REACTOME_NOTCH4_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 SNW1 SNW domain-containing protein 1 [1] -2.03[2] -1.51[3] -1.93[4] -2.26[5] -2.03[6] -3.24[7]
2 HES1 Transcription factor HES-1 [8] -1.46[9] -3.61[10] -1.80[11] -3.40[12] -3.76[13] -3.00[14]
3 SMAD3 Mothers against decapentaplegic homolog 3 [15] 0.90[16] 0.65[17] 0.43[18] -0.33[19] 1.03[20] -1.39[21]
4 NOTCH2 Neurogenic locus notch homolog protein 2 [22] -0.89[23] -6.28[24] 0.76[25] 0.91[26] 2.18[27] 1.72[28]
5 KAT2A Histone acetyltransferase KAT2A [29] 1.00[30] 1.21[31] -0.12[32] -1.00[33] -0.67[34] -1.32[35]
6 ACTA2 Actin, aortic smooth muscle [36] 1.09[37] 0.97[38] -5.74[39] 2.93[40] -0.76[41] 1.40[42]
7 RBPJ Recombining binding protein suppressor of hairless [43] 0.31[44] 1.24[45] 1.80[46] -0.11[47] 0.30[48] 0.25[49]
8 KAT2B Histone acetyltransferase KAT2B [50] -3.08[51] -3.85[52] -1.92[53] -2.19[54] -1.29[55] 0.18[56]
9 EP300 Histone acetyltransferase p300 [57] 1.69[58] 1.64[59] 2.09[60] 0.45[61] 0.97[62] 1.15[63]
10 MAML1 Mastermind-like protein 1 [64] 1.09[65] 1.40[66] 1.50[67] 0.12[68] 0.72[69] -0.52[70]
11 CREBBP CREB-binding protein [71] 1.87[72] 1.44[73] 1.60[74] 0.63[75] 1.11[76] 1.63[77]
12 MAMLD1 Mastermind-like domain-containing protein 1 [78] -2.93[79] -9.08[80] -3.26[81] -1.07[82] -0.78[83] -1.94[84]
13 HEY1 Hairy/enhancer-of-split related with YRPW motif protein 1 [85] 0.61[86] -0.58[87] -0.95[88] -2.62[89] -3.34[90] -1.56[91]
14 NOTCH1 Neurogenic locus notch homolog protein 1 [92] 0.87[93] 0.07[94] 0.96[95] 0.46[96] 1.29[97] 3.03[98]
15 HEY2 Hairy/enhancer-of-split related with YRPW motif protein 2 [99] -4.75[100] -6.20[101] -6.74[102] -5.99[103] -8.34[104] -0.85[105]
16 MAML3 Mastermind-like protein 3 [106] -1.41[107] -0.32[108] 2.27[109] -0.72[110] -1.63[111] 1.89[112]
17 FLT4 Vascular endothelial growth factor receptor 3 [113] -2.40[114] -0.81[115] -2.46[116] -3.36[117] -2.98[118] 2.92[119]
18 MAML2 Mastermind-like protein 2 [120] 2.46[121] 3.43[122] -3.58[123] 2.65[124] 1.99[125] 0.76[126]
19 NOTCH4 Neurogenic locus notch homolog protein 4 [127] -0.46[128] 0.45[129] -2.63[130] -4.13[131] -1.05[132] 4.61[133]
20 HES5 Transcription factor HES-5 [134] 2.20[135] -1.67[136] [137] [138] -4.01[139] -1.23[140]
[1]
ref_hepatocyte SNW1
Mean 24.9
Standard deviation 12
Values 34 38 27 15 9.7
[2]
HepG2 SNW1
Mean 27.5
Standard deviation 2.9
Values 25 29
[3]
HepG2.C3A SNW1
Mean 27.5
Standard deviation 0.76
Values 27 28
[4]
HuH.7 SNW1
Mean 26.8
Standard deviation 1.3
Values 26 26 28
[5]
SNU475 SNW1
Mean 41.5
Standard deviation 3.1
Values 39 44
[6]
THLE SNW1
Mean 39.4
Standard deviation 2.3
Values 38 41
[7]
liver SNW1
Mean 11.4
Standard deviation 4.1
Values 14 9.2 15 6.8
[8]
ref_hepatocyte HES1
Mean 7.15
Standard deviation 5.3
Values 9.1 1 3.7 15 7
[9]
HepG2 HES1
Mean 11.7
Standard deviation 5.7
Values 16 7.7
[10]
HepG2.C3A HES1
Mean 1.84
Standard deviation 0.56
Values 2.2 1.4
[11]
HuH.7 HES1
Mean 8.41
Standard deviation 1.4
Values 6.9 8.7 9.7
[12]
SNU475 HES1
Mean 5.42
Standard deviation 0.41
Values 5.7 5.1
[13]
THLE HES1
Mean 3.42
Standard deviation 0.023
Values 3.4 3.4
[14]
liver HES1
Mean 3.86
Standard deviation 1.7
Values 6.2 3 4.1 2.2
[15]
ref_hepatocyte SMAD3
Mean 5.99
Standard deviation 4.6
Values 4.8 8.4 13 1.9 2.2
[16]
HepG2 SMAD3
Mean 50.4
Standard deviation 14
Values 60 40
[17]
HepG2.C3A SMAD3
Mean 29.5
Standard deviation 11
Values 37 22
[18]
HuH.7 SMAD3
Mean 33.2
Standard deviation 6.9
Values 31 41 28
[19]
SNU475 SMAD3
Mean 38.2
Standard deviation 2.7
Values 40 36
[20]
THLE SMAD3
Mean 78.9
Standard deviation 8.4
Values 73 85
[21]
liver SMAD3
Mean 9.85
Standard deviation 3
Values 12 7.4 7.1 13
[22]
ref_hepatocyte NOTCH2
Mean 5.26
Standard deviation 4
Values 1.6 11 7.1 2.4 3.7
[23]
HepG2 NOTCH2
Mean 12.7
Standard deviation 3.4
Values 15 10
[24]
HepG2.C3A NOTCH2
Mean 0.213
Standard deviation 0.12
Values 0.13 0.3
[25]
HuH.7 NOTCH2
Mean 36.5
Standard deviation 12
Values 44 43 23
[26]
SNU475 NOTCH2
Mean 79.3
Standard deviation 13
Values 88 70
[27]
THLE NOTCH2
Mean 154
Standard deviation 35
Values 1.3e+02 1.8e+02
[28]
liver NOTCH2
Mean 74.9
Standard deviation 42
Values 39 1.2e+02 39 99
[29]
ref_hepatocyte KAT2A
Mean 4.96
Standard deviation 1.9
Values 2.4 3.8 6.7 6.8 5
[30]
HepG2 KAT2A
Mean 44.7
Standard deviation 6.9
Values 40 50
[31]
HepG2.C3A KAT2A
Mean 36.2
Standard deviation 5
Values 40 33
[32]
HuH.7 KAT2A
Mean 18.7
Standard deviation 8
Values 18 11 27
[33]
SNU475 KAT2A
Mean 19.9
Standard deviation 2.9
Values 18 22
[34]
THLE KAT2A
Mean 20.1
Standard deviation 3.5
Values 23 18
[35]
liver KAT2A
Mean 8.57
Standard deviation 1.6
Values 9.3 6.8 11 7.7
[36]
ref_hepatocyte ACTA2
Mean 4.03
Standard deviation 3.2
Values 8.9 1.5 5.7 2.6 1.4
[37]
HepG2 ACTA2
Mean 38.7
Standard deviation 3.2
Values 41 36
[38]
HepG2.C3A ACTA2
Mean 24.8
Standard deviation 2.3
Values 23 26
[39]
HuH.7 ACTA2
Mean 0.308
Standard deviation 0.12
Values 0.38 0.38 0.17
[40]
SNU475 ACTA2
Mean 246
Standard deviation 2.2e+02
Values 4e+02 87
[41]
THLE ACTA2
Mean 15.4
Standard deviation 1.4
Values 14 16
[42]
liver ACTA2
Mean 45.9
Standard deviation 34
Values 8.8 44 92 39
[43]
ref_hepatocyte RBPJ
Mean 3.53
Standard deviation 1.3
Values 5.4 3.5 3.8 2.1 2.8
[44]
HepG2 RBPJ
Mean 19.7
Standard deviation 8.2
Values 14 26
[45]
HepG2.C3A RBPJ
Mean 26.2
Standard deviation 1.4
Values 25 27
[46]
HuH.7 RBPJ
Mean 50.4
Standard deviation 6.7
Values 58 49 45
[47]
SNU475 RBPJ
Mean 26.3
Standard deviation 0.26
Values 26 26
[48]
THLE RBPJ
Mean 28.1
Standard deviation 3.7
Values 26 31
[49]
liver RBPJ
Mean 18.1
Standard deviation 2.4
Values 21 19 17 16
[50]
ref_hepatocyte KAT2B
Mean 3.02
Standard deviation 2.4
Values 0.53 4.6 0.74 3.2 6.1
[51]
HepG2 KAT2B
Mean 1.62
Standard deviation 1.1
Values 0.84 2.4
[52]
HepG2.C3A KAT2B
Mean 0.662
Standard deviation 0.012
Values 0.67 0.65
[53]
HuH.7 KAT2B
Mean 3.28
Standard deviation 0.41
Values 2.8 3.6 3.4
[54]
SNU475 KAT2B
Mean 5.31
Standard deviation 1.3
Values 6.2 4.4
[55]
THLE KAT2B
Mean 7.98
Standard deviation 1.1
Values 7.2 8.8
[56]
liver KAT2B
Mean 14.8
Standard deviation 5
Values 19 17 7.6 16
[57]
ref_hepatocyte EP300
Mean 2.46
Standard deviation 1.2
Values 3 1.8 4.4 1.4 1.8
[58]
HepG2 EP300
Mean 35.9
Standard deviation 5.7
Values 32 40
[59]
HepG2.C3A EP300
Mean 24.1
Standard deviation 1.4
Values 23 25
[60]
HuH.7 EP300
Mean 43
Standard deviation 15
Values 55 48 26
[61]
SNU475 EP300
Mean 26.9
Standard deviation 1.3
Values 28 26
[62]
THLE EP300
Mean 31.2
Standard deviation 11
Values 23 39
[63]
liver EP300
Mean 23.6
Standard deviation 8
Values 20 27 15 33
[64]
ref_hepatocyte MAML1
Mean 2.18
Standard deviation 1.5
Values 4.8 1.9 2.1 1.1 1
[65]
HepG2 MAML1
Mean 20.9
Standard deviation 0.74
Values 20 21
[66]
HepG2.C3A MAML1
Mean 18.1
Standard deviation 1.4
Values 19 17
[67]
HuH.7 MAML1
Mean 25.3
Standard deviation 3.3
Values 29 23 24
[68]
SNU475 MAML1
Mean 19
Standard deviation 0.56
Values 19 19
[69]
THLE MAML1
Mean 23.3
Standard deviation 2.6
Values 21 25
[70]
liver MAML1
Mean 6.56
Standard deviation 1.8
Values 6 5.9 5.1 9.3
[71]
ref_hepatocyte CREBBP
Mean 1.78
Standard deviation 0.69
Values 1.8 0.72 2.6 1.9 1.9
[72]
HepG2 CREBBP
Mean 29.3
Standard deviation 2.8
Values 27 31
[73]
HepG2.C3A CREBBP
Mean 15.2
Standard deviation 1
Values 16 14
[74]
HuH.7 CREBBP
Mean 22.2
Standard deviation 7.2
Values 28 24 14
[75]
SNU475 CREBBP
Mean 22.1
Standard deviation 0.2
Values 22 22
[76]
THLE CREBBP
Mean 24.9
Standard deviation 7.3
Values 20 30
[77]
liver CREBBP
Mean 23.8
Standard deviation 6
Values 30 21 17 28
[78]
ref_hepatocyte MAMLD1
Mean 0.833
Standard deviation 1.1
Values 0 0.39 2.7 0.16 0.94
[79]
HepG2 MAMLD1
Mean 0.493
Standard deviation 0.22
Values 0.34 0.65
[80]
HepG2.C3A MAMLD1
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[81]
HuH.7 MAMLD1
Mean 0.356
Standard deviation 0.046
Values 0.31 0.35 0.4
[82]
SNU475 MAMLD1
Mean 3.17
Standard deviation 0.79
Values 2.6 3.7
[83]
THLE MAMLD1
Mean 3.14
Standard deviation 0.38
Values 3.4 2.9
[84]
liver MAMLD1
Mean 0.94
Standard deviation 0.39
Values 1.1 0.64 1.4 0.62
[85]
ref_hepatocyte HEY1
Mean 0.786
Standard deviation 0.62
Values 1.6 0.56 1.2 0.43 0.098
[86]
HepG2 HEY1
Mean 5.41
Standard deviation 3.1
Values 7.6 3.2
[87]
HepG2.C3A HEY1
Mean 1.65
Standard deviation 0.44
Values 2 1.3
[88]
HuH.7 HEY1
Mean 1.67
Standard deviation 0.046
Values 1.6 1.7 1.7
[89]
SNU475 HEY1
Mean 1.02
Standard deviation 0.89
Values 0.39 1.7
[90]
THLE HEY1
Mean 0.501
Standard deviation 0.0059
Values 0.5 0.51
[91]
liver HEY1
Mean 1.16
Standard deviation 1.3
Values 3.1 0.3 0.62 0.61
[92]
ref_hepatocyte NOTCH1
Mean 0.644
Standard deviation 0.25
Values 0.33 0.55 0.55 0.91 0.89
[93]
HepG2 NOTCH1
Mean 5.33
Standard deviation 3.7
Values 8 2.7
[94]
HepG2.C3A NOTCH1
Mean 2.12
Standard deviation 0.1
Values 2.1 2.2
[95]
HuH.7 NOTCH1
Mean 5.14
Standard deviation 1.4
Values 5.4 6.4 3.6
[96]
SNU475 NOTCH1
Mean 7.09
Standard deviation 0.64
Values 6.6 7.5
[97]
THLE NOTCH1
Mean 10.2
Standard deviation 2.2
Values 8.6 12
[98]
liver NOTCH1
Mean 22.8
Standard deviation 16
Values 10 31 8.8 41
[99]
ref_hepatocyte HEY2
Mean 0.577
Standard deviation 0.4
Values 0.22 0.17 0.54 1.1 0.85
[100]
HepG2 HEY2
Mean 0.0967
Standard deviation 0.058
Values 0.14 0.056
[101]
HepG2.C3A HEY2
Mean 0.0248
Standard deviation 0.02
Values 0.039 0.011
[102]
HuH.7 HEY2
Mean 0.0222
Standard deviation 0.021
Values 0.041 0.026 0
[103]
SNU475 HEY2
Mean 0.0728
Standard deviation 0.0046
Values 0.07 0.076
[104]
THLE HEY2
Mean 0.0115
Standard deviation 0.0088
Values 0.018 0.0053
[105]
liver HEY2
Mean 1.38
Standard deviation 1.1
Values 2.6 0.27 1.9 0.75
[106]
ref_hepatocyte MAML3
Mean 0.411
Standard deviation 0.24
Values 0 0.58 0.59 0.46 0.43
[107]
HepG2 MAML3
Mean 0.699
Standard deviation 0.024
Values 0.72 0.68
[108]
HepG2.C3A MAML3
Mean 1.04
Standard deviation 0.079
Values 0.98 1.1
[109]
HuH.7 MAML3
Mean 8.13
Standard deviation 2.1
Values 9.1 9.5 5.8
[110]
SNU475 MAML3
Mean 1.99
Standard deviation 0.56
Values 2.4 1.6
[111]
THLE MAML3
Mean 0.858
Standard deviation 0.2
Values 0.72 1
[112]
liver MAML3
Mean 6.6
Standard deviation 2.8
Values 4.4 9.7 4 8.3
[113]
ref_hepatocyte FLT4
Mean 0.331
Standard deviation 0.28
Values 0.34 0 0.71 0.12 0.49
[114]
HepG2 FLT4
Mean 0.283
Standard deviation 0.013
Values 0.29 0.27
[115]
HepG2.C3A FLT4
Mean 0.597
Standard deviation 0.02
Values 0.58 0.61
[116]
HuH.7 FLT4
Mean 0.247
Standard deviation 0.037
Values 0.28 0.26 0.21
[117]
SNU475 FLT4
Mean 0.258
Standard deviation 0.05
Values 0.22 0.29
[118]
THLE FLT4
Mean 0.271
Standard deviation 0.06
Values 0.31 0.23
[119]
liver FLT4
Mean 10.8
Standard deviation 7.1
Values 4 15 5.5 19
[120]
ref_hepatocyte MAML2
Mean 0.226
Standard deviation 0.3
Values 0.69 0 0.36 0 0.089
[121]
HepG2 MAML2
Mean 5.61
Standard deviation 0.32
Values 5.8 5.4
[122]
HepG2.C3A MAML2
Mean 7.69
Standard deviation 1.2
Values 8.6 6.8
[123]
HuH.7 MAML2
Mean 0.0778
Standard deviation 0.056
Values 0.13 0.083 0.019
[124]
SNU475 MAML2
Mean 11.4
Standard deviation 0.01
Values 11 11
[125]
THLE MAML2
Mean 5.83
Standard deviation 0.93
Values 5.2 6.5
[126]
liver MAML2
Mean 1.66
Standard deviation 0.64
Values 1.1 1.9 1.2 2.4
[127]
ref_hepatocyte NOTCH4
Mean 0.117
Standard deviation 0.16
Values 0 0 0.03 0.18 0.37
[128]
HepG2 NOTCH4
Mean 0.383
Standard deviation 0.29
Values 0.59 0.18
[129]
HepG2.C3A NOTCH4
Mean 0.505
Standard deviation 0.14
Values 0.6 0.41
[130]
HuH.7 NOTCH4
Mean 0.0776
Standard deviation 0.023
Values 0.074 0.1 0.056
[131]
SNU475 NOTCH4
Mean 0.0534
Standard deviation 0.0034
Values 0.051 0.056
[132]
THLE NOTCH4
Mean 0.365
Standard deviation 0.019
Values 0.38 0.35
[133]
liver NOTCH4
Mean 12.3
Standard deviation 1.6
Values 13 11 11 14
[134]
ref_hepatocyte HES5
Mean 0.0207
Standard deviation 0.046
Values 0 0 0 0.1 0
[135]
HepG2 HES5
Mean 0.43
Standard deviation 0.39
Values 0.7 0.15
[136]
HepG2.C3A HES5
Mean 0.0204
Standard deviation 0.0014
Values 0.019 0.021
[137]
HuH.7 HES5
Mean 0
Standard deviation 0
Values 0 0 0
[138]
SNU475 HES5
Mean 0
Standard deviation 0
Values 0 0
[139]
THLE HES5
Mean 0.00828
Standard deviation 0.0033
Values 0.0059 0.011
[140]
liver HES5
Mean 0.0382
Standard deviation 0.05
Values 0.047 0 0 0.11