REACTOME_PHASE_II_CONJUGATION_OF_COMPOUNDS | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | MGST1 | Microsomal glutathione S-transferase 1 | [1] | -1.77[2] | -2.56[3] | -1.52[4] | -1.86[5] | -0.59[6] | -0.46[7] |
2 | NNMT | Nicotinamide N-methyltransferase | [8] | -10.84[9] | -12.61[10] | -5.19[11] | -3.40[12] | -0.20[13] | 0.09[14] |
3 | GSTA1 | Glutathione S-transferase A1 | [15] | -3.15[16] | -7.37[17] | -1.03[18] | -5.66[19] | -9.91[20] | -3.20[21] |
4 | SULT2A1 | Bile salt sulfotransferase | [22] | -0.79[23] | -0.30[24] | -1.43[25] | -10.24[26] | -9.47[27] | 0.70[28] |
5 | UGT1A6 | UDP-glucuronosyltransferase 1-6 | [29] | -6.35[30] | -14.54[31] | -8.51[32] | -5.50[33] | -10.77[34] | -3.48[35] |
6 | TRMT112 | Multifunctional methyltransferase subunit TRM112-like protein | [36] | -0.59[37] | -0.81[38] | -1.10[39] | -0.92[40] | -0.60[41] | -3.49[42] |
7 | MAT1A | S-adenosylmethionine synthase isoform type-1 | [43] | -1.03[44] | 0.41[45] | -1.38[46] | -8.07[47] | -10.02[48] | 1.35[49] |
8 | UGT2B4 | UDP-glucuronosyltransferase 2B4 | [50] | -6.96[51] | -7.59[52] | -2.20[53] | -8.74[54] | -11.66[55] | 1.18[56] |
9 | GSTA2 | Glutathione S-transferase A2 | [57] | -4.26[58] | -7.20[59] | -2.67[60] | -7.08[61] | -10.05[62] | -3.02[63] |
10 | UGDH | UDP-glucose 6-dehydrogenase | [64] | 1.45[65] | 0.91[66] | -0.02[67] | 0.96[68] | -1.62[69] | -0.16[70] |
11 | GSTO1 | Glutathione S-transferase omega-1 | [71] | 0.55[72] | 0.81[73] | 0.42[74] | -1.81[75] | 0.95[76] | -0.80[77] |
12 | UGP2 | UTP--glucose-1-phosphate uridylyltransferase | [78] | 0.30[79] | 0.47[80] | 0.03[81] | 0.57[82] | 0.66[83] | 0.16[84] |
13 | UGT2B7 | UDP-glucuronosyltransferase 2B7 | [85] | -0.86[86] | -1.16[87] | -6.49[88] | -9.95[89] | -10.95[90] | -0.11[91] |
14 | SULT1A1 | Sulfotransferase 1A1 | [92] | 0.98[93] | 1.17[94] | -2.17[95] | -1.23[96] | -0.59[97] | -1.74[98] |
15 | GSTK1 | Glutathione S-transferase kappa 1 | [99] | -0.54[100] | -0.41[101] | -0.03[102] | -0.76[103] | -0.76[104] | -0.62[105] |
16 | UGT2B10 | UDP-glucuronosyltransferase 2B10 | [106] | -1.28[107] | 0.90[108] | -6.62[109] | -10.08[110] | -12.98[111] | -1.19[112] |
17 | CYP1A2 | Cytochrome P450 1A2 | [113] | -8.43[114] | -7.58[115] | -8.11[116] | -7.72[117] | -7.57[118] | -1.24[119] |
18 | MGST2 | Microsomal glutathione S-transferase 2 | [120] | 0.41[121] | 1.35[122] | -0.21[123] | -1.60[124] | -1.06[125] | -1.51[126] |
19 | UGT2B15 | UDP-glucuronosyltransferase 2B15 | [127] | -9.19[128] | -8.09[129] | -7.24[130] | -9.82[131] | -9.79[132] | -0.57[133] |
20 | AHCY | Adenosylhomocysteinase | [134] | 3.47[135] | 3.45[136] | 3.82[137] | 1.59[138] | 1.73[139] | -0.60[140] |
21 | ACSM2B | Acyl-coenzyme A synthetase ACSM2B, mitochondrial | [141] | -4.58[142] | -4.74[143] | 0.14[144] | -10.81[145] | -9.03[146] | 1.24[147] |
22 | ACSM2A | Acyl-coenzyme A synthetase ACSM2A, mitochondrial | [148] | -5.83[149] | -6.63[150] | -0.89[151] | -13.34[152] | -10.66[153] | 1.25[154] |
23 | UGT1A1 | UDP-glucuronosyltransferase 1-1 | [155] | -3.88[156] | -10.58[157] | -5.29[158] | 0.03[159] | -9.41[160] | 0.36[161] |
24 | AKR1A1 | Alcohol dehydrogenase [NADP(+)] | [162] | 1.29[163] | 1.02[164] | 1.86[165] | -0.19[166] | 0.09[167] | 0.09[168] |
25 | UGT1A4 | UDP-glucuronosyltransferase 1-4 | [169] | -11.26[170] | [171] | -11.19[172] | -9.25[173] | [174] | 0.55[175] |
26 | GSTT1 | Glutathione S-transferase theta-1 | [176] | 0.45[177] | 0.19[178] | -9.96[179] | -10.64[180] | -1.68[181] | -0.59[182] |
27 | GLYATL1 | Glycine N-acyltransferase-like protein 1 | [183] | -6.43[184] | -8.78[185] | -4.81[186] | -7.73[187] | -6.40[188] | 0.82[189] |
28 | GLYAT | Glycine N-acyltransferase | [190] | -10.58[191] | -12.03[192] | [193] | [194] | -10.63[195] | -0.13[196] |
29 | GSTZ1 | Maleylacetoacetate isomerase | [197] | -1.48[198] | -1.14[199] | -1.40[200] | -1.99[201] | -1.39[202] | -1.40[203] |
30 | ESD | S-formylglutathione hydrolase | [204] | 1.36[205] | 1.35[206] | 1.83[207] | 0.42[208] | 1.43[209] | -0.29[210] |
31 | COMT | Catechol O-methyltransferase | [211] | 1.85[212] | 2.01[213] | -0.03[214] | 0.63[215] | 1.25[216] | 0.78[217] |
32 | ABHD14B | Protein ABHD14B | [218] | 1.64[219] | 1.44[220] | 0.44[221] | -0.08[222] | 1.14[223] | 0.40[224] |
33 | MGST3 | Microsomal glutathione S-transferase 3 | [225] | 0.30[226] | -0.12[227] | 0.75[228] | 1.53[229] | 2.06[230] | 0.20[231] |
34 | ACSM5 | Acyl-coenzyme A synthetase ACSM5, mitochondrial | [232] | -3.06[233] | -4.33[234] | -4.83[235] | -4.14[236] | -11.40[237] | 2.06[238] |
35 | CNDP2 | Cytosolic non-specific dipeptidase | [239] | 2.25[240] | 1.79[241] | 0.63[242] | 0.89[243] | 1.08[244] | 1.49[245] |
36 | GCLC | Glutamate--cysteine ligase catalytic subunit | [246] | 2.13[247] | 2.04[248] | 0.96[249] | 3.32[250] | 1.17[251] | 0.83[252] |
37 | TPST2 | Protein-tyrosine sulfotransferase 2 | [253] | 0.07[254] | -0.29[255] | 0.44[256] | 1.03[257] | -0.16[258] | 0.92[259] |
38 | TPMT | Thiopurine S-methyltransferase | [260] | 0.86[261] | 1.19[262] | -0.15[263] | 0.97[264] | 1.14[265] | 0.27[266] |
39 | MAT2A | S-adenosylmethionine synthase isoform type-2 | [267] | 3.00[268] | 2.89[269] | 2.82[270] | 3.19[271] | 3.99[272] | 1.29[273] |
40 | GGCT | Gamma-glutamylcyclotransferase | [274] | 0.53[275] | 0.86[276] | 2.06[277] | 0.92[278] | 1.51[279] | -1.75[280] |
41 | PAPSS2 | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 | [281] | -3.16[282] | -5.53[283] | 1.85[284] | 2.23[285] | 3.23[286] | 1.92[287] |
42 | SULT1A2 | Sulfotransferase 1A2 | [288] | 0.93[289] | 1.18[290] | -3.45[291] | -1.07[292] | -3.75[293] | -1.57[294] |
43 | GCLM | Glutamate--cysteine ligase regulatory subunit | [295] | 1.51[296] | 0.30[297] | 0.90[298] | 3.22[299] | 1.96[300] | -0.43[301] |
44 | GSS | Glutathione synthetase | [302] | 3.18[303] | 2.45[304] | 1.92[305] | 2.70[306] | 2.66[307] | 0.17[308] |
45 | UGT1A9 | UDP-glucuronosyltransferase 1-9 | [309] | -5.22[310] | -10.55[311] | -6.60[312] | -4.31[313] | -9.00[314] | -0.22[315] |
46 | GGT1 | Glutathione hydrolase 1 proenzyme | [316] | 1.81[317] | 1.10[318] | 1.01[319] | 0.18[320] | -3.79[321] | 1.13[322] |
47 | NAT2 | Arylamine N-acetyltransferase 2 | [323] | -5.47[324] | -5.47[325] | -3.77[326] | -7.24[327] | -6.73[328] | 0.55[329] |
48 | TPST1 | Protein-tyrosine sulfotransferase 1 | [330] | 0.74[331] | 0.92[332] | 1.45[333] | 1.80[334] | 2.02[335] | 0.55[336] |
49 | AS3MT | Arsenite methyltransferase | [337] | -3.67[338] | -3.67[339] | -2.36[340] | -5.42[341] | -3.89[342] | -5.35[343] |
50 | MAT2B | Methionine adenosyltransferase 2 subunit beta | [344] | 2.40[345] | 2.04[346] | 2.37[347] | 2.83[348] | 3.30[349] | 0.43[350] |
51 | PAPSS1 | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 | [351] | 3.21[352] | 3.23[353] | 2.64[354] | 2.57[355] | 3.22[356] | -1.08[357] |
52 | GSTA4 | Glutathione S-transferase A4 | [358] | 1.30[359] | 1.13[360] | 2.45[361] | 2.44[362] | 1.15[363] | -1.06[364] |
53 | UGT2B17 | UDP-glucuronosyltransferase 2B17 | [365] | -8.54[366] | -8.37[367] | -11.05[368] | [369] | [370] | -0.94[371] |
54 | SULT1A4 | Sulfotransferase 1A4 | [372] | [373] | [374] | [375] | [376] | [377] | [378] |
55 | SULT1A3 | Sulfotransferase 1A3 | [379] | [380] | [381] | [382] | [383] | [384] | [385] |
56 | SLC35B2 | Adenosine 3'-phospho 5'-phosphosulfate transporter 1 | [386] | 4.21[387] | 3.91[388] | 2.32[389] | 3.79[390] | 3.86[391] | 0.39[392] |
57 | GSTM4 | Glutathione S-transferase Mu 4 | [393] | 1.68[394] | 0.68[395] | 1.00[396] | 2.14[397] | -0.48[398] | 0.17[399] |
58 | SLC35D1 | UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter | [400] | 3.15[401] | 3.03[402] | 3.35[403] | 1.52[404] | 2.71[405] | 3.37[406] |
59 | UGT2A3 | UDP-glucuronosyltransferase 2A3 | [407] | 3.77[408] | 5.18[409] | -2.09[410] | -4.68[411] | -6.95[412] | 1.91[413] |
60 | CHAC1 | Glutathione-specific gamma-glutamylcyclotransferase 1 | [414] | -2.91[415] | -1.00[416] | 1.60[417] | -1.36[418] | 2.10[419] | -3.26[420] |
61 | ABHD10 | Mycophenolic acid acyl-glucuronide esterase, mitochondrial | [421] | 2.23[422] | 2.57[423] | 3.05[424] | 2.44[425] | 3.32[426] | 1.01[427] |
62 | UGT3A1 | UDP-glucuronosyltransferase 3A1 | [428] | [429] | -8.21[430] | [431] | [432] | -9.39[433] | 2.21[434] |
63 | GSTP1 | Glutathione S-transferase P | [435] | -1.48[436] | -1.04[437] | 6.78[438] | 8.08[439] | 6.41[440] | 0.35[441] |
64 | SLC35B3 | Adenosine 3'-phospho 5'-phosphosulfate transporter 2 | [442] | 1.99[443] | 2.02[444] | 1.87[445] | 2.31[446] | 2.26[447] | 0.32[448] |
65 | BPNT1 | 3'(2'),5'-bisphosphate nucleotidase 1 | [449] | 3.35[450] | 3.45[451] | 4.14[452] | 3.65[453] | 2.90[454] | 0.23[455] |
66 | MTRR | Methionine synthase reductase | [456] | 2.72[457] | 2.94[458] | 3.80[459] | 2.92[460] | 4.17[461] | 1.63[462] |
67 | OPLAH | 5-oxoprolinase | [463] | 3.43[464] | 3.03[465] | 1.64[466] | 1.95[467] | 0.47[468] | 2.08[469] |
68 | UGT1A3 | UDP-glucuronosyltransferase 1-3 | [470] | -0.48[471] | [472] | -7.45[473] | -4.05[474] | -8.59[475] | 1.65[476] |
69 | GSTT2 | Glutathione S-transferase theta-2 | [477] | -4.84[478] | -7.24[479] | -7.95[480] | -2.60[481] | -0.37[482] | -3.16[483] |
70 | N6AMT1 | HemK methyltransferase family member 2 | [484] | 0.96[485] | 0.74[486] | -1.23[487] | 0.94[488] | 1.43[489] | -1.33[490] |
71 | CHAC2 | Glutathione-specific gamma-glutamylcyclotransferase 2 | [491] | 1.38[492] | 1.42[493] | 0.68[494] | 1.76[495] | 2.44[496] | -0.74[497] |
72 | GSTM3 | Glutathione S-transferase Mu 3 | [498] | 4.86[499] | 3.75[500] | 1.57[501] | 5.24[502] | 5.64[503] | 1.93[504] |
73 | SULT1E1 | Estrogen sulfotransferase | [505] | -0.37[506] | 1.84[507] | 2.46[508] | -5.83[509] | 3.45[510] | 1.49[511] |
74 | SLC26A1 | Sulfate anion transporter 1 | [512] | 2.94[513] | 3.01[514] | 3.22[515] | 1.38[516] | 0.30[517] | 2.60[518] |
75 | NAT1 | Arylamine N-acetyltransferase 1 | [519] | 1.17[520] | 1.34[521] | 2.72[522] | 0.96[523] | 2.14[524] | 1.18[525] |
76 | SULT1C2 | Sulfotransferase 1C2 | [526] | 1.16[527] | 0.74[528] | 0.97[529] | 1.17[530] | -3.44[531] | -2.29[532] |
77 | GGT7 | Glutathione hydrolase 7 | [533] | 4.27[534] | 4.15[535] | 3.83[536] | 4.34[537] | 4.02[538] | 0.77[539] |
78 | PODXL2 | Podocalyxin-like protein 2 | [540] | 5.97[541] | -0.38[542] | 5.40[543] | 4.15[544] | 1.58[545] | -2.24[546] |
79 | MTR | Methionine synthase | [547] | 4.75[548] | 4.99[549] | 5.27[550] | 5.52[551] | 5.42[552] | 3.77[553] |
80 | GSTO2 | Glutathione S-transferase omega-2 | [554] | 1.25[555] | 3.47[556] | 1.17[557] | -2.46[558] | 0.27[559] | -0.83[560] |
81 | SLC26A2 | Sulfate transporter | [561] | 3.78[562] | 3.69[563] | 3.54[564] | 5.01[565] | 6.85[566] | 1.43[567] |
82 | GSTM2 | Glutathione S-transferase Mu 2 | [568] | 2.88[569] | 1.18[570] | 3.10[571] | 3.84[572] | 3.76[573] | 0.42[574] |
83 | GSTT2B | Glutathione S-transferase theta-2B | [575] | [576] | [577] | [578] | [579] | [580] | [581] |
84 | SULT1B1 | Sulfotransferase family cytosolic 1B member 1 | [582] | -2.38[583] | -1.52[584] | -2.19[585] | [586] | 1.20[587] | 3.37[588] |
85 | UGT2A2 | [589] | [590] | [591] | [592] | [593] | [594] | [595] | |
86 | GSTM1 | Glutathione S-transferase Mu 1 | [596] | 0.17[597] | -1.56[598] | 4.73[599] | 6.46[600] | -1.38[601] | 6.97[602] |
87 | UGT1A5 | UDP-glucuronosyltransferase 1-5 | [603] | -3.76[604] | [605] | -5.27[606] | -0.91[607] | [608] | 1.72[609] |
88 | UGT2B11 | UDP-glucuronosyltransferase 2B11 | [610] | 2.70[611] | 0.90[612] | 2.28[613] | -3.91[614] | [615] | 1.23[616] |
89 | GGT6 | Glutathione hydrolase 6 | [617] | 2.81[618] | 2.90[619] | 1.30[620] | 1.38[621] | 1.23[622] | 0.40[623] |
90 | UGT2B28 | UDP-glucuronosyltransferase 2B28 | [624] | 2.47[625] | 2.54[626] | -1.58[627] | -4.50[628] | [629] | 1.18[630] |
91 | UGT3A2 | UDP-glucuronosyltransferase 3A2 | [631] | -2.25[632] | [633] | [634] | -2.15[635] | 0.16[636] | -0.62[637] |
92 | ACSM1 | Acyl-coenzyme A synthetase ACSM1, mitochondrial | [638] | 2.64[639] | -0.05[640] | 0.72[641] | -2.77[642] | -2.47[643] | 0.44[644] |
93 | SULT1C4 | Sulfotransferase 1C4 | [645] | 3.35[646] | 2.82[647] | 1.80[648] | -4.97[649] | -4.37[650] | 1.05[651] |
94 | GGT5 | Glutathione hydrolase 5 proenzyme | [652] | 7.06[653] | 4.00[654] | -0.75[655] | 6.28[656] | 6.98[657] | 6.04[658] |
95 | GSTA5 | Glutathione S-transferase A5 | [659] | -4.58[660] | [661] | -4.32[662] | [663] | [664] | [665] |
96 | ACSM4 | Acyl-coenzyme A synthetase ACSM4, mitochondrial | [666] | -0.02[667] | 1.27[668] | -4.40[669] | [670] | -3.30[671] | -2.81[672] |
97 | HPGDS | Hematopoietic prostaglandin D synthase | [673] | [674] | [675] | [676] | -3.66[677] | -0.94[678] | 0.38[679] |
98 | GSTA3 | Glutathione S-transferase A3 | [680] | -3.84[681] | [682] | -1.43[683] | 0.37[684] | [685] | [686] |
99 | GLYATL3 | Glycine N-acyltransferase-like protein 3 | [687] | -1.67[688] | 0.65[689] | -1.20[690] | [691] | -0.48[692] | -1.32[693] |
100 | UGT1A7 | UDP-glucuronosyltransferase 1-7 | [694] | 1.66[695] | [696] | 0.62[697] | 7.07[698] | 2.26[699] | 3.66[700] |
101 | SULT4A1 | Sulfotransferase 4A1 | [701] | 2.62[702] | [703] | [704] | [705] | 8.65[706] | 0.55[707] |
102 | GLYATL2 | Glycine N-acyltransferase-like protein 2 | [708] | [709] | [710] | [711] | [712] | [713] | [714] |
103 | SULT2B1 | Sulfotransferase family cytosolic 2B member 1 | [715] | [716] | [717] | [718] | [719] | [720] | [721] |
104 | SULT6B1 | Sulfotransferase 6B1 | [722] | [723] | [724] | [725] | [726] | [727] | [728] |
105 | BPNT2 | [729] | [730] | [731] | [732] | [733] | [734] | [735] | |
106 | GSTM5 | Glutathione S-transferase Mu 5 | [736] | [737] | [738] | [739] | [740] | [741] | [742] |
107 | UGT2A1 | UDP-glucuronosyltransferase 2A1 | [743] | [744] | [745] | [746] | [747] | [748] | [749] |
108 | UGT1A10 | UDP-glucuronosyltransferase 1-10 | [750] | [751] | [752] | [753] | [754] | [755] | [756] |
109 | UGT1A8 | UDP-glucuronosyltransferase 1-8 | [757] | [758] | [759] | [760] | [761] | [762] | [763] |