REACTOME_OPIOID_SIGNALLING |
Return to index |
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Order |
Gene |
Description |
ref_hepatocyte |
HepG2 |
HepG2.C3A |
HuH.7 |
SNU475 |
THLE |
liver |
1 |
GNG5 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-5 |
-1.58[1] |
-1.36[2] |
-2.35[3] |
-2.50[4] |
-2.68[5] |
-2.02[6] |
2 |
PRKAR1A |
cAMP-dependent protein kinase type I-alpha regulatory subunit |
[7] |
-0.30[8] |
-0.14[9] |
-0.12[10] |
-0.78[11] |
-0.80[12] |
0.16[13] |
3 |
GNB1 |
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 |
[14] |
0.64[15] |
0.69[16] |
0.09[17] |
0.59[18] |
0.47[19] |
-1.67[20] |
4 |
PPP1CA |
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit |
[21] |
-0.40[22] |
-0.63[23] |
0.45[24] |
0.84[25] |
-1.47[26] |
-1.38[27] |
5 |
GNB2 |
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 |
[28] |
-0.98[29] |
-1.19[30] |
-0.98[31] |
-1.06[32] |
-0.91[33] |
-2.03[34] |
6 |
GNG10 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-10 |
-5.08[35] |
-4.75[36] |
-5.18[37] |
-4.50[38] |
-3.60[39] |
-4.77[40] |
7 |
GNAI2 |
Guanine nucleotide-binding protein G(i) subunit alpha-2 |
[41] |
-0.31[42] |
-1.33[43] |
-1.29[44] |
-0.86[45] |
0.29[46] |
-0.62[47] |
8 |
KPNA2 |
Importin subunit alpha-1 |
[48] |
0.40[49] |
0.32[50] |
0.72[51] |
-0.16[52] |
0.65[53] |
-2.22[54] |
9 |
CALM1 |
Calmodulin-1 |
[55] |
-0.30[56] |
-0.22[57] |
0.11[58] |
0.89[59] |
0.25[60] |
1.19[61] |
10 |
PPP2R1A |
Serine/threonine-protein phosphatase
2A 65 kDa regulatory subunit A alpha isoform |
0.42[62] |
0.29[63] |
0.09[64] |
0.52[65] |
-0.07[66] |
-0.28[67] |
11 |
PPP2CA |
Serine/threonine-protein phosphatase
2A catalytic subunit alpha isoform |
-0.11[68] |
0.03[69] |
-0.73[70] |
0.05[71] |
0.25[72] |
-0.53[73] |
12 |
PPP2CB |
Serine/threonine-protein phosphatase
2A catalytic subunit beta isoform |
-0.77[74] |
-1.07[75] |
-1.12[76] |
-1.15[77] |
-1.16[78] |
-1.42[79] |
13 |
AHCYL1 |
S-adenosylhomocysteine hydrolase-like protein 1 |
[80] |
-0.14[81] |
0.00[82] |
0.44[83] |
0.32[84] |
0.28[85] |
-0.13[86] |
14 |
GNG12 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-12 |
-5.13[87] |
-8.02[88] |
-0.20[89] |
1.19[90] |
1.37[91] |
0.05[92] |
15 |
PRKACA |
cAMP-dependent protein kinase catalytic subunit alpha |
[93] |
-0.54[94] |
-0.67[95] |
-0.80[96] |
-1.16[97] |
-0.49[98] |
-1.21[99] |
16 |
GNAI3 |
Guanine nucleotide-binding protein G(k) subunit alpha |
[100] |
-0.25[101] |
0.33[102] |
0.31[103] |
0.41[104] |
0.13[105] |
-0.20[106] |
17 |
PPP3R1 |
Calcineurin subunit B type 1 |
[107] |
-0.19[108] |
0.03[109] |
-0.18[110] |
0.01[111] |
-0.14[112] |
-1.58[113] |
18 |
PPP2R1B |
Serine/threonine-protein phosphatase
2A 65 kDa regulatory subunit A beta isoform |
0.07[114] |
-0.41[115] |
-0.12[116] |
-0.42[117] |
-0.55[118] |
2.50[119] |
19 |
MAPK1 |
Mitogen-activated protein kinase 1 |
[120] |
1.33[121] |
1.51[122] |
1.21[123] |
1.16[124] |
0.89[125] |
1.35[126] |
20 |
GNA11 |
Guanine nucleotide-binding protein subunit alpha-11 |
[127] |
-1.05[128] |
-1.08[129] |
-1.25[130] |
-1.87[131] |
-0.99[132] |
-1.69[133] |
21 |
CAMKK2 |
Calcium/calmodulin-dependent protein kinase kinase 2 |
[134] |
0.19[135] |
0.58[136] |
-0.38[137] |
-0.53[138] |
-0.54[139] |
0.52[140] |
22 |
PPP2R5D |
Serine/threonine-protein phosphatase
2A 56 kDa regulatory subunit delta isoform |
0.87[141] |
0.67[142] |
0.11[143] |
0.60[144] |
0.57[145] |
-0.70[146] |
23 |
PRKAR2A |
cAMP-dependent protein kinase type II-alpha regulatory subunit |
[147] |
-0.33[148] |
-0.60[149] |
0.38[150] |
-0.98[151] |
-1.03[152] |
-0.28[153] |
24 |
GNAI1 |
Guanine nucleotide-binding protein G(i) subunit alpha-1 |
[154] |
-2.03[155] |
-2.92[156] |
-0.91[157] |
0.53[158] |
-0.02[159] |
0.40[160] |
25 |
CAMK2D |
Calcium/calmodulin-dependent protein kinase type II subunit delta |
[161] |
-0.25[162] |
0.10[163] |
1.50[164] |
-0.01[165] |
-0.74[166] |
0.98[167] |
26 |
PRKAR1B |
cAMP-dependent protein kinase type I-beta regulatory subunit |
[168] |
0.60[169] |
0.09[170] |
-1.83[171] |
-4.79[172] |
-1.91[173] |
-0.60[174] |
27 |
ITPR2 |
Inositol 1,4,5-trisphosphate receptor type 2 |
[175] |
0.53[176] |
2.03[177] |
0.37[178] |
-0.68[179] |
-0.46[180] |
3.44[181] |
28 |
GNB5 |
Guanine nucleotide-binding protein subunit beta-5 |
[182] |
-0.28[183] |
-0.20[184] |
0.69[185] |
0.10[186] |
0.30[187] |
0.46[188] |
29 |
PPP3CB |
Serine/threonine-protein phosphatase
2B catalytic subunit beta isoform |
0.11[189] |
0.94[190] |
0.33[191] |
0.06[192] |
-0.10[193] |
-0.58[194] |
30 |
CDK5 |
Cyclin-dependent-like kinase 5 |
[195] |
-0.14[196] |
-0.79[197] |
-0.87[198] |
-0.06[199] |
-1.19[200] |
-1.31[201] |
31 |
PPP3CC |
Serine/threonine-protein phosphatase
2B catalytic subunit gamma isoform |
-1.08[202] |
-0.90[203] |
-1.42[204] |
-1.78[205] |
-0.78[206] |
-0.37[207] |
32 |
PRKCD |
Protein kinase C delta type |
[208] |
0.72[209] |
1.01[210] |
0.36[211] |
-1.19[212] |
0.05[213] |
-1.50[214] |
33 |
PPP3CA |
Serine/threonine-protein phosphatase
2B catalytic subunit alpha isoform |
0.35[215] |
0.15[216] |
-0.17[217] |
1.25[218] |
1.08[219] |
1.38[220] |
34 |
CAMK2G |
Calcium/calmodulin-dependent protein
kinase type II subunit gamma |
0.40[221] |
1.65[222] |
1.14[223] |
0.99[224] |
0.64[225] |
0.52[226] |
35 |
PRKACB |
cAMP-dependent protein kinase catalytic subunit beta |
[227] |
-1.21[228] |
-0.39[229] |
0.77[230] |
1.54[231] |
0.49[232] |
1.28[233] |
36 |
ADCY9 |
Adenylate cyclase type 9 |
[234] |
2.24[235] |
1.47[236] |
1.77[237] |
0.27[238] |
-0.10[239] |
1.98[240] |
37 |
PRKCA |
Protein kinase C alpha type |
[241] |
2.46[242] |
2.54[243] |
2.78[244] |
1.46[245] |
1.90[246] |
1.49[247] |
38 |
ITPR3 |
Inositol 1,4,5-trisphosphate receptor type 3 |
[248] |
4.91[249] |
3.81[250] |
2.17[251] |
1.66[252] |
3.92[253] |
-0.20[254] |
39 |
GNAQ |
Guanine nucleotide-binding protein G(q) subunit alpha |
[255] |
-0.30[256] |
0.52[257] |
0.90[258] |
0.90[259] |
1.20[260] |
1.01[261] |
40 |
ADCY6 |
Adenylate cyclase type 6 |
[262] |
1.67[263] |
2.18[264] |
2.01[265] |
1.82[266] |
2.57[267] |
2.21[268] |
41 |
CREB1 |
Cyclic AMP-responsive element-binding protein 1 |
[269] |
1.34[270] |
2.54[271] |
2.91[272] |
1.85[273] |
1.88[274] |
1.91[275] |
42 |
PLCB3 |
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 |
[276] |
1.63[277] |
1.15[278] |
1.49[279] |
2.02[280] |
1.75[281] |
0.30[282] |
43 |
GNG11 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-11 |
-8.56[283] |
-8.51[284] |
-7.95[285] |
1.57[286] |
2.98[287] |
1.80[288] |
44 |
PLCB1 |
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 |
[289] |
2.41[290] |
4.08[291] |
3.38[292] |
0.09[293] |
0.66[294] |
2.06[295] |
45 |
GNG7 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-7 |
1.18[296] |
0.87[297] |
1.55[298] |
-2.93[299] |
-2.22[300] |
-0.41[301] |
46 |
POMC |
Pro-opiomelanocortin |
[302] |
[303] |
-8.70[304] |
[305] |
[306] |
-7.72[307] |
-2.62[308] |
47 |
ADCY1 |
Adenylate cyclase type 1 |
[309] |
-1.21[310] |
-3.04[311] |
-3.37[312] |
-2.80[313] |
-2.73[314] |
4.56[315] |
48 |
GNG4 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-4 |
3.09[316] |
0.90[317] |
4.57[318] |
0.57[319] |
-1.46[320] |
-2.98[321] |
49 |
PRKX |
cAMP-dependent protein kinase catalytic subunit PRKX |
[322] |
-2.02[323] |
-2.21[324] |
2.59[325] |
0.56[326] |
2.18[327] |
1.01[328] |
50 |
CAMK2B |
Calcium/calmodulin-dependent protein kinase type II subunit beta |
[329] |
-2.91[330] |
-4.19[331] |
-7.28[332] |
-3.55[333] |
-2.83[334] |
0.72[335] |
51 |
ADCY7 |
Adenylate cyclase type 7 |
[336] |
3.13[337] |
2.80[338] |
1.63[339] |
2.62[340] |
2.18[341] |
2.49[342] |
52 |
PLCB2 |
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 |
[343] |
-2.00[344] |
-6.74[345] |
-8.71[346] |
-2.63[347] |
-3.25[348] |
1.81[349] |
53 |
PDE4C |
cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
[350] |
2.59[351] |
2.07[352] |
0.45[353] |
-1.88[354] |
-0.12[355] |
-1.30[356] |
54 |
ITPR1 |
Inositol 1,4,5-trisphosphate receptor type 1 |
[357] |
2.76[358] |
2.69[359] |
3.72[360] |
2.16[361] |
3.11[362] |
4.22[363] |
55 |
GNB4 |
Guanine nucleotide-binding protein subunit beta-4 |
[364] |
-0.75[365] |
-0.21[366] |
0.66[367] |
1.99[368] |
4.81[369] |
3.66[370] |
56 |
GNG2 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-2 |
-6.66[371] |
-7.49[372] |
[373] |
2.43[374] |
1.99[375] |
2.35[376] |
57 |
PDE4A |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A |
[377] |
2.74[378] |
1.72[379] |
2.96[380] |
-0.09[381] |
2.83[382] |
1.08[383] |
58 |
PDE4B |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
[384] |
[385] |
[386] |
-6.22[387] |
0.09[388] |
2.83[389] |
2.00[390] |
59 |
CAMKK1 |
Calcium/calmodulin-dependent protein kinase kinase 1 |
[391] |
0.87[392] |
0.21[393] |
-1.62[394] |
2.16[395] |
0.68[396] |
-0.34[397] |
60 |
GNA15 |
Guanine nucleotide-binding protein subunit alpha-15 |
[398] |
-3.76[399] |
-5.43[400] |
[401] |
-6.72[402] |
-3.07[403] |
-0.33[404] |
61 |
GNA14 |
Guanine nucleotide-binding protein subunit alpha-14 |
[405] |
-6.44[406] |
-6.79[407] |
-5.76[408] |
-6.98[409] |
-3.80[410] |
2.80[411] |
62 |
GNAL |
Guanine nucleotide-binding protein G(olf) subunit alpha |
[412] |
1.46[413] |
2.31[414] |
2.45[415] |
1.41[416] |
1.47[417] |
2.11[418] |
63 |
GNGT2 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-T2 |
[419] |
[420] |
[421] |
-2.76[422] |
-7.35[423] |
-0.32[424] |
64 |
GNG3 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-3 |
-1.23[425] |
0.64[426] |
-1.71[427] |
-1.39[428] |
-1.62[429] |
-0.51[430] |
65 |
PDE4D |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D |
[431] |
3.07[432] |
6.25[433] |
6.23[434] |
3.89[435] |
5.20[436] |
4.30[437] |
66 |
PRKAR2B |
cAMP-dependent protein kinase type II-beta regulatory subunit |
[438] |
-2.72[439] |
-0.85[440] |
3.31[441] |
4.40[442] |
2.99[443] |
2.88[444] |
67 |
ADCY3 |
Adenylate cyclase type 3 |
[445] |
1.08[446] |
-0.12[447] |
3.08[448] |
4.05[449] |
5.66[450] |
3.09[451] |
68 |
PPP1R1B |
Protein phosphatase 1 regulatory subunit 1B |
[452] |
-1.96[453] |
-2.79[454] |
-6.87[455] |
-4.04[456] |
-0.08[457] |
-2.71[458] |
69 |
ADCY2 |
Adenylate cyclase type 2 |
[459] |
-5.76[460] |
-3.78[461] |
-5.17[462] |
-3.42[463] |
-4.46[464] |
-4.55[465] |
70 |
NBEA |
Neurobeachin |
[466] |
3.61[467] |
3.34[468] |
1.01[469] |
1.25[470] |
3.68[471] |
4.39[472] |
71 |
PDE1B |
Calcium/calmodulin-dependent
3',5'-cyclic nucleotide phosphodiesterase 1B |
-4.06[473] |
-4.99[474] |
[475] |
-1.51[476] |
-2.51[477] |
3.43[478] |
72 |
GNB3 |
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 |
[479] |
1.21[480] |
3.51[481] |
2.68[482] |
0.32[483] |
3.12[484] |
-2.11[485] |
73 |
ADCY5 |
Adenylate cyclase type 5 |
[486] |
-0.23[487] |
0.82[488] |
1.72[489] |
-0.04[490] |
1.17[491] |
5.94[492] |
74 |
PRKCG |
Protein kinase C gamma type |
[493] |
-1.20[494] |
-0.48[495] |
-2.99[496] |
-1.75[497] |
-1.76[498] |
[499] |
75 |
CAMK4 |
Calcium/calmodulin-dependent protein kinase type IV |
[500] |
[501] |
-2.10[502] |
-2.89[503] |
0.75[504] |
2.91[505] |
3.82[506] |
76 |
PLA2G4A |
Cytosolic phospholipase A2 |
[507] |
-0.11[508] |
-2.62[509] |
5.36[510] |
2.81[511] |
6.66[512] |
3.92[513] |
77 |
PDE1A |
Calcium/calmodulin-dependent
3',5'-cyclic nucleotide phosphodiesterase 1A |
[514] |
-1.05[515] |
3.52[516] |
5.43[517] |
1.97[518] |
6.17[519] |
78 |
OPRM1 |
Mu-type opioid receptor |
[520] |
[521] |
-2.73[522] |
[523] |
[524] |
-3.78[525] |
-2.91[526] |
79 |
PLCB4 |
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 |
[527] |
-0.12[528] |
-0.24[529] |
0.64[530] |
8.94[531] |
6.74[532] |
3.36[533] |
80 |
ADCY4 |
Adenylate cyclase type 4 |
[534] |
-0.29[535] |
-1.32[536] |
1.20[537] |
[538] |
[539] |
7.94[540] |
81 |
PRKACG |
cAMP-dependent protein kinase catalytic subunit gamma |
[541] |
[542] |
[543] |
[544] |
[545] |
[546] |
[547] |
82 |
PDE1C |
Calcium/calmodulin-dependent
3',5'-cyclic nucleotide phosphodiesterase 1C |
[548] |
[549] |
[550] |
[551] |
[552] |
[553] |
83 |
GRK2 |
Beta-adrenergic receptor kinase 1 |
[554] |
[555] |
[556] |
[557] |
[558] |
[559] |
[560] |
84 |
GNAT3 |
Guanine nucleotide-binding protein G(t) subunit alpha-3 |
[561] |
[562] |
[563] |
[564] |
[565] |
[566] |
[567] |
85 |
CAMK2A |
Calcium/calmodulin-dependent protein kinase type II subunit alpha |
[568] |
[569] |
[570] |
[571] |
[572] |
[573] |
[574] |
86 |
GNGT1 |
Guanine nucleotide-binding protein G(T) subunit gamma-T1 |
[575] |
[576] |
[577] |
[578] |
[579] |
[580] |
[581] |
87 |
ADCY8 |
Adenylate cyclase type 8 |
[582] |
[583] |
[584] |
[585] |
[586] |
[587] |
[588] |
88 |
GNG13 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-13 |
[589] |
[590] |
[591] |
[592] |
[593] |
[594] |
89 |
GNG8 |
Guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-8 |
[595] |
[596] |
[597] |
[598] |
[599] |
[600] |
90 |
PDYN |
Proenkephalin-B |
[601] |
[602] |
[603] |
[604] |
[605] |
[606] |
[607] |
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