REACTOME_OVARIAN_TUMOR_DOMAIN_PROTEASES | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -0.81[2] | -1.00[3] | -0.89[4] | -0.98[5] | -0.91[6] | -0.51[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -0.36[16] | -0.25[17] | -0.52[18] | -0.12[19] | -0.53[20] | -0.06[21] |
4 | RHOA | Transforming protein RhoA | [22] | 0.45[23] | -0.04[24] | 0.15[25] | 0.58[26] | 0.65[27] | 0.04[28] |
5 | TNIP1 | TNFAIP3-interacting protein 1 | [29] | -0.24[30] | -0.68[31] | -0.84[32] | -0.49[33] | 0.80[34] | -0.84[35] |
6 | VCP | Transitional endoplasmic reticulum ATPase | [36] | 1.63[37] | 1.37[38] | 1.26[39] | 1.30[40] | 1.48[41] | 1.61[42] |
7 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [43] | 2.07[44] | 1.99[45] | 2.99[46] | 1.27[47] | 1.70[48] | 0.71[49] |
8 | RNF128 | E3 ubiquitin-protein ligase RNF128 | [50] | 0.31[51] | 1.32[52] | 1.41[53] | -0.33[54] | -4.43[55] | 1.29[56] |
9 | IKBKG | NF-kappa-B essential modulator | [57] | 0.50[58] | 0.66[59] | -1.63[60] | 0.95[61] | -0.65[62] | 0.76[63] |
10 | TNIP2 | TNFAIP3-interacting protein 2 | [64] | 0.71[65] | 0.78[66] | 0.46[67] | 1.14[68] | 0.12[69] | -0.09[70] |
11 | OTUB1 | Ubiquitin thioesterase OTUB1 | [71] | 2.27[72] | 2.09[73] | 1.34[74] | 2.01[75] | 1.87[76] | 1.31[77] |
12 | TNFAIP3 | Tumor necrosis factor alpha-induced protein 3 | [78] | 2.02[79] | 2.73[80] | -0.57[81] | 0.59[82] | 2.17[83] | 0.34[84] |
13 | OTUD5 | OTU domain-containing protein 5 | [85] | 2.06[86] | 1.69[87] | 2.61[88] | 2.24[89] | 1.80[90] | 0.79[91] |
14 | TRIM4 | E3 ubiquitin-protein ligase TRIM4 | [92] | 1.11[93] | 1.31[94] | 1.45[95] | 0.49[96] | 0.71[97] | 1.77[98] |
15 | PTEN | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protei | 0.85[99] | 2.25[100] | 2.41[101] | 1.24[102] | 2.10[103] | 3.84[104] | |
16 | TRIM25 | E3 ubiquitin/ISG15 ligase TRIM25 | [105] | 3.53[106] | 3.17[107] | 2.97[108] | 2.68[109] | 2.95[110] | 3.18[111] |
17 | CDK1 | Cyclin-dependent kinase 1 | [112] | 2.64[113] | 4.71[114] | 3.41[115] | 4.07[116] | 4.50[117] | -1.10[118] |
18 | ZRANB1 | Ubiquitin thioesterase ZRANB1 | [119] | 1.66[120] | 2.57[121] | 2.41[122] | 1.85[123] | 2.90[124] | 2.93[125] |
19 | TP53 | Cellular tumor antigen p53 | [126] | 3.03[127] | 2.60[128] | 3.32[129] | 3.10[130] | 2.37[131] | 1.32[132] |
20 | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2 | [133] | 0.82[134] | 1.43[135] | 1.40[136] | 1.60[137] | 1.18[138] | 0.24[139] |
21 | IFIH1 | Interferon-induced helicase C domain-containing protein 1 | [140] | -0.58[141] | -0.48[142] | -4.63[143] | 0.57[144] | 0.42[145] | 1.62[146] |
22 | RIPK1 | Receptor-interacting serine/threonine-protein kinase 1 | [147] | 1.68[148] | 1.85[149] | 1.49[150] | 2.88[151] | 2.02[152] | 2.85[153] |
23 | DDX58 | Probable ATP-dependent RNA helicase DDX58 | [154] | 0.69[155] | 0.68[156] | -0.18[157] | 1.02[158] | 1.19[159] | 2.48[160] |
24 | OTUD7B | OTU domain-containing protein 7B | [161] | 2.46[162] | 2.05[163] | 2.42[164] | 3.89[165] | 2.95[166] | 2.78[167] |
25 | UBE2D1 | Ubiquitin-conjugating enzyme E2 D1 | [168] | 2.19[169] | 3.06[170] | 3.37[171] | 3.32[172] | 2.70[173] | 1.87[174] |
26 | MAVS | Mitochondrial antiviral-signaling protein | [175] | 5.67[176] | 5.29[177] | 4.85[178] | 5.53[179] | 4.74[180] | 4.71[181] |
27 | ESR1 | Estrogen receptor | [182] | -5.91[183] | [184] | -4.43[185] | -2.36[186] | -5.01[187] | 3.77[188] |
28 | VCPIP1 | Deubiquitinating protein VCIP135 | [189] | 2.12[190] | 3.04[191] | 3.85[192] | 3.75[193] | 3.07[194] | 4.82[195] |
29 | TRAF3 | TNF receptor-associated factor 3 | [196] | 4.28[197] | 3.71[198] | 3.28[199] | 4.63[200] | 4.66[201] | 3.29[202] |
30 | YOD1 | Ubiquitin thioesterase OTU1 | [203] | 2.38[204] | 3.44[205] | 4.47[206] | 4.36[207] | 3.50[208] | 3.39[209] |
31 | APC | Adenomatous polyposis coli protein | [210] | 1.96[211] | 3.64[212] | 3.44[213] | 4.03[214] | 4.28[215] | 5.10[216] |
32 | OTUD3 | OTU domain-containing protein 3 | [217] | 3.36[218] | 4.28[219] | 3.17[220] | 4.24[221] | 3.42[222] | 2.24[223] |
33 | TRAF6 | TNF receptor-associated factor 6 | [224] | 2.48[225] | 2.38[226] | 2.91[227] | 3.47[228] | 2.53[229] | 4.27[230] |
34 | RNF135 | E3 ubiquitin-protein ligase RNF135 | [231] | -5.92[232] | -5.51[233] | -4.27[234] | -5.68[235] | 2.85[236] | 2.23[237] |
35 | OTUB2 | Ubiquitin thioesterase OTUB2 | [238] | 4.03[239] | 1.80[240] | 1.37[241] | 2.55[242] | 1.26[243] | 1.69[244] |
36 | NOD2 | Nucleotide-binding oligomerization domain-containing protein 2 | [245] | -0.51[246] | -2.47[247] | [248] | -1.81[249] | 1.36[250] | 0.84[251] |
37 | NOD1 | Nucleotide-binding oligomerization domain-containing protein 1 | [252] | 2.41[253] | 2.10[254] | 2.86[255] | 4.05[256] | 3.28[257] | 3.45[258] |
38 | OTUD7A | OTU domain-containing protein 7A | [259] | -0.33[260] | 0.20[261] | -1.24[262] | 0.34[263] | -0.24[264] | 2.57[265] |
39 | TNIP3 | TNFAIP3-interacting protein 3 | [266] | -1.03[267] | -0.78[268] | -1.24[269] | 4.24[270] | 4.50[271] | 1.84[272] |