REACTOME_NUCLEOTIDE_BIOSYNTHESIS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 IMPDH2 Inosine-5'-monophosphate dehydrogenase 2 [1] -0.58[2] -0.29[3] 0.78[4] -1.12[5] -1.02[6] -1.89[7]
2 PAICS Multifunctional protein ADE2 [8] 0.73[9] 1.02[10] 0.41[11] 0.41[12] 0.81[13] 0.43[14]
3 DHODH Dihydroorotate dehydrogenase (quinone), mitochondrial [15] -3.87[16] -3.94[17] -3.73[18] -3.58[19] -3.99[20] 0.75[21]
4 ADSL Adenylosuccinate lyase [22] -0.62[23] -0.57[24] -0.56[25] -0.95[26] -1.20[27] -0.89[28]
5 ATIC Bifunctional purine biosynthesis protein PURH [29] 0.36[30] 0.07[31] -0.37[32] -0.34[33] -0.33[34] -0.89[35]
6 GART Trifunctional purine biosynthetic protein adenosine-3 [36] 0.04[37] -0.34[38] -1.31[39] 0.21[40] 0.20[41] -0.14[42]
7 GMPS GMP synthase [glutamine-hydrolyzing] [43] -0.53[44] -0.52[45] -0.70[46] 0.91[47] 0.73[48] -0.27[49]
8 UMPS Uridine 5'-monophosphate synthase [50] 0.76[51] 0.87[52] -0.03[53] 0.57[54] 0.87[55] 2.00[56]
9 IMPDH1 Inosine-5'-monophosphate dehydrogenase 1 [57] 1.13[58] 0.27[59] -0.37[60] 2.10[61] 1.24[62] -0.87[63]
10 PPAT Amidophosphoribosyltransferase [64] 0.46[65] 0.85[66] 0.58[67] 0.77[68] 1.01[69] 0.65[70]
11 PFAS Phosphoribosylformylglycinamidine synthase [71] 1.97[72] 1.39[73] 1.74[74] 2.21[75] 2.18[76] 1.92[77]
12 CAD CAD protein [78] 2.54[79] 2.30[80] 2.36[81] 3.18[82] 2.97[83] 2.60[84]
13 ADSS1 [85] [86] [87] [88] [89] [90] [91]
14 ADSS2 [92] [93] [94] [95] [96] [97] [98]
[1]
ref_hepatocyte IMPDH2
Mean 45.4
Standard deviation 20
Values 52 62 61 38 15
[2]
HepG2 IMPDH2
Mean 115
Standard deviation 9.1
Values 1.2e+02 1.1e+02
[3]
HepG2.C3A IMPDH2
Mean 139
Standard deviation 31
Values 1.6e+02 1.2e+02
[4]
HuH.7 IMPDH2
Mean 368
Standard deviation 41
Values 3.5e+02 3.4e+02 4.2e+02
[5]
SNU475 IMPDH2
Mean 37.3
Standard deviation 14
Values 28 47
[6]
THLE IMPDH2
Mean 56.1
Standard deviation 6.5
Values 51 61
[7]
liver IMPDH2
Mean 13.5
Standard deviation 5.2
Values 13 13 20 7.8
[8]
ref_hepatocyte PAICS
Mean 28.4
Standard deviation 8.1
Values 34 32 14 28 33
[9]
HepG2 PAICS
Mean 178
Standard deviation 24
Values 1.6e+02 1.9e+02
[10]
HepG2.C3A PAICS
Mean 215
Standard deviation 76
Values 1.6e+02 2.7e+02
[11]
HuH.7 PAICS
Mean 177
Standard deviation 52
Values 1.9e+02 1.2e+02 2.2e+02
[12]
SNU475 PAICS
Mean 67.2
Standard deviation 4.6
Values 64 70
[13]
THLE PAICS
Mean 124
Standard deviation 21
Values 1.1e+02 1.4e+02
[14]
liver PAICS
Mean 42.1
Standard deviation 21
Values 62 24 57 25
[15]
ref_hepatocyte DHODH
Mean 27.3
Standard deviation 31
Values 3.2 5.2 5.7 67 55
[16]
HepG2 DHODH
Mean 7.06
Standard deviation 1
Values 7.8 6.4
[17]
HepG2.C3A DHODH
Mean 6.66
Standard deviation 0.088
Values 6.6 6.7
[18]
HuH.7 DHODH
Mean 9.66
Standard deviation 4.2
Values 12 4.8 12
[19]
SNU475 DHODH
Mean 4.06
Standard deviation 0.45
Values 3.7 4.4
[20]
THLE DHODH
Mean 4.31
Standard deviation 0.19
Values 4.2 4.4
[21]
liver DHODH
Mean 50.3
Standard deviation 12
Values 46 38 65 53
[22]
ref_hepatocyte ADSL
Mean 25
Standard deviation 12
Values 34 40 21 17 12
[23]
HepG2 ADSL
Mean 61.7
Standard deviation 4
Values 65 59
[24]
HepG2.C3A ADSL
Mean 63.3
Standard deviation 4.7
Values 60 67
[25]
HuH.7 ADSL
Mean 79.7
Standard deviation 15
Values 81 64 94
[26]
SNU475 ADSL
Mean 23.2
Standard deviation 2.7
Values 21 25
[27]
THLE ADSL
Mean 27.3
Standard deviation 7.7
Values 22 33
[28]
liver ADSL
Mean 14.9
Standard deviation 3.2
Values 14 16 18 11
[29]
ref_hepatocyte ATIC
Mean 24.9
Standard deviation 8.1
Values 32 32 28 19 14
[30]
HepG2 ATIC
Mean 121
Standard deviation 12
Values 1.3e+02 1.1e+02
[31]
HepG2.C3A ATIC
Mean 97.3
Standard deviation 10
Values 1e+02 90
[32]
HuH.7 ATIC
Mean 90.3
Standard deviation 22
Values 1e+02 65 1.1e+02
[33]
SNU475 ATIC
Mean 35.2
Standard deviation 3.4
Values 33 38
[34]
THLE ATIC
Mean 49.5
Standard deviation 10
Values 42 57
[35]
liver ATIC
Mean 14.7
Standard deviation 12
Values 21 5.3 29 4.1
[36]
ref_hepatocyte GART
Mean 21.4
Standard deviation 16
Values 17 43 33 8 7.1
[37]
HepG2 GART
Mean 83.2
Standard deviation 13
Values 92 74
[38]
HepG2.C3A GART
Mean 63.6
Standard deviation 1.3
Values 63 65
[39]
HuH.7 GART
Mean 40.7
Standard deviation 14
Values 48 25 50
[40]
SNU475 GART
Mean 44.2
Standard deviation 5.5
Values 40 48
[41]
THLE GART
Mean 61.8
Standard deviation 11
Values 54 69
[42]
liver GART
Mean 21.4
Standard deviation 7.5
Values 12 26 29 20
[43]
ref_hepatocyte GMPS
Mean 11.5
Standard deviation 5.8
Values 14 21 7.9 8.4 6.5
[44]
HepG2 GMPS
Mean 30
Standard deviation 2.7
Values 28 32
[45]
HepG2.C3A GMPS
Mean 29.9
Standard deviation 0.16
Values 30 30
[46]
HuH.7 GMPS
Mean 33.2
Standard deviation 3.7
Values 37 31 32
[47]
SNU475 GMPS
Mean 38.6
Standard deviation 7.3
Values 33 44
[48]
THLE GMPS
Mean 47.7
Standard deviation 4.7
Values 44 51
[49]
liver GMPS
Mean 10.5
Standard deviation 1.7
Values 11 10 12 8.1
[50]
ref_hepatocyte UMPS
Mean 5.13
Standard deviation 2
Values 7.5 7.1 4.2 3.6 3.3
[51]
HepG2 UMPS
Mean 32.8
Standard deviation 4.8
Values 29 36
[52]
HepG2.C3A UMPS
Mean 35
Standard deviation 4.5
Values 32 38
[53]
HuH.7 UMPS
Mean 23.6
Standard deviation 3.4
Values 26 20 25
[54]
SNU475 UMPS
Mean 13.6
Standard deviation 0.94
Values 13 14
[55]
THLE UMPS
Mean 23.4
Standard deviation 4.7
Values 20 27
[56]
liver UMPS
Mean 22.6
Standard deviation 3.3
Values 20 22 27 20
[57]
ref_hepatocyte IMPDH1
Mean 4.53
Standard deviation 3.3
Values 8.6 6.6 5.1 1.2 1.2
[58]
HepG2 IMPDH1
Mean 37.5
Standard deviation 10
Values 45 30
[59]
HepG2.C3A IMPDH1
Mean 20.5
Standard deviation 4.3
Values 24 17
[60]
HuH.7 IMPDH1
Mean 16.5
Standard deviation 2.6
Values 19 14 17
[61]
SNU475 IMPDH1
Mean 34.6
Standard deviation 1.1
Values 34 35
[62]
THLE IMPDH1
Mean 26.8
Standard deviation 3.7
Values 24 29
[63]
liver IMPDH1
Mean 2.72
Standard deviation 0.62
Values 2.2 2.2 3.1 3.4
[64]
ref_hepatocyte PPAT
Mean 3.8
Standard deviation 3
Values 7.8 6.1 1.8 1.5 1.7
[65]
HepG2 PPAT
Mean 19.7
Standard deviation 5
Values 16 23
[66]
HepG2.C3A PPAT
Mean 25.7
Standard deviation 7.5
Values 20 31
[67]
HuH.7 PPAT
Mean 26.6
Standard deviation 9.2
Values 34 16 30
[68]
SNU475 PPAT
Mean 11.6
Standard deviation 2.8
Values 9.6 14
[69]
THLE PPAT
Mean 19.1
Standard deviation 1.8
Values 18 20
[70]
liver PPAT
Mean 6.55
Standard deviation 0.98
Values 6.5 6.4 7.9 5.5
[71]
ref_hepatocyte PFAS
Mean 2.15
Standard deviation 0.73
Values 2.2 3.1 2.6 1.5 1.4
[72]
HepG2 PFAS
Mean 31.9
Standard deviation 2.2
Values 33 30
[73]
HepG2.C3A PFAS
Mean 21.1
Standard deviation 1.9
Values 20 22
[74]
HuH.7 PFAS
Mean 33.9
Standard deviation 17
Values 49 15 38
[75]
SNU475 PFAS
Mean 17.8
Standard deviation 1.9
Values 16 19
[76]
THLE PFAS
Mean 24.4
Standard deviation 5.7
Values 20 28
[77]
liver PFAS
Mean 8.96
Standard deviation 1.7
Values 6.5 9.8 9.5 10
[78]
ref_hepatocyte CAD
Mean 2.02
Standard deviation 0.66
Values 1.3 2.8 2.1 2.5 1.4
[79]
HepG2 CAD
Mean 44.5
Standard deviation 9.8
Values 51 38
[80]
HepG2.C3A CAD
Mean 37.1
Standard deviation 4.2
Values 40 34
[81]
HuH.7 CAD
Mean 48.6
Standard deviation 25
Values 72 22 51
[82]
SNU475 CAD
Mean 32.8
Standard deviation 3.1
Values 31 35
[83]
THLE CAD
Mean 39.6
Standard deviation 2.9
Values 38 42
[84]
liver CAD
Mean 13.5
Standard deviation 4.8
Values 8.5 17 10 18
[85]
ref_hepatocyte ADSS1
Missing
[86]
HepG2 ADSS1
Missing
[87]
HepG2.C3A ADSS1
Missing
[88]
HuH.7 ADSS1
Missing
[89]
SNU475 ADSS1
Missing
[90]
THLE ADSS1
Missing
[91]
liver ADSS1
Missing
[92]
ref_hepatocyte ADSS2
Missing
[93]
HepG2 ADSS2
Missing
[94]
HepG2.C3A ADSS2
Missing
[95]
HuH.7 ADSS2
Missing
[96]
SNU475 ADSS2
Missing
[97]
THLE ADSS2
Missing
[98]
liver ADSS2
Missing