REACTOME_PEPTIDE_HORMONE_METABOLISM | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | CES1 | Liver carboxylesterase 1 | [1] | -2.27[2] | -9.48[3] | -9.80[4] | -2.30[5] | -9.98[6] | -1.89[7] |
2 | AGT | Angiotensinogen | [8] | -0.55[9] | -0.07[10] | -1.09[11] | -5.15[12] | -10.03[13] | 1.47[14] |
3 | CPB2 | Carboxypeptidase B2 | [15] | -4.21[16] | -1.98[17] | -2.27[18] | -10.90[19] | -10.83[20] | 0.07[21] |
4 | CTSD | Cathepsin D | [22] | 1.28[23] | 0.14[24] | 0.73[25] | 1.58[26] | -0.16[27] | 0.18[28] |
5 | SEC11C | Signal peptidase complex catalytic subunit SEC11C | [29] | -2.83[30] | -1.16[31] | -2.93[32] | -2.86[33] | -3.73[34] | -2.41[35] |
6 | CTSZ | Cathepsin Z | [36] | -9.04[37] | -9.14[38] | -1.55[39] | -0.81[40] | -0.69[41] | -2.78[42] |
7 | SEC11A | Signal peptidase complex catalytic subunit SEC11A | [43] | -0.43[44] | -0.35[45] | 0.25[46] | -0.34[47] | -0.42[48] | -3.14[49] |
8 | SPCS1 | Signal peptidase complex subunit 1 | [50] | -0.94[51] | -1.44[52] | -1.77[53] | -1.56[54] | -0.66[55] | -1.78[56] |
9 | ANPEP | Aminopeptidase N | [57] | 0.28[58] | 0.36[59] | -1.97[60] | -3.83[61] | -1.00[62] | 0.30[63] |
10 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | [64] | 2.30[65] | 1.83[66] | 1.92[67] | 2.75[68] | 2.72[69] | -1.62[70] |
11 | CTNNB1 | Catenin beta-1 | [71] | 2.90[72] | 1.91[73] | 3.38[74] | 2.22[75] | 2.63[76] | 0.72[77] |
12 | ATP6AP2 | Renin receptor | [78] | 0.64[79] | -0.07[80] | 0.93[81] | 1.76[82] | 2.84[83] | -0.38[84] |
13 | CPE | Carboxypeptidase E | [85] | 3.37[86] | 4.60[87] | -1.21[88] | 0.73[89] | 3.32[90] | -3.83[91] |
14 | SPCS2 | Signal peptidase complex subunit 2 | [92] | 1.64[93] | 1.11[94] | 1.01[95] | 1.34[96] | 1.52[97] | -0.01[98] |
15 | SPCS3 | Signal peptidase complex subunit 3 | [99] | 1.16[100] | 1.65[101] | 2.76[102] | 1.97[103] | 2.48[104] | 0.70[105] |
16 | INHBE | Inhibin beta E chain | [106] | 1.06[107] | 0.50[108] | -0.05[109] | -5.73[110] | -3.88[111] | 0.74[112] |
17 | DPP4 | Dipeptidyl peptidase 4 | [113] | 1.23[114] | 2.26[115] | 2.86[116] | 0.46[117] | 1.88[118] | -0.95[119] |
18 | IGF1 | Insulin-like growth factor I | [120] | -7.14[121] | -8.56[122] | -6.20[123] | -0.08[124] | -7.73[125] | 0.53[126] |
19 | KIF5B | Kinesin-1 heavy chain | [127] | 1.69[128] | 3.19[129] | 3.52[130] | 4.31[131] | 3.58[132] | 0.94[133] |
20 | BCHE | Cholinesterase | [134] | -11.05[135] | -10.41[136] | -8.29[137] | -0.39[138] | 1.05[139] | -0.03[140] |
21 | EXOC7 | Exocyst complex component 7 | [141] | 3.07[142] | 3.08[143] | 2.59[144] | 2.69[145] | 2.38[146] | 0.81[147] |
22 | RAB27A | Ras-related protein Rab-27A | [148] | -0.20[149] | -0.07[150] | 0.47[151] | 1.00[152] | 2.35[153] | 0.26[154] |
23 | INHBC | Inhibin beta C chain | [155] | -1.10[156] | -1.15[157] | -4.05[158] | -7.48[159] | -9.34[160] | 2.07[161] |
24 | SLC30A5 | Zinc transporter 5 | [162] | 1.49[163] | 1.64[164] | 2.42[165] | 2.48[166] | 2.33[167] | 0.63[168] |
25 | VAMP2 | Vesicle-associated membrane protein 2 | [169] | -0.07[170] | -0.18[171] | 0.74[172] | 1.00[173] | 0.98[174] | -0.58[175] |
26 | EXOC3 | Exocyst complex component 3 | [176] | 1.47[177] | 0.46[178] | 1.61[179] | 1.81[180] | 1.65[181] | -0.23[182] |
27 | ENPEP | Glutamyl aminopeptidase | [183] | -8.03[184] | [185] | -1.40[186] | -0.12[187] | -2.47[188] | 2.06[189] |
28 | KLF4 | Krueppel-like factor 4 | [190] | -0.92[191] | -5.14[192] | -1.88[193] | -2.70[194] | 1.86[195] | -2.32[196] |
29 | EXOC5 | Exocyst complex component 5 | [197] | 2.30[198] | 2.76[199] | 3.20[200] | 3.87[201] | 3.63[202] | 1.72[203] |
30 | EXOC6 | Exocyst complex component 6 | [204] | 0.53[205] | 2.15[206] | 3.17[207] | 0.98[208] | 0.87[209] | 0.34[210] |
31 | EXOC4 | Exocyst complex component 4 | [211] | 2.65[212] | 2.03[213] | 3.89[214] | 3.20[215] | 3.17[216] | 1.45[217] |
32 | GATA4 | Transcription factor GATA-4 | [218] | 2.07[219] | 1.53[220] | 3.52[221] | 0.24[222] | 3.36[223] | 0.20[224] |
33 | SLC30A6 | Zinc transporter 6 | [225] | 2.62[226] | 2.86[227] | 2.87[228] | 3.34[229] | 3.06[230] | 1.01[231] |
34 | EXOC2 | Exocyst complex component 2 | [232] | 2.90[233] | 2.44[234] | 2.59[235] | 3.87[236] | 2.74[237] | 1.29[238] |
35 | SLC30A7 | Zinc transporter 7 | [239] | 2.03[240] | 2.53[241] | 3.07[242] | 2.69[243] | 2.96[244] | 2.95[245] |
36 | MME | Neprilysin | [246] | -6.64[247] | -7.06[248] | -5.68[249] | 0.90[250] | 5.45[251] | 1.28[252] |
37 | EXOC1 | Exocyst complex component 1 | [253] | 1.91[254] | 1.74[255] | 2.41[256] | 2.96[257] | 3.36[258] | 0.79[259] |
38 | TCF7L2 | Transcription factor 7-like 2 | [260] | 2.15[261] | 2.44[262] | 3.21[263] | 2.16[264] | 2.32[265] | 1.34[266] |
39 | MYRIP | Rab effector MyRIP | [267] | -4.01[268] | -8.69[269] | -3.54[270] | -5.77[271] | -5.05[272] | 1.80[273] |
40 | ACHE | Acetylcholinesterase | [274] | -0.81[275] | -3.61[276] | -0.01[277] | -3.69[278] | -2.88[279] | -4.84[280] |
41 | EXOC8 | Exocyst complex component 8 | [281] | 1.86[282] | 1.53[283] | 3.77[284] | 3.25[285] | 3.08[286] | 1.59[287] |
42 | INHBB | Inhibin beta B chain | [288] | 4.44[289] | -2.71[290] | -4.10[291] | -0.95[292] | 5.23[293] | -0.10[294] |
43 | INHBA | Inhibin beta A chain | [295] | -6.21[296] | -6.40[297] | -5.38[298] | 4.39[299] | 0.96[300] | 0.22[301] |
44 | POMC | Pro-opiomelanocortin | [302] | [303] | -7.56[304] | [305] | [306] | -5.47[307] | -2.58[308] |
45 | PLA2G7 | Platelet-activating factor acetylhydrolase | [309] | -4.86[310] | -3.57[311] | 4.49[312] | -3.31[313] | -2.85[314] | -0.45[315] |
46 | CTSG | Cathepsin G | [316] | [317] | [318] | [319] | [320] | [321] | -2.55[322] |
47 | STX1A | Syntaxin-1A | [323] | 2.22[324] | 1.71[325] | 0.79[326] | 4.06[327] | 3.24[328] | -1.55[329] |
48 | MYO5A | Unconventional myosin-Va | [330] | 3.72[331] | 3.48[332] | 3.17[333] | 6.18[334] | 5.81[335] | 2.70[336] |
49 | UCN | Urocortin | [337] | -0.70[338] | 0.42[339] | 0.23[340] | -0.49[341] | -1.17[342] | -2.41[343] |
50 | CPA3 | Mast cell carboxypeptidase A | [344] | [345] | [346] | [347] | -2.03[348] | -3.90[349] | -0.83[350] |
51 | ACE | Angiotensin-converting enzyme | [351] | -3.47[352] | -6.45[353] | -3.36[354] | -0.54[355] | -1.21[356] | 1.79[357] |
52 | ACE2 | Angiotensin-converting enzyme 2 | [358] | 0.97[359] | 1.83[360] | 1.43[361] | -5.55[362] | -4.78[363] | -0.46[364] |
53 | CMA1 | Chymase | [365] | -3.56[366] | -5.82[367] | [368] | -6.27[369] | [370] | -2.75[371] |
54 | REN | Renin | [372] | -1.66[373] | [374] | [375] | -0.40[376] | [377] | -2.23[378] |
55 | GZMH | Granzyme H | [379] | [380] | [381] | [382] | [383] | [384] | -0.78[385] |
56 | INHA | Inhibin alpha chain | [386] | 5.92[387] | 6.21[388] | 3.76[389] | 1.20[390] | 3.23[391] | -2.83[392] |
57 | KIF5C | Kinesin heavy chain isoform 5C | [393] | 4.53[394] | -2.34[395] | 6.85[396] | 3.85[397] | 5.80[398] | 0.96[399] |
58 | CGA | Glycoprotein hormones alpha chain | [400] | [401] | [402] | -0.98[403] | -2.05[404] | -3.18[405] | -4.49[406] |
59 | PAX6 | Paired box protein Pax-6 | [407] | 6.95[408] | 4.80[409] | 7.04[410] | 6.22[411] | 3.24[412] | 1.98[413] |
60 | GPR119 | Glucose-dependent insulinotropic receptor | [414] | 1.36[415] | 3.01[416] | -0.15[417] | [418] | [419] | [420] |
61 | GNB3 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 | [421] | 2.87[422] | 4.65[423] | 4.51[424] | 2.47[425] | 5.37[426] | -2.07[427] |
62 | KIF5A | Kinesin heavy chain isoform 5A | [428] | 5.01[429] | 7.22[430] | 1.39[431] | 7.22[432] | 6.52[433] | -2.92[434] |
63 | MBOAT4 | Ghrelin O-acyltransferase | [435] | 4.56[436] | 4.34[437] | 6.82[438] | 2.16[439] | 0.89[440] | 1.85[441] |
64 | PCSK1 | Neuroendocrine convertase 1 | [442] | -2.09[443] | 1.06[444] | 1.82[445] | 5.78[446] | 7.75[447] | 4.82[448] |
65 | LEP | Leptin | [449] | -0.04[450] | 0.45[451] | 0.48[452] | 0.61[453] | -0.53[454] | 1.92[455] |
66 | SLC30A8 | Zinc transporter 8 | [456] | 1.85[457] | 2.45[458] | 2.32[459] | 10.45[460] | 3.54[461] | -0.28[462] |
67 | CRHR2 | Corticotropin-releasing factor receptor 2 | [463] | -1.85[464] | [465] | 1.49[466] | -0.64[467] | 1.89[468] | -0.31[469] |
68 | CDX2 | Homeobox protein CDX-2 | [470] | 4.02[471] | 3.16[472] | 13.16[473] | 2.95[474] | 2.36[475] | -1.71[476] |
69 | PCSK2 | Neuroendocrine convertase 2 | [477] | [478] | [479] | -0.79[480] | 4.10[481] | [482] | 3.20[483] |
70 | FFAR4 | Free fatty acid receptor 4 | [484] | [485] | [486] | [487] | [488] | [489] | [490] |
71 | ERO1A | ERO1-like protein alpha | [491] | [492] | [493] | [494] | [495] | [496] | [497] |
72 | LHB | Lutropin subunit beta | [498] | [499] | [500] | [501] | [502] | [503] | [504] |
73 | CPB1 | Carboxypeptidase B | [505] | [506] | [507] | [508] | [509] | [510] | [511] |
74 | CLTRN | [512] | [513] | [514] | [515] | [516] | [517] | [518] | |
75 | INS | Insulin | [519] | [520] | [521] | [522] | [523] | [524] | [525] |
76 | GNG13 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 | [526] | [527] | [528] | [529] | [530] | [531] | |
77 | GHRL | Appetite-regulating hormone | [532] | [533] | [534] | [535] | [536] | [537] | [538] |
78 | CGB5 | [539] | [540] | [541] | [542] | [543] | [544] | [545] | |
79 | CGB8 | [546] | [547] | [548] | [549] | [550] | [551] | [552] | |
80 | GCG | Glucagon | [553] | [554] | [555] | [556] | [557] | [558] | [559] |
81 | ISL1 | Insulin gene enhancer protein ISL-1 | [560] | [561] | [562] | [563] | [564] | [565] | [566] |
82 | ERO1B | ERO1-like protein beta | [567] | [568] | [569] | [570] | [571] | [572] | [573] |
83 | CGB3 | Choriogonadotropin subunit beta 3 | [574] | [575] | [576] | [577] | [578] | [579] | [580] |
84 | GNAT3 | Guanine nucleotide-binding protein G(t) subunit alpha-3 | [581] | [582] | [583] | [584] | [585] | [586] | [587] |
85 | FSHB | Follitropin subunit beta | [588] | [589] | [590] | [591] | [592] | [593] | [594] |
86 | AOPEP | Aminopeptidase O | [595] | [596] | [597] | [598] | [599] | [600] | [601] |
87 | GRP | Gastrin-releasing peptide | [602] | [603] | [604] | [605] | [606] | [607] | [608] |
88 | TSHB | Thyrotropin subunit beta | [609] | [610] | [611] | [612] | [613] | [614] | [615] |
89 | FFAR1 | Free fatty acid receptor 1 | [616] | [617] | [618] | [619] | [620] | [621] | [622] |
90 | GIP | Gastric inhibitory polypeptide | [623] | [624] | [625] | [626] | [627] | [628] | [629] |
91 | GH1 | Somatotropin | [630] | [631] | [632] | [633] | [634] | [635] | [636] |