REACTOME_NUCLEAR_EVENTS_STIMULATED_BY_ALK_SIGNALING_IN_CANCER Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 RPS6 40S ribosomal protein S6 [1] [2] [3] [4] [5] [6] [7]
2 NPM1 Nucleophosmin [8] -2.04[9] -1.02[10] -0.36[11] -2.22[12] -2.29[13] -3.34[14]
3 FN1 Fibronectin [15] 3.34[16] 2.97[17] 2.84[18] 3.18[19] 3.28[20] 2.90[21]
4 SKP1 S-phase kinase-associated protein 1 [22] -1.13[23] -0.58[24] -1.48[25] -0.25[26] -0.13[27] -0.09[28]
5 RBX1 E3 ubiquitin-protein ligase RBX1 [29] -2.21[30] -1.62[31] -1.76[32] -2.45[33] -2.12[34] -1.49[35]
6 JUNB Transcription factor jun-B [36] -2.11[37] -2.81[38] -2.13[39] -1.91[40] -1.17[41] -0.78[42]
7 CEBPB CCAAT/enhancer-binding protein beta [43] -1.32[44] -1.80[45] -1.80[46] -1.16[47] -0.32[48] -1.07[49]
8 STAT3 Signal transducer and activator of transcription 3 [50] 0.40[51] -0.94[52] -0.23[53] 0.50[54] -0.33[55] 3.01[56]
9 CLTC Clathrin heavy chain 1 [57] 1.47[58] 1.72[59] 1.87[60] 1.94[61] 1.98[62] 3.06[63]
10 CUL1 Cullin-1 [64] -0.53[65] 0.30[66] -0.17[67] 0.84[68] 0.39[69] 1.35[70]
11 KIF5B Kinesin-1 heavy chain [71] 0.26[72] 2.40[73] 2.13[74] 3.11[75] 2.09[76] 1.94[77]
12 MAPK1 Mitogen-activated protein kinase 1 [78] 1.56[79] 1.85[80] 1.66[81] 2.11[82] 1.65[83] 2.38[84]
13 EML4 Echinoderm microtubule-associated protein-like 4 [85] 2.94[86] 4.20[87] 2.71[88] 2.36[89] 0.74[90] 2.73[91]
14 BCL2A1 Bcl-2-related protein A1 [92] -4.92[93] -6.59[94] -11.02[95] -9.00[96] -5.56[97] -4.28[98]
15 ZC3HC1 Nuclear-interacting partner of ALK [99] -0.04[100] -0.06[101] 0.36[102] 0.75[103] 0.18[104] 0.24[105]
16 MECP2 Methyl-CpG-binding protein 2 [106] 0.58[107] 1.02[108] 1.20[109] 1.84[110] 1.85[111] 1.44[112]
17 MAPK3 Mitogen-activated protein kinase 3 [113] 1.70[114] 1.90[115] 1.92[116] 0.68[117] 0.60[118] -0.43[119]
18 STAT5A Signal transducer and activator of transcription 5A [120] -2.10[121] -0.77[122] -1.73[123] -0.59[124] 0.07[125] 0.84[126]
19 ALK ALK tyrosine kinase receptor [127] [128] [129] [130] [131] [132] [133]
[1]
ref_hepatocyte RPS6
Mean 819
Standard deviation 2.5e+02
Values 6.5e+02 6.1e+02 9e+02 1.2e+03 7.2e+02
[2]
HepG2 RPS6
Missing
[3]
HepG2.C3A RPS6
Missing
[4]
HuH.7 RPS6
Missing
[5]
SNU475 RPS6
Missing
[6]
THLE RPS6
Missing
[7]
liver RPS6
Missing
[8]
ref_hepatocyte NPM1
Mean 751
Standard deviation 7.3e+02
Values 1.1e+03 1.9e+03 4.5e+02 2.1e+02 1.2e+02
[9]
HepG2 NPM1
Mean 448
Standard deviation 23
Values 4.3e+02 4.6e+02
[10]
HepG2.C3A NPM1
Mean 727
Standard deviation 15
Values 7.2e+02 7.4e+02
[11]
HuH.7 NPM1
Mean 1.12e+03
Standard deviation 1e+02
Values 1e+03 1.2e+03 1.2e+03
[12]
SNU475 NPM1
Mean 248
Standard deviation 24
Values 2.3e+02 2.6e+02
[13]
THLE NPM1
Mean 283
Standard deviation 68
Values 2.3e+02 3.3e+02
[14]
liver NPM1
Mean 69.2
Standard deviation 20
Values 69 85 81 41
[15]
ref_hepatocyte FN1
Mean 152
Standard deviation 1.4e+02
Values 1.3e+02 57 27 1.7e+02 3.8e+02
[16]
HepG2 FN1
Mean 3.78e+03
Standard deviation 3.9e+02
Values 4.1e+03 3.5e+03
[17]
HepG2.C3A FN1
Mean 2.34e+03
Standard deviation 1.3e+03
Values 3.2e+03 1.4e+03
[18]
HuH.7 FN1
Mean 2.08e+03
Standard deviation 9.6e+02
Values 1.8e+03 3.1e+03 1.3e+03
[19]
SNU475 FN1
Mean 2.11e+03
Standard deviation 1.4e+02
Values 2e+03 2.2e+03
[20]
THLE FN1
Mean 2.73e+03
Standard deviation 1.5e+03
Values 1.7e+03 3.8e+03
[21]
liver FN1
Mean 1.06e+03
Standard deviation 3.8e+02
Values 5.9e+02 1.3e+03 9.3e+02 1.4e+03
[22]
ref_hepatocyte SKP1
Mean 80.8
Standard deviation 44
Values 1.5e+02 92 24 71 71
[23]
HepG2 SKP1
Mean 90.4
Standard deviation 11
Values 83 98
[24]
HepG2.C3A SKP1
Mean 106
Standard deviation 20
Values 91 1.2e+02
[25]
HuH.7 SKP1
Mean 55.5
Standard deviation 13
Values 57 42 67
[26]
SNU475 SKP1
Mean 105
Standard deviation 22
Values 1.2e+02 89
[27]
THLE SKP1
Mean 137
Standard deviation 18
Values 1.2e+02 1.5e+02
[28]
liver SKP1
Mean 71
Standard deviation 55
Values 1.1e+02 27 1.3e+02 20
[29]
ref_hepatocyte RBX1
Mean 54.3
Standard deviation 41
Values 88 1.1e+02 7.4 33 36
[30]
HepG2 RBX1
Mean 28.8
Standard deviation 5.7
Values 25 33
[31]
HepG2.C3A RBX1
Mean 34.6
Standard deviation 13
Values 26 44
[32]
HuH.7 RBX1
Mean 30.6
Standard deviation 15
Values 29 17 46
[33]
SNU475 RBX1
Mean 15.3
Standard deviation 1.3
Values 16 14
[34]
THLE RBX1
Mean 23
Standard deviation 3.5
Values 21 25
[35]
liver RBX1
Mean 18
Standard deviation 18
Values 36 2.5 32 1.8
[36]
ref_hepatocyte JUNB
Mean 38
Standard deviation 34
Values 4.3 9.7 61 84 31
[37]
HepG2 JUNB
Mean 21.6
Standard deviation 12
Values 30 13
[38]
HepG2.C3A JUNB
Mean 10.6
Standard deviation 6.5
Values 15 6
[39]
HuH.7 JUNB
Mean 16.6
Standard deviation 6.7
Values 12 24 14
[40]
SNU475 JUNB
Mean 15.5
Standard deviation 3.7
Values 13 18
[41]
THLE JUNB
Mean 31.2
Standard deviation 6
Values 27 35
[42]
liver JUNB
Mean 20.6
Standard deviation 9
Values 28 18 9.1 28
[43]
ref_hepatocyte CEBPB
Mean 37.2
Standard deviation 25
Values 9 26 24 65 62
[44]
HepG2 CEBPB
Mean 36.4
Standard deviation 26
Values 55 18
[45]
HepG2.C3A CEBPB
Mean 20.9
Standard deviation 13
Values 30 12
[46]
HuH.7 CEBPB
Mean 20.5
Standard deviation 6.4
Values 13 25 23
[47]
SNU475 CEBPB
Mean 25.6
Standard deviation 11
Values 18 33
[48]
THLE CEBPB
Mean 55
Standard deviation 10
Values 48 62
[49]
liver CEBPB
Mean 16.5
Standard deviation 5.6
Values 18 16 9.1 22
[50]
ref_hepatocyte STAT3
Mean 30.1
Standard deviation 11
Values 26 25 18 46 36
[51]
HepG2 STAT3
Mean 97.5
Standard deviation 10
Values 90 1e+02
[52]
HepG2.C3A STAT3
Mean 30.7
Standard deviation 5.2
Values 34 27
[53]
HuH.7 STAT3
Mean 49.1
Standard deviation 15
Values 47 65 35
[54]
SNU475 STAT3
Mean 65.4
Standard deviation 12
Values 74 57
[55]
THLE STAT3
Mean 44.3
Standard deviation 6
Values 40 49
[56]
liver STAT3
Mean 227
Standard deviation 42
Values 1.9e+02 2.3e+02 2.8e+02 2e+02
[57]
ref_hepatocyte CLTC
Mean 30
Standard deviation 17
Values 53 42 13 19 24
[58]
HepG2 CLTC
Mean 203
Standard deviation 93
Values 1.4e+02 2.7e+02
[59]
HepG2.C3A CLTC
Mean 193
Standard deviation 28
Values 1.7e+02 2.1e+02
[60]
HuH.7 CLTC
Mean 209
Standard deviation 37
Values 2.5e+02 2.1e+02 1.7e+02
[61]
SNU475 CLTC
Mean 176
Standard deviation 18
Values 1.9e+02 1.6e+02
[62]
THLE CLTC
Mean 218
Standard deviation 18
Values 2.1e+02 2.3e+02
[63]
liver CLTC
Mean 234
Standard deviation 1.1e+02
Values 1.2e+02 3.7e+02 1.8e+02 2.7e+02
[64]
ref_hepatocyte CUL1
Mean 14.3
Standard deviation 4.3
Values 13 22 12 14 11
[65]
HepG2 CUL1
Mean 24.2
Standard deviation 10
Values 17 31
[66]
HepG2.C3A CUL1
Mean 34.5
Standard deviation 8.6
Values 28 41
[67]
HuH.7 CUL1
Mean 24.2
Standard deviation 1.9
Values 26 22 25
[68]
SNU475 CUL1
Mean 39.3
Standard deviation 2.3
Values 41 38
[69]
THLE CUL1
Mean 34.6
Standard deviation 5.4
Values 31 38
[70]
liver CUL1
Mean 34
Standard deviation 1.6
Values 32 35 34 36
[71]
ref_hepatocyte KIF5B
Mean 13.8
Standard deviation 9.5
Values 24 23 13 3.8 5.2
[72]
HepG2 KIF5B
Mean 40.4
Standard deviation 19
Values 27 54
[73]
HepG2.C3A KIF5B
Mean 142
Standard deviation 30
Values 1.2e+02 1.6e+02
[74]
HuH.7 KIF5B
Mean 115
Standard deviation 18
Values 1.3e+02 1.3e+02 94
[75]
SNU475 KIF5B
Mean 183
Standard deviation 2.9
Values 1.8e+02 1.8e+02
[76]
THLE KIF5B
Mean 108
Standard deviation 25
Values 1.3e+02 91
[77]
liver KIF5B
Mean 49.2
Standard deviation 8.6
Values 51 57 37 51
[78]
ref_hepatocyte MAPK1
Mean 10.7
Standard deviation 3.7
Values 14 13 13 6.1 7.4
[79]
HepG2 MAPK1
Mean 77.6
Standard deviation 22
Values 62 93
[80]
HepG2.C3A MAPK1
Mean 76.1
Standard deviation 7.2
Values 71 81
[81]
HuH.7 MAPK1
Mean 64.8
Standard deviation 7.4
Values 73 60 61
[82]
SNU475 MAPK1
Mean 71.1
Standard deviation 8
Values 77 65
[83]
THLE MAPK1
Mean 62.4
Standard deviation 14
Values 53 72
[84]
liver MAPK1
Mean 52.3
Standard deviation 14
Values 39 68 41 61
[85]
ref_hepatocyte EML4
Mean 7.28
Standard deviation 3.9
Values 14 7.3 5.4 4.5 5.2
[86]
HepG2 EML4
Mean 137
Standard deviation 43
Values 1.1e+02 1.7e+02
[87]
HepG2.C3A EML4
Mean 262
Standard deviation 7.4
Values 2.7e+02 2.6e+02
[88]
HuH.7 EML4
Mean 91
Standard deviation 20
Values 1.1e+02 74 86
[89]
SNU475 EML4
Mean 57.3
Standard deviation 1.7
Values 56 59
[90]
THLE EML4
Mean 22.4
Standard deviation 1.3
Values 21 23
[91]
liver EML4
Mean 45.2
Standard deviation 4.2
Values 41 50 43 46
[92]
ref_hepatocyte BCL2A1
Mean 5.7
Standard deviation 7.9
Values 0 6.2 19 2.5 0.74
[93]
HepG2 BCL2A1
Mean 0.462
Standard deviation 0.014
Values 0.45 0.47
[94]
HepG2.C3A BCL2A1
Mean 0.116
Standard deviation 0.11
Values 0.039 0.19
[95]
HuH.7 BCL2A1
Mean 0.00526
Standard deviation 0.0048
Values 0 0.0064 0.0094
[96]
SNU475 BCL2A1
Mean 0.0171
Standard deviation 0.0045
Values 0.014 0.02
[97]
THLE BCL2A1
Mean 0.223
Standard deviation 0.044
Values 0.25 0.19
[98]
liver BCL2A1
Mean 0.273
Standard deviation 0.092
Values 0.31 0.17 0.23 0.38
[99]
ref_hepatocyte ZC3HC1
Mean 5.5
Standard deviation 1.2
Values 3.5 6.4 6.3 5 6.3
[100]
HepG2 ZC3HC1
Mean 13.1
Standard deviation 1.3
Values 12 14
[101]
HepG2.C3A ZC3HC1
Mean 10.3
Standard deviation 0.91
Values 9.7 11
[102]
HuH.7 ZC3HC1
Mean 13.5
Standard deviation 3.9
Values 16 9 16
[103]
SNU475 ZC3HC1
Mean 14.2
Standard deviation 0.17
Values 14 14
[104]
THLE ZC3HC1
Mean 11.5
Standard deviation 0.098
Values 11 12
[105]
liver ZC3HC1
Mean 6.04
Standard deviation 3.8
Values 9.1 3.3 9.5 2.3
[106]
ref_hepatocyte MECP2
Mean 4.65
Standard deviation 3.2
Values 0.97 2.9 9 6.8 3.6
[107]
HepG2 MECP2
Mean 17
Standard deviation 0.35
Values 17 17
[108]
HepG2.C3A MECP2
Mean 18.5
Standard deviation 2.1
Values 20 17
[109]
HuH.7 MECP2
Mean 20.4
Standard deviation 2.7
Values 24 19 19
[110]
SNU475 MECP2
Mean 25.6
Standard deviation 3.5
Values 28 23
[111]
THLE MECP2
Mean 30.9
Standard deviation 2.7
Values 29 33
[112]
liver MECP2
Mean 11.7
Standard deviation 2.4
Values 14 9.6 9.8 14
[113]
ref_hepatocyte MAPK3
Mean 4.16
Standard deviation 1.3
Values 5.1 2.8 3.6 6 3.3
[114]
HepG2 MAPK3
Mean 33.1
Standard deviation 5.2
Values 37 29
[115]
HepG2.C3A MAPK3
Mean 30.4
Standard deviation 12
Values 39 22
[116]
HuH.7 MAPK3
Mean 30
Standard deviation 4.8
Values 34 25 32
[117]
SNU475 MAPK3
Mean 10.2
Standard deviation 2.4
Values 12 8.5
[118]
THLE MAPK3
Mean 11.6
Standard deviation 1.1
Values 11 12
[119]
liver MAPK3
Mean 2.87
Standard deviation 2.4
Values 5 0.81 4.8 0.82
[120]
ref_hepatocyte STAT5A
Mean 2.36
Standard deviation 1.6
Values 1.8 2.7 5 1.5 0.95
[121]
HepG2 STAT5A
Mean 1.35
Standard deviation 0.098
Values 1.4 1.3
[122]
HepG2.C3A STAT5A
Mean 2.72
Standard deviation 0.23
Values 2.6 2.9
[123]
HuH.7 STAT5A
Mean 1.37
Standard deviation 0.38
Values 1.1 1.8 1.2
[124]
SNU475 STAT5A
Mean 2.42
Standard deviation 0.13
Values 2.5 2.3
[125]
THLE STAT5A
Mean 4.58
Standard deviation 0.3
Values 4.8 4.4
[126]
liver STAT5A
Mean 3.96
Standard deviation 1.5
Values 3 3.5 3.3 6.2
[127]
ref_hepatocyte ALK
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[128]
HepG2 ALK
Mean 0
Standard deviation 0
Values 0 0
[129]
HepG2.C3A ALK
Mean 0
Standard deviation 0
Values 0 0
[130]
HuH.7 ALK
Mean 0.00642
Standard deviation 0.011
Values 0 0.019 0
[131]
SNU475 ALK
Mean 0.0319
Standard deviation 0.012
Values 0.023 0.041
[132]
THLE ALK
Mean 0.00828
Standard deviation 0.0033
Values 0.0059 0.011
[133]
liver ALK
Mean 0.137
Standard deviation 0.12
Values 0.047 0.19 0.026 0.29