REACTOME_PD_1_SIGNALING Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 HLA-DRA HLA class II histocompatibility antigen, DR alpha chain [1] -11.99[2] [3] -13.18[4] -4.53[5] -7.15[6] -0.49[7]
2 PTPN11 Tyrosine-protein phosphatase non-receptor type 11 [8] 1.72[9] 1.97[10] 1.92[11] 2.11[12] 2.05[13] 1.34[14]
3 HLA-DRB1 HLA class II histocompatibility antigen, DRB1-15 beta chain [15] -7.16[16] [17] [18] -4.88[19] -10.65[20] -1.58[21]
4 CD4 T-cell surface glycoprotein CD4 [22] -4.48[23] -2.48[24] -5.11[25] -6.23[26] -8.98[27] 0.00[28]
5 CSK Tyrosine-protein kinase CSK [29] 1.65[30] 0.97[31] 1.34[32] 1.21[33] 0.11[34] -0.78[35]
6 HLA-DPA1 HLA class II histocompatibility antigen, DP alpha 1 chain [36] -5.66[37] -9.35[38] [39] -3.87[40] -6.42[41] -0.20[42]
7 HLA-DRB5 HLA class II histocompatibility antigen, DR beta 5 chain [43] -9.81[44] [45] [46] -7.14[47] [48] -5.77[49]
8 PTPN6 Tyrosine-protein phosphatase non-receptor type 6 [50] 0.81[51] 0.82[52] 1.40[53] -5.92[54] -1.59[55] -0.10[56]
9 HLA-DPB1 HLA class II histocompatibility antigen, DP beta 1 chain [57] -7.76[58] -9.01[59] [60] -2.72[61] -1.41[62] 0.59[63]
10 HLA-DQA1 HLA class II histocompatibility antigen, DQ alpha 1 chain [64] [65] [66] [67] -5.55[68] -9.89[69] -0.79[70]
11 HLA-DQB1 HLA class II histocompatibility antigen, DQ beta 1 chain [71] -3.68[72] [73] [74] -2.56[75] [76] -0.88[77]
12 HLA-DQA2 HLA class II histocompatibility antigen, DQ alpha 2 chain [78] [79] [80] [81] -7.51[82] [83] -3.39[84]
13 CD3E T-cell surface glycoprotein CD3 epsilon chain [85] -7.59[86] [87] -4.30[88] [89] [90] -0.53[91]
14 CD274 Programmed cell death 1 ligand 1 [92] -1.87[93] -3.32[94] -4.76[95] 0.98[96] 4.68[97] 0.73[98]
15 CD247 T-cell surface glycoprotein CD3 zeta chain [99] -3.59[100] -4.45[101] -5.95[102] -2.29[103] -4.37[104] 0.07[105]
16 CD3D T-cell surface glycoprotein CD3 delta chain [106] 2.67[107] 0.48[108] -1.89[109] -5.28[110] -3.98[111] -0.25[112]
17 LCK Tyrosine-protein kinase Lck [113] 4.05[114] 3.95[115] -6.05[116] -3.86[117] -4.76[118] 1.31[119]
18 CD3G T-cell surface glycoprotein CD3 gamma chain [120] -2.32[121] -1.74[122] -2.81[123] -3.39[124] -3.49[125] -0.26[126]
19 PDCD1LG2 Programmed cell death 1 ligand 2 [127] -5.22[128] [129] [130] 0.80[131] 4.71[132] 1.58[133]
20 HLA-DQB2 HLA class II histocompatibility antigen, DQ beta 2 chain [134] [135] [136] [137] -2.19[138] [139] -2.88[140]
21 PDCD1 Programmed cell death protein 1 [141] 6.11[142] 2.62[143] [144] 0.99[145] [146] 2.70[147]
22 TRAV8-4 T-cell receptor alpha variable 8-4 (Fragment) [148] [149] [150] [151] [152] [153] [154]
23 TRBV7-9 T-cell receptor beta variable 7-9 (Fragment) [155] [156] [157] [158] [159] [160] [161]
24 TRBV12-3 T-cell receptor beta chain V region YT35 [162] [163] [164] [165] [166] [167] [168]
25 TRAV29DV5 [169] [170] [171] [172] [173] [174] [175]
26 TRAV19 T-cell receptor alpha variable 19 (Fragment) [176] [177] [178] [179] [180] [181] [182]
27 HLA-DRB3 HLA class II histocompatibility antigen, DR beta 3 chain [183] [184] [185] [186] [187] [188] [189]
28 HLA-DRB4 HLA class II histocompatibility antigen, DR beta 4 chain [190] [191] [192] [193] [194] [195] [196]
[1]
ref_hepatocyte HLA-DRA
Mean 28.7
Standard deviation 43
Values 0 1.6 6.7 33 1e+02
[2]
HepG2 HLA-DRA
Mean 0.00643
Standard deviation 0.0091
Values 0 0.013
[3]
HepG2.C3A HLA-DRA
Mean 0
Standard deviation 0
Values 0 0
[4]
HuH.7 HLA-DRA
Mean 0.00273
Standard deviation 0.0047
Values 0.0082 0 0
[5]
SNU475 HLA-DRA
Mean 0.979
Standard deviation 0.57
Values 0.58 1.4
[6]
THLE HLA-DRA
Mean 0.289
Standard deviation 0.31
Values 0.51 0.069
[7]
liver HLA-DRA
Mean 27.5
Standard deviation 9.7
Values 29 26 39 16
[8]
ref_hepatocyte PTPN11
Mean 22.2
Standard deviation 20
Values 33 53 10 7.5 7.4
[9]
HepG2 PTPN11
Mean 66.7
Standard deviation 12
Values 58 76
[10]
HepG2.C3A PTPN11
Mean 80.2
Standard deviation 17
Values 68 92
[11]
HuH.7 PTPN11
Mean 74.5
Standard deviation 12
Values 86 77 61
[12]
SNU475 PTPN11
Mean 75.4
Standard deviation 0.72
Values 75 76
[13]
THLE PTPN11
Mean 131
Standard deviation 5.1
Values 1.3e+02 1.3e+02
[14]
liver PTPN11
Mean 75.4
Standard deviation 18
Values 60 99 62 80
[15]
ref_hepatocyte HLA-DRB1
Mean 19
Standard deviation 28
Values 0 0.7 4 24 66
[16]
HepG2 HLA-DRB1
Mean 0.121
Standard deviation 0.017
Values 0.11 0.13
[17]
HepG2.C3A HLA-DRB1
Mean 0
Standard deviation 0
Values 0 0
[18]
HuH.7 HLA-DRB1
Mean 0
Standard deviation 0
Values 0 0 0
[19]
SNU475 HLA-DRB1
Mean 0.506
Standard deviation 0.45
Values 0.19 0.83
[20]
THLE HLA-DRB1
Mean 0.0169
Standard deviation 0.0013
Values 0.018 0.016
[21]
liver HLA-DRB1
Mean 8.55
Standard deviation 3.8
Values 10 6.5 13 4.6
[22]
ref_hepatocyte CD4
Mean 14.9
Standard deviation 25
Values 0.42 0 1.1 15 59
[23]
HepG2 CD4
Mean 0.611
Standard deviation 0.26
Values 0.42 0.8
[24]
HepG2.C3A CD4
Mean 2.47
Standard deviation 0.32
Values 2.2 2.7
[25]
HuH.7 CD4
Mean 0.383
Standard deviation 0.15
Values 0.28 0.55 0.32
[26]
SNU475 CD4
Mean 0.157
Standard deviation 0.028
Values 0.18 0.14
[27]
THLE CD4
Mean 0.0423
Standard deviation 0.0071
Values 0.047 0.037
[28]
liver CD4
Mean 20
Standard deviation 8
Values 22 15 30 13
[29]
ref_hepatocyte CSK
Mean 10.6
Standard deviation 1.8
Values 11 8.9 13 9 11
[30]
HepG2 CSK
Mean 30.4
Standard deviation 3.7
Values 33 28
[31]
HepG2.C3A CSK
Mean 19.1
Standard deviation 3
Values 21 17
[32]
HuH.7 CSK
Mean 23.7
Standard deviation 5.3
Values 27 18 26
[33]
SNU475 CSK
Mean 19.3
Standard deviation 0.29
Values 19 20
[34]
THLE CSK
Mean 16.3
Standard deviation 1.9
Values 15 18
[35]
liver CSK
Mean 8.27
Standard deviation 2.7
Values 7.6 6.5 6.7 12
[36]
ref_hepatocyte HLA-DPA1
Mean 7.23
Standard deviation 11
Values 0 0 0.78 9.4 26
[37]
HepG2 HLA-DPA1
Mean 0.13
Standard deviation 0.022
Values 0.11 0.15
[38]
HepG2.C3A HLA-DPA1
Mean 0.0102
Standard deviation 0.00071
Values 0.0097 0.011
[39]
HuH.7 HLA-DPA1
Mean 0
Standard deviation 0
Values 0 0 0
[40]
SNU475 HLA-DPA1
Mean 0.388
Standard deviation 0.18
Values 0.26 0.52
[41]
THLE HLA-DPA1
Mean 0.12
Standard deviation 0.0028
Values 0.12 0.12
[42]
liver HLA-DPA1
Mean 8.44
Standard deviation 3.8
Values 8 7.7 14 4.4
[43]
ref_hepatocyte HLA-DRB5
Mean 7.06
Standard deviation 9.7
Values 0 0.3 1.2 12 22
[44]
HepG2 HLA-DRB5
Mean 0.00716
Standard deviation 0.002
Values 0.0057 0.0086
[45]
HepG2.C3A HLA-DRB5
Mean 0
Standard deviation 0
Values 0 0
[46]
HuH.7 HLA-DRB5
Mean 0
Standard deviation 0
Values 0 0 0
[47]
SNU475 HLA-DRB5
Mean 0.0395
Standard deviation 0.023
Values 0.023 0.056
[48]
THLE HLA-DRB5
Mean 0
Standard deviation 0
Values 0 0
[49]
liver HLA-DRB5
Mean 0.174
Standard deviation 0.13
Values 0.024 0.21 0.13 0.33
[50]
ref_hepatocyte PTPN6
Mean 5.33
Standard deviation 3
Values 2.2 3.1 4.4 7.6 9.3
[51]
HepG2 PTPN6
Mean 8.54
Standard deviation 0.054
Values 8.5 8.6
[52]
HepG2.C3A PTPN6
Mean 8.69
Standard deviation 0.18
Values 8.6 8.8
[53]
HuH.7 PTPN6
Mean 12.4
Standard deviation 1.9
Values 13 10 14
[54]
SNU475 PTPN6
Mean 0.0694
Standard deviation 0.026
Values 0.088 0.051
[55]
THLE PTPN6
Mean 2.52
Standard deviation 0.67
Values 2 3
[56]
liver PTPN6
Mean 6.69
Standard deviation 2
Values 7.5 4.8 9.1 5.4
[57]
ref_hepatocyte HLA-DPB1
Mean 2.72
Standard deviation 4.1
Values 0 0.057 0.57 3.4 9.5
[58]
HepG2 HLA-DPB1
Mean 0.0115
Standard deviation 0.016
Values 0.023 0
[59]
HepG2.C3A HLA-DPB1
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[60]
HuH.7 HLA-DPB1
Mean 0
Standard deviation 0
Values 0 0 0
[61]
SNU475 HLA-DPB1
Mean 0.326
Standard deviation 0.21
Values 0.18 0.48
[62]
THLE HLA-DPB1
Mean 1.46
Standard deviation 0.22
Values 1.6 1.3
[63]
liver HLA-DPB1
Mean 5.52
Standard deviation 1.3
Values 4.5 5 7.5 5.1
[64]
ref_hepatocyte HLA-DQA1
Mean 1.97
Standard deviation 2.6
Values 0 0 1.1 2.4 6.3
[65]
HepG2 HLA-DQA1
Mean 0
Standard deviation 0
Values 0 0
[66]
HepG2.C3A HLA-DQA1
Mean 0
Standard deviation 0
Values 0 0
[67]
HuH.7 HLA-DQA1
Mean 0
Standard deviation 0
Values 0 0 0
[68]
SNU475 HLA-DQA1
Mean 0.0329
Standard deviation 0.047
Values 0 0.066
[69]
THLE HLA-DQA1
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[70]
liver HLA-DQA1
Mean 1.53
Standard deviation 0.68
Values 0.8 2 1.1 2.2
[71]
ref_hepatocyte HLA-DQB1
Mean 1.81
Standard deviation 2.6
Values 0 0 0.095 3 5.9
[72]
HepG2 HLA-DQB1
Mean 0.129
Standard deviation 0.037
Values 0.15 0.1
[73]
HepG2.C3A HLA-DQB1
Mean 0
Standard deviation 0
Values 0 0
[74]
HuH.7 HLA-DQB1
Mean 0
Standard deviation 0
Values 0 0 0
[75]
SNU475 HLA-DQB1
Mean 0.24
Standard deviation 0.25
Values 0.06 0.42
[76]
THLE HLA-DQB1
Mean 0
Standard deviation 0
Values 0 0
[77]
liver HLA-DQB1
Mean 1.32
Standard deviation 1.6
Values 0.45 0.33 0.85 3.6
[78]
ref_hepatocyte HLA-DQA2
Mean 1.18
Standard deviation 2.3
Values 0 0 0.022 0.67 5.2
[79]
HepG2 HLA-DQA2
Mean 0
Standard deviation 0
Values 0 0
[80]
HepG2.C3A HLA-DQA2
Mean 0
Standard deviation 0
Values 0 0
[81]
HuH.7 HLA-DQA2
Mean 0
Standard deviation 0
Values 0 0 0
[82]
SNU475 HLA-DQA2
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[83]
THLE HLA-DQA2
Mean 0
Standard deviation 0
Values 0 0
[84]
liver HLA-DQA2
Mean 0.15
Standard deviation 0.059
Values 0.16 0.23 0.1 0.11
[85]
ref_hepatocyte CD3E
Mean 0.605
Standard deviation 0.94
Values 0 0.078 0 0.75 2.2
[86]
HepG2 CD3E
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[87]
HepG2.C3A CD3E
Mean 0
Standard deviation 0
Values 0 0
[88]
HuH.7 CD3E
Mean 0.0273
Standard deviation 0.032
Values 0.0082 0.064 0.0094
[89]
SNU475 CD3E
Mean 0
Standard deviation 0
Values 0 0
[90]
THLE CD3E
Mean 0
Standard deviation 0
Values 0 0
[91]
liver CD3E
Mean 0.564
Standard deviation 0.34
Values 0.94 0.21 0.74 0.36
[92]
ref_hepatocyte CD274
Mean 0.501
Standard deviation 0.62
Values 0 0.6 1.5 0.23 0.13
[93]
HepG2 CD274
Mean 0.125
Standard deviation 0.025
Values 0.14 0.11
[94]
HepG2.C3A CD274
Mean 0.0463
Standard deviation 0.01
Values 0.039 0.054
[95]
HuH.7 CD274
Mean 0.0164
Standard deviation 0.01
Values 0.0082 0.013 0.028
[96]
SNU475 CD274
Mean 0.776
Standard deviation 0.17
Values 0.65 0.9
[97]
THLE CD274
Mean 18.4
Standard deviation 4.5
Values 22 15
[98]
liver CD274
Mean 1.12
Standard deviation 0.24
Values 0.99 1.5 0.92 1.1
[99]
ref_hepatocyte CD247
Mean 0.369
Standard deviation 0.47
Values 0 0 0.22 0.51 1.1
[100]
HepG2 CD247
Mean 0.0279
Standard deviation 0.015
Values 0.017 0.039
[101]
HepG2.C3A CD247
Mean 0.0156
Standard deviation 0.0083
Values 0.0097 0.021
[102]
HuH.7 CD247
Mean 0.00526
Standard deviation 0.0048
Values 0 0.0064 0.0094
[103]
SNU475 CD247
Mean 0.0593
Standard deviation 0.038
Values 0.032 0.086
[104]
THLE CD247
Mean 0.0254
Standard deviation 0.0059
Values 0.03 0.021
[105]
liver CD247
Mean 0.518
Standard deviation 0.17
Values 0.28 0.51 0.69 0.58
[106]
ref_hepatocyte CD3D
Mean 0.343
Standard deviation 0.47
Values 0 0.4 0 0.2 1.1
[107]
HepG2 CD3D
Mean 2
Standard deviation 2.2
Values 3.6 0.42
[108]
HepG2.C3A CD3D
Mean 0.441
Standard deviation 0.23
Values 0.28 0.6
[109]
HuH.7 CD3D
Mean 0.082
Standard deviation 0.059
Values 0.033 0.15 0.066
[110]
SNU475 CD3D
Mean 0.00696
Standard deviation 0.0098
Values 0.014 0
[111]
THLE CD3D
Mean 0.031
Standard deviation 0.0063
Values 0.035 0.027
[112]
liver CD3D
Mean 0.389
Standard deviation 0.39
Values 0.42 0.11 0.92 0.093
[113]
ref_hepatocyte LCK
Mean 0.319
Standard deviation 0.43
Values 0.11 0 0.49 0 0.99
[114]
HepG2 LCK
Mean 4.84
Standard deviation 4.4
Values 8 1.7
[115]
HepG2.C3A LCK
Mean 4.55
Standard deviation 0.16
Values 4.4 4.7
[116]
HuH.7 LCK
Mean 0.00428
Standard deviation 0.0074
Values 0 0.013 0
[117]
SNU475 LCK
Mean 0.0173
Standard deviation 0.011
Values 0.0093 0.025
[118]
THLE LCK
Mean 0.0169
Standard deviation 0.0013
Values 0.018 0.016
[119]
liver LCK
Mean 1.07
Standard deviation 0.51
Values 1.2 0.49 1.7 0.91
[120]
ref_hepatocyte CD3G
Mean 0.262
Standard deviation 0.26
Values 0.28 0 0 0.49 0.54
[121]
HepG2 CD3G
Mean 0.048
Standard deviation 0.013
Values 0.057 0.039
[122]
HepG2.C3A CD3G
Mean 0.0721
Standard deviation 0.019
Values 0.058 0.086
[123]
HuH.7 CD3G
Mean 0.0331
Standard deviation 0.0052
Values 0.033 0.039 0.028
[124]
SNU475 CD3G
Mean 0.0196
Standard deviation 0.0081
Values 0.014 0.025
[125]
THLE CD3G
Mean 0.0331
Standard deviation 0.013
Values 0.024 0.043
[126]
liver CD3G
Mean 0.293
Standard deviation 0.14
Values 0.14 0.46 0.23 0.34
[127]
ref_hepatocyte PDCD1LG2
Mean 0.234
Standard deviation 0.35
Values 0 0 0.84 0.23 0.098
[128]
HepG2 PDCD1LG2
Mean 0.00573
Standard deviation 0.0081
Values 0.011 0
[129]
HepG2.C3A PDCD1LG2
Mean 0
Standard deviation 0
Values 0 0
[130]
HuH.7 PDCD1LG2
Mean 0
Standard deviation 0
Values 0 0 0
[131]
SNU475 PDCD1LG2
Mean 0.321
Standard deviation 0.19
Values 0.19 0.46
[132]
THLE PDCD1LG2
Mean 8.77
Standard deviation 0.85
Values 9.4 8.2
[133]
liver PDCD1LG2
Mean 0.941
Standard deviation 0.52
Values 0.52 1.6 1.1 0.57
[134]
ref_hepatocyte HLA-DQB2
Mean 0.158
Standard deviation 0.28
Values 0 0 0 0.15 0.64
[135]
HepG2 HLA-DQB2
Mean 0
Standard deviation 0
Values 0 0
[136]
HepG2.C3A HLA-DQB2
Mean 0
Standard deviation 0
Values 0 0
[137]
HuH.7 HLA-DQB2
Mean 0
Standard deviation 0
Values 0 0 0
[138]
SNU475 HLA-DQB2
Mean 0.0272
Standard deviation 0.019
Values 0.014 0.041
[139]
THLE HLA-DQB2
Mean 0
Standard deviation 0
Values 0 0
[140]
liver HLA-DQB2
Mean 0.0289
Standard deviation 0.021
Values 0.047 0.043 0.026 0
[141]
ref_hepatocyte PDCD1
Mean 0.0138
Standard deviation 0.031
Values 0 0 0 0.069 0
[142]
HepG2 PDCD1
Mean 0.867
Standard deviation 0.25
Values 1 0.69
[143]
HepG2.C3A PDCD1
Mean 0.0779
Standard deviation 0.041
Values 0.049 0.11
[144]
HuH.7 PDCD1
Mean 0
Standard deviation 0
Values 0 0 0
[145]
SNU475 PDCD1
Mean 0.0215
Standard deviation 0.0089
Values 0.028 0.015
[146]
THLE PDCD1
Mean 0
Standard deviation 0
Values 0 0
[147]
liver PDCD1
Mean 0.12
Standard deviation 0.086
Values 0.047 0.057 0.23 0.15
[148]
ref_hepatocyte TRAV8-4
Missing
[149]
HepG2 TRAV8-4
Missing
[150]
HepG2.C3A TRAV8-4
Missing
[151]
HuH.7 TRAV8-4
Missing
[152]
SNU475 TRAV8-4
Missing
[153]
THLE TRAV8-4
Missing
[154]
liver TRAV8-4
Missing
[155]
ref_hepatocyte TRBV7-9
Missing
[156]
HepG2 TRBV7-9
Missing
[157]
HepG2.C3A TRBV7-9
Missing
[158]
HuH.7 TRBV7-9
Missing
[159]
SNU475 TRBV7-9
Missing
[160]
THLE TRBV7-9
Missing
[161]
liver TRBV7-9
Missing
[162]
ref_hepatocyte TRBV12-3
Missing
[163]
HepG2 TRBV12-3
Missing
[164]
HepG2.C3A TRBV12-3
Missing
[165]
HuH.7 TRBV12-3
Missing
[166]
SNU475 TRBV12-3
Missing
[167]
THLE TRBV12-3
Missing
[168]
liver TRBV12-3
Missing
[169]
ref_hepatocyte TRAV29DV5
Missing
[170]
HepG2 TRAV29DV5
Missing
[171]
HepG2.C3A TRAV29DV5
Missing
[172]
HuH.7 TRAV29DV5
Missing
[173]
SNU475 TRAV29DV5
Missing
[174]
THLE TRAV29DV5
Missing
[175]
liver TRAV29DV5
Missing
[176]
ref_hepatocyte TRAV19
Missing
[177]
HepG2 TRAV19
Missing
[178]
HepG2.C3A TRAV19
Missing
[179]
HuH.7 TRAV19
Missing
[180]
SNU475 TRAV19
Missing
[181]
THLE TRAV19
Missing
[182]
liver TRAV19
Missing
[183]
ref_hepatocyte HLA-DRB3
Missing
[184]
HepG2 HLA-DRB3
Missing
[185]
HepG2.C3A HLA-DRB3
Missing
[186]
HuH.7 HLA-DRB3
Missing
[187]
SNU475 HLA-DRB3
Missing
[188]
THLE HLA-DRB3
Missing
[189]
liver HLA-DRB3
Missing
[190]
ref_hepatocyte HLA-DRB4
Missing
[191]
HepG2 HLA-DRB4
Missing
[192]
HepG2.C3A HLA-DRB4
Missing
[193]
HuH.7 HLA-DRB4
Missing
[194]
SNU475 HLA-DRB4
Missing
[195]
THLE HLA-DRB4
Missing
[196]
liver HLA-DRB4
Missing