REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -1.12[2] | -1.21[3] | -1.14[4] | -1.77[5] | -1.31[6] | -0.83[7] |
2 | SQSTM1 | Sequestosome-1 | [8] | -0.67[9] | -1.62[10] | -1.14[11] | -0.16[12] | -0.25[13] | -0.75[14] |
3 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [15] | [16] | [17] | [18] | [19] | [20] | [21] |
4 | UBC | Polyubiquitin-C | [22] | -0.67[23] | -0.46[24] | -0.77[25] | -0.92[26] | -0.93[27] | -0.38[28] |
5 | YWHAE | 14-3-3 protein epsilon | [29] | -0.16[30] | 0.06[31] | 0.33[32] | 0.14[33] | 0.19[34] | -0.51[35] |
6 | RHOA | Transforming protein RhoA | [36] | 0.14[37] | -0.25[38] | -0.10[39] | -0.22[40] | 0.24[41] | -0.28[42] |
7 | RTN4 | Reticulon-4 | [43] | 0.45[44] | -0.13[45] | 0.33[46] | 0.81[47] | 0.91[48] | 0.87[49] |
8 | ARHGDIA | Rho GDP-dissociation inhibitor 1 | [50] | 0.56[51] | -0.01[52] | -0.83[53] | 0.01[54] | 0.38[55] | -0.78[56] |
9 | NFKBIA | NF-kappa-B inhibitor alpha | [57] | 0.03[58] | -1.66[59] | -2.11[60] | -2.51[61] | -0.63[62] | -0.09[63] |
10 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [64] | 1.76[65] | 1.78[66] | 2.74[67] | 0.48[68] | 1.29[69] | 0.39[70] |
11 | RAC1 | Ras-related C3 botulinum toxin substrate 1 | [71] | 0.69[72] | 0.47[73] | 1.10[74] | 1.02[75] | 1.01[76] | 0.08[77] |
12 | APH1A | Gamma-secretase subunit APH-1A | [78] | 1.01[79] | 1.40[80] | 1.54[81] | 0.74[82] | 0.64[83] | 0.03[84] |
13 | PSENEN | Gamma-secretase subunit PEN-2 | [85] | -0.98[86] | -0.86[87] | -0.47[88] | -0.88[89] | -1.30[90] | -1.02[91] |
14 | MAGED1 | Melanoma-associated antigen D1 | [92] | 2.48[93] | 2.36[94] | -6.71[95] | 2.88[96] | 1.38[97] | 1.25[98] |
15 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | [99] | 2.50[100] | 2.00[101] | 0.90[102] | 1.80[103] | 2.17[104] | 0.36[105] |
16 | HDAC1 | Histone deacetylase 1 | [106] | 1.59[107] | 1.71[108] | 2.32[109] | 1.65[110] | 1.44[111] | 0.58[112] |
17 | AATF | Protein AATF | [113] | 0.73[114] | -0.11[115] | 0.55[116] | 0.63[117] | 0.00[118] | -0.73[119] |
18 | BAD | Bcl2-associated agonist of cell death | [120] | -0.59[121] | -0.35[122] | -1.38[123] | -0.06[124] | 0.34[125] | -0.37[126] |
19 | NCSTN | Nicastrin | [127] | 2.43[128] | 1.69[129] | 1.77[130] | 2.10[131] | 1.98[132] | 1.44[133] |
20 | RELA | Transcription factor p65 | [134] | 1.22[135] | 0.82[136] | 0.88[137] | 0.95[138] | 0.86[139] | 0.17[140] |
21 | NET1 | Neuroepithelial cell-transforming gene 1 protein | [141] | 1.38[142] | 2.10[143] | 2.04[144] | 1.19[145] | 0.51[146] | 1.45[147] |
22 | CASP3 | Caspase-3 | [148] | 1.22[149] | 2.00[150] | -0.62[151] | 0.11[152] | 1.11[153] | 0.24[154] |
23 | HDAC3 | Histone deacetylase 3 | [155] | 1.56[156] | 1.72[157] | 1.45[158] | 0.96[159] | 1.12[160] | 0.65[161] |
24 | MYD88 | Myeloid differentiation primary response protein MyD88 | [162] | 0.90[163] | 1.06[164] | 0.42[165] | -0.03[166] | 0.27[167] | 1.84[168] |
25 | GNA13 | Guanine nucleotide-binding protein subunit alpha-13 | [169] | 1.20[170] | 1.48[171] | 1.87[172] | 2.20[173] | 1.03[174] | 1.59[175] |
26 | ARHGEF35 | Rho guanine nucleotide exchange factor 35 | [176] | -6.56[177] | -6.12[178] | -5.88[179] | -2.62[180] | -2.04[181] | -2.05[182] |
27 | ITSN1 | Intersectin-1 | [183] | 0.97[184] | 1.19[185] | 1.88[186] | 2.01[187] | 2.28[188] | 2.77[189] |
28 | VAV2 | Guanine nucleotide exchange factor VAV2 | [190] | 2.38[191] | 2.74[192] | 2.15[193] | 0.47[194] | 0.90[195] | 1.56[196] |
29 | ARHGEF10 | Rho guanine nucleotide exchange factor 10-like protein | [197] | 1.59[198] | 4.00[199] | 2.72[200] | 0.92[201] | -0.66[202] | 4.05[203] |
30 | MAPK8 | Mitogen-activated protein kinase 8 | [204] | -0.36[205] | 1.16[206] | -0.05[207] | 0.10[208] | -0.04[209] | 0.54[210] |
31 | SOS1 | Son of sevenless homolog 1 | [211] | 0.98[212] | 2.62[213] | 2.05[214] | 1.85[215] | 1.09[216] | 1.59[217] |
32 | HDAC2 | Histone deacetylase 2 | [218] | 2.81[219] | 4.24[220] | 3.54[221] | 3.17[222] | 3.31[223] | 1.25[224] |
33 | PSEN1 | Presenilin-1 | [225] | 2.14[226] | 2.46[227] | 1.96[228] | 2.26[229] | 2.14[230] | 2.04[231] |
34 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | [232] | 1.75[233] | 1.54[234] | 1.25[235] | 0.76[236] | 1.67[237] | 1.50[238] |
35 | ARHGEF12 | Rho guanine nucleotide exchange factor 12 | [239] | 3.09[240] | 2.97[241] | 2.53[242] | 4.00[243] | 3.17[244] | 5.21[245] |
36 | ARHGEF1 | Rho guanine nucleotide exchange factor 1 | [246] | 2.00[247] | 2.42[248] | 2.66[249] | 1.93[250] | 2.20[251] | 1.43[252] |
37 | ARHGEF2 | Rho guanine nucleotide exchange factor 2 | [253] | 1.72[254] | 1.74[255] | 1.76[256] | 2.85[257] | 3.24[258] | -0.03[259] |
38 | ARHGEF5 | Rho guanine nucleotide exchange factor 5 | [260] | -2.93[261] | -1.58[262] | -1.42[263] | -1.29[264] | -1.21[265] | -1.36[266] |
39 | ADAM17 | Disintegrin and metalloproteinase domain-containing protein 17 | [267] | 1.76[268] | 1.75[269] | 1.41[270] | 2.75[271] | 1.88[272] | 1.13[273] |
40 | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2 | [274] | 0.51[275] | 1.21[276] | 1.15[277] | 0.80[278] | 0.78[279] | -0.08[280] |
41 | ARHGEF40 | Rho guanine nucleotide exchange factor 40 | [281] | 1.79[282] | 2.68[283] | 0.88[284] | 2.88[285] | 2.49[286] | 3.00[287] |
42 | PSEN2 | Presenilin-2 | [288] | 0.39[289] | -0.36[290] | -4.25[291] | 1.09[292] | -0.28[293] | 0.95[294] |
43 | PRKCI | Protein kinase C iota type | [295] | 2.14[296] | 2.93[297] | 4.45[298] | 2.16[299] | 2.57[300] | 1.30[301] |
44 | NGEF | Ephexin-1 | [302] | 1.43[303] | 2.43[304] | 2.53[305] | -4.01[306] | -1.40[307] | 1.85[308] |
45 | TRIO | Triple functional domain protein | [309] | 3.08[310] | 2.92[311] | 3.09[312] | 3.61[313] | 4.50[314] | 3.80[315] |
46 | ITGB3BP | Centromere protein R | [316] | 0.16[317] | 1.97[318] | 2.18[319] | 0.64[320] | 1.31[321] | -0.40[322] |
47 | ECT2 | Protein ECT2 | [323] | 1.76[324] | 3.56[325] | 4.49[326] | 3.13[327] | 3.73[328] | 0.17[329] |
48 | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | [330] | 1.60[331] | 1.77[332] | 1.80[333] | 1.26[334] | 1.36[335] | 2.23[336] |
49 | AKAP13 | A-kinase anchor protein 13 | [337] | 2.82[338] | 2.05[339] | 2.94[340] | 3.71[341] | 3.33[342] | 5.18[343] |
50 | SMPD2 | Sphingomyelin phosphodiesterase 2 | [344] | 0.13[345] | 0.57[346] | -0.12[347] | -0.77[348] | 0.35[349] | -0.56[350] |
51 | ARHGEF7 | Rho guanine nucleotide exchange factor 7 | [351] | 2.70[352] | 2.80[353] | 2.58[354] | 2.82[355] | 2.57[356] | 3.40[357] |
52 | ARHGEF18 | Rho guanine nucleotide exchange factor 18 | [358] | 3.76[359] | 2.95[360] | 3.69[361] | 2.34[362] | 2.67[363] | 2.64[364] |
53 | SOS2 | Son of sevenless homolog 2 | [365] | 1.06[366] | 2.29[367] | 1.44[368] | 2.69[369] | 2.56[370] | 2.89[371] |
54 | PRDM4 | PR domain zinc finger protein 4 | [372] | 2.31[373] | 2.82[374] | 2.07[375] | 2.75[376] | 2.91[377] | 1.60[378] |
55 | ARHGEF26 | Rho guanine nucleotide exchange factor 26 | [379] | 0.13[380] | 1.23[381] | 1.74[382] | 1.38[383] | 2.98[384] | 4.27[385] |
56 | RTN4R | Reticulon-4 receptor | [386] | -1.99[387] | -2.00[388] | -0.60[389] | -0.95[390] | -1.44[391] | -0.17[392] |
57 | ARHGEF11 | Rho guanine nucleotide exchange factor 11 | [393] | 3.12[394] | 3.34[395] | 2.96[396] | 4.27[397] | 3.57[398] | 3.63[399] |
58 | FGD4 | FYVE, RhoGEF and PH domain-containing protein 4 | [400] | 0.42[401] | 2.65[402] | 2.05[403] | 1.77[404] | 2.23[405] | 4.35[406] |
59 | BCL2L11 | Bcl-2-like protein 11 | [407] | 2.59[408] | 2.70[409] | 2.95[410] | 2.87[411] | 1.85[412] | 3.03[413] |
60 | CASP2 | Caspase-2 | [414] | 2.78[415] | 2.52[416] | 3.25[417] | 2.88[418] | 3.31[419] | 2.63[420] |
61 | ARHGEF3 | Rho guanine nucleotide exchange factor 3 | [421] | 3.65[422] | 2.46[423] | 1.56[424] | 2.46[425] | 2.71[426] | 1.19[427] |
62 | MCF2L | Guanine nucleotide exchange factor DBS | [428] | 3.36[429] | 3.65[430] | 1.38[431] | -3.61[432] | -6.83[433] | 2.56[434] |
63 | ARHGEF16 | Rho guanine nucleotide exchange factor 16 | [435] | 3.96[436] | 5.43[437] | 1.53[438] | 2.97[439] | -0.59[440] | 1.94[441] |
64 | TRAF6 | TNF receptor-associated factor 6 | [442] | 2.17[443] | 2.17[444] | 2.66[445] | 2.67[446] | 2.12[447] | 3.96[448] |
65 | RASGRF2 | Ras-specific guanine nucleotide-releasing factor 2 | [449] | 4.93[450] | 4.29[451] | -0.11[452] | -1.93[453] | 0.30[454] | 1.56[455] |
66 | KALRN | Kalirin | [456] | 2.43[457] | 4.08[458] | 3.50[459] | 2.91[460] | -1.75[461] | 4.61[462] |
67 | ABR | Active breakpoint cluster region-related protein | [463] | 5.03[464] | 4.71[465] | 4.17[466] | 4.44[467] | 5.15[468] | 2.88[469] |
68 | APH1B | Gamma-secretase subunit APH-1B | [470] | 0.85[471] | 1.76[472] | 4.81[473] | 4.10[474] | 3.14[475] | 2.27[476] |
69 | TIAM1 | T-lymphoma invasion and metastasis-inducing protein 1 | [477] | -3.62[478] | -0.84[479] | -6.10[480] | -0.35[481] | 1.70[482] | 4.39[483] |
70 | VAV3 | Guanine nucleotide exchange factor VAV3 | [484] | 2.89[485] | 1.28[486] | 3.38[487] | 4.69[488] | -1.28[489] | 2.40[490] |
71 | ARHGEF9 | Rho guanine nucleotide exchange factor 9 | [491] | -0.36[492] | -1.46[493] | -6.82[494] | 3.18[495] | 3.18[496] | 3.40[497] |
72 | FGD2 | FYVE, RhoGEF and PH domain-containing protein 2 | [498] | -4.48[499] | -5.37[500] | -7.10[501] | -3.05[502] | -5.82[503] | 3.92[504] |
73 | VAV1 | Proto-oncogene vav | [505] | -7.42[506] | -2.48[507] | -4.27[508] | -5.08[509] | -6.34[510] | 2.23[511] |
74 | ARHGEF6 | Rho guanine nucleotide exchange factor 6 | [512] | -4.94[513] | -2.58[514] | -3.27[515] | 4.24[516] | 2.76[517] | 4.18[518] |
75 | ARHGEF19 | Rho guanine nucleotide exchange factor 19 | [519] | 2.58[520] | 4.10[521] | 2.55[522] | 2.75[523] | 3.66[524] | 1.92[525] |
76 | PLEKHG2 | Pleckstrin homology domain-containing family G member 2 | [526] | 4.79[527] | 4.33[528] | 5.11[529] | 5.73[530] | 4.78[531] | 2.56[532] |
77 | PREX1 | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein | 0.67[533] | -5.05[534] | -2.82[535] | 6.12[536] | 4.47[537] | 5.25[538] | |
78 | FGD3 | FYVE, RhoGEF and PH domain-containing protein 3 | [539] | 1.71[540] | 2.18[541] | 0.84[542] | 0.18[543] | -4.12[544] | 3.31[545] |
79 | ARHGEF10 | Rho guanine nucleotide exchange factor 10 | [546] | -2.93[547] | -2.34[548] | -3.38[549] | 4.12[550] | 4.99[551] | 2.92[552] |
80 | ARHGEF37 | Rho guanine nucleotide exchange factor 37 | [553] | 1.86[554] | -2.97[555] | -0.18[556] | 3.21[557] | 2.18[558] | 3.76[559] |
81 | PLEKHG5 | Pleckstrin homology domain-containing family G member 5 | [560] | 4.59[561] | 4.18[562] | 2.86[563] | 3.37[564] | 3.79[565] | 2.51[566] |
82 | ARHGEF17 | Rho guanine nucleotide exchange factor 17 | [567] | 6.27[568] | 7.04[569] | 5.62[570] | 8.76[571] | 6.55[572] | 5.39[573] |
83 | FGD1 | FYVE, RhoGEF and PH domain-containing protein 1 | [574] | 3.83[575] | 4.43[576] | 3.25[577] | 6.24[578] | 5.70[579] | 2.69[580] |
84 | TIAM2 | T-lymphoma invasion and metastasis-inducing protein 2 | [581] | 4.99[582] | 4.51[583] | 5.86[584] | 5.54[585] | 3.42[586] | 1.02[587] |
85 | ARHGEF15 | Rho guanine nucleotide exchange factor 15 | [588] | [589] | -3.76[590] | [591] | -2.91[592] | [593] | 5.00[594] |
86 | LINGO1 | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-int | 0.14[595] | [596] | 0.89[597] | 1.09[598] | 0.79[599] | 1.20[600] | |
87 | MAG | Myelin-associated glycoprotein | [601] | 3.54[602] | 0.94[603] | [604] | -0.35[605] | 0.63[606] | -2.24[607] |
88 | NGFR | Tumor necrosis factor receptor superfamily member 16 | [608] | 9.55[609] | 2.81[610] | -1.27[611] | 2.76[612] | 3.70[613] | 8.65[614] |
89 | OBSCN | Obscurin | [615] | 5.01[616] | 2.52[617] | 3.10[618] | 8.82[619] | 5.99[620] | 7.67[621] |
90 | ARHGEF4 | Rho guanine nucleotide exchange factor 4 | [622] | 3.40[623] | -1.96[624] | -2.95[625] | 5.95[626] | 6.27[627] | 3.01[628] |
91 | OMG | Oligodendrocyte-myelin glycoprotein | [629] | 0.41[630] | -1.32[631] | 0.90[632] | -0.27[633] | 2.33[634] | 6.36[635] |
92 | ARHGEF38 | Rho guanine nucleotide exchange factor 38 | [636] | 0.31[637] | 2.66[638] | 7.61[639] | 1.37[640] | 0.99[641] | 5.33[642] |
93 | ARHGEF33 | Rho guanine nucleotide exchange factor 33 | [643] | 2.45[644] | 4.02[645] | 2.48[646] | 3.30[647] | 6.30[648] | 5.90[649] |
94 | MCF2 | Proto-oncogene DBL | [650] | [651] | [652] | [653] | [654] | [655] | [656] |
95 | ARHGEF39 | Rho guanine nucleotide exchange factor 39 | [657] | [658] | [659] | [660] | [661] | [662] | [663] |
96 | BEX3 | Protein BEX3 | [664] | [665] | [666] | [667] | [668] | [669] | [670] |
97 | NGF | Beta-nerve growth factor | [671] | [672] | [673] | [674] | [675] | [676] | [677] |