REACTOME_NOTCH4_ACTIVATION_AND_TRANSMISSION_OF_SIGNAL_TO_THE_NUCLEUS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 YWHAZ 14-3-3 protein zeta/delta [1] -0.75[2] -0.58[3] -0.44[4] 0.19[5] -0.31[6] -0.81[7]
2 APH1A Gamma-secretase subunit APH-1A [8] -0.24[9] 0.35[10] 0.40[11] -0.98[12] -0.17[13] -0.18[14]
3 PSENEN Gamma-secretase subunit PEN-2 [15] -2.24[16] -1.91[17] -1.61[18] -2.60[19] -2.10[20] -1.23[21]
4 NCSTN Nicastrin [22] 1.17[23] 0.65[24] 0.63[25] 0.38[26] 1.17[27] 1.23[28]
5 ADAM10 Disintegrin and metalloproteinase domain-containing protein 10 [29] 0.81[30] 1.61[31] 1.46[32] 0.57[33] 1.89[34] 1.64[35]
6 PSEN1 Presenilin-1 [36] 0.88[37] 1.42[38] 0.82[39] 0.54[40] 1.33[41] 1.83[42]
7 PSEN2 Presenilin-2 [43] -0.86[44] -1.40[45] -5.39[46] -0.63[47] -1.09[48] 0.74[49]
8 JAG1 Protein jagged-1 [50] 4.60[51] 3.51[52] 2.80[53] 0.81[54] 0.36[55] 1.89[56]
9 APH1B Gamma-secretase subunit APH-1B [57] -0.41[58] 0.72[59] 3.67[60] 2.39[61] 2.34[62] 2.06[63]
10 DLL4 Delta-like protein 4 [64] 0.57[65] 1.60[66] 0.20[67] -3.84[68] -1.64[69] 4.04[70]
11 NOTCH4 Neurogenic locus notch homolog protein 4 [71] 0.39[72] 1.28[73] -1.54[74] -2.72[75] 0.80[76] 7.05[77]
[1]
ref_hepatocyte YWHAZ
Mean 161
Standard deviation 1.6e+02
Values 1.3e+02 4.3e+02 1.6e+02 40 41
[2]
HepG2 YWHAZ
Mean 239
Standard deviation 21
Values 2.2e+02 2.5e+02
[3]
HepG2.C3A YWHAZ
Mean 191
Standard deviation 28
Values 1.7e+02 2.1e+02
[4]
HuH.7 YWHAZ
Mean 229
Standard deviation 23
Values 2.5e+02 2.1e+02 2.3e+02
[5]
SNU475 YWHAZ
Mean 552
Standard deviation 94
Values 6.2e+02 4.9e+02
[6]
THLE YWHAZ
Mean 232
Standard deviation 39
Values 2e+02 2.6e+02
[7]
liver YWHAZ
Mean 73.1
Standard deviation 31
Values 81 60 1.1e+02 39
[8]
ref_hepatocyte APH1A
Mean 33
Standard deviation 14
Values 23 24 22 47 49
[9]
HepG2 APH1A
Mean 69.5
Standard deviation 1.3
Values 69 70
[10]
HepG2.C3A APH1A
Mean 75
Standard deviation 1.3
Values 76 74
[11]
HuH.7 APH1A
Mean 83.8
Standard deviation 7.5
Values 79 80 92
[12]
SNU475 APH1A
Mean 50.3
Standard deviation 16
Values 61 39
[13]
THLE APH1A
Mean 52.6
Standard deviation 11
Values 45 60
[14]
liver APH1A
Mean 23.2
Standard deviation 0.44
Values 23 24 23 24
[15]
ref_hepatocyte PSENEN
Mean 26.8
Standard deviation 21
Values 8.7 7.6 23 58 37
[16]
HepG2 PSENEN
Mean 14.1
Standard deviation 1.6
Values 13 15
[17]
HepG2.C3A PSENEN
Mean 12.7
Standard deviation 0.49
Values 12 13
[18]
HuH.7 PSENEN
Mean 16.9
Standard deviation 4
Values 17 13 21
[19]
SNU475 PSENEN
Mean 13.3
Standard deviation 0.61
Values 13 14
[20]
THLE PSENEN
Mean 11.1
Standard deviation 0.49
Values 11 11
[21]
liver PSENEN
Mean 9.09
Standard deviation 9.1
Values 17 1.1 17 1.3
[22]
ref_hepatocyte NCSTN
Mean 16.1
Standard deviation 1.3
Values 18 15 16 16 15
[23]
HepG2 NCSTN
Mean 90.9
Standard deviation 5.4
Values 95 87
[24]
HepG2.C3A NCSTN
Mean 45.1
Standard deviation 8.2
Values 51 39
[25]
HuH.7 NCSTN
Mean 48.2
Standard deviation 2.5
Values 47 46 51
[26]
SNU475 NCSTN
Mean 63.1
Standard deviation 12
Values 72 55
[27]
THLE NCSTN
Mean 65
Standard deviation 14
Values 55 75
[28]
liver NCSTN
Mean 30.1
Standard deviation 12
Values 32 22 46 20
[29]
ref_hepatocyte ADAM10
Mean 8.78
Standard deviation 8.3
Values 21 13 2.8 3.4 3.4
[30]
HepG2 ADAM10
Mean 38.3
Standard deviation 10
Values 31 46
[31]
HepG2.C3A ADAM10
Mean 47.7
Standard deviation 4.9
Values 44 51
[32]
HuH.7 ADAM10
Mean 46.6
Standard deviation 9
Values 51 53 36
[33]
SNU475 ADAM10
Mean 39.1
Standard deviation 5.2
Values 43 35
[34]
THLE ADAM10
Mean 58.2
Standard deviation 3.8
Values 56 61
[35]
liver ADAM10
Mean 21.7
Standard deviation 10
Values 13 34 14 26
[36]
ref_hepatocyte PSEN1
Mean 6.64
Standard deviation 2.1
Values 8.7 7.5 8.3 4.7 4.1
[37]
HepG2 PSEN1
Mean 30.5
Standard deviation 2.4
Values 29 32
[38]
HepG2.C3A PSEN1
Mean 31.6
Standard deviation 3.9
Values 34 29
[39]
HuH.7 PSEN1
Mean 22.5
Standard deviation 3.1
Values 23 25 19
[40]
SNU475 PSEN1
Mean 29.1
Standard deviation 1.1
Values 30 28
[41]
THLE PSEN1
Mean 30
Standard deviation 4
Values 27 33
[42]
liver PSEN1
Mean 18.8
Standard deviation 3
Values 15 22 19 19
[43]
ref_hepatocyte PSEN2
Mean 4.44
Standard deviation 2.5
Values 2.3 4.3 8.7 3.4 3.5
[44]
HepG2 PSEN2
Mean 6.08
Standard deviation 0.97
Values 6.8 5.4
[45]
HepG2.C3A PSEN2
Mean 2.99
Standard deviation 0.53
Values 3.4 2.6
[46]
HuH.7 PSEN2
Mean 0.204
Standard deviation 0.067
Values 0.13 0.22 0.26
[47]
SNU475 PSEN2
Mean 8.62
Standard deviation 2.2
Values 10 7.1
[48]
THLE PSEN2
Mean 3.74
Standard deviation 0.46
Values 3.4 4.1
[49]
liver PSEN2
Mean 5.9
Standard deviation 0.87
Values 7.1 5.8 5.8 5
[50]
ref_hepatocyte JAG1
Mean 2.61
Standard deviation 3.4
Values 8.4 2.4 1.7 0.3 0.21
[51]
HepG2 JAG1
Mean 158
Standard deviation 86
Values 2.2e+02 97
[52]
HepG2.C3A JAG1
Mean 52.9
Standard deviation 7.2
Values 58 48
[53]
HuH.7 JAG1
Mean 35.1
Standard deviation 12
Values 45 21 39
[54]
SNU475 JAG1
Mean 13.7
Standard deviation 0.39
Values 13 14
[55]
THLE JAG1
Mean 6
Standard deviation 0.4
Values 5.7 6.3
[56]
liver JAG1
Mean 7.68
Standard deviation 5.1
Values 4.1 8.6 3.5 15
[57]
ref_hepatocyte APH1B
Mean 0.759
Standard deviation 0.26
Values 0.86 1.2 0.64 0.63 0.5
[58]
HepG2 APH1B
Mean 1.42
Standard deviation 0.39
Values 1.7 1.1
[59]
HepG2.C3A APH1B
Mean 2.22
Standard deviation 0.15
Values 2.3 2.1
[60]
HuH.7 APH1B
Mean 18.6
Standard deviation 5.3
Values 23 13 20
[61]
SNU475 APH1B
Mean 11.9
Standard deviation 2.9
Values 14 9.9
[62]
THLE APH1B
Mean 6.86
Standard deviation 0.17
Values 7 6.7
[63]
liver APH1B
Mean 2.52
Standard deviation 0.52
Values 3 2.6 2.7 1.8
[64]
ref_hepatocyte DLL4
Mean 0.192
Standard deviation 0.12
Values 0.27 0 0.32 0.21 0.16
[65]
HepG2 DLL4
Mean 0.711
Standard deviation 0.21
Values 0.86 0.56
[66]
HepG2.C3A DLL4
Mean 1.04
Standard deviation 0.087
Values 1.1 0.98
[67]
HuH.7 DLL4
Mean 0.424
Standard deviation 0.13
Values 0.45 0.54 0.28
[68]
SNU475 DLL4
Mean 0.0403
Standard deviation 0.05
Values 0.0046 0.076
[69]
THLE DLL4
Mean 0.111
Standard deviation 0.039
Values 0.083 0.14
[70]
liver DLL4
Mean 2.51
Standard deviation 0.68
Values 3.4 2 2 2.7
[71]
ref_hepatocyte NOTCH4
Mean 0.117
Standard deviation 0.16
Values 0 0 0.03 0.18 0.37
[72]
HepG2 NOTCH4
Mean 0.383
Standard deviation 0.29
Values 0.59 0.18
[73]
HepG2.C3A NOTCH4
Mean 0.505
Standard deviation 0.14
Values 0.6 0.41
[74]
HuH.7 NOTCH4
Mean 0.0776
Standard deviation 0.023
Values 0.074 0.1 0.056
[75]
SNU475 NOTCH4
Mean 0.0534
Standard deviation 0.0034
Values 0.051 0.056
[76]
THLE NOTCH4
Mean 0.365
Standard deviation 0.019
Values 0.38 0.35
[77]
liver NOTCH4
Mean 12.3
Standard deviation 1.6
Values 13 11 11 14