REACTOME_NRIF_SIGNALS_CELL_DEATH_FROM_THE_NUCLEUS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 UBB Polyubiquitin-B [1] -0.34[2] -0.29[3] -0.44[4] -0.80[5] -0.44[6] 0.01[7]
2 SQSTM1 Sequestosome-1 [8] 0.10[9] -0.70[10] -0.45[11] 0.81[12] 0.62[13] 0.09[14]
3 RPS27A Ubiquitin-40S ribosomal protein S27a [15] [16] [17] [18] [19] [20] [21]
4 UBC Polyubiquitin-C [22] 0.10[23] 0.46[24] -0.08[25] 0.05[26] -0.06[27] 0.46[28]
5 UBA52 Ubiquitin-60S ribosomal protein L40 [29] 2.54[30] 2.70[31] 3.44[32] 1.45[33] 2.17[34] 1.23[35]
6 APH1A Gamma-secretase subunit APH-1A [36] 1.79[37] 2.32[38] 2.24[39] 1.71[40] 1.51[41] 0.87[42]
7 PSENEN Gamma-secretase subunit PEN-2 [43] -0.21[44] 0.06[45] 0.22[46] 0.09[47] -0.43[48] -0.18[49]
8 NCSTN Nicastrin [50] 3.21[51] 2.62[52] 2.47[53] 3.07[54] 2.85[55] 2.27[56]
9 MAPK8 Mitogen-activated protein kinase 8 [57] 0.41[58] 2.08[59] 0.64[60] 1.07[61] 0.84[62] 1.37[63]
10 PSEN1 Presenilin-1 [64] 2.92[65] 3.39[66] 2.65[67] 3.23[68] 3.01[69] 2.88[70]
11 PSEN2 Presenilin-2 [71] 1.17[72] 0.57[73] -3.55[74] 2.06[75] 0.59[76] 1.79[77]
12 ITGB3BP Centromere protein R [78] 0.94[79] 2.89[80] 2.88[81] 1.61[82] 2.18[83] 0.44[84]
13 TRAF6 TNF receptor-associated factor 6 [85] 2.95[86] 3.09[87] 3.35[88] 3.64[89] 3.00[90] 4.79[91]
14 APH1B Gamma-secretase subunit APH-1B [92] 1.62[93] 2.68[94] 5.51[95] 5.07[96] 4.02[97] 3.11[98]
15 NGFR Tumor necrosis factor receptor superfamily member 16 [99] 10.32[100] 3.73[101] -0.57[102] 3.73[103] 4.57[104] 9.49[105]
16 NGF Beta-nerve growth factor [106] [107] [108] [109] [110] [111] [112]
[1]
ref_hepatocyte UBB
Mean 764
Standard deviation 4.8e+02
Values 3.8e+02 3.5e+02 5.3e+02 1.2e+03 1.3e+03
[2]
HepG2 UBB
Mean 368
Standard deviation 39
Values 4e+02 3.4e+02
[3]
HepG2.C3A UBB
Mean 285
Standard deviation 14
Values 2.8e+02 3e+02
[4]
HuH.7 UBB
Mean 304
Standard deviation 40
Values 2.9e+02 2.7e+02 3.5e+02
[5]
SNU475 UBB
Mean 204
Standard deviation 3.3
Values 2.1e+02 2e+02
[6]
THLE UBB
Mean 315
Standard deviation 34
Values 2.9e+02 3.4e+02
[7]
liver UBB
Mean 296
Standard deviation 1.3e+02
Values 4.3e+02 2.1e+02 3.9e+02 1.5e+02
[8]
ref_hepatocyte SQSTM1
Mean 520
Standard deviation 6e+02
Values 2e+02 1.6e+03 4.7e+02 1.7e+02 1.9e+02
[9]
HepG2 SQSTM1
Mean 340
Standard deviation 1.6e+02
Values 4.5e+02 2.3e+02
[10]
HepG2.C3A SQSTM1
Mean 146
Standard deviation 39
Values 1.7e+02 1.2e+02
[11]
HuH.7 SQSTM1
Mean 205
Standard deviation 98
Values 1.5e+02 3.2e+02 1.5e+02
[12]
SNU475 SQSTM1
Mean 424
Standard deviation 77
Values 3.7e+02 4.8e+02
[13]
THLE SQSTM1
Mean 447
Standard deviation 1.3e+02
Values 3.6e+02 5.4e+02
[14]
liver SQSTM1
Mean 213
Standard deviation 1.3e+02
Values 2.6e+02 1.4e+02 3.7e+02 80
[15]
ref_hepatocyte RPS27A
Mean 499
Standard deviation 2.2e+02
Values 6.6e+02 6.1e+02 1.7e+02 6.8e+02 3.8e+02
[16]
HepG2 RPS27A
Missing
[17]
HepG2.C3A RPS27A
Missing
[18]
HuH.7 RPS27A
Missing
[19]
SNU475 RPS27A
Missing
[20]
THLE RPS27A
Missing
[21]
liver RPS27A
Missing
[22]
ref_hepatocyte UBC
Mean 480
Standard deviation 2.8e+02
Values 1.8e+02 3.5e+02 9.1e+02 5.8e+02 3.8e+02
[23]
HepG2 UBC
Mean 314
Standard deviation 38
Values 3.4e+02 2.9e+02
[24]
HepG2.C3A UBC
Mean 302
Standard deviation 41
Values 3.3e+02 2.7e+02
[25]
HuH.7 UBC
Mean 246
Standard deviation 64
Values 2.4e+02 3.1e+02 1.9e+02
[26]
SNU475 UBC
Mean 232
Standard deviation 63
Values 2.8e+02 1.9e+02
[27]
THLE UBC
Mean 257
Standard deviation 41
Values 2.3e+02 2.9e+02
[28]
liver UBC
Mean 254
Standard deviation 78
Values 2.2e+02 3.1e+02 3.3e+02 1.6e+02
[29]
ref_hepatocyte UBA52
Mean 57.3
Standard deviation 43
Values 14 23 49 1.2e+02 81
[30]
HepG2 UBA52
Mean 203
Standard deviation 20
Values 2.2e+02 1.9e+02
[31]
HepG2.C3A UBA52
Mean 169
Standard deviation 3.3
Values 1.7e+02 1.7e+02
[32]
HuH.7 UBA52
Mean 334
Standard deviation 46
Values 3.4e+02 2.8e+02 3.7e+02
[33]
SNU475 UBA52
Mean 72.9
Standard deviation 11
Values 65 81
[34]
THLE UBA52
Mean 144
Standard deviation 15
Values 1.3e+02 1.5e+02
[35]
liver UBA52
Mean 51.7
Standard deviation 26
Values 79 32 68 28
[36]
ref_hepatocyte APH1A
Mean 33
Standard deviation 14
Values 23 24 22 47 49
[37]
HepG2 APH1A
Mean 69.5
Standard deviation 1.3
Values 69 70
[38]
HepG2.C3A APH1A
Mean 75
Standard deviation 1.3
Values 76 74
[39]
HuH.7 APH1A
Mean 83.8
Standard deviation 7.5
Values 79 80 92
[40]
SNU475 APH1A
Mean 50.3
Standard deviation 16
Values 61 39
[41]
THLE APH1A
Mean 52.6
Standard deviation 11
Values 45 60
[42]
liver APH1A
Mean 23.2
Standard deviation 0.44
Values 23 24 23 24
[43]
ref_hepatocyte PSENEN
Mean 26.8
Standard deviation 21
Values 8.7 7.6 23 58 37
[44]
HepG2 PSENEN
Mean 14.1
Standard deviation 1.6
Values 13 15
[45]
HepG2.C3A PSENEN
Mean 12.7
Standard deviation 0.49
Values 12 13
[46]
HuH.7 PSENEN
Mean 16.9
Standard deviation 4
Values 17 13 21
[47]
SNU475 PSENEN
Mean 13.3
Standard deviation 0.61
Values 13 14
[48]
THLE PSENEN
Mean 11.1
Standard deviation 0.49
Values 11 11
[49]
liver PSENEN
Mean 9.09
Standard deviation 9.1
Values 17 1.1 17 1.3
[50]
ref_hepatocyte NCSTN
Mean 16.1
Standard deviation 1.3
Values 18 15 16 16 15
[51]
HepG2 NCSTN
Mean 90.9
Standard deviation 5.4
Values 95 87
[52]
HepG2.C3A NCSTN
Mean 45.1
Standard deviation 8.2
Values 51 39
[53]
HuH.7 NCSTN
Mean 48.2
Standard deviation 2.5
Values 47 46 51
[54]
SNU475 NCSTN
Mean 63.1
Standard deviation 12
Values 72 55
[55]
THLE NCSTN
Mean 65
Standard deviation 14
Values 55 75
[56]
liver NCSTN
Mean 30.1
Standard deviation 12
Values 32 22 46 20
[57]
ref_hepatocyte MAPK8
Mean 7.1
Standard deviation 4.4
Values 6.5 5.6 15 3.8 4.7
[58]
HepG2 MAPK8
Mean 5.76
Standard deviation 1
Values 5.1 6.5
[59]
HepG2.C3A MAPK8
Mean 13.6
Standard deviation 4
Values 11 17
[60]
HuH.7 MAPK8
Mean 5.99
Standard deviation 0.68
Values 6.5 6.2 5.2
[61]
SNU475 MAPK8
Mean 6.98
Standard deviation 0.5
Values 7.3 6.6
[62]
THLE MAPK8
Mean 7.08
Standard deviation 1
Values 6.4 7.8
[63]
liver MAPK8
Mean 7.08
Standard deviation 1
Values 7.3 7.8 5.6 7.6
[64]
ref_hepatocyte PSEN1
Mean 6.64
Standard deviation 2.1
Values 8.7 7.5 8.3 4.7 4.1
[65]
HepG2 PSEN1
Mean 30.5
Standard deviation 2.4
Values 29 32
[66]
HepG2.C3A PSEN1
Mean 31.6
Standard deviation 3.9
Values 34 29
[67]
HuH.7 PSEN1
Mean 22.5
Standard deviation 3.1
Values 23 25 19
[68]
SNU475 PSEN1
Mean 29.1
Standard deviation 1.1
Values 30 28
[69]
THLE PSEN1
Mean 30
Standard deviation 4
Values 27 33
[70]
liver PSEN1
Mean 18.8
Standard deviation 3
Values 15 22 19 19
[71]
ref_hepatocyte PSEN2
Mean 4.44
Standard deviation 2.5
Values 2.3 4.3 8.7 3.4 3.5
[72]
HepG2 PSEN2
Mean 6.08
Standard deviation 0.97
Values 6.8 5.4
[73]
HepG2.C3A PSEN2
Mean 2.99
Standard deviation 0.53
Values 3.4 2.6
[74]
HuH.7 PSEN2
Mean 0.204
Standard deviation 0.067
Values 0.13 0.22 0.26
[75]
SNU475 PSEN2
Mean 8.62
Standard deviation 2.2
Values 10 7.1
[76]
THLE PSEN2
Mean 3.74
Standard deviation 0.46
Values 3.4 4.1
[77]
liver PSEN2
Mean 5.9
Standard deviation 0.87
Values 7.1 5.8 5.8 5
[78]
ref_hepatocyte ITGB3BP
Mean 3.6
Standard deviation 2.3
Values 1.8 5.1 0.79 4 6.4
[79]
HepG2 ITGB3BP
Mean 4.2
Standard deviation 1.2
Values 3.3 5.1
[80]
HepG2.C3A ITGB3BP
Mean 12.1
Standard deviation 4.9
Values 8.7 16
[81]
HuH.7 ITGB3BP
Mean 14.3
Standard deviation 4.5
Values 14 9.9 19
[82]
SNU475 ITGB3BP
Mean 5.13
Standard deviation 0.48
Values 5.5 4.8
[83]
THLE ITGB3BP
Mean 9.11
Standard deviation 0.19
Values 9.2 9
[84]
liver ITGB3BP
Mean 1.88
Standard deviation 1.1
Values 2.1 1.2 3.4 0.83
[85]
ref_hepatocyte TRAF6
Mean 0.965
Standard deviation 0.32
Values 0.82 1 1.5 0.7 0.8
[86]
HepG2 TRAF6
Mean 4.54
Standard deviation 0.72
Values 4 5
[87]
HepG2.C3A TRAF6
Mean 3.74
Standard deviation 0.086
Values 3.8 3.7
[88]
HuH.7 TRAF6
Mean 5.32
Standard deviation 1
Values 5 6.4 4.5
[89]
SNU475 TRAF6
Mean 5.61
Standard deviation 0.46
Values 5.9 5.3
[90]
THLE TRAF6
Mean 4.31
Standard deviation 0.54
Values 3.9 4.7
[91]
liver TRAF6
Mean 10.3
Standard deviation 0.99
Values 9.7 12 9.8 10
[92]
ref_hepatocyte APH1B
Mean 0.759
Standard deviation 0.26
Values 0.86 1.2 0.64 0.63 0.5
[93]
HepG2 APH1B
Mean 1.42
Standard deviation 0.39
Values 1.7 1.1
[94]
HepG2.C3A APH1B
Mean 2.22
Standard deviation 0.15
Values 2.3 2.1
[95]
HuH.7 APH1B
Mean 18.6
Standard deviation 5.3
Values 23 13 20
[96]
SNU475 APH1B
Mean 11.9
Standard deviation 2.9
Values 14 9.9
[97]
THLE APH1B
Mean 6.86
Standard deviation 0.17
Values 7 6.7
[98]
liver APH1B
Mean 2.52
Standard deviation 0.52
Values 3 2.6 2.7 1.8
[99]
ref_hepatocyte NGFR
Mean 0.0296
Standard deviation 0.032
Values 0 0 0.03 0.078 0.041
[100]
HepG2 NGFR
Mean 23.1
Standard deviation 11
Values 15 31
[101]
HepG2.C3A NGFR
Mean 0.179
Standard deviation 0.0052
Values 0.17 0.18
[102]
HuH.7 NGFR
Mean 0.0107
Standard deviation 0.0051
Values 0.016 0.0064 0.0094
[103]
SNU475 NGFR
Mean 0.183
Standard deviation 0.21
Values 0.037 0.33
[104]
THLE NGFR
Mean 0.394
Standard deviation 0.045
Values 0.43 0.36
[105]
liver NGFR
Mean 8.18
Standard deviation 5.6
Values 16 3.2 5.7 7.7
[106]
ref_hepatocyte NGF
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[107]
HepG2 NGF
Mean 0
Standard deviation 0
Values 0 0
[108]
HepG2.C3A NGF
Mean 0
Standard deviation 0
Values 0 0
[109]
HuH.7 NGF
Mean 0
Standard deviation 0
Values 0 0 0
[110]
SNU475 NGF
Mean 1.32
Standard deviation 0.58
Values 0.91 1.7
[111]
THLE NGF
Mean 0.258
Standard deviation 0.011
Values 0.27 0.25
[112]
liver NGF
Mean 0.426
Standard deviation 0.42
Values 1 0.071 0.46 0.16