REACTOME_PCNA_DEPENDENT_LONG_PATCH_BASE_EXCISION_REPAIR Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 APEX1 DNA-(apurinic or apyrimidinic site) lyase [1] 0.12[2] -0.37[3] 0.28[4] -0.86[5] -1.23[6] -0.74[7]
2 PCNA Proliferating cell nuclear antigen [8] 0.91[9] 0.75[10] -0.93[11] -0.27[12] -0.01[13] -2.14[14]
3 POLD2 DNA polymerase delta subunit 2 [15] -0.58[16] -0.55[17] -0.30[18] -0.92[19] -0.57[20] 0.81[21]
4 POLD4 DNA polymerase delta subunit 4 [22] -2.11[23] -2.59[24] -0.78[25] 1.39[26] -2.22[27] 0.46[28]
5 POLE3 DNA polymerase epsilon subunit 3 [29] -0.77[30] -1.04[31] -1.02[32] -1.10[33] -0.09[34] -0.64[35]
6 POLE4 DNA polymerase epsilon subunit 4 [36] -1.03[37] -0.43[38] -4.15[39] -1.68[40] -2.17[41] -0.87[42]
7 RPA2 Replication protein A 32 kDa subunit [43] -1.44[44] -1.50[45] -1.21[46] -0.79[47] -0.74[48] -1.46[49]
8 RFC4 Replication factor C subunit 4 [50] -0.95[51] -0.46[52] -0.15[53] -1.02[54] 0.29[55] -1.82[56]
9 POLB DNA polymerase beta [57] -0.91[58] -1.01[59] -1.22[60] -2.34[61] -2.17[62] -0.57[63]
10 RFC1 Replication factor C subunit 1 [64] 0.16[65] 1.31[66] 1.42[67] 0.27[68] 1.09[69] 1.71[70]
11 RFC2 Replication factor C subunit 2 [71] -0.25[72] -0.53[73] -0.75[74] 0.13[75] 0.57[76] 0.16[77]
12 FEN1 Flap endonuclease 1 [78] 1.05[79] 0.70[80] 1.29[81] 0.63[82] 1.51[83] -0.16[84]
13 RPA1 Replication protein A 70 kDa DNA-binding subunit [85] 1.33[86] 0.93[87] 0.94[88] 1.80[89] 1.80[90] 0.94[91]
14 RPA3 Replication protein A 14 kDa subunit [92] -0.35[93] 0.32[94] 0.77[95] -0.95[96] -0.69[97] 0.24[98]
15 RFC5 Replication factor C subunit 5 [99] 0.15[100] 0.47[101] 0.40[102] 0.22[103] 0.72[104] 0.06[105]
16 RFC3 Replication factor C subunit 3 [106] 1.19[107] 1.92[108] 1.79[109] 1.20[110] 1.78[111] 0.06[112]
17 LIG1 DNA ligase 1 [113] 1.65[114] 1.53[115] 1.90[116] 0.46[117] 1.18[118] 0.56[119]
18 POLD1 DNA polymerase delta catalytic subunit [120] 1.88[121] 1.96[122] 2.51[123] 1.77[124] 2.51[125] 1.60[126]
19 POLD3 DNA polymerase delta subunit 3 [127] 1.19[128] 0.93[129] 1.63[130] 2.06[131] 2.53[132] 1.92[133]
20 POLE DNA polymerase epsilon catalytic subunit A [134] 3.06[135] 3.55[136] 3.33[137] 2.69[138] 3.68[139] 3.87[140]
21 POLE2 DNA polymerase epsilon subunit 2 [141] 0.72[142] 1.38[143] 2.10[144] 1.10[145] 1.62[146] -0.22[147]
[1]
ref_hepatocyte APEX1
Mean 47.5
Standard deviation 8.3
Values 54 48 56 42 37
[2]
HepG2 APEX1
Mean 112
Standard deviation 14
Values 1.2e+02 1e+02
[3]
HepG2.C3A APEX1
Mean 78.4
Standard deviation 5.9
Values 83 74
[4]
HuH.7 APEX1
Mean 142
Standard deviation 16
Values 1.4e+02 1.3e+02 1.6e+02
[5]
SNU475 APEX1
Mean 49.7
Standard deviation 2
Values 48 51
[6]
THLE APEX1
Mean 43.8
Standard deviation 9.3
Values 37 50
[7]
liver APEX1
Mean 21.1
Standard deviation 12
Values 32 12 31 9.4
[8]
ref_hepatocyte PCNA
Mean 36
Standard deviation 33
Values 92 37 14 19 17
[9]
HepG2 PCNA
Mean 147
Standard deviation 54
Values 1.1e+02 1.9e+02
[10]
HepG2.C3A PCNA
Mean 130
Standard deviation 86
Values 69 1.9e+02
[11]
HuH.7 PCNA
Mean 46.8
Standard deviation 33
Values 53 10 76
[12]
SNU475 PCNA
Mean 56.8
Standard deviation 7.7
Values 51 62
[13]
THLE PCNA
Mean 77.4
Standard deviation 13
Values 68 86
[14]
liver PCNA
Mean 6.07
Standard deviation 2.5
Values 7.3 5.2 8.8 3
[15]
ref_hepatocyte POLD2
Mean 32.3
Standard deviation 18
Values 10 23 30 58 40
[16]
HepG2 POLD2
Mean 47
Standard deviation 5.6
Values 51 43
[17]
HepG2.C3A POLD2
Mean 47.2
Standard deviation 5.4
Values 43 51
[18]
HuH.7 POLD2
Mean 64.5
Standard deviation 25
Values 79 36 79
[19]
SNU475 POLD2
Mean 32.5
Standard deviation 4.3
Values 29 35
[20]
THLE POLD2
Mean 47.1
Standard deviation 7.9
Values 41 53
[21]
liver POLD2
Mean 42.1
Standard deviation 24
Values 67 21 57 23
[22]
ref_hepatocyte POLD4
Mean 31.5
Standard deviation 27
Values 1.6 16 19 64 57
[23]
HepG2 POLD4
Mean 15.9
Standard deviation 3.9
Values 19 13
[24]
HepG2.C3A POLD4
Mean 11.1
Standard deviation 4
Values 14 8.3
[25]
HuH.7 POLD4
Mean 45.1
Standard deviation 6.1
Values 39 51 46
[26]
SNU475 POLD4
Mean 157
Standard deviation 53
Values 1.9e+02 1.2e+02
[27]
THLE POLD4
Mean 14.6
Standard deviation 1.8
Values 13 16
[28]
liver POLD4
Mean 32.1
Standard deviation 32
Values 48 6 69 5.3
[29]
ref_hepatocyte POLE3
Mean 29.6
Standard deviation 21
Values 23 62 36 15 11
[30]
HepG2 POLE3
Mean 37.9
Standard deviation 13
Values 29 47
[31]
HepG2.C3A POLE3
Mean 30.6
Standard deviation 16
Values 19 42
[32]
HuH.7 POLE3
Mean 36
Standard deviation 15
Values 40 20 48
[33]
SNU475 POLE3
Mean 26.1
Standard deviation 0.99
Values 25 27
[34]
THLE POLE3
Mean 60
Standard deviation 7.2
Values 55 65
[35]
liver POLE3
Mean 14.1
Standard deviation 6.6
Values 15 11 23 7.8
[36]
ref_hepatocyte POLE4
Mean 27.1
Standard deviation 15
Values 28 15 9.6 45 38
[37]
HepG2 POLE4
Mean 28.9
Standard deviation 4.6
Values 26 32
[38]
HepG2.C3A POLE4
Mean 43
Standard deviation 18
Values 30 56
[39]
HuH.7 POLE4
Mean 3.76
Standard deviation 1.5
Values 3.8 2.3 5.3
[40]
SNU475 POLE4
Mean 16.1
Standard deviation 1
Values 17 15
[41]
THLE POLE4
Mean 13
Standard deviation 1.2
Values 12 14
[42]
liver POLE4
Mean 11
Standard deviation 11
Values 24 1.7 18 1.1
[43]
ref_hepatocyte RPA2
Mean 23.6
Standard deviation 12
Values 23 41 28 15 11
[44]
HepG2 RPA2
Mean 19
Standard deviation 3.9
Values 16 22
[45]
HepG2.C3A RPA2
Mean 17.8
Standard deviation 8.2
Values 12 24
[46]
HuH.7 RPA2
Mean 25.2
Standard deviation 11
Values 27 14 35
[47]
SNU475 RPA2
Mean 25.9
Standard deviation 7.9
Values 20 31
[48]
THLE RPA2
Mean 30.6
Standard deviation 2.7
Values 29 33
[49]
liver RPA2
Mean 6.36
Standard deviation 3.6
Values 6.9 4.2 11 3.2
[50]
ref_hepatocyte RFC4
Mean 11
Standard deviation 7.9
Values 17 21 9.8 4.7 2.4
[51]
HepG2 RFC4
Mean 12.4
Standard deviation 2.7
Values 10 14
[52]
HepG2.C3A RFC4
Mean 17
Standard deviation 7.7
Values 12 22
[53]
HuH.7 RFC4
Mean 24.4
Standard deviation 12
Values 26 12 35
[54]
SNU475 RFC4
Mean 10.3
Standard deviation 3.5
Values 7.8 13
[55]
THLE RFC4
Mean 29.1
Standard deviation 0.079
Values 29 29
[56]
liver RFC4
Mean 2.31
Standard deviation 1.2
Values 2.3 1.9 4 1
[57]
ref_hepatocyte POLB
Mean 10.8
Standard deviation 1.8
Values 9.3 13 12 8.8 11
[58]
HepG2 POLB
Mean 12.5
Standard deviation 2.5
Values 11 14
[59]
HepG2.C3A POLB
Mean 11.5
Standard deviation 2.8
Values 9.5 13
[60]
HuH.7 POLB
Mean 11.5
Standard deviation 2.4
Values 10 10 14
[61]
SNU475 POLB
Mean 4.06
Standard deviation 0.015
Values 4.1 4.1
[62]
THLE POLB
Mean 5.21
Standard deviation 0.74
Values 5.7 4.7
[63]
liver POLB
Mean 5.42
Standard deviation 4
Values 7.1 2.8 10 1.5
[64]
ref_hepatocyte RFC1
Mean 9.26
Standard deviation 5.4
Values 15 15 7.1 4.1 5
[65]
HepG2 RFC1
Mean 22.5
Standard deviation 11
Values 15 30
[66]
HepG2.C3A RFC1
Mean 49.1
Standard deviation 4.6
Values 46 52
[67]
HuH.7 RFC1
Mean 61.4
Standard deviation 8.8
Values 66 67 51
[68]
SNU475 RFC1
Mean 21.2
Standard deviation 2
Values 20 23
[69]
THLE RFC1
Mean 42.7
Standard deviation 3.9
Values 45 40
[70]
liver RFC1
Mean 22.6
Standard deviation 3.4
Values 24 26 18 23
[71]
ref_hepatocyte RFC2
Mean 8.95
Standard deviation 3.2
Values 7.3 13 6.2 11 6.5
[72]
HepG2 RFC2
Mean 16.5
Standard deviation 2.8
Values 14 18
[73]
HepG2.C3A RFC2
Mean 13.3
Standard deviation 5.7
Values 9.3 17
[74]
HuH.7 RFC2
Mean 13.1
Standard deviation 6.2
Values 15 6.1 18
[75]
SNU475 RFC2
Mean 18.6
Standard deviation 4.4
Values 16 22
[76]
THLE RFC2
Mean 28.7
Standard deviation 3.4
Values 26 31
[77]
liver RFC2
Mean 7.44
Standard deviation 4.1
Values 10 4.9 11 3.1
[78]
ref_hepatocyte FEN1
Mean 8.88
Standard deviation 4.9
Values 17 9.6 7.8 7 3.4
[79]
HepG2 FEN1
Mean 40
Standard deviation 13
Values 31 49
[80]
HepG2.C3A FEN1
Mean 30.8
Standard deviation 20
Values 17 45
[81]
HuH.7 FEN1
Mean 53.6
Standard deviation 31
Values 63 19 79
[82]
SNU475 FEN1
Mean 26.1
Standard deviation 5.2
Values 22 30
[83]
THLE FEN1
Mean 54.6
Standard deviation 11
Values 47 62
[84]
liver FEN1
Mean 5.91
Standard deviation 2.9
Values 3.7 5.8 10 4.1
[85]
ref_hepatocyte RPA1
Mean 8.25
Standard deviation 3.9
Values 9.2 15 5.5 5.3 6.7
[86]
HepG2 RPA1
Mean 45.3
Standard deviation 8.3
Values 39 51
[87]
HepG2.C3A RPA1
Mean 33.6
Standard deviation 11
Values 26 41
[88]
HuH.7 RPA1
Mean 39
Standard deviation 14
Values 47 23 48
[89]
SNU475 RPA1
Mean 54.6
Standard deviation 1
Values 55 54
[90]
THLE RPA1
Mean 62.1
Standard deviation 11
Values 54 70
[91]
liver RPA1
Mean 11.7
Standard deviation 1.8
Values 12 12 14 9.5
[92]
ref_hepatocyte RPA3
Mean 8.22
Standard deviation 4.8
Values 6.2 7.6 1.9 11 15
[93]
HepG2 RPA3
Mean 14.1
Standard deviation 4
Values 11 17
[94]
HepG2.C3A RPA3
Mean 21.8
Standard deviation 13
Values 13 31
[95]
HuH.7 RPA3
Mean 34.5
Standard deviation 16
Values 35 18 50
[96]
SNU475 RPA3
Mean 8.05
Standard deviation 1.5
Values 9.1 7
[97]
THLE RPA3
Mean 11
Standard deviation 2.9
Values 8.9 13
[98]
liver RPA3
Mean 7.22
Standard deviation 6.1
Values 13 2.4 12 1.4
[99]
ref_hepatocyte RFC5
Mean 5.54
Standard deviation 4.9
Values 13 7.4 0.42 3.6 3.2
[100]
HepG2 RFC5
Mean 13.4
Standard deviation 5.4
Values 9.6 17
[101]
HepG2.C3A RFC5
Mean 16.4
Standard deviation 10
Values 9 24
[102]
HuH.7 RFC5
Mean 18.1
Standard deviation 6.8
Values 23 10 21
[103]
SNU475 RFC5
Mean 12.2
Standard deviation 2.4
Values 11 14
[104]
THLE RFC5
Mean 19.8
Standard deviation 2.4
Values 18 22
[105]
liver RFC5
Mean 4.29
Standard deviation 1.7
Values 4.9 3.5 6.3 2.5
[106]
ref_hepatocyte RFC3
Mean 3.17
Standard deviation 3.1
Values 6.3 6.7 1.4 0.35 1.1
[107]
HepG2 RFC3
Mean 15.8
Standard deviation 7.8
Values 10 21
[108]
HepG2.C3A RFC3
Mean 25.6
Standard deviation 17
Values 14 37
[109]
HuH.7 RFC3
Mean 27.1
Standard deviation 12
Values 35 14 33
[110]
SNU475 RFC3
Mean 13.8
Standard deviation 3.5
Values 11 16
[111]
THLE RFC3
Mean 23.5
Standard deviation 5.4
Values 20 27
[112]
liver RFC3
Mean 2.46
Standard deviation 0.85
Values 2 2.9 3.4 1.5
[113]
ref_hepatocyte LIG1
Mean 3.08
Standard deviation 2.7
Values 7.4 3.8 0.82 2.1 1.3
[114]
HepG2 LIG1
Mean 21.1
Standard deviation 4.6
Values 18 24
[115]
HepG2.C3A LIG1
Mean 19
Standard deviation 5
Values 15 23
[116]
HuH.7 LIG1
Mean 28.4
Standard deviation 13
Values 35 13 37
[117]
SNU475 LIG1
Mean 8.05
Standard deviation 0.33
Values 8.3 7.8
[118]
THLE LIG1
Mean 15.1
Standard deviation 4
Values 12 18
[119]
liver LIG1
Mean 3.39
Standard deviation 0.66
Values 3.3 3.3 4.3 2.7
[120]
ref_hepatocyte POLD1
Mean 2.41
Standard deviation 0.8
Values 2 3.5 2.7 2.4 1.4
[121]
HepG2 POLD1
Mean 19.3
Standard deviation 1.9
Values 21 18
[122]
HepG2.C3A POLD1
Mean 20.1
Standard deviation 2.3
Values 18 22
[123]
HuH.7 POLD1
Mean 34
Standard deviation 15
Values 42 16 44
[124]
SNU475 POLD1
Mean 15.6
Standard deviation 2.9
Values 14 18
[125]
THLE POLD1
Mean 29.7
Standard deviation 2.6
Values 28 32
[126]
liver POLD1
Mean 5.43
Standard deviation 0.68
Values 6.2 4.7 5.8 5.1
[127]
ref_hepatocyte POLD3
Mean 1.46
Standard deviation 0.56
Values 1.9 1.9 1 1.8 0.71
[128]
HepG2 POLD3
Mean 7.29
Standard deviation 0.95
Values 6.6 8
[129]
HepG2.C3A POLD3
Mean 5.94
Standard deviation 4
Values 3.1 8.8
[130]
HuH.7 POLD3
Mean 11.2
Standard deviation 6.1
Values 15 4.1 14
[131]
SNU475 POLD3
Mean 11.6
Standard deviation 3.7
Values 9 14
[132]
THLE POLD3
Mean 18.3
Standard deviation 1.6
Values 17 19
[133]
liver POLD3
Mean 4.11
Standard deviation 1.1
Values 3.6 4.3 5.6 3
[134]
ref_hepatocyte POLE
Mean 1.41
Standard deviation 0.61
Values 1.7 0.95 0.68 1.5 2.2
[135]
HepG2 POLE
Mean 25.6
Standard deviation 5.9
Values 22 30
[136]
HepG2.C3A POLE
Mean 35.2
Standard deviation 15
Values 24 46
[137]
HuH.7 POLE
Mean 35.1
Standard deviation 18
Values 50 15 40
[138]
SNU475 POLE
Mean 17.2
Standard deviation 0.14
Values 17 17
[139]
THLE POLE
Mean 39
Standard deviation 5
Values 35 43
[140]
liver POLE
Mean 15.3
Standard deviation 8.7
Values 11 19 6 25
[141]
ref_hepatocyte POLE2
Mean 1.24
Standard deviation 0.85
Values 1.7 2.2 0.24 1.6 0.46
[142]
HepG2 POLE2
Mean 4.44
Standard deviation 2.1
Values 3 5.9
[143]
HepG2.C3A POLE2
Mean 6.88
Standard deviation 5.4
Values 3.1 11
[144]
HuH.7 POLE2
Mean 13.1
Standard deviation 7.8
Values 15 4.4 20
[145]
SNU475 POLE2
Mean 5.05
Standard deviation 2
Values 3.6 6.4
[146]
THLE POLE2
Mean 8.23
Standard deviation 0.9
Values 7.6 8.9
[147]
liver POLE2
Mean 0.788
Standard deviation 0.23
Values 0.68 1 0.9 0.53