REACTOME_ONCOGENIC_MAPK_SIGNALING | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | FGG | Fibrinogen gamma chain | [1] | -4.21[2] | -2.93[3] | -2.76[4] | -10.55[5] | -12.41[6] | -0.62[7] |
2 | FGA | Fibrinogen alpha chain | [8] | -3.87[9] | -3.17[10] | -2.65[11] | -9.76[12] | -12.43[13] | 0.05[14] |
3 | FGB | Fibrinogen beta chain | [15] | -5.08[16] | -3.95[17] | -1.67[18] | -7.89[19] | -11.06[20] | 0.83[21] |
4 | ACTB | Actin, cytoplasmic 1 | [22] | 1.00[23] | 0.62[24] | 1.16[25] | 1.74[26] | 1.38[27] | -1.24[28] |
5 | ACTG1 | Actin, cytoplasmic 2 | [29] | 2.28[30] | 1.26[31] | 1.27[32] | 1.55[33] | 1.97[34] | -1.99[35] |
6 | PEBP1 | Phosphatidylethanolamine-binding protein 1 | [36] | 0.54[37] | 1.21[38] | 0.10[39] | -2.06[40] | -1.45[41] | -0.78[42] |
7 | FN1 | Fibronectin | [43] | 5.88[44] | 5.66[45] | 5.46[46] | 5.65[47] | 5.88[48] | 2.24[49] |
8 | RAP1B | Ras-related protein Rap-1b | [50] | 0.08[51] | 1.01[52] | 0.69[53] | 2.21[54] | 1.99[55] | -1.95[56] |
9 | LMNA | Prelamin-A/C | [57] | 2.25[58] | 2.01[59] | 0.53[60] | 3.25[61] | 2.50[62] | -1.02[63] |
10 | PHB | Prohibitin | [64] | 2.47[65] | 2.67[66] | 2.00[67] | 1.48[68] | 1.52[69] | -1.06[70] |
11 | YWHAB | 14-3-3 protein beta/alpha | [71] | 3.43[72] | 3.45[73] | 2.63[74] | 4.03[75] | 3.50[76] | -0.15[77] |
12 | SND1 | Staphylococcal nuclease domain-containing protein 1 | [78] | 3.26[79] | 3.66[80] | 4.11[81] | 3.02[82] | 2.62[83] | 0.98[84] |
13 | PPP1CB | Serine/threonine-protein phosphatase PP1-beta catalytic subunit | [85] | 2.15[86] | 3.02[87] | 3.02[88] | 3.49[89] | 3.34[90] | 0.44[91] |
14 | CALM1 | Calmodulin-1 | [92] | 2.47[93] | 2.81[94] | 3.18[95] | 4.32[96] | 3.62[97] | 1.56[98] |
15 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [99] | 1.46[100] | 1.44[101] | 1.92[102] | 2.19[103] | 2.72[104] | -1.25[105] |
16 | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | [106] | 2.44[107] | 2.43[108] | 3.20[109] | 1.89[110] | 2.40[111] | -1.76[112] |
17 | PPP1CC | Serine/threonine-protein phosphatase PP1-gamma catalytic subunit | 3.07[113] | 4.16[114] | 4.29[115] | 2.97[116] | 3.10[117] | -1.14[118] | |
18 | RAP1A | Ras-related protein Rap-1A | [119] | 1.34[120] | 1.59[121] | 2.33[122] | 2.52[123] | 2.31[124] | -1.35[125] |
19 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | [126] | 2.33[127] | 3.04[128] | 4.21[129] | 2.55[130] | 3.44[131] | 1.04[132] |
20 | DUSP6 | Dual specificity protein phosphatase 6 | [133] | 1.90[134] | 4.29[135] | 3.47[136] | -1.18[137] | 2.64[138] | 0.20[139] |
21 | NRAS | GTPase NRas | [140] | 3.02[141] | 3.76[142] | 4.07[143] | 3.73[144] | 3.33[145] | -0.31[146] |
22 | ARAF | Serine/threonine-protein kinase A-Raf | [147] | 1.93[148] | 1.94[149] | 2.11[150] | 2.64[151] | 2.70[152] | 0.82[153] |
23 | TLN1 | Talin-1 | [154] | 5.38[155] | 4.32[156] | 5.00[157] | 5.84[158] | 5.89[159] | 3.30[160] |
24 | VCL | Vinculin | [161] | 3.16[162] | 3.18[163] | 3.23[164] | 5.56[165] | 4.68[166] | 0.75[167] |
25 | PAPSS1 | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 | [168] | 3.11[169] | 3.88[170] | 3.06[171] | 2.93[172] | 3.04[173] | -1.55[174] |
26 | HRAS | GTPase HRas | [175] | 1.38[176] | 0.98[177] | 0.10[178] | 1.78[179] | 1.59[180] | -2.72[181] |
27 | APBB1IP | Amyloid beta A4 precursor protein-binding family B member 1-interacting protein | -6.14[182] | [183] | -4.00[184] | -0.56[185] | -3.31[186] | -0.59[187] | |
28 | MAP3K11 | Mitogen-activated protein kinase kinase kinase 11 | [188] | 3.47[189] | 3.73[190] | 3.26[191] | 2.88[192] | 2.77[193] | 0.40[194] |
29 | MAPK1 | Mitogen-activated protein kinase 1 | [195] | 4.10[196] | 4.55[197] | 4.28[198] | 4.58[199] | 4.26[200] | 1.72[201] |
30 | CSK | Tyrosine-protein kinase CSK | [202] | 2.76[203] | 2.57[204] | 2.85[205] | 2.72[206] | 2.34[207] | -0.92[208] |
31 | TRIM24 | Transcription intermediary factor 1-alpha | [209] | 4.22[210] | 3.65[211] | 3.66[212] | 1.03[213] | 1.33[214] | -0.18[215] |
32 | AGTRAP | Type-1 angiotensin II receptor-associated protein | [216] | 2.55[217] | 3.23[218] | 2.03[219] | 3.02[220] | 3.09[221] | -1.58[222] |
33 | KRAS | GTPase KRas | [223] | 1.87[224] | 2.16[225] | 3.66[226] | 3.53[227] | 3.22[228] | 0.62[229] |
34 | MARK3 | MAP/microtubule affinity-regulating kinase 3 | [230] | 2.31[231] | 2.89[232] | 2.78[233] | 3.87[234] | 3.58[235] | 0.21[236] |
35 | DUSP9 | Dual specificity protein phosphatase 9 | [237] | 5.85[238] | 6.51[239] | 4.89[240] | -2.28[241] | -2.42[242] | -4.34[243] |
36 | DUSP16 | Dual specificity protein phosphatase 16 | [244] | 3.95[245] | 4.28[246] | 3.92[247] | 1.33[248] | 2.26[249] | 1.39[250] |
37 | ARRB2 | Beta-arrestin-2 | [251] | 2.56[252] | 3.25[253] | 3.11[254] | 1.42[255] | 2.25[256] | -0.93[257] |
38 | DUSP10 | Dual specificity protein phosphatase 10 | [258] | -0.61[259] | -1.05[260] | 0.30[261] | 1.94[262] | 0.97[263] | -0.05[264] |
39 | SHOC2 | Leucine-rich repeat protein SHOC-2 | [265] | 1.63[266] | 3.30[267] | 2.81[268] | 2.86[269] | 3.17[270] | 0.63[271] |
40 | AP3B1 | AP-3 complex subunit beta-1 | [272] | 3.13[273] | 4.01[274] | 3.83[275] | 3.93[276] | 3.84[277] | 0.55[278] |
41 | FXR1 | Fragile X mental retardation syndrome-related protein 1 | [279] | 3.73[280] | 5.22[281] | 5.54[282] | 4.58[283] | 4.87[284] | 0.76[285] |
42 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | [286] | 2.52[287] | 3.14[288] | 4.56[289] | 3.41[290] | 2.63[291] | 1.35[292] |
43 | ZC3HAV1 | Zinc finger CCCH-type antiviral protein 1 | [293] | 2.84[294] | 2.78[295] | 3.40[296] | 4.26[297] | 3.69[298] | 1.84[299] |
44 | AGGF1 | Angiogenic factor with G patch and FHA domains 1 | [300] | 1.87[301] | 3.25[302] | 3.35[303] | 3.49[304] | 3.24[305] | 1.17[306] |
45 | IQGAP1 | Ras GTPase-activating-like protein IQGAP1 | [307] | 4.24[308] | 4.10[309] | 4.42[310] | 6.70[311] | 6.57[312] | 1.97[313] |
46 | QKI | Protein quaking | [314] | 4.47[315] | 5.09[316] | 4.85[317] | 5.01[318] | 5.27[319] | 2.64[320] |
47 | MAPK3 | Mitogen-activated protein kinase 3 | [321] | 4.24[322] | 4.59[323] | 4.54[324] | 3.16[325] | 3.20[326] | -1.10[327] |
48 | FAM114A | Protein FAM114A2 | [328] | 2.02[329] | 2.37[330] | 2.42[331] | 3.02[332] | 2.86[333] | 0.46[334] |
49 | MPRIP | Myosin phosphatase Rho-interacting protein | [335] | 4.57[336] | 4.66[337] | 4.94[338] | 6.25[339] | 6.50[340] | 2.15[341] |
50 | SRC | Proto-oncogene tyrosine-protein kinase Src | [342] | 5.41[343] | 5.71[344] | 4.61[345] | 5.13[346] | 4.33[347] | -0.91[348] |
51 | MRAS | Ras-related protein M-Ras | [349] | 4.14[350] | -1.22[351] | -0.14[352] | 3.19[353] | 3.53[354] | -1.72[355] |
52 | BRAP | BRCA1-associated protein | [356] | 2.74[357] | 3.26[358] | 3.24[359] | 3.61[360] | 3.75[361] | 0.69[362] |
53 | AGK | Acylglycerol kinase, mitochondrial | [363] | 3.62[364] | 4.01[365] | 3.59[366] | 3.69[367] | 3.70[368] | 0.65[369] |
54 | CAMK2G | Calcium/calmodulin-dependent protein kinase type II subunit gamma | 3.16[370] | 4.69[371] | 4.20[372] | 4.42[373] | 4.01[374] | 0.90[375] | |
55 | TRAK1 | Trafficking kinesin-binding protein 1 | [376] | 4.72[377] | 4.70[378] | 4.49[379] | 4.14[380] | 4.10[381] | 1.40[382] |
56 | SPRED2 | Sprouty-related, EVH1 domain-containing protein 2 | [383] | 4.47[384] | 5.03[385] | 4.70[386] | 3.88[387] | 4.31[388] | 0.86[389] |
57 | AKAP9 | A-kinase anchor protein 9 | [390] | 2.41[391] | 5.43[392] | 5.52[393] | 4.53[394] | 4.67[395] | 5.01[396] |
58 | ATG7 | Ubiquitin-like modifier-activating enzyme ATG7 | [397] | 3.38[398] | 3.20[399] | 3.84[400] | 3.41[401] | 4.30[402] | 1.70[403] |
59 | CLCN6 | Chloride transport protein 6 | [404] | 3.09[405] | 5.97[406] | 4.31[407] | 4.14[408] | 2.97[409] | 1.36[410] |
60 | NF1 | Neurofibromin | [411] | 4.85[412] | 5.49[413] | 6.21[414] | 6.70[415] | 6.17[416] | 4.05[417] |
61 | DUSP8 | Dual specificity protein phosphatase 8 | [418] | 3.53[419] | 3.28[420] | 2.36[421] | 1.31[422] | 1.91[423] | -3.88[424] |
62 | BCL2L11 | Bcl-2-like protein 11 | [425] | 3.89[426] | 4.21[427] | 4.44[428] | 4.60[429] | 3.60[430] | 1.93[431] |
63 | DUSP7 | Dual specificity protein phosphatase 7 | [432] | 3.94[433] | 3.34[434] | 4.49[435] | 2.31[436] | 4.72[437] | -0.03[438] |
64 | ITGB3 | Integrin beta-3 | [439] | 0.76[440] | -1.64[441] | 1.78[442] | 5.58[443] | 5.28[444] | 1.27[445] |
65 | BRAF | Serine/threonine-protein kinase B-raf | [446] | 2.64[447] | 2.67[448] | 4.61[449] | 3.47[450] | 3.19[451] | 1.80[452] |
66 | JAK2 | Tyrosine-protein kinase JAK2 | [453] | 2.62[454] | 2.92[455] | 2.38[456] | 3.50[457] | 4.12[458] | 2.65[459] |
67 | SPRED1 | Sprouty-related, EVH1 domain-containing protein 1 | [460] | 4.80[461] | 5.62[462] | 5.44[463] | 6.71[464] | 7.22[465] | 2.73[466] |
68 | ARRB1 | Beta-arrestin-1 | [467] | 5.97[468] | 6.09[469] | 5.29[470] | 4.88[471] | 4.72[472] | 3.21[473] |
69 | CAMK2B | Calcium/calmodulin-dependent protein kinase type II subunit beta | [474] | -0.15[475] | -1.16[476] | -4.22[477] | -0.13[478] | 0.53[479] | 1.09[480] |
70 | CNKSR1 | Connector enhancer of kinase suppressor of ras 1 | [481] | 4.65[482] | 6.44[483] | 2.24[484] | 1.53[485] | 1.01[486] | 0.33[487] |
71 | KSR1 | Kinase suppressor of Ras 1 | [488] | 5.65[489] | 5.66[490] | 2.48[491] | 4.78[492] | 5.30[493] | 0.67[494] |
72 | ESRP1 | Epithelial splicing regulatory protein 1 | [495] | 0.46[496] | 6.15[497] | 3.90[498] | -0.32[499] | -0.76[500] | 0.04[501] |
73 | KIAA1549 | UPF0606 protein KIAA1549 | [502] | 6.64[503] | 5.98[504] | 6.22[505] | 8.27[506] | 6.46[507] | 1.91[508] |
74 | CNKSR2 | Connector enhancer of kinase suppressor of ras 2 | [509] | -1.40[510] | -1.13[511] | 8.42[512] | 6.43[513] | 4.61[514] | 3.07[515] |
75 | VWF | von Willebrand factor | [516] | 3.36[517] | 1.51[518] | -0.97[519] | 2.89[520] | 0.33[521] | 5.66[522] |
76 | SPRED3 | Sprouty-related, EVH1 domain-containing protein 3 | [523] | 6.08[524] | 4.78[525] | 5.15[526] | 5.32[527] | 7.26[528] | -0.48[529] |
77 | ITGA2B | Integrin alpha-IIb | [530] | 5.99[531] | 6.59[532] | 6.49[533] | 5.75[534] | 4.14[535] | 2.56[536] |
78 | KSR2 | Kinase suppressor of Ras 2 | [537] | 2.62[538] | 1.92[539] | [540] | 1.47[541] | [542] | 1.26[543] |
79 | FAM131B | Protein FAM131B | [544] | -1.26[545] | [546] | -1.24[547] | 6.58[548] | 5.56[549] | 0.90[550] |
80 | CAMK2A | Calcium/calmodulin-dependent protein kinase type II subunit alpha | [551] | [552] | [553] | [554] | [555] | [556] | [557] |
81 | KDM7A | Lysine-specific demethylase 7A | [558] | [559] | [560] | [561] | [562] | [563] | [564] |
82 | TENT4A | [565] | [566] | [567] | [568] | [569] | [570] | [571] |