REACTOME_PCP_CE_PATHWAY | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -1.15[2] | -1.16[3] | -1.12[4] | -1.52[5] | -1.17[6] | -0.48[7] |
2 | PFN1 | Profilin-1 | [8] | -1.21[9] | -1.42[10] | -1.27[11] | -0.77[12] | -1.20[13] | -1.44[14] |
3 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [15] | [16] | [17] | [18] | [19] | [20] | [21] |
4 | UBC | Polyubiquitin-C | [22] | -0.71[23] | -0.41[24] | -0.75[25] | -0.67[26] | -0.79[27] | -0.03[28] |
5 | RHOA | Transforming protein RhoA | [29] | 0.11[30] | -0.20[31] | -0.09[32] | 0.03[33] | 0.38[34] | 0.07[35] |
6 | PSME1 | Proteasome activator complex subunit 1 | [36] | -0.48[37] | -2.00[38] | -1.72[39] | -1.39[40] | -2.02[41] | -0.98[42] |
7 | CLTA | Clathrin light chain A | [43] | -0.83[44] | -0.82[45] | -0.81[46] | -1.20[47] | -0.94[48] | -1.87[49] |
8 | PSME2 | Proteasome activator complex subunit 2 | [50] | -0.29[51] | -1.62[52] | -1.81[53] | -1.17[54] | -1.55[55] | -0.60[56] |
9 | PSMA7 | Proteasome subunit alpha type-7 | [57] | 0.66[58] | 0.85[59] | -0.56[60] | 0.45[61] | -0.08[62] | 0.42[63] |
10 | PSMB1 | Proteasome subunit beta type-1 | [64] | 0.21[65] | 0.40[66] | -0.76[67] | -0.79[68] | -0.12[69] | 0.26[70] |
11 | PSMB3 | Proteasome subunit beta type-3 | [71] | -0.27[72] | -0.99[73] | -0.04[74] | -0.81[75] | -1.02[76] | -0.04[77] |
12 | PSMB4 | Proteasome subunit beta type-4 | [78] | -0.03[79] | 0.21[80] | 0.26[81] | 0.62[82] | 0.52[83] | -0.37[84] |
13 | PSMB7 | Proteasome subunit beta type-7 | [85] | -0.97[86] | -0.89[87] | -0.84[88] | -1.16[89] | -0.81[90] | -0.81[91] |
14 | PSMB5 | Proteasome subunit beta type-5 | [92] | 1.43[93] | 0.07[94] | -0.08[95] | -0.44[96] | -0.24[97] | -0.33[98] |
15 | PSMA6 | Proteasome subunit alpha type-6 | [99] | 1.55[100] | 0.35[101] | 0.20[102] | 0.09[103] | 0.02[104] | -0.25[105] |
16 | PSMA4 | Proteasome subunit alpha type-4 | [106] | -0.38[107] | 0.37[108] | 0.08[109] | 0.40[110] | 0.13[111] | -0.33[112] |
17 | PSMC3 | 26S proteasome regulatory subunit 6A | [113] | -0.41[114] | -0.39[115] | 0.14[116] | -0.80[117] | -0.69[118] | 0.14[119] |
18 | PSMA3 | Proteasome subunit alpha type-3 | [120] | -1.00[121] | 0.09[122] | -0.67[123] | -0.06[124] | -0.59[125] | -0.08[126] |
19 | PSMB6 | Proteasome subunit beta type-6 | [127] | -0.45[128] | -0.22[129] | -0.15[130] | -0.60[131] | -0.96[132] | 0.08[133] |
20 | PSMA2 | Proteasome subunit alpha type-2 | [134] | -0.53[135] | 0.51[136] | 0.76[137] | -0.11[138] | 0.18[139] | 0.30[140] |
21 | PSMD4 | 26S proteasome non-ATPase regulatory subunit 4 | [141] | -0.01[142] | 0.08[143] | 0.20[144] | 0.59[145] | -0.02[146] | -0.02[147] |
22 | PSMD7 | 26S proteasome non-ATPase regulatory subunit 7 | [148] | -0.10[149] | 0.36[150] | 0.14[151] | -0.49[152] | -0.10[153] | -0.20[154] |
23 | PSMD8 | 26S proteasome non-ATPase regulatory subunit 8 | [155] | 0.07[156] | 0.40[157] | 0.45[158] | -0.22[159] | 0.46[160] | -0.17[161] |
24 | PSMD2 | 26S proteasome non-ATPase regulatory subunit 2 | [162] | 1.60[163] | 0.87[164] | 0.85[165] | 0.89[166] | 2.10[167] | 0.86[168] |
25 | PSMC1 | 26S proteasome regulatory subunit 4 | [169] | -0.07[170] | 0.07[171] | -0.66[172] | 1.08[173] | 0.52[174] | 0.02[175] |
26 | PSMA1 | Proteasome subunit alpha type-1 | [176] | 0.11[177] | 0.58[178] | 0.56[179] | 0.65[180] | 0.07[181] | 0.51[182] |
27 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [183] | 1.73[184] | 1.82[185] | 2.76[186] | 0.73[187] | 1.43[188] | 0.74[189] |
28 | PSMC5 | 26S proteasome regulatory subunit 8 | [190] | 0.43[191] | 0.40[192] | 0.40[193] | 0.06[194] | 0.39[195] | 0.28[196] |
29 | RAC1 | Ras-related C3 botulinum toxin substrate 1 | [197] | 0.66[198] | 0.51[199] | 1.12[200] | 1.27[201] | 1.15[202] | 0.43[203] |
30 | PSMD3 | 26S proteasome non-ATPase regulatory subunit 3 | [204] | 0.82[205] | 0.40[206] | 0.91[207] | 0.59[208] | 0.73[209] | -0.01[210] |
31 | PSMB8 | Proteasome subunit beta type-8 | [211] | -1.57[212] | -2.08[213] | -9.38[214] | 0.57[215] | -0.82[216] | -0.69[217] |
32 | CLTB | Clathrin light chain B | [218] | 0.48[219] | -1.34[220] | -1.63[221] | -1.39[222] | -1.14[223] | -0.90[224] |
33 | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14 | [225] | 0.00[226] | 0.69[227] | 0.86[228] | 0.46[229] | 0.41[230] | -0.15[231] |
34 | PSMC4 | 26S proteasome regulatory subunit 6B | [232] | 0.43[233] | 0.54[234] | 0.39[235] | 0.09[236] | 0.12[237] | 0.33[238] |
35 | PSMD6 | 26S proteasome non-ATPase regulatory subunit 6 | [239] | -0.73[240] | -0.16[241] | -1.33[242] | -0.54[243] | 0.19[244] | -0.26[245] |
36 | PSMD13 | 26S proteasome non-ATPase regulatory subunit 13 | [246] | 0.47[247] | 0.67[248] | 1.08[249] | 0.52[250] | -0.05[251] | -0.08[252] |
37 | AP2M1 | AP-2 complex subunit mu | [253] | 1.27[254] | 1.26[255] | 0.65[256] | 2.23[257] | 2.64[258] | 1.23[259] |
38 | PSMD12 | 26S proteasome non-ATPase regulatory subunit 12 | [260] | -0.35[261] | -0.19[262] | -0.58[263] | 0.14[264] | 0.12[265] | -0.15[266] |
39 | AP2S1 | AP-2 complex subunit sigma | [267] | -0.57[268] | -0.41[269] | 0.19[270] | 0.51[271] | 0.84[272] | 0.37[273] |
40 | PSMC6 | 26S proteasome regulatory subunit 10B | [274] | -0.05[275] | 1.61[276] | 0.34[277] | 0.50[278] | 0.35[279] | 0.50[280] |
41 | PSMD11 | 26S proteasome non-ATPase regulatory subunit 11 | [281] | 0.83[282] | 0.53[283] | 1.03[284] | 0.90[285] | 0.98[286] | 1.32[287] |
42 | PSMC2 | 26S proteasome regulatory subunit 7 | [288] | 0.58[289] | 1.07[290] | 0.76[291] | 1.30[292] | 1.04[293] | 1.38[294] |
43 | CLTC | Clathrin heavy chain 1 | [295] | 2.67[296] | 2.95[297] | 3.02[298] | 2.94[299] | 2.97[300] | 3.85[301] |
44 | PSME3 | Proteasome activator complex subunit 3 | [302] | 1.81[303] | 1.61[304] | 1.21[305] | 1.32[306] | 1.51[307] | 0.94[308] |
45 | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1 | [309] | 1.57[310] | 1.97[311] | 1.77[312] | 2.13[313] | 2.05[314] | 2.13[315] |
46 | PSMB10 | Proteasome subunit beta type-10 | [316] | -1.15[317] | -0.47[318] | -2.44[319] | -0.08[320] | -1.33[321] | -0.02[322] |
47 | PSMA5 | Proteasome subunit alpha type-5 | [323] | 1.90[324] | 2.41[325] | 1.89[326] | 2.18[327] | 1.66[328] | 1.97[329] |
48 | PSMF1 | Proteasome inhibitor PI31 subunit | [330] | 2.28[331] | 2.41[332] | 1.13[333] | 1.19[334] | 0.87[335] | 1.91[336] |
49 | PSMB2 | Proteasome subunit beta type-2 | [337] | 2.06[338] | 1.88[339] | 2.18[340] | 2.49[341] | 2.39[342] | 2.46[343] |
50 | PSMB9 | Proteasome subunit beta type-9 | [344] | -1.95[345] | -4.48[346] | -6.88[347] | 1.74[348] | -0.61[349] | -0.44[350] |
51 | PSMD9 | 26S proteasome non-ATPase regulatory subunit 9 | [351] | 0.44[352] | 1.01[353] | -0.06[354] | 0.36[355] | 0.72[356] | 0.79[357] |
52 | DVL1 | Segment polarity protein dishevelled homolog DVL-1 | [358] | 1.85[359] | 2.50[360] | 1.27[361] | 1.33[362] | 1.25[363] | 0.64[364] |
53 | AP2A1 | AP-2 complex subunit alpha-1 | [365] | 2.26[366] | 2.10[367] | 2.83[368] | 2.66[369] | 2.62[370] | 2.35[371] |
54 | PSMD10 | 26S proteasome non-ATPase regulatory subunit 10 | [372] | 0.99[373] | 1.40[374] | 1.34[375] | 2.03[376] | 1.27[377] | 0.77[378] |
55 | RYK | Tyrosine-protein kinase RYK | [379] | 1.93[380] | 1.86[381] | 1.15[382] | 1.67[383] | 1.72[384] | 0.91[385] |
56 | AP2B1 | AP-2 complex subunit beta | [386] | 3.29[387] | 3.20[388] | 4.83[389] | 3.81[390] | 3.56[391] | 2.33[392] |
57 | AP2A2 | AP-2 complex subunit alpha-2 | [393] | 2.31[394] | 2.34[395] | 2.36[396] | 2.10[397] | 1.64[398] | 2.07[399] |
58 | WNT11 | Protein Wnt-11 | [400] | -0.37[401] | -5.89[402] | -4.98[403] | -5.27[404] | -5.81[405] | -1.69[406] |
59 | PSME4 | Proteasome activator complex subunit 4 | [407] | 2.52[408] | 3.51[409] | 3.43[410] | 2.59[411] | 2.47[412] | 3.04[413] |
60 | ARRB2 | Beta-arrestin-2 | [414] | 1.22[415] | 1.79[416] | 1.64[417] | -0.06[418] | 0.64[419] | 0.52[420] |
61 | PSMD5 | 26S proteasome non-ATPase regulatory subunit 5 | [421] | 1.41[422] | 1.05[423] | 2.52[424] | 2.42[425] | 2.42[426] | 2.22[427] |
62 | FZD5 | Frizzled-5 | [428] | 2.02[429] | 3.07[430] | 3.96[431] | 0.12[432] | -1.30[433] | 3.98[434] |
63 | DVL3 | Segment polarity protein dishevelled homolog DVL-3 | [435] | 2.54[436] | 2.94[437] | 2.23[438] | 2.73[439] | 2.69[440] | 1.71[441] |
64 | SCRIB | Protein scribble homolog | [442] | 3.22[443] | 2.74[444] | 3.07[445] | 3.24[446] | 2.42[447] | 1.86[448] |
65 | RAC2 | Ras-related C3 botulinum toxin substrate 2 | [449] | -0.66[450] | -6.47[451] | -7.18[452] | -0.13[453] | 3.56[454] | 0.17[455] |
66 | SMURF1 | E3 ubiquitin-protein ligase SMURF1 | [456] | 2.49[457] | 2.12[458] | 2.93[459] | 2.47[460] | 2.25[461] | 2.78[462] |
67 | RAC3 | Ras-related C3 botulinum toxin substrate 3 | [463] | 0.68[464] | 3.93[465] | 2.66[466] | 1.37[467] | -0.22[468] | -2.08[469] |
68 | DAAM1 | Disheveled-associated activator of morphogenesis 1 | [470] | 1.41[471] | 2.62[472] | 1.67[473] | 2.07[474] | 2.01[475] | 3.36[476] |
69 | FZD4 | Frizzled-4 | [477] | 5.14[478] | 4.26[479] | 3.19[480] | 1.95[481] | 1.17[482] | 4.35[483] |
70 | PRKCA | Protein kinase C alpha type | [484] | 3.89[485] | 4.11[486] | 4.37[487] | 3.41[488] | 3.66[489] | 3.32[490] |
71 | DVL2 | Segment polarity protein dishevelled homolog DVL-2 | [491] | 3.17[492] | 3.11[493] | 3.98[494] | 3.48[495] | 3.02[496] | 1.41[497] |
72 | SMURF2 | E3 ubiquitin-protein ligase SMURF2 | [498] | 2.77[499] | 2.98[500] | 1.38[501] | 2.45[502] | 2.78[503] | 1.53[504] |
73 | FZD6 | Frizzled-6 | [505] | 2.83[506] | 3.84[507] | 1.23[508] | 5.99[509] | 4.64[510] | 2.52[511] |
74 | PARD6A | Partitioning defective 6 homolog alpha | [512] | 0.64[513] | 0.79[514] | -2.32[515] | 0.07[516] | -1.05[517] | 0.26[518] |
75 | FZD8 | Frizzled-8 | [519] | -2.08[520] | -7.23[521] | 0.04[522] | -1.71[523] | -0.60[524] | 1.20[525] |
76 | WNT5B | Protein Wnt-5b | [526] | -3.89[527] | -4.87[528] | 1.58[529] | 2.83[530] | -1.09[531] | 0.19[532] |
77 | FZD7 | Frizzled-7 | [533] | 3.25[534] | -0.60[535] | 5.30[536] | 5.82[537] | 3.12[538] | 1.42[539] |
78 | WNT4 | Protein Wnt-4 | [540] | -2.64[541] | -1.59[542] | -2.81[543] | -0.11[544] | -1.54[545] | 1.61[546] |
79 | FZD1 | Frizzled-1 | [547] | 2.60[548] | 0.83[549] | 4.40[550] | 3.67[551] | 4.69[552] | 4.18[553] |
80 | WNT5A | Protein Wnt-5a | [554] | -2.14[555] | -1.95[556] | -0.88[557] | 7.85[558] | 9.31[559] | 2.71[560] |
81 | PRKCB | Protein kinase C beta type | [561] | -5.76[562] | -4.38[563] | [564] | 3.74[565] | -1.67[566] | 4.93[567] |
82 | FZD3 | Frizzled-3 | [568] | 3.98[569] | 5.10[570] | 6.69[571] | 5.05[572] | 4.17[573] | 5.04[574] |
83 | FZD2 | Frizzled-2 | [575] | 2.20[576] | 0.77[577] | 3.38[578] | 8.15[579] | 5.49[580] | 1.04[581] |
84 | ROR1 | Inactive tyrosine-protein kinase transmembrane receptor ROR1 | [582] | 0.46[583] | -0.05[584] | 5.79[585] | 6.91[586] | 6.49[587] | 3.13[588] |
85 | PRKCG | Protein kinase C gamma type | [589] | 0.23[590] | 1.09[591] | -1.40[592] | 0.20[593] | 0.00[594] | [595] |
86 | PRICKLE1 | Prickle-like protein 1 | [596] | 0.20[597] | -0.73[598] | 4.33[599] | 6.49[600] | 5.09[601] | 6.18[602] |
87 | VANGL2 | Vang-like protein 2 | [603] | 4.04[604] | -1.33[605] | 8.13[606] | 8.14[607] | 7.49[608] | 3.06[609] |
88 | ROR2 | Tyrosine-protein kinase transmembrane receptor ROR2 | [610] | -1.63[611] | [612] | 0.14[613] | 8.04[614] | 9.59[615] | 4.95[616] |
89 | PSMB11 | Proteasome subunit beta type-11 | [617] | [618] | [619] | [620] | [621] | [622] | [623] |
90 | SEM1 | Putative protein SEM1, isoform 2 | [624] | [625] | [626] | [627] | [628] | [629] | [630] |
91 | WNT1 | Proto-oncogene Wnt-1 | [631] | [632] | [633] | [634] | [635] | [636] | [637] |
92 | PSMA8 | Proteasome subunit alpha type-7-like | [638] | [639] | [640] | [641] | [642] | [643] | [644] |