 6.6
Values 49 48 37
[33]
SNU475 IRS1
Mean 18.3
Standard deviation 5.2
Values 15 22
[34]
THLE IRS1
Mean 15.3
Standard deviation 0.24
Values 15 15
[35]
liver IRS1
Mean 18.8
Standard deviation 4.8
Values 23 18 12 22
[36]
ref_hepatocyte IRS2
Mean 2.12
Standard deviation 2.3
Values 0.019 0.61 1.4 5.7 2.9
[37]
HepG2 IRS2
Mean 0.0931
Standard deviation 0.071
Values 0.14 0.043
[38]
HepG2.C3A IRS2
Mean 0
Standard deviation 0
Values 0 0
[39]
HuH.7 IRS2
Mean 0.575
Standard deviation 0.68
Values 0.2 1.4 0.17
[40]
SNU475 IRS2
Mean 2.45
Standard deviation 0.45
Values 2.1 2.8
[41]
THLE IRS2
Mean 39
Standard deviation 5.9
Values 35 43
[42]
liver IRS2
Mean 15.7
Standard deviation 9.9
Values 29 11 6.3 17
[43]
ref_hepatocyte PIK3CA
Mean 1.87
Standard deviation 0.73
Values 2.3 2.6 2.3 1.2 0.94
[44]
HepG2 PIK3CA
Mean 3.17
Standard deviation 1.6
Values 2.1 4.3
[45]
HepG2.C3A PIK3CA
Mean 8.78
Standard deviation 1.1
Values 8 9.6
[46]
HuH.7 PIK3CA
Mean 9.59
Standard deviation 2.4
Values 10 12 7
[47]
SNU475 PIK3CA
Mean 7.49
Standard deviation 0.93
Values 8.1 6.8
[48]
THLE PIK3CA
Mean 9.67
Standard deviation 0.66
Values 10 9.2
[49]
liver PIK3CA
Mean 9.99
Standard deviation 4.7
Values 6.1 15 6 13
[50]
ref_hepatocyte NTRK1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[51]
HepG2 NTRK1
Mean 0.0172
Standard deviation 0.024
Values 0.034 0
[52]
HepG2.C3A NTRK1
Mean 0
Standard deviation 0
Values 0 0
[53]
HuH.7 NTRK1
Mean 0
Standard deviation 0
Values 0 0 0
[54]
SNU475 NTRK1
Mean 0.439
Standard deviation 0.25
Values 0.26 0.62
[55]
THLE NTRK1
Mean 0.0556
Standard deviation 0.012
Values 0.047 0.064
[56]
liver NTRK1
Mean 0.0711
Standard deviation 0.026
Values 0.071 0.071 0.1 0.04
[57]
ref_hepatocyte NGF
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[58]
HepG2 NGF
Mean 0
Standard deviation 0
Values 0 0
[59]
HepG2.C3A NGF
Mean 0
Standard deviation 0
Values 0 0
[60]
HuH.7 NGF
Mean 0
Standard deviation 0
Values 0 0 0
[61]
SNU475 NGF
Mean 1.32
Standard deviation 0.58
Values 0.91 1.7
[62]
THLE NGF
Mean 0.258
Standard deviation 0.011
Values 0.27 0.25
[63]
liver NGF
Mean 0.426
Standard deviation 0.42
Values 1 0.071 0.46 0.16