REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | RAC1 | Ras-related C3 botulinum toxin substrate 1 | [1] | -1.10[2] | -1.62[3] | -0.67[4] | -1.19[5] | -0.81[6] | -2.22[7] |
2 | MAGED1 | Melanoma-associated antigen D1 | [8] | 0.70[9] | 0.27[10] | -8.48[11] | 0.67[12] | -0.44[13] | -1.06[14] |
3 | AATF | Protein AATF | [15] | -1.05[16] | -2.19[17] | -1.22[18] | -1.57[19] | -1.82[20] | -3.03[21] |
4 | BAD | Bcl2-associated agonist of cell death | [22] | -2.37[23] | -2.44[24] | -3.14[25] | -2.27[26] | -1.48[27] | -2.68[28] |
5 | NET1 | Neuroepithelial cell-transforming gene 1 protein | [29] | -0.40[30] | 0.01[31] | 0.28[32] | -1.02[33] | -1.31[34] | -0.85[35] |
6 | GNA13 | Guanine nucleotide-binding protein subunit alpha-13 | [36] | -0.58[37] | -0.61[38] | 0.11[39] | -0.01[40] | -0.79[41] | -0.72[42] |
7 | ARHGEF35 | Rho guanine nucleotide exchange factor 35 | [43] | -8.34[44] | -8.21[45] | -7.65[46] | -4.82[47] | -3.86[48] | -4.35[49] |
8 | ITSN1 | Intersectin-1 | [50] | -0.82[51] | -0.89[52] | 0.11[53] | -0.19[54] | 0.45[55] | 0.47[56] |
9 | VAV2 | Guanine nucleotide exchange factor VAV2 | [57] | 0.60[58] | 0.65[59] | 0.39[60] | -1.73[61] | -0.93[62] | -0.74[63] |
10 | ARHGEF10 | Rho guanine nucleotide exchange factor 10-like protein | [64] | -0.19[65] | 1.91[66] | 0.96[67] | -1.28[68] | -2.48[69] | 1.75[70] |
11 | MAPK8 | Mitogen-activated protein kinase 8 | [71] | -2.15[72] | -0.93[73] | -1.82[74] | -2.10[75] | -1.86[76] | -1.77[77] |
12 | SOS1 | Son of sevenless homolog 1 | [78] | -0.80[79] | 0.53[80] | 0.28[81] | -0.36[82] | -0.73[83] | -0.72[84] |
13 | ARHGEF12 | Rho guanine nucleotide exchange factor 12 | [85] | 1.31[86] | 0.88[87] | 0.76[88] | 1.79[89] | 1.34[90] | 2.91[91] |
14 | ARHGEF1 | Rho guanine nucleotide exchange factor 1 | [92] | 0.22[93] | 0.34[94] | 0.90[95] | -0.28[96] | 0.38[97] | -0.87[98] |
15 | ARHGEF2 | Rho guanine nucleotide exchange factor 2 | [99] | -0.06[100] | -0.34[101] | -0.01[102] | 0.65[103] | 1.42[104] | -2.33[105] |
16 | ARHGEF5 | Rho guanine nucleotide exchange factor 5 | [106] | -4.71[107] | -3.67[108] | -3.19[109] | -3.50[110] | -3.03[111] | -3.66[112] |
17 | ARHGEF40 | Rho guanine nucleotide exchange factor 40 | [113] | 0.00[114] | 0.59[115] | -0.89[116] | 0.67[117] | 0.67[118] | 0.70[119] |
18 | NGEF | Ephexin-1 | [120] | -0.35[121] | 0.35[122] | 0.77[123] | -6.22[124] | -3.22[125] | -0.45[126] |
19 | TRIO | Triple functional domain protein | [127] | 1.30[128] | 0.83[129] | 1.32[130] | 1.40[131] | 2.68[132] | 1.50[133] |
20 | ECT2 | Protein ECT2 | [134] | -0.02[135] | 1.48[136] | 2.73[137] | 0.93[138] | 1.91[139] | -2.14[140] |
21 | AKAP13 | A-kinase anchor protein 13 | [141] | 1.04[142] | -0.03[143] | 1.18[144] | 1.50[145] | 1.50[146] | 2.88[147] |
22 | ARHGEF7 | Rho guanine nucleotide exchange factor 7 | [148] | 0.92[149] | 0.71[150] | 0.81[151] | 0.61[152] | 0.75[153] | 1.10[154] |
23 | ARHGEF18 | Rho guanine nucleotide exchange factor 18 | [155] | 1.97[156] | 0.87[157] | 1.92[158] | 0.13[159] | 0.85[160] | 0.34[161] |
24 | SOS2 | Son of sevenless homolog 2 | [162] | -0.73[163] | 0.20[164] | -0.32[165] | 0.49[166] | 0.74[167] | 0.59[168] |
25 | ARHGEF26 | Rho guanine nucleotide exchange factor 26 | [169] | -1.66[170] | -0.86[171] | -0.03[172] | -0.83[173] | 1.16[174] | 1.97[175] |
26 | ARHGEF11 | Rho guanine nucleotide exchange factor 11 | [176] | 1.34[177] | 1.26[178] | 1.19[179] | 2.07[180] | 1.75[181] | 1.33[182] |
27 | FGD4 | FYVE, RhoGEF and PH domain-containing protein 4 | [183] | -1.36[184] | 0.57[185] | 0.28[186] | -0.43[187] | 0.41[188] | 2.05[189] |
28 | BCL2L11 | Bcl-2-like protein 11 | [190] | 0.80[191] | 0.62[192] | 1.19[193] | 0.67[194] | 0.03[195] | 0.73[196] |
29 | ARHGEF3 | Rho guanine nucleotide exchange factor 3 | [197] | 1.87[198] | 0.38[199] | -0.21[200] | 0.26[201] | 0.89[202] | -1.11[203] |
30 | MCF2L | Guanine nucleotide exchange factor DBS | [204] | 1.57[205] | 1.57[206] | -0.39[207] | -5.82[208] | -8.65[209] | 0.26[210] |
31 | ARHGEF16 | Rho guanine nucleotide exchange factor 16 | [211] | 2.17[212] | 3.34[213] | -0.23[214] | 0.76[215] | -2.41[216] | -0.36[217] |
32 | RASGRF2 | Ras-specific guanine nucleotide-releasing factor 2 | [218] | 3.14[219] | 2.20[220] | -1.87[221] | -4.14[222] | -1.52[223] | -0.74[224] |
33 | KALRN | Kalirin | [225] | 0.64[226] | 1.99[227] | 1.73[228] | 0.71[229] | -3.57[230] | 2.31[231] |
34 | ABR | Active breakpoint cluster region-related protein | [232] | 3.25[233] | 2.63[234] | 2.41[235] | 2.23[236] | 3.33[237] | 0.58[238] |
35 | TIAM1 | T-lymphoma invasion and metastasis-inducing protein 1 | [239] | -5.40[240] | -2.92[241] | -7.87[242] | -2.56[243] | -0.12[244] | 2.09[245] |
36 | VAV3 | Guanine nucleotide exchange factor VAV3 | [246] | 1.11[247] | -0.80[248] | 1.62[249] | 2.48[250] | -3.10[251] | 0.10[252] |
37 | ARHGEF9 | Rho guanine nucleotide exchange factor 9 | [253] | -2.14[254] | -3.54[255] | -8.58[256] | 0.98[257] | 1.36[258] | 1.10[259] |
38 | FGD2 | FYVE, RhoGEF and PH domain-containing protein 2 | [260] | -6.27[261] | -7.46[262] | -8.87[263] | -5.26[264] | -7.64[265] | 1.62[266] |
39 | VAV1 | Proto-oncogene vav | [267] | -9.20[268] | -4.57[269] | -6.03[270] | -7.29[271] | -8.16[272] | -0.07[273] |
40 | ARHGEF6 | Rho guanine nucleotide exchange factor 6 | [274] | -6.72[275] | -4.67[276] | -5.04[277] | 2.03[278] | 0.94[279] | 1.88[280] |
41 | ARHGEF19 | Rho guanine nucleotide exchange factor 19 | [281] | 0.79[282] | 2.02[283] | 0.78[284] | 0.55[285] | 1.84[286] | -0.38[287] |
42 | PLEKHG2 | Pleckstrin homology domain-containing family G member 2 | [288] | 3.01[289] | 2.24[290] | 3.34[291] | 3.52[292] | 2.96[293] | 0.25[294] |
43 | PREX1 | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein | -1.12[295] | -7.14[296] | -4.58[297] | 3.91[298] | 2.65[299] | 2.95[300] | |
44 | FGD3 | FYVE, RhoGEF and PH domain-containing protein 3 | [301] | -0.08[302] | 0.09[303] | -0.92[304] | -2.02[305] | -5.94[306] | 1.01[307] |
45 | ARHGEF10 | Rho guanine nucleotide exchange factor 10 | [308] | -4.71[309] | -4.43[310] | -5.14[311] | 1.91[312] | 3.17[313] | 0.61[314] |
46 | ARHGEF37 | Rho guanine nucleotide exchange factor 37 | [315] | 0.08[316] | -5.06[317] | -1.95[318] | 1.01[319] | 0.36[320] | 1.46[321] |
47 | PLEKHG5 | Pleckstrin homology domain-containing family G member 5 | [322] | 2.80[323] | 2.10[324] | 1.09[325] | 1.16[326] | 1.97[327] | 0.21[328] |
48 | ARHGEF17 | Rho guanine nucleotide exchange factor 17 | [329] | 4.49[330] | 4.95[331] | 3.86[332] | 6.55[333] | 4.73[334] | 3.09[335] |
49 | FGD1 | FYVE, RhoGEF and PH domain-containing protein 1 | [336] | 2.04[337] | 2.35[338] | 1.48[339] | 4.04[340] | 3.88[341] | 0.39[342] |
50 | TIAM2 | T-lymphoma invasion and metastasis-inducing protein 2 | [343] | 3.21[344] | 2.42[345] | 4.09[346] | 3.34[347] | 1.60[348] | -1.28[349] |
51 | ARHGEF15 | Rho guanine nucleotide exchange factor 15 | [350] | [351] | -5.85[352] | [353] | -5.12[354] | [355] | 2.70[356] |
52 | NGFR | Tumor necrosis factor receptor superfamily member 16 | [357] | 7.76[358] | 0.72[359] | -3.03[360] | 0.55[361] | 1.88[362] | 6.35[363] |
53 | OBSCN | Obscurin | [364] | 3.22[365] | 0.43[366] | 1.33[367] | 6.61[368] | 4.17[369] | 5.36[370] |
54 | ARHGEF4 | Rho guanine nucleotide exchange factor 4 | [371] | 1.62[372] | -4.04[373] | -4.71[374] | 3.74[375] | 4.45[376] | 0.71[377] |
55 | ARHGEF38 | Rho guanine nucleotide exchange factor 38 | [378] | -1.47[379] | 0.58[380] | 5.85[381] | -0.83[382] | -0.83[383] | 3.03[384] |
56 | ARHGEF33 | Rho guanine nucleotide exchange factor 33 | [385] | 0.67[386] | 1.93[387] | 0.72[388] | 1.09[389] | 4.48[390] | 3.60[391] |
57 | NGF | Beta-nerve growth factor | [392] | [393] | [394] | [395] | [396] | [397] | [398] |
58 | MCF2 | Proto-oncogene DBL | [399] | [400] | [401] | [402] | [403] | [404] | [405] |
59 | ARHGEF39 | Rho guanine nucleotide exchange factor 39 | [406] | [407] | [408] | [409] | [410] | [411] | [412] |