REACTOME_PHENYLALANINE_AND_TYROSINE_METABOLISM Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 HPD 4-hydroxyphenylpyruvate dioxygenase [1] -0.30[2] -0.13[3] -9.54[4] -4.57[5] -6.51[6] -1.46[7]
2 PAH Phenylalanine-4-hydroxylase [8] 0.16[9] 0.68[10] 1.79[11] -5.49[12] -5.43[13] 0.64[14]
3 PCBD1 Pterin-4-alpha-carbinolamine dehydratase [15] 0.10[16] -0.10[17] -0.55[18] 1.59[19] 0.36[20] -0.93[21]
4 TAT Tyrosine aminotransferase [22] -4.86[23] -2.97[24] -4.27[25] -5.75[26] -6.33[27] 1.92[28]
5 HGD Homogentisate 1,2-dioxygenase [29] 1.30[30] 0.91[31] 1.97[32] -0.12[33] -4.93[34] 0.74[35]
6 FAH Fumarylacetoacetase [36] 0.29[37] -0.19[38] -0.97[39] 1.75[40] 3.19[41] 0.00[42]
7 QDPR Dihydropteridine reductase [43] 0.83[44] -0.31[45] 0.90[46] 2.63[47] 1.84[48] -0.41[49]
8 GSTZ1 Maleylacetoacetate isomerase [50] -1.50[51] -1.52[52] -0.72[53] 0.50[54] 0.56[55] -1.75[56]
9 ASRGL1 Isoaspartyl peptidase/L-asparaginase [57] 3.93[58] 4.04[59] 4.94[60] 3.72[61] 4.46[62] 0.44[63]
10 IL4I1 L-amino-acid oxidase [64] -2.30[65] -4.00[66] 0.32[67] 4.77[68] 2.72[69] -1.25[70]
11 KYAT1 Kynurenine--oxoglutarate transaminase 1 [71] [72] [73] [74] [75] [76] [77]
[1]
ref_hepatocyte HPD
Mean 473
Standard deviation 3e+02
Values 2.3e+02 5.5e+02 1.1e+02 6.6e+02 8.2e+02
[2]
HepG2 HPD
Mean 154
Standard deviation 24
Values 1.4e+02 1.7e+02
[3]
HepG2.C3A HPD
Mean 270
Standard deviation 6.6
Values 2.7e+02 2.7e+02
[4]
HuH.7 HPD
Mean 0.167
Standard deviation 0.047
Values 0.11 0.18 0.21
[5]
SNU475 HPD
Mean 1.26
Standard deviation 0.42
Values 1.6 0.96
[6]
THLE HPD
Mean 0.361
Standard deviation 0.24
Values 0.19 0.53
[7]
liver HPD
Mean 235
Standard deviation 86
Values 2.5e+02 2e+02 3.5e+02 1.4e+02
[8]
ref_hepatocyte PAH
Mean 136
Standard deviation 1.9e+02
Values 42 11 6.3 1.6e+02 4.6e+02
[9]
HepG2 PAH
Mean 61
Standard deviation 30
Values 40 82
[10]
HepG2.C3A PAH
Mean 135
Standard deviation 6.2
Values 1.3e+02 1.4e+02
[11]
HuH.7 PAH
Mean 123
Standard deviation 14
Values 1.2e+02 1.1e+02 1.4e+02
[12]
SNU475 PAH
Mean 0.19
Standard deviation 0.12
Values 0.1 0.28
[13]
THLE PAH
Mean 0.219
Standard deviation 0.17
Values 0.34 0.096
[14]
liver PAH
Mean 289
Standard deviation 1.2e+02
Values 4.3e+02 2.7e+02 3.1e+02 1.5e+02
[15]
ref_hepatocyte PCBD1
Mean 108
Standard deviation 96
Values 19 33 69 1.9e+02 2.3e+02
[16]
HepG2 PCBD1
Mean 46.6
Standard deviation 10
Values 39 54
[17]
HepG2.C3A PCBD1
Mean 62.9
Standard deviation 3.3
Values 61 65
[18]
HuH.7 PCBD1
Mean 19.4
Standard deviation 4.8
Values 21 14 23
[19]
SNU475 PCBD1
Mean 20.6
Standard deviation 6.7
Values 25 16
[20]
THLE PCBD1
Mean 9.64
Standard deviation 0.16
Values 9.5 9.8
[21]
liver PCBD1
Mean 77.4
Standard deviation 76
Values 1.7e+02 16 1.1e+02 14
[22]
ref_hepatocyte TAT
Mean 98.7
Standard deviation 1.4e+02
Values 1.5 2 8.6 3e+02 1.8e+02
[23]
HepG2 TAT
Mean 1.36
Standard deviation 0.56
Values 1.8 0.97
[24]
HepG2.C3A TAT
Mean 7.84
Standard deviation 2.3
Values 9.4 6.2
[25]
HuH.7 TAT
Mean 1.34
Standard deviation 0.97
Values 0.76 2.5 0.8
[26]
SNU475 TAT
Mean 0.116
Standard deviation 0.013
Values 0.13 0.11
[27]
THLE TAT
Mean 0.0852
Standard deviation 0.03
Values 0.11 0.064
[28]
liver TAT
Mean 507
Standard deviation 1.5e+02
Values 6.4e+02 4.6e+02 6.1e+02 3.2e+02
[29]
ref_hepatocyte HGD
Mean 67.1
Standard deviation 70
Values 27 12 10 1.4e+02 1.5e+02
[30]
HepG2 HGD
Mean 66.3
Standard deviation 9.6
Values 60 73
[31]
HepG2.C3A HGD
Mean 78.1
Standard deviation 18
Values 91 65
[32]
HuH.7 HGD
Mean 68.8
Standard deviation 7.4
Values 67 62 77
[33]
SNU475 HGD
Mean 3.88
Standard deviation 2.5
Values 5.6 2.1
[34]
THLE HGD
Mean 0.153
Standard deviation 0.13
Values 0.24 0.064
[35]
liver HGD
Mean 153
Standard deviation 55
Values 1.5e+02 1.5e+02 2.2e+02 88
[36]
ref_hepatocyte FAH
Mean 64.6
Standard deviation 60
Values 29 30 9.4 1.1e+02 1.5e+02
[37]
HepG2 FAH
Mean 31.6
Standard deviation 3
Values 34 29
[38]
HepG2.C3A FAH
Mean 35.2
Standard deviation 1
Values 34 36
[39]
HuH.7 FAH
Mean 8.61
Standard deviation 2.9
Values 9.9 5.3 11
[40]
SNU475 FAH
Mean 13.7
Standard deviation 1.3
Values 15 13
[41]
THLE FAH
Mean 40.9
Standard deviation 4.9
Values 37 44
[42]
liver FAH
Mean 88
Standard deviation 56
Values 1.3e+02 37 1.4e+02 42
[43]
ref_hepatocyte QDPR
Mean 49.7
Standard deviation 36
Values 35 34 18 51 1.1e+02
[44]
HepG2 QDPR
Mean 35.4
Standard deviation 4.8
Values 32 39
[45]
HepG2.C3A QDPR
Mean 24.9
Standard deviation 0.24
Values 25 25
[46]
HuH.7 QDPR
Mean 24.3
Standard deviation 7.7
Values 27 16 30
[47]
SNU475 QDPR
Mean 19.4
Standard deviation 2.9
Values 21 17
[48]
THLE QDPR
Mean 12.3
Standard deviation 2
Values 11 14
[49]
liver QDPR
Mean 51.1
Standard deviation 40
Values 88 16 83 17
[50]
ref_hepatocyte GSTZ1
Mean 46.1
Standard deviation 60
Values 4.8 6.8 9 66 1.4e+02
[51]
HepG2 GSTZ1
Mean 6.52
Standard deviation 0.28
Values 6.7 6.3
[52]
HepG2.C3A GSTZ1
Mean 9.98
Standard deviation 2.1
Values 11 8.5
[53]
HuH.7 GSTZ1
Mean 7.32
Standard deviation 1
Values 6.6 6.9 8.5
[54]
SNU475 GSTZ1
Mean 4.11
Standard deviation 1.9
Values 5.4 2.8
[55]
THLE GSTZ1
Mean 4.72
Standard deviation 0.55
Values 4.3 5.1
[56]
liver GSTZ1
Mean 18.6
Standard deviation 9.1
Values 28 7.5 16 23
[57]
ref_hepatocyte ASRGL1
Mean 2.66
Standard deviation 1.9
Values 5 1.3 1.2 4.6 1.3
[58]
HepG2 ASRGL1
Mean 16.2
Standard deviation 4.5
Values 13 19
[59]
HepG2.C3A ASRGL1
Mean 27.1
Standard deviation 4.2
Values 24 30
[60]
HuH.7 ASRGL1
Mean 21.4
Standard deviation 4.7
Values 23 16 25
[61]
SNU475 ASRGL1
Mean 2.21
Standard deviation 0.056
Values 2.3 2.2
[62]
THLE ASRGL1
Mean 4.08
Standard deviation 0.52
Values 4.4 3.7
[63]
liver ASRGL1
Mean 4.9
Standard deviation 4.2
Values 1.9 3.6 11 3
[64]
ref_hepatocyte IL4I1
Mean 0.263
Standard deviation 0.43
Values 0 0 1 0.078 0.22
[65]
HepG2 IL4I1
Mean 0.0215
Standard deviation 0.018
Values 0.034 0.0086
[66]
HepG2.C3A IL4I1
Mean 0.0102
Standard deviation 0.00071
Values 0.0097 0.011
[67]
HuH.7 IL4I1
Mean 0.086
Standard deviation 0.025
Values 0.11 0.058 0.094
[68]
SNU475 IL4I1
Mean 0.452
Standard deviation 0.29
Values 0.25 0.66
[69]
THLE IL4I1
Mean 0.12
Standard deviation 0.011
Values 0.11 0.13
[70]
liver IL4I1
Mean 0.15
Standard deviation 0.14
Values 0.12 0.071 0.36 0.053
[71]
ref_hepatocyte KYAT1
Missing
[72]
HepG2 KYAT1
Missing
[73]
HepG2.C3A KYAT1
Missing
[74]
HuH.7 KYAT1
Missing
[75]
SNU475 KYAT1
Missing
[76]
THLE KYAT1
Missing
[77]
liver KYAT1
Missing