REACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 CYP2E1 Cytochrome P450 2E1 [1] -12.11[2] -12.23[3] -9.15[4] -13.86[5] -11.32[6] -0.22[7]
2 CES1 Liver carboxylesterase 1 [8] -1.17[9] -7.86[10] -8.93[11] -1.19[12] -8.07[13] -1.32[14]
3 ADH1B Alcohol dehydrogenase 1B [15] -11.29[16] [17] -7.69[18] [19] [20] 0.24[21]
4 HSP90AB1 Heat shock protein HSP 90-beta [22] 2.61[23] 2.74[24] 1.76[25] 2.03[26] 2.39[27] -1.92[28]
5 ALDH2 Aldehyde dehydrogenase, mitochondrial [29] -0.52[30] -1.37[31] -1.22[32] -1.87[33] -0.88[34] -0.27[35]
6 ADH4 Alcohol dehydrogenase 4 [36] -4.08[37] -4.56[38] -8.93[39] -12.34[40] -9.40[41] -2.29[42]
7 ALDH1A1 Retinal dehydrogenase 1 [43] 0.88[44] 0.07[45] 2.93[46] 2.70[47] -4.69[48] -1.21[49]
8 ADH1A Alcohol dehydrogenase 1A [50] -12.71[51] [52] -8.28[53] -15.43[54] [55] -1.75[56]
9 CYP2C8 Cytochrome P450 2C8 [57] -14.10[58] -9.34[59] -7.32[60] -10.94[61] [62] 0.70[63]
10 EPHX1 Epoxide hydrolase 1 [64] -0.66[65] -2.11[66] -3.14[67] 1.39[68] -0.92[69] -0.77[70]
11 CYP2C9 Cytochrome P450 2C9 [71] [72] -14.26[73] -7.53[74] -13.63[75] -11.85[76] 1.20[77]
12 CYP3A4 Cytochrome P450 3A4 [78] -9.36[79] -9.45[80] -11.34[81] -13.94[82] -11.42[83] 0.91[84]
13 CYP2A6 Cytochrome P450 2A6 [85] -15.47[86] [87] -7.78[88] -10.70[89] -12.16[90] -1.43[91]
14 PTGES3 Prostaglandin E synthase 3 [92] 1.61[93] 1.98[94] 2.15[95] 1.89[96] 2.82[97] -1.89[98]
15 CYP3A5 Cytochrome P450 3A5 [99] -4.42[100] -2.17[101] -5.09[102] -6.51[103] -7.76[104] 1.28[105]
16 CYP27A1 Sterol 26-hydroxylase, mitochondrial [106] 0.30[107] 1.12[108] -2.14[109] -1.98[110] -2.56[111] 0.27[112]
17 ADH1C Alcohol dehydrogenase 1C [113] -13.08[114] -10.88[115] -9.67[116] -9.24[117] -10.61[118] -0.94[119]
18 FMO3 Dimethylaniline monooxygenase [N-oxide-forming] 3 [120] [121] -13.11[122] -6.44[123] -6.20[124] -12.06[125] -0.92[126]
19 CYP4A11 Cytochrome P450 4A11 [127] -12.28[128] -9.62[129] -11.66[130] -9.76[131] -9.80[132] 1.06[133]
20 POR NADPH--cytochrome P450 reductase [134] 1.46[135] 2.07[136] 0.66[137] 0.80[138] 0.75[139] 1.54[140]
21 CYP1A2 Cytochrome P450 1A2 [141] -8.53[142] -7.21[143] -8.04[144] -7.51[145] -6.95[146] -1.47[147]
22 AADAC Arylacetamide deacetylase [148] -6.63[149] -4.04[150] -0.15[151] -6.47[152] -5.27[153] 0.52[154]
23 ADH6 Alcohol dehydrogenase 6 [155] -1.16[156] -0.37[157] -0.46[158] -8.24[159] -7.44[160] -0.52[161]
24 ADH5 Alcohol dehydrogenase class-3 [162] 2.10[163] 2.10[164] 2.45[165] 1.49[166] 2.74[167] -0.18[168]
25 CYP51A1 Lanosterol 14-alpha demethylase [169] -0.33[170] 2.11[171] 1.86[172] 0.15[173] 0.78[174] 0.98[175]
26 CYP2B6 Cytochrome P450 2B6 [176] -7.25[177] -3.80[178] -2.60[179] -8.50[180] -8.52[181] 2.58[182]
27 CES2 Cocaine esterase [183] 1.38[184] 1.98[185] -0.41[186] 0.17[187] 0.77[188] 1.47[189]
28 ALDH1B1 Aldehyde dehydrogenase X, mitochondrial [190] 1.73[191] 1.72[192] -0.34[193] 0.44[194] 0.89[195] -0.06[196]
29 MAOB Amine oxidase [flavin-containing] B [197] 0.02[198] -0.36[199] 0.13[200] 0.36[201] -6.38[202] 0.18[203]
30 CYP1A1 Cytochrome P450 1A1 [204] -2.08[205] -3.64[206] -0.15[207] -2.91[208] -2.48[209] -5.62[210]
31 CYP2C18 Cytochrome P450 2C18 [211] -9.08[212] -10.53[213] -4.86[214] -10.77[215] -7.86[216] -0.28[217]
32 CYB5R3 NADH-cytochrome b5 reductase 3 [218] 3.03[219] 3.33[220] 2.63[221] 2.17[222] 3.52[223] 0.81[224]
33 CYP2D6 Cytochrome P450 2D6 [225] -5.51[226] -3.01[227] -5.71[228] -7.01[229] -6.55[230] 1.40[231]
34 NQO2 Ribosyldihydronicotinamide dehydrogenase [quinone] [232] -0.26[233] 0.40[234] 0.37[235] 0.97[236] 0.95[237] -0.59[238]
35 CYP8B1 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase [239] -5.83[240] -3.26[241] -7.36[242] -7.40[243] -8.26[244] 2.63[245]
36 CYP4F2 Phylloquinone omega-hydroxylase CYP4F2 [246] -4.24[247] -0.59[248] -12.46[249] -10.97[250] -8.11[251] 1.00[252]
37 CYP3A7 Cytochrome P450 3A7 [253] -4.54[254] -2.24[255] -7.15[256] [257] -9.22[258] -1.49[259]
38 ACSS2 Acetyl-coenzyme A synthetase, cytoplasmic [260] 0.71[261] 2.40[262] 1.94[263] 0.88[264] 1.47[265] 0.19[266]
39 CYP2J2 Cytochrome P450 2J2 [267] -3.02[268] -2.99[269] -0.04[270] -5.61[271] -3.16[272] 0.45[273]
40 MAOA Amine oxidase [flavin-containing] A [274] -0.81[275] 0.00[276] 2.09[277] -2.07[278] 4.09[279] 1.68[280]
41 NR1H4 Bile acid receptor [281] 0.79[282] 1.40[283] 3.02[284] -5.48[285] -4.53[286] 0.70[287]
42 CYB5B Cytochrome b5 type B [288] 3.47[289] 4.09[290] 3.53[291] 2.51[292] 3.72[293] -0.15[294]
43 CMBL Carboxymethylenebutenolidase homolog [295] 2.01[296] 1.00[297] 0.48[298] 2.54[299] 1.80[300] 0.20[301]
44 CYP2C19 Cytochrome P450 2C19 [302] [303] [304] -4.68[305] -11.32[306] -10.15[307] 1.76[308]
45 AIP AH receptor-interacting protein [309] 1.87[310] 1.96[311] 2.97[312] 3.18[313] 2.73[314] -1.52[315]
46 BPHL Valacyclovir hydrolase [316] 0.77[317] 1.91[318] 2.00[319] 0.85[320] -0.03[321] 0.18[322]
47 CYP2A7 Cytochrome P450 2A7 [323] [324] [325] -3.18[326] -9.30[327] [328] -1.59[329]
48 CYP4F11 Phylloquinone omega-hydroxylase CYP4F11 [330] -0.14[331] -0.54[332] -8.01[333] 1.46[334] -7.61[335] 0.93[336]
49 SMOX Spermine oxidase [337] 2.56[338] 1.36[339] 1.07[340] 1.40[341] 3.04[342] -3.96[343]
50 RXRA Retinoic acid receptor RXR-alpha [344] 2.33[345] 2.16[346] 2.83[347] 2.59[348] 3.23[349] 2.33[350]
51 CYP4F3 Docosahexaenoic acid omega-hydroxylase CYP4F3 [351] -1.07[352] -0.13[353] 0.96[354] -1.94[355] -7.11[356] 2.36[357]
52 FDX1 Adrenodoxin, mitochondrial [358] 1.69[359] 1.28[360] -0.42[361] 2.28[362] 3.17[363] 0.99[364]
53 CYP4V2 Cytochrome P450 4V2 [365] -0.85[366] 0.92[367] -1.19[368] -1.30[369] 0.22[370] 1.94[371]
54 CBR3 Carbonyl reductase [NADPH] 3 [372] -8.28[373] -6.55[374] -5.37[375] 0.31[376] 1.62[377] -6.06[378]
55 CYP4F12 Cytochrome P450 4F12 [379] -0.32[380] 1.05[381] 2.05[382] -2.37[383] -5.44[384] 0.38[385]
56 FDXR NADPH:adrenodoxin oxidoreductase, mitochondrial [386] 4.99[387] 4.35[388] 1.03[389] 0.68[390] 2.74[391] -1.74[392]
57 CYP39A1 24-hydroxycholesterol 7-alpha-hydroxylase [393] -2.68[394] -2.83[395] 1.64[396] -2.36[397] 0.57[398] 0.65[399]
58 CES3 Carboxylesterase 3 [400] 1.13[401] 2.43[402] -0.53[403] -1.15[404] -0.82[405] 0.40[406]
59 ARNT Aryl hydrocarbon receptor nuclear translocator [407] 2.80[408] 2.62[409] 3.32[410] 3.94[411] 4.69[412] 1.71[413]
60 CYP21A2 Steroid 21-hydroxylase [414] -3.48[415] -1.52[416] -6.07[417] -1.66[418] -5.99[419] -0.09[420]
61 AHR Aryl hydrocarbon receptor [421] 3.51[422] 3.84[423] 4.68[424] 3.12[425] 5.01[426] 2.77[427]
62 CYP7A1 Cholesterol 7-alpha-monooxygenase [428] -1.96[429] -4.26[430] -7.97[431] -7.39[432] [433] -2.78[434]
63 PAOX Peroxisomal N(1)-acetyl-spermine/spermidine oxidase [435] -1.84[436] 0.57[437] 0.07[438] 0.01[439] 0.29[440] 0.71[441]
64 CYP4A22 Cytochrome P450 4A22 [442] [443] [444] [445] [446] [447] 2.44[448]
65 ACSS1 Acetyl-coenzyme A synthetase 2-like, mitochondrial [449] 5.09[450] 3.72[451] -5.56[452] -0.54[453] 1.07[454] 2.27[455]
66 CYP2R1 Vitamin D 25-hydroxylase [456] -1.59[457] 0.23[458] 2.27[459] 1.25[460] 1.72[461] -0.70[462]
67 CYP4F22 Cytochrome P450 4F22 [463] -3.49[464] [465] -8.65[466] -7.38[467] -4.60[468] -0.79[469]
68 CYP1B1 Cytochrome P450 1B1 [470] -4.66[471] -4.07[472] -0.14[473] 4.08[474] 7.66[475] 1.19[476]
69 ALDH3A1 Aldehyde dehydrogenase, dimeric NADP-preferring [477] -0.12[478] -4.21[479] -1.81[480] 0.80[481] -1.27[482] -2.39[483]
70 NCOA1 Nuclear receptor coactivator 1 [484] 2.85[485] 3.45[486] 3.47[487] 4.37[488] 4.80[489] 2.83[490]
71 CYP3A43 Cytochrome P450 3A43 [491] -2.47[492] 0.45[493] 0.09[494] [495] -6.59[496] 1.56[497]
72 CYP7B1 25-hydroxycholesterol 7-alpha-hydroxylase [498] -5.65[499] -4.33[500] [501] -6.45[502] -1.75[503] 2.45[504]
73 NCOA2 Nuclear receptor coactivator 2 [505] 3.96[506] 4.81[507] 6.46[508] 5.77[509] 5.04[510] 4.78[511]
74 CYP19A1 Aromatase [512] 4.32[513] 5.36[514] -1.26[515] 0.92[516] -0.55[517] -6.16[518]
75 CYP2U1 Cytochrome P450 2U1 [519] 2.56[520] -1.21[521] -1.19[522] 3.80[523] 5.57[524] 2.25[525]
76 AOC3 Membrane primary amine oxidase [526] 4.27[527] 6.70[528] 3.22[529] 1.16[530] 2.07[531] 2.31[532]
77 POMC Pro-opiomelanocortin [533] [534] -5.95[535] [536] [537] -3.57[538] -2.01[539]
78 TBXAS1 Thromboxane-A synthase [540] -0.58[541] 1.51[542] -1.86[543] 3.22[544] 2.74[545] 1.83[546]
79 CYP11A1 Cholesterol side-chain cleavage enzyme, mitochondrial [547] 1.73[548] -0.76[549] [550] -0.69[551] 4.34[552] 0.65[553]
80 CYP2W1 Cytochrome P450 2W1 [554] 6.08[555] 8.02[556] 1.76[557] -0.85[558] -0.29[559] -3.84[560]
81 CYP2S1 Cytochrome P450 2S1 [561] 5.30[562] 4.19[563] 3.20[564] 3.75[565] 4.81[566] -0.47[567]
82 AOC2 Retina-specific copper amine oxidase [568] 2.70[569] 3.52[570] 4.78[571] 3.42[572] 4.47[573] 0.65[574]
83 CYP24A1 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial [575] 10.53[576] 5.69[577] -0.13[578] 6.68[579] 0.85[580] -6.92[581]
84 CYP26A1 Cytochrome P450 26A1 [582] 5.55[583] -0.25[584] 3.11[585] 2.72[586] -1.99[587] 1.18[588]
85 PTGIS Prostacyclin synthase [589] 0.83[590] 1.98[591] 5.78[592] 3.69[593] 10.61[594] 5.02[595]
86 AHRR Aryl hydrocarbon receptor repressor [596] 3.77[597] 2.92[598] 3.05[599] 7.37[600] 6.73[601] 0.91[602]
87 PTGS1 Prostaglandin G/H synthase 1 [603] 3.73[604] -3.15[605] -1.58[606] 5.25[607] 9.07[608] 3.16[609]
88 FMO1 Dimethylaniline monooxygenase [N-oxide-forming] 1 [610] -2.76[611] -1.24[612] 5.37[613] -1.52[614] [615] 1.59[616]
89 CYP2A13 Cytochrome P450 2A13 [617] [618] [619] [620] [621] [622] -0.34[623]
90 CYP27B1 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial [624] 5.06[625] 6.53[626] 5.75[627] 3.76[628] 5.48[629] 1.85[630]
91 CYP46A1 Cholesterol 24-hydroxylase [631] -1.40[632] -0.03[633] -1.23[634] 0.01[635] 2.19[636] 2.43[637]
92 ADH7 Alcohol dehydrogenase class 4 mu/sigma chain [638] [639] [640] [641] [642] [643] -2.83[644]
93 CYP2F1 Cytochrome P450 2F1 [645] 1.61[646] 0.02[647] 4.15[648] 4.01[649] 3.88[650] 1.15[651]
94 ARNT2 Aryl hydrocarbon receptor nuclear translocator 2 [652] 7.77[653] -0.20[654] 0.95[655] 9.00[656] 11.74[657] 5.13[658]
95 CYP26B1 Cytochrome P450 26B1 [659] 7.28[660] 4.25[661] 11.28[662] 9.28[663] 9.49[664] 5.71[665]
96 CYP11B1 Cytochrome P450 11B1, mitochondrial [666] [667] [668] [669] [670] [671] [672]
97 CYP11B2 Cytochrome P450 11B2, mitochondrial [673] [674] [675] [676] [677] [678] [679]
98 FMO2 Dimethylaniline monooxygenase [N-oxide-forming] 2 [680] [681] [682] [683] [684] [685] [686]
99 CYP26C1 Cytochrome P450 26C1 [687] [688] [689] [690] [691] [692] [693]
100 FDX2 Ferredoxin-2, mitochondrial [694] [695] [696] [697] [698] [699] [700]
101 MTARC2 [701] [702] [703] [704] [705] [706] [707]
102 CYP4F8 Cytochrome P450 4F8 [708] [709] [710] [711] [712] [713] [714]
103 PDCD6-AHRR [715] [716] [717] [718] [719] [720] [721]
104 MTARC1 [722] [723] [724] [725] [726] [727] [728]
105 AOC1 Amiloride-sensitive amine oxidase [copper-containing] [729] [730] [731] [732] [733] [734] [735]
106 CYP4B1 Cytochrome P450 4B1 [736] [737] [738] [739] [740] [741] [742]
[1]
ref_hepatocyte CYP2E1
Mean 1.39e+03
Standard deviation 1.9e+03
Values 0 4.6 90 2.7e+03 4.1e+03
[2]
HepG2 CYP2E1
Mean 0.133
Standard deviation 0.1
Values 0.21 0.06
[3]
HepG2.C3A CYP2E1
Mean 0.107
Standard deviation 0.15
Values 0.21 0
[4]
HuH.7 CYP2E1
Mean 0.975
Standard deviation 0.29
Values 0.67 1.3 0.99
[5]
SNU475 CYP2E1
Mean 0.0289
Standard deviation 0.005
Values 0.032 0.025
[6]
THLE CYP2E1
Mean 0.0955
Standard deviation 0.082
Values 0.15 0.037
[7]
liver CYP2E1
Mean 1.49e+03
Standard deviation 8.2e+02
Values 2.6e+03 1e+03 1.7e+03 6.9e+02
[8]
ref_hepatocyte CES1
Mean 819
Standard deviation 9e+02
Values 1.5e+02 1.8e+02 1.5e+02 1.9e+03 1.7e+03
[9]
HepG2 CES1
Mean 154
Standard deviation 89
Values 2.2e+02 91
[10]
HepG2.C3A CES1
Mean 1.3
Standard deviation 0.53
Values 1.7 0.92
[11]
HuH.7 CES1
Mean 0.67
Standard deviation 0.32
Values 0.52 1 0.46
[12]
SNU475 CES1
Mean 111
Standard deviation 23
Values 1.3e+02 94
[13]
THLE CES1
Mean 0.535
Standard deviation 0.14
Values 0.63 0.44
[14]
liver CES1
Mean 411
Standard deviation 2.6e+02
Values 4.6e+02 3.2e+02 7.4e+02 1.3e+02
[15]
ref_hepatocyte ADH1B
Mean 512
Standard deviation 8.3e+02
Values 0.096 0.69 6.9 6.3e+02 1.9e+03
[16]
HepG2 ADH1B
Mean 0.0866
Standard deviation 0.017
Values 0.074 0.099
[17]
HepG2.C3A ADH1B
Mean 0
Standard deviation 0
Values 0 0
[18]
HuH.7 ADH1B
Mean 0.991
Standard deviation 1.6
Values 0.049 2.9 0.028
[19]
SNU475 ADH1B
Mean 0
Standard deviation 0
Values 0 0
[20]
THLE ADH1B
Mean 0
Standard deviation 0
Values 0 0
[21]
liver ADH1B
Mean 756
Standard deviation 3.8e+02
Values 1.3e+03 5.3e+02 5.5e+02 6.2e+02
[22]
ref_hepatocyte HSP90AB1
Mean 469
Standard deviation 3.2e+02
Values 8.1e+02 7.8e+02 4e+02 2.1e+02 1.4e+02
[23]
HepG2 HSP90AB1
Mean 1.22e+03
Standard deviation 89
Values 1.2e+03 1.3e+03
[24]
HepG2.C3A HSP90AB1
Mean 1.16e+03
Standard deviation 1.2e+02
Values 1.2e+03 1.1e+03
[25]
HuH.7 HSP90AB1
Mean 634
Standard deviation 9.5
Values 6.3e+02 6.2e+02 6.4e+02
[26]
SNU475 HSP90AB1
Mean 591
Standard deviation 65
Values 5.4e+02 6.4e+02
[27]
THLE HSP90AB1
Mean 431
Standard deviation 80
Values 3.7e+02 4.9e+02
[28]
liver HSP90AB1
Mean 156
Standard deviation 26
Values 1.5e+02 1.4e+02 1.9e+02 1.3e+02
[29]
ref_hepatocyte ALDH2
Mean 413
Standard deviation 5.9e+02
Values 20 27 22 6.4e+02 1.4e+03
[30]
HepG2 ALDH2
Mean 122
Standard deviation 2.9
Values 1.2e+02 1.2e+02
[31]
HepG2.C3A ALDH2
Mean 58.8
Standard deviation 8.6
Values 65 53
[32]
HuH.7 ALDH2
Mean 71
Standard deviation 19
Values 81 49 83
[33]
SNU475 ALDH2
Mean 34.9
Standard deviation 8.2
Values 41 29
[34]
THLE ALDH2
Mean 39.5
Standard deviation 1.8
Values 38 41
[35]
liver ALDH2
Mean 429
Standard deviation 2.9e+02
Values 7.1e+02 1.8e+02 6.5e+02 1.8e+02
[36]
ref_hepatocyte ADH4
Mean 397
Standard deviation 7e+02
Values 29 4.9 1.5 3.3e+02 1.6e+03
[37]
HepG2 ADH4
Mean 9.95
Standard deviation 0.32
Values 9.7 10
[38]
HepG2.C3A ADH4
Mean 6.21
Standard deviation 2.8
Values 4.3 8.2
[39]
HuH.7 ADH4
Mean 0.326
Standard deviation 0.33
Values 0.2 0.71 0.075
[40]
SNU475 ADH4
Mean 0.0236
Standard deviation 0.019
Values 0.037 0.01
[41]
THLE ADH4
Mean 0.103
Standard deviation 0.02
Values 0.089 0.12
[42]
liver ADH4
Mean 102
Standard deviation 66
Values 1.9e+02 40 58 1.2e+02
[43]
ref_hepatocyte ALDH1A1
Mean 382
Standard deviation 2.7e+02
Values 4.1e+02 7.6e+02 20 2.8e+02 4.3e+02
[44]
HepG2 ALDH1A1
Mean 298
Standard deviation 51
Values 2.6e+02 3.3e+02
[45]
HepG2.C3A ALDH1A1
Mean 148
Standard deviation 48
Values 1.1e+02 1.8e+02
[46]
HuH.7 ALDH1A1
Mean 1.17e+03
Standard deviation 3.9e+02
Values 1.4e+03 7.1e+02 1.4e+03
[47]
SNU475 ALDH1A1
Mean 768
Standard deviation 3.3e+02
Values 1e+03 5.4e+02
[48]
THLE ALDH1A1
Mean 2.59
Standard deviation 1.5
Values 3.6 1.6
[49]
liver ALDH1A1
Mean 207
Standard deviation 1.4e+02
Values 1.2e+02 2.8e+02 3.6e+02 68
[50]
ref_hepatocyte ADH1A
Mean 362
Standard deviation 6e+02
Values 0 0.45 9.8 4.1e+02 1.4e+03
[51]
HepG2 ADH1A
Mean 0.0229
Standard deviation 0.016
Values 0.011 0.034
[52]
HepG2.C3A ADH1A
Mean 0
Standard deviation 0
Values 0 0
[53]
HuH.7 ADH1A
Mean 0.465
Standard deviation 0.75
Values 0.057 1.3 0.0094
[54]
SNU475 ADH1A
Mean 0.00253
Standard deviation 0.0036
Values 0 0.0051
[55]
THLE ADH1A
Mean 0
Standard deviation 0
Values 0 0
[56]
liver ADH1A
Mean 135
Standard deviation 1.5e+02
Values 3.6e+02 47 93 38
[57]
ref_hepatocyte CYP2C8
Mean 328
Standard deviation 4.4e+02
Values 0 1.2 19 7.1e+02 9.1e+02
[58]
HepG2 CYP2C8
Mean 0.00788
Standard deviation 0.0051
Values 0.011 0.0043
[59]
HepG2.C3A CYP2C8
Mean 0.186
Standard deviation 0.071
Values 0.14 0.24
[60]
HuH.7 CYP2C8
Mean 0.822
Standard deviation 1
Values 0.16 2 0.3
[61]
SNU475 CYP2C8
Mean 0.0515
Standard deviation 0.02
Values 0.037 0.066
[62]
THLE CYP2C8
Mean 0
Standard deviation 0
Values 0 0
[63]
liver CYP2C8
Mean 666
Standard deviation 3.9e+02
Values 6.8e+02 6.2e+02 1.2e+03 2e+02
[64]
ref_hepatocyte EPHX1
Mean 300
Standard deviation 3.6e+02
Values 43 21 48 7.2e+02 6.7e+02
[65]
HepG2 EPHX1
Mean 80.5
Standard deviation 9
Values 87 74
[66]
HepG2.C3A EPHX1
Mean 25.6
Standard deviation 6.3
Values 30 21
[67]
HuH.7 EPHX1
Mean 13.6
Standard deviation 1.2
Values 14 14 12
[68]
SNU475 EPHX1
Mean 243
Standard deviation 68
Values 2.9e+02 2e+02
[69]
THLE EPHX1
Mean 27.8
Standard deviation 0.14
Values 28 28
[70]
liver EPHX1
Mean 220
Standard deviation 1.4e+02
Values 1.4e+02 3.1e+02 3.7e+02 61
[71]
ref_hepatocyte CYP2C9
Mean 285
Standard deviation 4.1e+02
Values 0.064 20 21 4.7e+02 9.2e+02
[72]
HepG2 CYP2C9
Mean 0
Standard deviation 0
Values 0 0
[73]
HepG2.C3A CYP2C9
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[74]
HuH.7 CYP2C9
Mean 0.616
Standard deviation 0.63
Values 0.25 1.3 0.25
[75]
SNU475 CYP2C9
Mean 0.00696
Standard deviation 0.0098
Values 0.014 0
[76]
THLE CYP2C9
Mean 0.0136
Standard deviation 0.011
Values 0.0059 0.021
[77]
liver CYP2C9
Mean 822
Standard deviation 5.3e+02
Values 8.6e+02 6.1e+02 1.5e+03 2.9e+02
[78]
ref_hepatocyte CYP3A4
Mean 259
Standard deviation 4.1e+02
Values 0.24 11 11 3.2e+02 9.6e+02
[79]
HepG2 CYP3A4
Mean 0.167
Standard deviation 0.098
Values 0.097 0.24
[80]
HepG2.C3A CYP3A4
Mean 0.136
Standard deviation 0.096
Values 0.068 0.2
[81]
HuH.7 CYP3A4
Mean 0.0397
Standard deviation 0.029
Values 0.0082 0.064 0.047
[82]
SNU475 CYP3A4
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[83]
THLE CYP3A4
Mean 0.0166
Standard deviation 0.0067
Values 0.012 0.021
[84]
liver CYP3A4
Mean 610
Standard deviation 5.3e+02
Values 4.3e+02 6.4e+02 1.3e+03 49
[85]
ref_hepatocyte CYP2A6
Mean 231
Standard deviation 3e+02
Values 0 4.6 38 5.6e+02 5.5e+02
[86]
HepG2 CYP2A6
Mean 0.00214
Standard deviation 0.003
Values 0 0.0043
[87]
HepG2.C3A CYP2A6
Mean 0
Standard deviation 0
Values 0 0
[88]
HuH.7 CYP2A6
Mean 0.421
Standard deviation 0.53
Values 0.11 1 0.12
[89]
SNU475 CYP2A6
Mean 0.0428
Standard deviation 0.025
Values 0.06 0.025
[90]
THLE CYP2A6
Mean 0.00887
Standard deviation 0.013
Values 0.018 0
[91]
liver CYP2A6
Mean 107
Standard deviation 1e+02
Values 29 1.8e+02 2.1e+02 13
[92]
ref_hepatocyte PTGES3
Mean 143
Standard deviation 59
Values 1.7e+02 2.3e+02 1.1e+02 1e+02 97
[93]
HepG2 PTGES3
Mean 184
Standard deviation 15
Values 1.7e+02 1.9e+02
[94]
HepG2.C3A PTGES3
Mean 207
Standard deviation 42
Values 1.8e+02 2.4e+02
[95]
HuH.7 PTGES3
Mean 253
Standard deviation 51
Values 2.8e+02 1.9e+02 2.8e+02
[96]
SNU475 PTGES3
Mean 164
Standard deviation 5.7
Values 1.7e+02 1.6e+02
[97]
THLE PTGES3
Mean 177
Standard deviation 27
Values 1.6e+02 2e+02
[98]
liver PTGES3
Mean 48.2
Standard deviation 31
Values 67 22 82 23
[99]
ref_hepatocyte CYP3A5
Mean 139
Standard deviation 1.6e+02
Values 22 55 35 2e+02 3.9e+02
[100]
HepG2 CYP3A5
Mean 2.75
Standard deviation 2.1
Values 1.3 4.2
[101]
HepG2.C3A CYP3A5
Mean 11.4
Standard deviation 3.8
Values 14 8.7
[102]
HuH.7 CYP3A5
Mean 1.63
Standard deviation 1.6
Values 0.58 3.5 0.83
[103]
SNU475 CYP3A5
Mean 0.471
Standard deviation 0.12
Values 0.56 0.39
[104]
THLE CYP3A5
Mean 0.113
Standard deviation 0.032
Values 0.14 0.09
[105]
liver CYP3A5
Mean 424
Standard deviation 3.2e+02
Values 9e+02 2.7e+02 2.5e+02 2.8e+02
[106]
ref_hepatocyte CYP27A1
Mean 135
Standard deviation 1.6e+02
Values 62 8 18 2.1e+02 3.7e+02
[107]
HepG2 CYP27A1
Mean 70.5
Standard deviation 16
Values 59 82
[108]
HepG2.C3A CYP27A1
Mean 108
Standard deviation 25
Values 1.3e+02 90
[109]
HuH.7 CYP27A1
Mean 12.2
Standard deviation 7.3
Values 7.2 21 8.9
[110]
SNU475 CYP27A1
Mean 10.5
Standard deviation 1.6
Values 12 9.4
[111]
THLE CYP27A1
Mean 4.01
Standard deviation 0.91
Values 4.7 3.4
[112]
liver CYP27A1
Mean 204
Standard deviation 1e+02
Values 3.3e+02 1.2e+02 2.5e+02 1.1e+02
[113]
ref_hepatocyte ADH1C
Mean 132
Standard deviation 2e+02
Values 0.14 2.1 4 2e+02 4.5e+02
[114]
HepG2 ADH1C
Mean 0.00643
Standard deviation 0.0091
Values 0 0.013
[115]
HepG2.C3A ADH1C
Mean 0.0258
Standard deviation 0.009
Values 0.019 0.032
[116]
HuH.7 ADH1C
Mean 0.0645
Standard deviation 0.029
Values 0.041 0.096 0.056
[117]
SNU475 ADH1C
Mean 0.0673
Standard deviation 0.062
Values 0.023 0.11
[118]
THLE ADH1C
Mean 0.0148
Standard deviation 0.021
Values 0.03 0
[119]
liver ADH1C
Mean 86.2
Standard deviation 1.1e+02
Values 2.6e+02 32 44 13
[120]
ref_hepatocyte FMO3
Mean 129
Standard deviation 2.2e+02
Values 0 3.5 4.9 1.2e+02 5.1e+02
[121]
HepG2 FMO3
Mean 0
Standard deviation 0
Values 0 0
[122]
HepG2.C3A FMO3
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[123]
HuH.7 FMO3
Mean 0.593
Standard deviation 0.31
Values 0.36 0.95 0.47
[124]
SNU475 FMO3
Mean 0.542
Standard deviation 0.086
Values 0.6 0.48
[125]
THLE FMO3
Mean 0.00532
Standard deviation 0.0075
Values 0 0.011
[126]
liver FMO3
Mean 85.3
Standard deviation 26
Values 1.2e+02 64 75 80
[127]
ref_hepatocyte CYP4A11
Mean 109
Standard deviation 1.6e+02
Values 0 0 4 2e+02 3.4e+02
[128]
HepG2 CYP4A11
Mean 0.0093
Standard deviation 0.005
Values 0.0057 0.013
[129]
HepG2.C3A CYP4A11
Mean 0.0511
Standard deviation 0.0036
Values 0.049 0.054
[130]
HuH.7 CYP4A11
Mean 0.0135
Standard deviation 0.0098
Values 0.025 0.0064 0.0094
[131]
SNU475 CYP4A11
Mean 0.039
Standard deviation 0.0093
Values 0.032 0.046
[132]
THLE CYP4A11
Mean 0.0216
Standard deviation 0.022
Values 0.0059 0.037
[133]
liver CYP4A11
Mean 286
Standard deviation 2.2e+02
Values 5.7e+02 87 3.6e+02 1.3e+02
[134]
ref_hepatocyte POR
Mean 97
Standard deviation 75
Values 90 32 26 2.1e+02 1.3e+02
[135]
HepG2 POR
Mean 113
Standard deviation 40
Values 1.4e+02 85
[136]
HepG2.C3A POR
Mean 150
Standard deviation 87
Values 2.1e+02 88
[137]
HuH.7 POR
Mean 61.3
Standard deviation 8.5
Values 57 71 56
[138]
SNU475 POR
Mean 52.1
Standard deviation 1.3
Values 51 53
[139]
THLE POR
Mean 28.6
Standard deviation 2.7
Values 27 31
[140]
liver POR
Mean 355
Standard deviation 1.6e+02
Values 2.7e+02 3.2e+02 5.9e+02 2.3e+02
[141]
ref_hepatocyte CYP1A2
Mean 78.9
Standard deviation 1.3e+02
Values 0.4 18 0.97 71 3e+02
[142]
HepG2 CYP1A2
Mean 0.0901
Standard deviation 0.055
Values 0.052 0.13
[143]
HepG2.C3A CYP1A2
Mean 0.197
Standard deviation 0.066
Values 0.24 0.15
[144]
HuH.7 CYP1A2
Mean 0.12
Standard deviation 0.026
Values 0.11 0.1 0.15
[145]
SNU475 CYP1A2
Mean 0.134
Standard deviation 0.091
Values 0.07 0.2
[146]
THLE CYP1A2
Mean 0.112
Standard deviation 0.068
Values 0.16 0.064
[147]
liver CYP1A2
Mean 35.7
Standard deviation 24
Values 55 12 58 19
[148]
ref_hepatocyte AADAC
Mean 78.6
Standard deviation 78
Values 3.7 58 16 1.3e+02 1.9e+02
[149]
HepG2 AADAC
Mean 0.335
Standard deviation 0.25
Values 0.16 0.51
[150]
HepG2.C3A AADAC
Mean 1.76
Standard deviation 0.75
Values 1.2 2.3
[151]
HuH.7 AADAC
Mean 28.4
Standard deviation 1.8
Values 26 29 29
[152]
SNU475 AADAC
Mean 0.273
Standard deviation 0.21
Values 0.13 0.42
[153]
THLE AADAC
Mean 0.357
Standard deviation 0.11
Values 0.28 0.44
[154]
liver AADAC
Mean 142
Standard deviation 64
Values 2.2e+02 92 1.6e+02 88
[155]
ref_hepatocyte ADH6
Mean 72.8
Standard deviation 92
Values 50 11 1.2 72 2.3e+02
[156]
HepG2 ADH6
Mean 13.8
Standard deviation 5.3
Values 10 17
[157]
HepG2.C3A ADH6
Mean 20.8
Standard deviation 0.45
Values 21 20
[158]
HuH.7 ADH6
Mean 21.2
Standard deviation 7
Values 19 29 15
[159]
SNU475 ADH6
Mean 0.0743
Standard deviation 0.053
Values 0.037 0.11
[160]
THLE ADH6
Mean 0.0733
Standard deviation 0.013
Values 0.083 0.064
[161]
liver ADH6
Mean 63.7
Standard deviation 33
Values 1.1e+02 30 46 74
[162]
ref_hepatocyte ADH5
Mean 65.9
Standard deviation 32
Values 84 59 19 61 1.1e+02
[163]
HepG2 ADH5
Mean 119
Standard deviation 17
Values 1.1e+02 1.3e+02
[164]
HepG2.C3A ADH5
Mean 104
Standard deviation 26
Values 86 1.2e+02
[165]
HuH.7 ADH5
Mean 144
Standard deviation 17
Values 1.3e+02 1.4e+02 1.6e+02
[166]
SNU475 ADH5
Mean 57.2
Standard deviation 13
Values 66 48
[167]
THLE ADH5
Mean 77.4
Standard deviation 11
Values 69 85
[168]
liver ADH5
Mean 73.2
Standard deviation 37
Values 1.2e+02 49 76 43
[169]
ref_hepatocyte CYP51A1
Mean 63
Standard deviation 38
Values 1.2e+02 88 38 27 46
[170]
HepG2 CYP51A1
Mean 21.2
Standard deviation 5.5
Values 17 25
[171]
HepG2.C3A CYP51A1
Mean 99.9
Standard deviation 49
Values 1.3e+02 66
[172]
HuH.7 CYP51A1
Mean 91.5
Standard deviation 23
Values 79 1.2e+02 78
[173]
SNU475 CYP51A1
Mean 21.5
Standard deviation 2.5
Values 23 20
[174]
THLE CYP51A1
Mean 19
Standard deviation 1.2
Values 18 20
[175]
liver CYP51A1
Mean 156
Standard deviation 52
Values 89 1.8e+02 2.1e+02 1.5e+02
[176]
ref_hepatocyte CYP2B6
Mean 49.6
Standard deviation 62
Values 0 4.1 12 1.3e+02 1e+02
[177]
HepG2 CYP2B6
Mean 0.138
Standard deviation 0.15
Values 0.24 0.034
[178]
HepG2.C3A CYP2B6
Mean 1.32
Standard deviation 0.56
Values 1.7 0.92
[179]
HuH.7 CYP2B6
Mean 3.27
Standard deviation 2.3
Values 2.1 5.9 1.9
[180]
SNU475 CYP2B6
Mean 0.0424
Standard deviation 0.04
Values 0.014 0.071
[181]
THLE CYP2B6
Mean 0.0237
Standard deviation 0.033
Values 0.047 0
[182]
liver CYP2B6
Mean 372
Standard deviation 5.3e+02
Values 23 3.2e+02 1.1e+03 7.4
[183]
ref_hepatocyte CES2
Mean 49.3
Standard deviation 49
Values 14 17 11 94 1.1e+02
[184]
HepG2 CES2
Mean 54.1
Standard deviation 2.1
Values 53 56
[185]
HepG2.C3A CES2
Mean 71.8
Standard deviation 6.4
Values 76 67
[186]
HuH.7 CES2
Mean 14.9
Standard deviation 3.2
Values 17 11 16
[187]
SNU475 CES2
Mean 17.1
Standard deviation 1.6
Values 18 16
[188]
THLE CES2
Mean 14.8
Standard deviation 0.53
Values 14 15
[189]
liver CES2
Mean 171
Standard deviation 92
Values 2.4e+02 89 2.6e+02 95
[190]
ref_hepatocyte ALDH1B1
Mean 46.8
Standard deviation 30
Values 84 73 19 22 36
[191]
HepG2 ALDH1B1
Mean 65.8
Standard deviation 15
Values 56 76
[192]
HepG2.C3A ALDH1B1
Mean 56.7
Standard deviation 1.3
Values 56 58
[193]
HuH.7 ALDH1B1
Mean 14.8
Standard deviation 4.6
Values 18 9.5 17
[194]
SNU475 ALDH1B1
Mean 19.6
Standard deviation 10
Values 27 12
[195]
THLE ALDH1B1
Mean 15.3
Standard deviation 3.4
Values 13 18
[196]
liver ALDH1B1
Mean 56.5
Standard deviation 35
Values 1.1e+02 31 57 32
[197]
ref_hepatocyte MAOB
Mean 46.4
Standard deviation 48
Values 20 15 6.9 70 1.2e+02
[198]
HepG2 MAOB
Mean 19.9
Standard deviation 8.1
Values 14 26
[199]
HepG2.C3A MAOB
Mean 13.4
Standard deviation 5.7
Values 9.3 17
[200]
HuH.7 MAOB
Mean 20.3
Standard deviation 0.76
Values 21 21 19
[201]
SNU475 MAOB
Mean 18.4
Standard deviation 15
Values 29 7.7
[202]
THLE MAOB
Mean 0.0976
Standard deviation 0.012
Values 0.089 0.11
[203]
liver MAOB
Mean 66.2
Standard deviation 42
Values 1.1e+02 35 92 26
[204]
ref_hepatocyte CYP1A1
Mean 43.8
Standard deviation 36
Values 77 43 0.06 17 82
[205]
HepG2 CYP1A1
Mean 4.39
Standard deviation 2.6
Values 6.2 2.6
[206]
HepG2.C3A CYP1A1
Mean 1.3
Standard deviation 0.1
Values 1.4 1.2
[207]
HuH.7 CYP1A1
Mean 15.8
Standard deviation 1.4
Values 14 17 17
[208]
SNU475 CYP1A1
Mean 1.8
Standard deviation 1.8
Values 0.49 3.1
[209]
THLE CYP1A1
Mean 1.38
Standard deviation 0.04
Values 1.4 1.4
[210]
liver CYP1A1
Mean 1.12
Standard deviation 0.58
Values 1.2 0.47 0.92 1.8
[211]
ref_hepatocyte CYP2C18
Mean 43
Standard deviation 35
Values 0 90 18 51 56
[212]
HepG2 CYP2C18
Mean 0.0336
Standard deviation 0.017
Values 0.046 0.021
[213]
HepG2.C3A CYP2C18
Mean 0.0107
Standard deviation 0.015
Values 0 0.021
[214]
HuH.7 CYP2C18
Mean 0.593
Standard deviation 0.1
Values 0.53 0.71 0.53
[215]
SNU475 CYP2C18
Mean 0.0076
Standard deviation 0.011
Values 0 0.015
[216]
THLE CYP2C18
Mean 0.0325
Standard deviation 0.029
Values 0.012 0.053
[217]
liver CYP2C18
Mean 44.5
Standard deviation 13
Values 36 57 54 31
[218]
ref_hepatocyte CYB5R3
Mean 42.2
Standard deviation 22
Values 15 25 57 68 46
[219]
HepG2 CYB5R3
Mean 146
Standard deviation 25
Values 1.6e+02 1.3e+02
[220]
HepG2.C3A CYB5R3
Mean 157
Standard deviation 66
Values 2e+02 1.1e+02
[221]
HuH.7 CYB5R3
Mean 105
Standard deviation 6.2
Values 1.1e+02 1e+02 1e+02
[222]
SNU475 CYB5R3
Mean 58.8
Standard deviation 13
Values 68 49
[223]
THLE CYB5R3
Mean 85
Standard deviation 17
Values 73 97
[224]
liver CYB5R3
Mean 92.7
Standard deviation 83
Values 1.7e+02 15 1.5e+02 28
[225]
ref_hepatocyte CYP2D6
Mean 41.3
Standard deviation 55
Values 0.24 0.47 3.7 1.1e+02 87
[226]
HepG2 CYP2D6
Mean 0.382
Standard deviation 0.03
Values 0.36 0.4
[227]
HepG2.C3A CYP2D6
Mean 1.89
Standard deviation 1
Values 2.6 1.2
[228]
HuH.7 CYP2D6
Mean 0.314
Standard deviation 0.087
Values 0.23 0.4 0.31
[229]
SNU475 CYP2D6
Mean 0.0992
Standard deviation 0.004
Values 0.1 0.096
[230]
THLE CYP2D6
Mean 0.0775
Standard deviation 0.049
Values 0.11 0.043
[231]
liver CYP2D6
Mean 137
Standard deviation 1.2e+02
Values 3.1e+02 53 1.3e+02 57
[232]
ref_hepatocyte NQO2
Mean 35.6
Standard deviation 23
Values 12 22 26 50 68
[233]
HepG2 NQO2
Mean 12.5
Standard deviation 1.4
Values 14 12
[234]
HepG2.C3A NQO2
Mean 17.3
Standard deviation 1.9
Values 16 19
[235]
HuH.7 NQO2
Mean 18.4
Standard deviation 6.7
Values 19 11 25
[236]
SNU475 NQO2
Mean 21.5
Standard deviation 5.5
Values 25 18
[237]
THLE NQO2
Mean 12.1
Standard deviation 0.38
Values 12 12
[238]
liver NQO2
Mean 29.7
Standard deviation 19
Values 51 11 39 18
[239]
ref_hepatocyte CYP8B1
Mean 34.6
Standard deviation 44
Values 1.2 0.33 6.4 79 86
[240]
HepG2 CYP8B1
Mean 0.257
Standard deviation 0.2
Values 0.11 0.4
[241]
HepG2.C3A CYP8B1
Mean 1.33
Standard deviation 0.5
Values 1.7 0.98
[242]
HuH.7 CYP8B1
Mean 0.084
Standard deviation 0.016
Values 0.09 0.096 0.066
[243]
SNU475 CYP8B1
Mean 0.0631
Standard deviation 0.004
Values 0.06 0.066
[244]
THLE CYP8B1
Mean 0.0198
Standard deviation 0.0054
Values 0.024 0.016
[245]
liver CYP8B1
Mean 269
Standard deviation 1.3e+02
Values 4.2e+02 1.3e+02 3e+02 2.2e+02
[246]
ref_hepatocyte CYP4F2
Mean 30.2
Standard deviation 38
Values 1.2 0.054 11 51 87
[247]
HepG2 CYP4F2
Mean 0.677
Standard deviation 0.5
Values 1 0.32
[248]
HepG2.C3A CYP4F2
Mean 7.41
Standard deviation 4.8
Values 11 4
[249]
HuH.7 CYP4F2
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[250]
SNU475 CYP4F2
Mean 0.00464
Standard deviation 0.0066
Values 0.0093 0
[251]
THLE CYP4F2
Mean 0.0192
Standard deviation 0.01
Values 0.012 0.027
[252]
liver CYP4F2
Mean 75.6
Standard deviation 42
Values 86 50 1.3e+02 36
[253]
ref_hepatocyte CYP3A7
Mean 29.1
Standard deviation 41
Values 8.7 0.12 5 1e+02 32
[254]
HepG2 CYP3A7
Mean 0.531
Standard deviation 0.38
Values 0.26 0.8
[255]
HepG2.C3A CYP3A7
Mean 2.26
Standard deviation 0.013
Values 2.3 2.3
[256]
HuH.7 CYP3A7
Mean 0.0822
Standard deviation 0.074
Values 0.033 0.17 0.047
[257]
SNU475 CYP3A7
Mean 0
Standard deviation 0
Values 0 0
[258]
THLE CYP3A7
Mean 0.00858
Standard deviation 0.0046
Values 0.012 0.0053
[259]
liver CYP3A7
Mean 13
Standard deviation 12
Values 30 5.2 11 5.1
[260]
ref_hepatocyte ACSS2
Mean 25.9
Standard deviation 16
Values 33 11 11 27 48
[261]
HepG2 ACSS2
Mean 17.9
Standard deviation 3.4
Values 16 20
[262]
HepG2.C3A ACSS2
Mean 50.5
Standard deviation 28
Values 70 31
[263]
HuH.7 ACSS2
Mean 39.6
Standard deviation 8.6
Values 33 49 36
[264]
SNU475 ACSS2
Mean 14.8
Standard deviation 2.6
Values 17 13
[265]
THLE ACSS2
Mean 12.6
Standard deviation 0.71
Values 13 12
[266]
liver ACSS2
Mean 37.1
Standard deviation 10
Values 24 34 48 42
[267]
ref_hepatocyte CYP2J2
Mean 23.2
Standard deviation 23
Values 1.9 9.2 9.9 44 51
[268]
HepG2 CYP2J2
Mean 1.21
Standard deviation 0.23
Values 1.4 1
[269]
HepG2.C3A CYP2J2
Mean 1.08
Standard deviation 0.51
Values 1.4 0.72
[270]
HuH.7 CYP2J2
Mean 8.98
Standard deviation 0.32
Values 8.6 9 9.3
[271]
SNU475 CYP2J2
Mean 0.147
Standard deviation 0.13
Values 0.056 0.24
[272]
THLE CYP2J2
Mean 0.454
Standard deviation 0.094
Values 0.52 0.39
[273]
liver CYP2J2
Mean 39.7
Standard deviation 21
Values 66 21 48 24
[274]
ref_hepatocyte MAOA
Mean 22.1
Standard deviation 16
Values 3.4 23 8.6 34 41
[275]
HepG2 MAOA
Mean 5.32
Standard deviation 0.22
Values 5.5 5.2
[276]
HepG2.C3A MAOA
Mean 8.16
Standard deviation 2.3
Values 9.8 6.5
[277]
HuH.7 MAOA
Mean 37.5
Standard deviation 10
Values 36 49 28
[278]
SNU475 MAOA
Mean 1.62
Standard deviation 0.75
Values 1.1 2.1
[279]
THLE MAOA
Mean 66.1
Standard deviation 1.4
Values 67 65
[280]
liver MAOA
Mean 88.9
Standard deviation 19
Values 1.1e+02 90 88 65
[281]
ref_hepatocyte NR1H4
Mean 20.8
Standard deviation 17
Values 15 9.3 3.8 43 33
[282]
HepG2 NR1H4
Mean 15.2
Standard deviation 6.4
Values 11 20
[283]
HepG2.C3A NR1H4
Mean 20.3
Standard deviation 1.1
Values 19 21
[284]
HuH.7 NR1H4
Mean 67.4
Standard deviation 13
Values 62 82 58
[285]
SNU475 NR1H4
Mean 0.144
Standard deviation 0.04
Values 0.12 0.17
[286]
THLE NR1H4
Mean 0.158
Standard deviation 0.028
Values 0.18 0.14
[287]
liver NR1H4
Mean 42.4
Standard deviation 11
Values 59 37 35 39
[288]
ref_hepatocyte CYB5B
Mean 20.4
Standard deviation 19
Values 53 22 9.5 7.9 9.5
[289]
HepG2 CYB5B
Mean 95.5
Standard deviation 22
Values 80 1.1e+02
[290]
HepG2.C3A CYB5B
Mean 127
Standard deviation 43
Values 97 1.6e+02
[291]
HuH.7 CYB5B
Mean 93.6
Standard deviation 26
Values 1.1e+02 64 1.1e+02
[292]
SNU475 CYB5B
Mean 35.8
Standard deviation 4.4
Values 39 33
[293]
THLE CYB5B
Mean 47.2
Standard deviation 2.2
Values 46 49
[294]
liver CYB5B
Mean 23
Standard deviation 8
Values 28 17 32 16
[295]
ref_hepatocyte CMBL
Mean 19.3
Standard deviation 23
Values 5 12 2 20 58
[296]
HepG2 CMBL
Mean 33
Standard deviation 6.1
Values 37 29
[297]
HepG2.C3A CMBL
Mean 14.2
Standard deviation 2.5
Values 12 16
[298]
HuH.7 CMBL
Mean 10.7
Standard deviation 1.1
Values 9.5 12 11
[299]
SNU475 CMBL
Mean 34.8
Standard deviation 18
Values 47 22
[300]
THLE CMBL
Mean 11.8
Standard deviation 2.2
Values 13 10
[301]
liver CMBL
Mean 27.9
Standard deviation 19
Values 50 8.9 37 15
[302]
ref_hepatocyte CYP2C19
Mean 19.2
Standard deviation 30
Values 0 5.9 0 18 72
[303]
HepG2 CYP2C19
Mean 0
Standard deviation 0
Values 0 0
[304]
HepG2.C3A CYP2C19
Mean 0
Standard deviation 0
Values 0 0
[305]
HuH.7 CYP2C19
Mean 0.3
Standard deviation 0.27
Values 0.098 0.6 0.2
[306]
SNU475 CYP2C19
Mean 0.00232
Standard deviation 0.0033
Values 0.0046 0
[307]
THLE CYP2C19
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[308]
liver CYP2C19
Mean 81.4
Standard deviation 39
Values 65 92 1.3e+02 38
[309]
ref_hepatocyte AIP
Mean 17.8
Standard deviation 7.8
Values 10 8.7 21 25 23
[310]
HepG2 AIP
Mean 27.4
Standard deviation 5.9
Values 32 23
[311]
HepG2.C3A AIP
Mean 25.5
Standard deviation 6
Values 30 21
[312]
HuH.7 AIP
Mean 55.7
Standard deviation 6.7
Values 50 54 63
[313]
SNU475 AIP
Mean 49.9
Standard deviation 2.6
Values 52 48
[314]
THLE AIP
Mean 20.7
Standard deviation 0.15
Values 21 21
[315]
liver AIP
Mean 7.77
Standard deviation 4.7
Values 13 4 10 3.6
[316]
ref_hepatocyte BPHL
Mean 16.7
Standard deviation 19
Values 8.7 1.7 0.74 26 46
[317]
HepG2 BPHL
Mean 12.1
Standard deviation 0.9
Values 13 11
[318]
HepG2.C3A BPHL
Mean 23
Standard deviation 4.5
Values 26 20
[319]
HuH.7 BPHL
Mean 26.6
Standard deviation 6.5
Values 25 21 34
[320]
SNU475 BPHL
Mean 9.29
Standard deviation 3.4
Values 12 6.9
[321]
THLE BPHL
Mean 2.86
Standard deviation 0.029
Values 2.9 2.8
[322]
liver BPHL
Mean 23.6
Standard deviation 15
Values 41 11 33 9.9
[323]
ref_hepatocyte CYP2A7
Mean 15.1
Standard deviation 22
Values 0 0.06 11 52 12
[324]
HepG2 CYP2A7
Mean 0
Standard deviation 0
Values 0 0
[325]
HepG2.C3A CYP2A7
Mean 0
Standard deviation 0
Values 0 0
[326]
HuH.7 CYP2A7
Mean 0.663
Standard deviation 0.76
Values 0.16 1.5 0.3
[327]
SNU475 CYP2A7
Mean 0.00739
Standard deviation 0.0039
Values 0.0046 0.01
[328]
THLE CYP2A7
Mean 0
Standard deviation 0
Values 0 0
[329]
liver CYP2A7
Mean 6.31
Standard deviation 5.5
Values 2 13 9 1.4
[330]
ref_hepatocyte CYP4F11
Mean 14.8
Standard deviation 11
Values 1.7 6.9 14 28 23
[331]
HepG2 CYP4F11
Mean 5.67
Standard deviation 2.2
Values 7.3 4.1
[332]
HepG2.C3A CYP4F11
Mean 3.76
Standard deviation 0.42
Values 4.1 3.5
[333]
HuH.7 CYP4F11
Mean 0.023
Standard deviation 0.029
Values 0 0.013 0.056
[334]
SNU475 CYP4F11
Mean 12.6
Standard deviation 0.65
Values 12 13
[335]
THLE CYP4F11
Mean 0.0133
Standard deviation 0.019
Values 0 0.027
[336]
liver CYP4F11
Mean 35.3
Standard deviation 12
Values 20 46 34 42
[337]
ref_hepatocyte SMOX
Mean 14.6
Standard deviation 12
Values 27 16 25 4.1 0.7
[338]
HepG2 SMOX
Mean 36.6
Standard deviation 15
Values 47 26
[339]
HepG2.C3A SMOX
Mean 13.8
Standard deviation 3.6
Values 16 11
[340]
HuH.7 SMOX
Mean 12.2
Standard deviation 2
Values 13 10 14
[341]
SNU475 SMOX
Mean 11.9
Standard deviation 11
Values 4.1 20
[342]
THLE SMOX
Mean 21.1
Standard deviation 3.8
Values 24 18
[343]
liver SMOX
Mean 1.18
Standard deviation 0.63
Values 1.3 0.76 2 0.62
[344]
ref_hepatocyte RXRA
Mean 14.5
Standard deviation 6.1
Values 15 7.5 9.4 22 18
[345]
HepG2 RXRA
Mean 30.9
Standard deviation 2.8
Values 33 29
[346]
HepG2.C3A RXRA
Mean 23.9
Standard deviation 6.1
Values 28 20
[347]
HuH.7 RXRA
Mean 41.2
Standard deviation 10
Values 42 51 30
[348]
SNU475 RXRA
Mean 26.9
Standard deviation 8.3
Values 33 21
[349]
THLE RXRA
Mean 23.9
Standard deviation 7.5
Values 19 29
[350]
liver RXRA
Mean 91.4
Standard deviation 37
Values 1.3e+02 72 49 1.2e+02
[351]
ref_hepatocyte CYP4F3
Mean 13.8
Standard deviation 15
Values 3.1 2 2.4 29 33
[352]
HepG2 CYP4F3
Mean 2.77
Standard deviation 0.38
Values 3 2.5
[353]
HepG2.C3A CYP4F3
Mean 4.62
Standard deviation 0.54
Values 5 4.2
[354]
HuH.7 CYP4F3
Mean 10.7
Standard deviation 7.3
Values 7.3 19 5.8
[355]
SNU475 CYP4F3
Mean 1.11
Standard deviation 0.19
Values 1.2 0.97
[356]
THLE CYP4F3
Mean 0.0175
Standard deviation 0.017
Values 0.03 0.0053
[357]
liver CYP4F3
Mean 88.9
Standard deviation 26
Values 68 1.2e+02 95 70
[358]
ref_hepatocyte FDX1
Mean 11.4
Standard deviation 6.1
Values 10 11 2.2 14 19
[359]
HepG2 FDX1
Mean 15.5
Standard deviation 0.65
Values 15 16
[360]
HepG2.C3A FDX1
Mean 10.2
Standard deviation 2.3
Values 8.6 12
[361]
HuH.7 FDX1
Mean 3.41
Standard deviation 0.095
Values 3.3 3.4 3.5
[362]
SNU475 FDX1
Mean 17.1
Standard deviation 1.7
Values 18 16
[363]
THLE FDX1
Mean 18.1
Standard deviation 3.7
Values 15 21
[364]
liver FDX1
Mean 28.4
Standard deviation 18
Values 44 15 44 12
[365]
ref_hepatocyte CYP4V2
Mean 11.2
Standard deviation 14
Values 1.9 3.8 1.4 13 36
[366]
HepG2 CYP4V2
Mean 2.61
Standard deviation 0.57
Values 2.2 3
[367]
HepG2.C3A CYP4V2
Mean 7.77
Standard deviation 2.1
Values 9.2 6.3
[368]
HuH.7 CYP4V2
Mean 1.95
Standard deviation 0.48
Values 1.8 2.5 1.6
[369]
SNU475 CYP4V2
Mean 1.4
Standard deviation 0.069
Values 1.5 1.4
[370]
THLE CYP4V2
Mean 2.28
Standard deviation 0.08
Values 2.3 2.2
[371]
liver CYP4V2
Mean 53.7
Standard deviation 9.2
Values 62 52 41 59
[372]
ref_hepatocyte CBR3
Mean 10.6
Standard deviation 19
Values 0.11 43 9.5 0 0.081
[373]
HepG2 CBR3
Mean 0.0143
Standard deviation 0.02
Values 0.029 0
[374]
HepG2.C3A CBR3
Mean 0.0414
Standard deviation 0.017
Values 0.029 0.054
[375]
HuH.7 CBR3
Mean 0.102
Standard deviation 0.011
Values 0.09 0.1 0.11
[376]
SNU475 CBR3
Mean 4.03
Standard deviation 0.6
Values 3.6 4.5
[377]
THLE CBR3
Mean 5.68
Standard deviation 0.87
Values 5.1 6.3
[378]
liver CBR3
Mean 0.199
Standard deviation 0.12
Values 0.16 0.086 0.36 0.19
[379]
ref_hepatocyte CYP4F12
Mean 7.85
Standard deviation 7.8
Values 11 0.13 0.73 8.4 19
[380]
HepG2 CYP4F12
Mean 2.67
Standard deviation 0.39
Values 2.9 2.4
[381]
HepG2.C3A CYP4F12
Mean 5.98
Standard deviation 2.1
Values 7.5 4.5
[382]
HuH.7 CYP4F12
Mean 13
Standard deviation 3.4
Values 9.3 16 14
[383]
SNU475 CYP4F12
Mean 0.47
Standard deviation 0.47
Values 0.8 0.14
[384]
THLE CYP4F12
Mean 0.0316
Standard deviation 0.022
Values 0.047 0.016
[385]
liver CYP4F12
Mean 12.8
Standard deviation 14
Values 34 5.3 8.3 3.9
[386]
ref_hepatocyte FDXR
Mean 7.28
Standard deviation 6.2
Values 18 3.2 2.7 8.3 4.5
[387]
HepG2 FDXR
Mean 97.8
Standard deviation 8.7
Values 92 1e+02
[388]
HepG2.C3A FDXR
Mean 54.6
Standard deviation 14
Values 45 64
[389]
HuH.7 FDXR
Mean 5.93
Standard deviation 2.4
Values 6.5 3.4 8
[390]
SNU475 FDXR
Mean 3.59
Standard deviation 0.45
Values 3.9 3.3
[391]
THLE FDXR
Mean 8.51
Standard deviation 1.3
Values 9.4 7.6
[392]
liver FDXR
Mean 2.74
Standard deviation 1.3
Values 3.3 2 4.4 1.3
[393]
ref_hepatocyte CYP39A1
Mean 7.02
Standard deviation 11
Values 0.052 1.3 0.69 8.1 25
[394]
HepG2 CYP39A1
Mean 0.464
Standard deviation 0.049
Values 0.5 0.43
[395]
HepG2.C3A CYP39A1
Mean 0.363
Standard deviation 0.032
Values 0.34 0.39
[396]
HuH.7 CYP39A1
Mean 8.71
Standard deviation 0.36
Values 8.7 9.1 8.4
[397]
SNU475 CYP39A1
Mean 0.422
Standard deviation 0.11
Values 0.35 0.5
[398]
THLE CYP39A1
Mean 1.83
Standard deviation 0.14
Values 1.9 1.7
[399]
liver CYP39A1
Mean 13.9
Standard deviation 9.4
Values 28 8.3 13 7.1
[400]
ref_hepatocyte CES3
Mean 6.53
Standard deviation 8
Values 1.7 0.79 1.3 9.7 19
[401]
HepG2 CES3
Mean 6.06
Standard deviation 0.99
Values 5.4 6.8
[402]
HepG2.C3A CES3
Mean 13
Standard deviation 5.7
Values 17 8.9
[403]
HuH.7 CES3
Mean 1.8
Standard deviation 0.042
Values 1.8 1.8 1.8
[404]
SNU475 CES3
Mean 0.906
Standard deviation 0.074
Values 0.85 0.96
[405]
THLE CES3
Mean 0.649
Standard deviation 0.28
Values 0.85 0.45
[406]
liver CES3
Mean 10.8
Standard deviation 2.4
Values 13 10 7.9 12
[407]
ref_hepatocyte ARNT
Mean 5.93
Standard deviation 1.4
Values 7.7 6.5 4.1 4.8 6.5
[408]
HepG2 ARNT
Mean 17.5
Standard deviation 1.2
Values 17 18
[409]
HepG2.C3A ARNT
Mean 13.5
Standard deviation 3
Values 16 11
[410]
HuH.7 ARNT
Mean 23.6
Standard deviation 6.3
Values 22 31 19
[411]
SNU475 ARNT
Mean 28.1
Standard deviation 0.55
Values 28 28
[412]
THLE ARNT
Mean 26.8
Standard deviation 1.6
Values 26 28
[413]
liver ARNT
Mean 24.4
Standard deviation 4.2
Values 29 19 26 23
[414]
ref_hepatocyte CYP21A2
Mean 5.14
Standard deviation 5.5
Values 0.5 0.83 2.4 13 9.3
[415]
HepG2 CYP21A2
Mean 0.195
Standard deviation 0.0088
Values 0.19 0.2
[416]
HepG2.C3A CYP21A2
Mean 0.66
Standard deviation 0.51
Values 1 0.3
[417]
HuH.7 CYP21A2
Mean 0.0306
Standard deviation 0.027
Values 0 0.045 0.047
[418]
SNU475 CYP21A2
Mean 0.502
Standard deviation 0.11
Values 0.43 0.58
[419]
THLE CYP21A2
Mean 0.0142
Standard deviation 0.005
Values 0.018 0.011
[420]
liver CYP21A2
Mean 6.05
Standard deviation 3.4
Values 2 6 10 5.9
[421]
ref_hepatocyte AHR
Mean 4.68
Standard deviation 3.7
Values 1.7 5.3 2.7 2.8 11
[422]
HepG2 AHR
Mean 22.5
Standard deviation 5.4
Values 19 26
[423]
HepG2.C3A AHR
Mean 24.6
Standard deviation 3.3
Values 27 22
[424]
HuH.7 AHR
Mean 47.9
Standard deviation 14
Values 46 63 34
[425]
SNU475 AHR
Mean 12.5
Standard deviation 1.6
Values 11 14
[426]
THLE AHR
Mean 26.4
Standard deviation 1.2
Values 26 27
[427]
liver AHR
Mean 40.1
Standard deviation 20
Values 28 58 19 55
[428]
ref_hepatocyte CYP7A1
Mean 4.03
Standard deviation 5.2
Values 9.8 0 0 0.69 9.7
[429]
HepG2 CYP7A1
Mean 0.438
Standard deviation 0.47
Values 0.11 0.77
[430]
HepG2.C3A CYP7A1
Mean 0.0774
Standard deviation 0.027
Values 0.058 0.097
[431]
HuH.7 CYP7A1
Mean 0.00642
Standard deviation 0.011
Values 0 0.019 0
[432]
SNU475 CYP7A1
Mean 0.00739
Standard deviation 0.0039
Values 0.0046 0.01
[433]
THLE CYP7A1
Mean 0
Standard deviation 0
Values 0 0
[434]
liver CYP7A1
Mean 0.737
Standard deviation 0.45
Values 1.1 0.94 0.82 0.079
[435]
ref_hepatocyte PAOX
Mean 3.17
Standard deviation 2.4
Values 0.19 2.4 3.1 3.5 6.7
[436]
HepG2 PAOX
Mean 0.376
Standard deviation 0.17
Values 0.5 0.25
[437]
HepG2.C3A PAOX
Mean 1.73
Standard deviation 0.71
Values 2.2 1.2
[438]
HuH.7 PAOX
Mean 1.33
Standard deviation 0.21
Values 1.1 1.5 1.4
[439]
SNU475 PAOX
Mean 0.987
Standard deviation 0.34
Values 1.2 0.75
[440]
THLE PAOX
Mean 0.68
Standard deviation 0.016
Values 0.67 0.69
[441]
liver PAOX
Mean 6.5
Standard deviation 2.9
Values 11 3.6 6.3 5.6
[442]
ref_hepatocyte CYP4A22
Mean 3.13
Standard deviation 4
Values 0 0.14 0.49 7.2 7.8
[443]
HepG2 CYP4A22
Mean 0
Standard deviation 0
Values 0 0
[444]
HepG2.C3A CYP4A22
Mean 0
Standard deviation 0
Values 0 0
[445]
HuH.7 CYP4A22
Mean 0
Standard deviation 0
Values 0 0 0
[446]
SNU475 CYP4A22
Mean 0
Standard deviation 0
Values 0 0
[447]
THLE CYP4A22
Mean 0
Standard deviation 0
Values 0 0
[448]
liver CYP4A22
Mean 21.4
Standard deviation 17
Values 46 6.3 15 18
[449]
ref_hepatocyte ACSS1
Mean 3.12
Standard deviation 4.7
Values 11 0.2 1.2 1.4 1.4
[450]
HepG2 ACSS1
Mean 44.9
Standard deviation 0.52
Values 45 45
[451]
HepG2.C3A ACSS1
Mean 15.1
Standard deviation 1.4
Values 16 14
[452]
HuH.7 ACSS1
Mean 0.0263
Standard deviation 0.013
Values 0.041 0.019 0.019
[453]
SNU475 ACSS1
Mean 0.664
Standard deviation 0.15
Values 0.77 0.56
[454]
THLE ACSS1
Mean 1.15
Standard deviation 0.53
Values 1.5 0.77
[455]
liver ACSS1
Mean 18.9
Standard deviation 24
Values 7.8 5.8 6.5 56
[456]
ref_hepatocyte CYP2R1
Mean 2.89
Standard deviation 1.8
Values 0 4.7 3.6 3.9 2.3
[457]
HepG2 CYP2R1
Mean 0.405
Standard deviation 0.2
Values 0.54 0.27
[458]
HepG2.C3A CYP2R1
Mean 1.25
Standard deviation 0.41
Values 1.5 0.95
[459]
HuH.7 CYP2R1
Mean 5.56
Standard deviation 0.93
Values 4.6 5.8 6.4
[460]
SNU475 CYP2R1
Mean 2.12
Standard deviation 0.069
Values 2.2 2.1
[461]
THLE CYP2R1
Mean 1.67
Standard deviation 0.39
Values 1.9 1.4
[462]
liver CYP2R1
Mean 2.24
Standard deviation 0.78
Values 3.4 1.6 2 2
[463]
ref_hepatocyte CYP4F22
Mean 2.74
Standard deviation 3.4
Values 0 0.23 8.2 3.5 1.8
[464]
HepG2 CYP4F22
Mean 0.103
Standard deviation 0.15
Values 0.21 0
[465]
HepG2.C3A CYP4F22
Mean 0
Standard deviation 0
Values 0 0
[466]
HuH.7 CYP4F22
Mean 0.00273
Standard deviation 0.0047
Values 0.0082 0 0
[467]
SNU475 CYP4F22
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[468]
THLE CYP4F22
Mean 0.0198
Standard deviation 0.0054
Values 0.024 0.016
[469]
liver CYP4F22
Mean 1.99
Standard deviation 1.8
Values 4.7 0.59 1.6 1.1
[470]
ref_hepatocyte CYP1B1
Mean 2.62
Standard deviation 3.2
Values 0.024 8 0.92 2.7 1.4
[471]
HepG2 CYP1B1
Mean 0.0437
Standard deviation 0.019
Values 0.057 0.03
[472]
HepG2.C3A CYP1B1
Mean 0.0575
Standard deviation 0.04
Values 0.029 0.086
[473]
HuH.7 CYP1B1
Mean 0.95
Standard deviation 0.082
Values 0.87 1 0.95
[474]
SNU475 CYP1B1
Mean 13.6
Standard deviation 3.1
Values 16 11
[475]
THLE CYP1B1
Mean 93
Standard deviation 14
Values 1e+02 83
[476]
liver CYP1B1
Mean 7.5
Standard deviation 1.4
Values 6.9 7.4 9.5 6.2
[477]
ref_hepatocyte ALDH3A1
Mean 2.58
Standard deviation 5.2
Values 12 0.4 0 0.24 0.37
[478]
HepG2 ALDH3A1
Mean 1
Standard deviation 0.21
Values 1.2 0.85
[479]
HepG2.C3A ALDH3A1
Mean 0.0511
Standard deviation 0.0036
Values 0.049 0.054
[480]
HuH.7 ALDH3A1
Mean 0.294
Standard deviation 0.089
Values 0.36 0.19 0.33
[481]
SNU475 ALDH3A1
Mean 1.39
Standard deviation 0.1
Values 1.3 1.5
[482]
THLE ALDH3A1
Mean 0.187
Standard deviation 0.07
Values 0.24 0.14
[483]
liver ALDH3A1
Mean 0.614
Standard deviation 0.76
Values 0.071 0.59 1.7 0.11
[484]
ref_hepatocyte NCOA1
Mean 2.09
Standard deviation 0.73
Values 1.8 2 1.1 2.8 2.8
[485]
HepG2 NCOA1
Mean 6.38
Standard deviation 1.4
Values 5.4 7.4
[486]
HepG2.C3A NCOA1
Mean 8.42
Standard deviation 0.79
Values 7.9 9
[487]
HuH.7 NCOA1
Mean 9.25
Standard deviation 2.7
Values 9.2 12 6.6
[488]
SNU475 NCOA1
Mean 13.3
Standard deviation 1
Values 14 13
[489]
THLE NCOA1
Mean 10.2
Standard deviation 0.47
Values 9.9 11
[490]
liver NCOA1
Mean 18.7
Standard deviation 4.8
Values 17 23 13 22
[491]
ref_hepatocyte CYP3A43
Mean 1.46
Standard deviation 2.7
Values 0.059 0 0 1.1 6.1
[492]
HepG2 CYP3A43
Mean 0.112
Standard deviation 0.061
Values 0.069 0.15
[493]
HepG2.C3A CYP3A43
Mean 0.735
Standard deviation 0.42
Values 1 0.44
[494]
HuH.7 CYP3A43
Mean 0.622
Standard deviation 0.91
Values 0.057 1.7 0.14
[495]
SNU475 CYP3A43
Mean 0
Standard deviation 0
Values 0 0
[496]
THLE CYP3A43
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[497]
liver CYP3A43
Mean 5.41
Standard deviation 4.2
Values 12 2.9 3.4 3.6
[498]
ref_hepatocyte CYP7B1
Mean 1.44
Standard deviation 1
Values 0 2.2 1.1 1.2 2.7
[499]
HepG2 CYP7B1
Mean 0.0122
Standard deviation 0.001
Values 0.011 0.013
[500]
HepG2.C3A CYP7B1
Mean 0.0263
Standard deviation 0.023
Values 0.0097 0.043
[501]
HuH.7 CYP7B1
Mean 0
Standard deviation 0
Values 0 0 0
[502]
SNU475 CYP7B1
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[503]
THLE CYP7B1
Mean 0.0751
Standard deviation 0.014
Values 0.065 0.085
[504]
liver CYP7B1
Mean 9.87
Standard deviation 5.4
Values 6.3 17 4.8 12
[505]
ref_hepatocyte NCOA2
Mean 1.14
Standard deviation 0.47
Values 1.5 1.7 1.2 0.47 0.91
[506]
HepG2 NCOA2
Mean 7.51
Standard deviation 4.4
Values 4.4 11
[507]
HepG2.C3A NCOA2
Mean 11.8
Standard deviation 4.3
Values 8.7 15
[508]
HuH.7 NCOA2
Mean 40.1
Standard deviation 18
Values 55 45 21
[509]
SNU475 NCOA2
Mean 19.2
Standard deviation 3.8
Values 22 17
[510]
THLE NCOA2
Mean 6.6
Standard deviation 1.4
Values 5.6 7.6
[511]
liver NCOA2
Mean 39.3
Standard deviation 20
Values 25 56 20 57
[512]
ref_hepatocyte CYP19A1
Mean 1.13
Standard deviation 2.3
Values 5.3 0.08 0.28 0 0
[513]
HepG2 CYP19A1
Mean 9.51
Standard deviation 0.87
Values 8.9 10
[514]
HepG2.C3A CYP19A1
Mean 17.1
Standard deviation 5.6
Values 21 13
[515]
HuH.7 CYP19A1
Mean 0.188
Standard deviation 0.27
Values 0.016 0.5 0.047
[516]
SNU475 CYP19A1
Mean 0.66
Standard deviation 0.58
Values 0.25 1.1
[517]
THLE CYP19A1
Mean 0.135
Standard deviation 0.018
Values 0.15 0.12
[518]
liver CYP19A1
Mean 0.0199
Standard deviation 0.04
Values 0 0 0 0.079
[519]
ref_hepatocyte CYP2U1
Mean 1.09
Standard deviation 0.48
Values 0.81 1.1 0.46 1.4 1.7
[520]
HepG2 CYP2U1
Mean 2.73
Standard deviation 0.62
Values 2.3 3.2
[521]
HepG2.C3A CYP2U1
Mean 0.173
Standard deviation 0.15
Values 0.068 0.28
[522]
HuH.7 CYP2U1
Mean 0.192
Standard deviation 0.045
Values 0.16 0.17 0.24
[523]
SNU475 CYP2U1
Mean 4.71
Standard deviation 1
Values 5.4 4
[524]
THLE CYP2U1
Mean 9.13
Standard deviation 0.16
Values 9 9.2
[525]
liver CYP2U1
Mean 6.54
Standard deviation 1.6
Values 5.5 8.3 7.4 5
[526]
ref_hepatocyte AOC3
Mean 0.938
Standard deviation 0.67
Values 1.2 0 0.5 1.4 1.6
[527]
HepG2 AOC3
Mean 7.65
Standard deviation 3
Values 9.8 5.5
[528]
HepG2.C3A AOC3
Mean 35.8
Standard deviation 5.7
Values 40 32
[529]
HuH.7 AOC3
Mean 3.49
Standard deviation 0.42
Values 3.1 3.9 3.5
[530]
SNU475 AOC3
Mean 0.646
Standard deviation 0.46
Values 0.32 0.97
[531]
THLE AOC3
Mean 0.692
Standard deviation 0.44
Values 1 0.38
[532]
liver AOC3
Mean 5.85
Standard deviation 3.6
Values 2.7 4.7 11 5.1
[533]
ref_hepatocyte POMC
Mean 0.898
Standard deviation 0.87
Values 0 1.1 0 1.4 2
[534]
HepG2 POMC
Mean 0
Standard deviation 0
Values 0 0
[535]
HepG2.C3A POMC
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[536]
HuH.7 POMC
Mean 0
Standard deviation 0
Values 0 0 0
[537]
SNU475 POMC
Mean 0
Standard deviation 0
Values 0 0
[538]
THLE POMC
Mean 0.0133
Standard deviation 0.019
Values 0 0.027
[539]
liver POMC
Mean 0.28
Standard deviation 0.16
Values 0.35 0.17 0.46 0.13
[540]
ref_hepatocyte TBXAS1
Mean 0.896
Standard deviation 0.62
Values 0.56 0.49 0.32 1.7 1.4
[541]
HepG2 TBXAS1
Mean 0.253
Standard deviation 0.096
Values 0.32 0.18
[542]
HepG2.C3A TBXAS1
Mean 0.938
Standard deviation 0.16
Values 1 0.83
[543]
HuH.7 TBXAS1
Mean 0.0986
Standard deviation 0.058
Values 0.12 0.032 0.14
[544]
SNU475 TBXAS1
Mean 2.57
Standard deviation 0.093
Values 2.5 2.6
[545]
THLE TBXAS1
Mean 1.05
Standard deviation 0.095
Values 1.1 0.98
[546]
liver TBXAS1
Mean 4
Standard deviation 1.4
Values 2.1 4.8 4.1 5.1
[547]
ref_hepatocyte CYP11A1
Mean 0.602
Standard deviation 0.44
Values 0.18 0.47 0.44 0.59 1.3
[548]
HepG2 CYP11A1
Mean 0.843
Standard deviation 0.49
Values 1.2 0.49
[549]
HepG2.C3A CYP11A1
Mean 0.131
Standard deviation 0.049
Values 0.17 0.097
[550]
HuH.7 CYP11A1
Mean 0
Standard deviation 0
Values 0 0 0
[551]
SNU475 CYP11A1
Mean 0.115
Standard deviation 0.045
Values 0.083 0.15
[552]
THLE CYP11A1
Mean 2.14
Standard deviation 0.87
Values 2.8 1.5
[553]
liver CYP11A1
Mean 1.18
Standard deviation 0.65
Values 1.4 0.57 2 0.75
[554]
ref_hepatocyte CYP2W1
Mean 0.591
Standard deviation 1.2
Values 2.8 0 0 0.16 0
[555]
HepG2 CYP2W1
Mean 16.9
Standard deviation 4.5
Values 14 20
[556]
HepG2.C3A CYP2W1
Mean 56.5
Standard deviation 39
Values 84 29
[557]
HuH.7 CYP2W1
Mean 0.798
Standard deviation 0.23
Values 0.68 1.1 0.65
[558]
SNU475 CYP2W1
Mean 0.101
Standard deviation 0.028
Values 0.12 0.081
[559]
THLE CYP2W1
Mean 0.0849
Standard deviation 0.022
Values 0.1 0.069
[560]
liver CYP2W1
Mean 0.0517
Standard deviation 0.06
Values 0 0.11 0 0.093
[561]
ref_hepatocyte CYP2S1
Mean 0.536
Standard deviation 0.51
Values 0.27 0.31 1.4 0.1 0.61
[562]
HepG2 CYP2S1
Mean 8.91
Standard deviation 2.7
Values 11 7
[563]
HepG2.C3A CYP2S1
Mean 3.61
Standard deviation 0.85
Values 4.2 3
[564]
HuH.7 CYP2S1
Mean 1.97
Standard deviation 1.2
Values 3 0.73 2.2
[565]
SNU475 CYP2S1
Mean 2.23
Standard deviation 1.5
Values 1.2 3.3
[566]
THLE CYP2S1
Mean 2.64
Standard deviation 0.9
Values 2 3.3
[567]
liver CYP2S1
Mean 0.486
Standard deviation 0.16
Values 0.38 0.4 0.72 0.45
[568]
ref_hepatocyte AOC2
Mean 0.43
Standard deviation 0.52
Values 0 0.36 1.3 0.53 0
[569]
HepG2 AOC2
Mean 1.18
Standard deviation 0.25
Values 1.4 1
[570]
HepG2.C3A AOC2
Mean 1.82
Standard deviation 0.54
Values 2.2 1.4
[571]
HuH.7 AOC2
Mean 4.72
Standard deviation 0.32
Values 4.4 4.7 5
[572]
SNU475 AOC2
Mean 1.42
Standard deviation 0.78
Values 0.87 2
[573]
THLE AOC2
Mean 1.67
Standard deviation 0.78
Values 2.2 1.1
[574]
liver AOC2
Mean 0.848
Standard deviation 0.61
Values 0.19 0.98 0.59 1.6
[575]
ref_hepatocyte CYP24A1
Mean 0.344
Standard deviation 0.69
Values 1.6 0.15 0 0 0
[576]
HepG2 CYP24A1
Mean 215
Standard deviation 90
Values 2.8e+02 1.5e+02
[577]
HepG2.C3A CYP24A1
Mean 6.56
Standard deviation 2.9
Values 4.5 8.6
[578]
HuH.7 CYP24A1
Mean 0.126
Standard deviation 0.11
Values 0.11 0.24 0.019
[579]
SNU475 CYP24A1
Mean 10.9
Standard deviation 10
Values 3.8 18
[580]
THLE CYP24A1
Mean 0.109
Standard deviation 0.079
Values 0.053 0.16
[581]
liver CYP24A1
Mean 0.00357
Standard deviation 0.0071
Values 0 0.014 0 0
[582]
ref_hepatocyte CYP26A1
Mean 0.247
Standard deviation 0.38
Values 0 0 0 0.86 0.37
[583]
HepG2 CYP26A1
Mean 4.9
Standard deviation 3.4
Values 7.3 2.5
[584]
HepG2.C3A CYP26A1
Mean 0.0764
Standard deviation 0.0019
Values 0.078 0.075
[585]
HuH.7 CYP26A1
Mean 0.853
Standard deviation 0.36
Values 0.55 1.3 0.76
[586]
SNU475 CYP26A1
Mean 0.504
Standard deviation 0.37
Values 0.77 0.24
[587]
THLE CYP26A1
Mean 0.0109
Standard deviation 0.0071
Values 0.0059 0.016
[588]
liver CYP26A1
Mean 0.705
Standard deviation 0.82
Values 0.19 0.74 1.8 0.04
[589]
ref_hepatocyte PTGIS
Mean 0.218
Standard deviation 0.14
Values 0.14 0.08 0.32 0.4 0.15
[590]
HepG2 PTGIS
Mean 0.163
Standard deviation 0.012
Values 0.17 0.15
[591]
HepG2.C3A PTGIS
Mean 0.316
Standard deviation 0.0069
Values 0.32 0.31
[592]
HuH.7 PTGIS
Mean 4.77
Standard deviation 0.64
Values 5.5 4.3 4.5
[593]
SNU475 PTGIS
Mean 0.868
Standard deviation 0.11
Values 0.79 0.94
[594]
THLE PTGIS
Mean 59.9
Standard deviation 32
Values 37 82
[595]
liver PTGIS
Mean 8.86
Standard deviation 2.8
Values 5.9 11 12 7.1
[596]
ref_hepatocyte AHRR
Mean 0.118
Standard deviation 0.18
Values 0.44 0.06 0 0.026 0.065
[597]
HepG2 AHRR
Mean 0.681
Standard deviation 0.23
Values 0.84 0.52
[598]
HepG2.C3A AHRR
Mean 0.329
Standard deviation 0.22
Values 0.49 0.17
[599]
HuH.7 AHRR
Mean 0.388
Standard deviation 0.1
Values 0.3 0.37 0.5
[600]
SNU475 AHRR
Mean 5.99
Standard deviation 1.7
Values 7.2 4.8
[601]
THLE AHRR
Mean 2.19
Standard deviation 0.32
Values 2.4 2
[602]
liver AHRR
Mean 0.277
Standard deviation 0.057
Values 0.33 0.26 0.21 0.32
[603]
ref_hepatocyte PTGS1
Mean 0.117
Standard deviation 0.16
Values 0 0 0.13 0.06 0.39
[604]
HepG2 PTGS1
Mean 0.657
Standard deviation 0.75
Values 1.2 0.13
[605]
HepG2.C3A PTGS1
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[606]
HuH.7 PTGS1
Mean 0.0156
Standard deviation 0.02
Values 0.0082 0.039 0
[607]
SNU475 PTGS1
Mean 1.38
Standard deviation 0.25
Values 1.5 1.2
[608]
THLE PTGS1
Mean 11
Standard deviation 1.1
Values 10 12
[609]
liver PTGS1
Mean 1.31
Standard deviation 0.36
Values 1.4 1.5 1.6 0.78
[610]
ref_hepatocyte FMO1
Mean 0.0687
Standard deviation 0.12
Values 0 0.27 0 0.069 0
[611]
HepG2 FMO1
Mean 0.00429
Standard deviation 0.0061
Values 0 0.0086
[612]
HepG2.C3A FMO1
Mean 0.0107
Standard deviation 0.015
Values 0 0.021
[613]
HuH.7 FMO1
Mean 1.13
Standard deviation 1.7
Values 0.16 3.1 0.094
[614]
SNU475 FMO1
Mean 0.00739
Standard deviation 0.0039
Values 0.0046 0.01
[615]
THLE FMO1
Mean 0
Standard deviation 0
Values 0 0
[616]
liver FMO1
Mean 0.26
Standard deviation 0.27
Values 0.66 0.043 0.21 0.13
[617]
ref_hepatocyte CYP2A13
Mean 0.0683
Standard deviation 0.12
Values 0 0 0 0.28 0.057
[618]
HepG2 CYP2A13
Mean 0
Standard deviation 0
Values 0 0
[619]
HepG2.C3A CYP2A13
Mean 0
Standard deviation 0
Values 0 0
[620]
HuH.7 CYP2A13
Mean 0
Standard deviation 0
Values 0 0 0
[621]
SNU475 CYP2A13
Mean 0
Standard deviation 0
Values 0 0
[622]
THLE CYP2A13
Mean 0
Standard deviation 0
Values 0 0
[623]
liver CYP2A13
Mean 0.0677
Standard deviation 0.059
Values 0 0.13 0.1 0.04
[624]
ref_hepatocyte CYP27B1
Mean 0.0505
Standard deviation 0.082
Values 0 0 0.19 0 0.065
[625]
HepG2 CYP27B1
Mean 0.715
Standard deviation 0.14
Values 0.62 0.81
[626]
HepG2.C3A CYP27B1
Mean 1.72
Standard deviation 0.25
Values 1.9 1.5
[627]
HuH.7 CYP27B1
Mean 1.08
Standard deviation 0.18
Values 1.1 0.89 1.3
[628]
SNU475 CYP27B1
Mean 0.211
Standard deviation 0.1
Values 0.14 0.28
[629]
THLE CYP27B1
Mean 0.395
Standard deviation 0.14
Values 0.5 0.29
[630]
liver CYP27B1
Mean 0.228
Standard deviation 0.17
Values 0.071 0.14 0.46 0.24
[631]
ref_hepatocyte CYP46A1
Mean 0.0447
Standard deviation 0.068
Values 0 0 0 0.069 0.15
[632]
HepG2 CYP46A1
Mean 0.00716
Standard deviation 0.002
Values 0.0057 0.0086
[633]
HepG2.C3A CYP46A1
Mean 0.0161
Standard deviation 0.023
Values 0 0.032
[634]
HuH.7 CYP46A1
Mean 0.00761
Standard deviation 0.0083
Values 0.016 0.0064 0
[635]
SNU475 CYP46A1
Mean 0.0139
Standard deviation 0.02
Values 0.028 0
[636]
THLE CYP46A1
Mean 0.0358
Standard deviation 0.017
Values 0.024 0.048
[637]
liver CYP46A1
Mean 0.303
Standard deviation 0.093
Values 0.38 0.17 0.36 0.3
[638]
ref_hepatocyte ADH7
Mean 0.0374
Standard deviation 0.084
Values 0 0 0 0 0.19
[639]
HepG2 ADH7
Mean 0
Standard deviation 0
Values 0 0
[640]
HepG2.C3A ADH7
Mean 0
Standard deviation 0
Values 0 0
[641]
HuH.7 ADH7
Mean 0
Standard deviation 0
Values 0 0 0
[642]
SNU475 ADH7
Mean 0
Standard deviation 0
Values 0 0
[643]
THLE ADH7
Mean 0
Standard deviation 0
Values 0 0
[644]
liver ADH7
Mean 0.00662
Standard deviation 0.013
Values 0 0 0 0.026
[645]
ref_hepatocyte CYP2F1
Mean 0.026
Standard deviation 0.058
Values 0 0 0 0 0.13
[646]
HepG2 CYP2F1
Mean 0.0336
Standard deviation 0.007
Values 0.029 0.039
[647]
HepG2.C3A CYP2F1
Mean 0.00972
Standard deviation 0.014
Values 0.019 0
[648]
HuH.7 CYP2F1
Mean 0.185
Standard deviation 0.058
Values 0.16 0.25 0.14
[649]
SNU475 CYP2F1
Mean 0.129
Standard deviation 0.047
Values 0.16 0.096
[650]
THLE CYP2F1
Mean 0.0674
Standard deviation 0.0051
Values 0.071 0.064
[651]
liver CYP2F1
Mean 0.0726
Standard deviation 0.035
Values 0.024 0.071 0.1 0.093
[652]
ref_hepatocyte ARNT2
Mean 0.0152
Standard deviation 0.021
Values 0.035 0 0 0 0.041
[653]
HepG2 ARNT2
Mean 1.4
Standard deviation 0.00016
Values 1.4 1.4
[654]
HepG2.C3A ARNT2
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[655]
HuH.7 ARNT2
Mean 0.0117
Standard deviation 0.01
Values 0.016 0 0.019
[656]
SNU475 ARNT2
Mean 2.4
Standard deviation 1.8
Values 3.7 1.1
[657]
THLE ARNT2
Mean 9.12
Standard deviation 1.9
Values 7.8 10
[658]
liver ARNT2
Mean 0.665
Standard deviation 0.33
Values 0.38 0.67 0.49 1.1
[659]
ref_hepatocyte CYP26B1
Mean 0.0121
Standard deviation 0.027
Values 0 0 0 0.06 0
[660]
HepG2 CYP26B1
Mean 0.791
Standard deviation 0.35
Values 1 0.54
[661]
HepG2.C3A CYP26B1
Mean 0.0848
Standard deviation 0.092
Values 0.019 0.15
[662]
HuH.7 CYP26B1
Mean 12
Standard deviation 3.7
Values 14 7.7 14
[663]
SNU475 CYP26B1
Mean 2.31
Standard deviation 2.1
Values 0.84 3.8
[664]
THLE CYP26B1
Mean 1.52
Standard deviation 0.59
Values 1.9 1.1
[665]
liver CYP26B1
Mean 0.794
Standard deviation 0.48
Values 0.78 0.43 0.49 1.5
[666]
ref_hepatocyte CYP11B1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[667]
HepG2 CYP11B1
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[668]
HepG2.C3A CYP11B1
Mean 0
Standard deviation 0
Values 0 0
[669]
HuH.7 CYP11B1
Mean 0
Standard deviation 0
Values 0 0 0
[670]
SNU475 CYP11B1
Mean 0
Standard deviation 0
Values 0 0
[671]
THLE CYP11B1
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[672]
liver CYP11B1
Mean 0.00331
Standard deviation 0.0066
Values 0 0 0 0.013
[673]
ref_hepatocyte CYP11B2
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[674]
HepG2 CYP11B2
Missing
[675]
HepG2.C3A CYP11B2
Missing
[676]
HuH.7 CYP11B2
Missing
[677]
SNU475 CYP11B2
Missing
[678]
THLE CYP11B2
Missing
[679]
liver CYP11B2
Missing
[680]
ref_hepatocyte FMO2
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[681]
HepG2 FMO2
Mean 0
Standard deviation 0
Values 0 0
[682]
HepG2.C3A FMO2
Mean 0
Standard deviation 0
Values 0 0
[683]
HuH.7 FMO2
Mean 0.141
Standard deviation 0.053
Values 0.13 0.2 0.094
[684]
SNU475 FMO2
Mean 0.0548
Standard deviation 0.027
Values 0.074 0.035
[685]
THLE FMO2
Mean 0.00798
Standard deviation 0.011
Values 0 0.016
[686]
liver FMO2
Mean 2.49
Standard deviation 1.6
Values 1.4 3.9 3.8 0.91
[687]
ref_hepatocyte CYP26C1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[688]
HepG2 CYP26C1
Mean 0
Standard deviation 0
Values 0 0
[689]
HepG2.C3A CYP26C1
Mean 0
Standard deviation 0
Values 0 0
[690]
HuH.7 CYP26C1
Mean 0.176
Standard deviation 0.084
Values 0.26 0.17 0.094
[691]
SNU475 CYP26C1
Mean 0
Standard deviation 0
Values 0 0
[692]
THLE CYP26C1
Mean 0.0166
Standard deviation 0.0067
Values 0.012 0.021
[693]
liver CYP26C1
Mean 0.0165
Standard deviation 0.033
Values 0 0 0 0.066
[694]
ref_hepatocyte FDX2
Missing
[695]
HepG2 FDX2
Missing
[696]
HepG2.C3A FDX2
Missing
[697]
HuH.7 FDX2
Missing
[698]
SNU475 FDX2
Missing
[699]
THLE FDX2
Missing
[700]
liver FDX2
Missing
[701]
ref_hepatocyte MTARC2
Missing
[702]
HepG2 MTARC2
Missing
[703]
HepG2.C3A MTARC2
Missing
[704]
HuH.7 MTARC2
Missing
[705]
SNU475 MTARC2
Missing
[706]
THLE MTARC2
Missing
[707]
liver MTARC2
Missing
[708]
ref_hepatocyte CYP4F8
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[709]
HepG2 CYP4F8
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[710]
HepG2.C3A CYP4F8
Mean 0
Standard deviation 0
Values 0 0
[711]
HuH.7 CYP4F8
Mean 0.00312
Standard deviation 0.0054
Values 0 0 0.0094
[712]
SNU475 CYP4F8
Mean 0.00253
Standard deviation 0.0036
Values 0 0.0051
[713]
THLE CYP4F8
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[714]
liver CYP4F8
Mean 0
Standard deviation 0
Values 0 0 0 0
[715]
ref_hepatocyte PDCD6-AHRR
Missing
[716]
HepG2 PDCD6-AHRR
Missing
[717]
HepG2.C3A PDCD6-AHRR
Missing
[718]
HuH.7 PDCD6-AHRR
Missing
[719]
SNU475 PDCD6-AHRR
Missing
[720]
THLE PDCD6-AHRR
Missing
[721]
liver PDCD6-AHRR
Missing
[722]
ref_hepatocyte MTARC1
Missing
[723]
HepG2 MTARC1
Missing
[724]
HepG2.C3A MTARC1
Missing
[725]
HuH.7 MTARC1
Missing
[726]
SNU475 MTARC1
Missing
[727]
THLE MTARC1
Missing
[728]
liver MTARC1
Missing
[729]
ref_hepatocyte AOC1
Missing
[730]
HepG2 AOC1
Missing
[731]
HepG2.C3A AOC1
Missing
[732]
HuH.7 AOC1
Missing
[733]
SNU475 AOC1
Missing
[734]
THLE AOC1
Missing
[735]
liver AOC1
Missing
[736]
ref_hepatocyte CYP4B1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[737]
HepG2 CYP4B1
Mean 0.00501
Standard deviation 0.001
Values 0.0057 0.0043
[738]
HepG2.C3A CYP4B1
Mean 0
Standard deviation 0
Values 0 0
[739]
HuH.7 CYP4B1
Mean 0
Standard deviation 0
Values 0 0 0
[740]
SNU475 CYP4B1
Mean 0.0177
Standard deviation 0.025
Values 0 0.035
[741]
THLE CYP4B1
Mean 0.129
Standard deviation 0.077
Values 0.18 0.074
[742]
liver CYP4B1
Mean 0.0575
Standard deviation 0.045
Values 0.047 0 0.077 0.11