REACTOME_ONCOGENE_INDUCED_SENESCENCE | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -0.97[2] | -1.19[3] | -1.06[4] | -1.09[5] | -0.92[6] | -0.50[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -0.52[16] | -0.44[17] | -0.70[18] | -0.23[19] | -0.54[20] | -0.04[21] |
4 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [22] | 1.91[23] | 1.79[24] | 2.81[25] | 1.16[26] | 1.68[27] | 0.72[28] |
5 | ETS2 | Protein C-ets-2 | [29] | 1.02[30] | 0.50[31] | -1.42[32] | -0.31[33] | -0.34[34] | 1.58[35] |
6 | ID1 | DNA-binding protein inhibitor ID-1 | [36] | 3.21[37] | 2.45[38] | 2.03[39] | 2.01[40] | 1.96[41] | 0.19[42] |
7 | CDK4 | Cyclin-dependent kinase 4 | [43] | 2.56[44] | 3.12[45] | 2.73[46] | 1.87[47] | 2.23[48] | 0.54[49] |
8 | TFDP1 | Transcription factor Dp-1 | [50] | 1.90[51] | 1.20[52] | 1.25[53] | 2.30[54] | 2.58[55] | 0.24[56] |
9 | ETS1 | Protein C-ets-1 | [57] | -1.57[58] | -10.94[59] | -8.16[60] | 1.60[61] | 2.16[62] | 1.29[63] |
10 | MAPK1 | Mitogen-activated protein kinase 1 | [64] | 2.94[65] | 3.05[66] | 2.86[67] | 3.54[68] | 2.90[69] | 3.16[70] |
11 | MOV10 | Putative helicase MOV-10 | [71] | 2.22[72] | 2.41[73] | 2.37[74] | 2.77[75] | 2.32[76] | 2.46[77] |
12 | ERF | ETS domain-containing transcription factor ERF | [78] | 2.45[79] | 2.19[80] | 2.58[81] | 1.81[82] | 1.84[83] | 0.35[84] |
13 | MDM2 | E3 ubiquitin-protein ligase Mdm2 | [85] | 3.34[86] | 4.74[87] | 1.95[88] | 2.20[89] | 2.78[90] | 3.54[91] |
14 | TP53 | Cellular tumor antigen p53 | [92] | 2.87[93] | 2.41[94] | 3.15[95] | 2.98[96] | 2.35[97] | 1.34[98] |
15 | MAPK3 | Mitogen-activated protein kinase 3 | [99] | 3.08[100] | 3.10[101] | 3.12[102] | 2.12[103] | 1.84[104] | 0.34[105] |
16 | CDK6 | Cyclin-dependent kinase 6 | [106] | 3.28[107] | 3.95[108] | 2.34[109] | 2.61[110] | 3.12[111] | 3.45[112] |
17 | SP1 | Transcription factor Sp1 | [113] | 3.05[114] | 3.27[115] | 4.31[116] | 4.36[117] | 3.75[118] | 3.53[119] |
18 | RB1 | Retinoblastoma-associated protein | [120] | 2.45[121] | 2.92[122] | 3.47[123] | 3.97[124] | 4.00[125] | 2.86[126] |
19 | TNRC6A | Trinucleotide repeat-containing gene 6A protein | [127] | 3.48[128] | 4.10[129] | 3.27[130] | 3.98[131] | 3.72[132] | 4.38[133] |
20 | E2F1 | Transcription factor E2F1 | [134] | 3.18[135] | 3.01[136] | 3.12[137] | 3.56[138] | 3.70[139] | -2.24[140] |
21 | CDKN2B | Cyclin-dependent kinase 4 inhibitor B | [141] | 1.60[142] | -2.90[143] | 0.94[144] | 2.85[145] | 2.86[146] | -0.70[147] |
22 | E2F3 | Transcription factor E2F3 | [148] | 2.95[149] | 2.75[150] | 1.99[151] | 4.32[152] | 3.48[153] | 1.21[154] |
23 | CDKN2C | Cyclin-dependent kinase 4 inhibitor C | [155] | 1.46[156] | 2.04[157] | 2.17[158] | 3.87[159] | 3.70[160] | 0.57[161] |
24 | TFDP2 | Transcription factor Dp-2 | [162] | 3.14[163] | 3.80[164] | 3.80[165] | 4.08[166] | 4.01[167] | 3.73[168] |
25 | CDKN2D | Cyclin-dependent kinase 4 inhibitor D | [169] | 0.73[170] | 1.08[171] | 0.82[172] | 0.86[173] | 2.03[174] | -0.33[175] |
26 | MDM4 | Protein Mdm4 | [176] | 2.87[177] | 3.86[178] | 4.27[179] | 3.99[180] | 3.57[181] | 5.94[182] |
27 | TNRC6B | Trinucleotide repeat-containing gene 6B protein | [183] | 3.46[184] | 3.64[185] | 5.30[186] | 4.41[187] | 4.09[188] | 6.72[189] |
28 | TNRC6C | Trinucleotide repeat-containing gene 6C protein | [190] | 3.32[191] | 3.24[192] | 3.51[193] | 2.46[194] | 2.14[195] | 4.68[196] |
29 | CDKN2A | Cyclin-dependent kinase inhibitor 2A | [197] | 5.32[198] | 3.06[199] | 6.44[200] | 6.90[201] | 8.39[202] | -0.77[203] |
30 | E2F2 | Transcription factor E2F2 | [204] | 5.48[205] | 6.35[206] | 5.84[207] | 5.74[208] | 5.78[209] | 2.80[210] |
31 | MIR24-1 | [211] | [212] | [213] | [214] | [215] | [216] | [217] | |
32 | AGO1 | Protein argonaute-1 | [218] | [219] | [220] | [221] | [222] | [223] | [224] |
33 | MIR24-2 | [225] | [226] | [227] | [228] | [229] | [230] | [231] | |
34 | AGO4 | Protein argonaute-4 | [232] | [233] | [234] | [235] | [236] | [237] | [238] |
35 | AGO3 | Protein argonaute-3 | [239] | [240] | [241] | [242] | [243] | [244] | [245] |