REACTOME_NOTCH3_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 SNW1 SNW domain-containing protein 1 [1] -2.00[2] -1.40[3] -1.83[4] -2.09[5] -1.36[6] -2.61[7]
2 STAT1 Signal transducer and activator of transcription 1-alpha/beta [8] -1.07[9] -1.57[10] -0.90[11] 0.57[12] -0.72[13] -0.02[14]
3 HES1 Transcription factor HES-1 [15] -1.43[16] -3.51[17] -1.70[18] -3.23[19] -3.09[20] -2.37[21]
4 WWC1 Protein KIBRA [22] -0.15[23] -0.47[24] -0.48[25] -3.70[26] -0.79[27] -0.51[28]
5 KAT2A Histone acetyltransferase KAT2A [29] 1.03[30] 1.32[31] -0.02[32] -0.83[33] 0.00[34] -0.69[35]
6 DLGAP5 Disks large-associated protein 5 [36] -1.48[37] 0.72[38] 0.47[39] -0.46[40] 1.01[41] -4.12[42]
7 RBPJ Recombining binding protein suppressor of hairless [43] 0.34[44] 1.34[45] 1.90[46] 0.06[47] 0.97[48] 0.88[49]
8 KAT2B Histone acetyltransferase KAT2B [50] -3.05[51] -3.74[52] -1.82[53] -2.02[54] -0.63[55] 0.81[56]
9 EP300 Histone acetyltransferase p300 [57] 1.72[58] 1.74[59] 2.19[60] 0.61[61] 1.64[62] 1.78[63]
10 MAML1 Mastermind-like protein 1 [64] 1.11[65] 1.50[66] 1.60[67] 0.29[68] 1.39[69] 0.11[70]
11 CREBBP CREB-binding protein [71] 1.90[72] 1.54[73] 1.71[74] 0.80[75] 1.78[76] 2.26[77]
12 PLXND1 Plexin-D1 [78] 4.62[79] 3.85[80] 1.24[81] 4.17[82] 1.44[83] 2.80[84]
13 MAMLD1 Mastermind-like domain-containing protein 1 [85] -2.90[86] -8.97[87] -3.16[88] -0.91[89] -0.11[90] -1.31[91]
14 HEY1 Hairy/enhancer-of-split related with YRPW motif protein 1 [92] 0.64[93] -0.48[94] -0.85[95] -2.45[96] -2.68[97] -0.92[98]
15 NOTCH1 Neurogenic locus notch homolog protein 1 [99] 0.90[100] 0.17[101] 1.06[102] 0.63[103] 1.95[104] 3.66[105]
16 HEY2 Hairy/enhancer-of-split related with YRPW motif protein 2 [106] -4.72[107] -6.09[108] -6.63[109] -5.82[110] -7.67[111] -0.22[112]
17 PBX1 Pre-B-cell leukemia transcription factor 1 [113] -3.90[114] -5.36[115] 2.64[116] 3.82[117] 4.04[118] 1.19[119]
18 MAML3 Mastermind-like protein 3 [120] -1.38[121] -0.21[122] 2.37[123] -0.56[124] -0.96[125] 2.52[126]
19 MAML2 Mastermind-like protein 2 [127] 2.49[128] 3.53[129] -3.47[130] 2.82[131] 2.66[132] 1.39[133]
20 IKZF1 DNA-binding protein Ikaros [134] -6.92[135] [136] [137] [138] -6.92[139] 2.51[140]
21 NOTCH3 Neurogenic locus notch homolog protein 3 [141] 3.07[142] -0.87[143] 4.65[144] 4.29[145] 3.11[146] 3.11[147]
22 PTCRA Pre T-cell antigen receptor alpha [148] [149] -4.89[150] [151] -6.53[152] [153] -2.14[154]
23 HES5 Transcription factor HES-5 [155] 2.23[156] -1.57[157] [158] [159] -3.35[160] -0.60[161]
24 HEYL Hairy/enhancer-of-split related with YRPW motif-like protein [162] 1.24[163] 0.50[164] 1.99[165] 3.79[166] 1.87[167] 5.15[168]
25 FABP7 Fatty acid-binding protein, brain [169] [170] [171] [172] [173] [174] [175]
[1]
ref_hepatocyte SNW1
Mean 24.9
Standard deviation 12
Values 34 38 27 15 9.7
[2]
HepG2 SNW1
Mean 27.5
Standard deviation 2.9
Values 25 29
[3]
HepG2.C3A SNW1
Mean 27.5
Standard deviation 0.76
Values 27 28
[4]
HuH.7 SNW1
Mean 26.8
Standard deviation 1.3
Values 26 26 28
[5]
SNU475 SNW1
Mean 41.5
Standard deviation 3.1
Values 39 44
[6]
THLE SNW1
Mean 39.4
Standard deviation 2.3
Values 38 41
[7]
liver SNW1
Mean 11.4
Standard deviation 4.1
Values 14 9.2 15 6.8
[8]
ref_hepatocyte STAT1
Mean 20.3
Standard deviation 8.7
Values 17 35 19 12 18
[9]
HepG2 STAT1
Mean 42.7
Standard deviation 9.4
Values 36 49
[10]
HepG2.C3A STAT1
Mean 20.1
Standard deviation 7.2
Values 15 25
[11]
HuH.7 STAT1
Mean 41.6
Standard deviation 4.5
Values 47 38 40
[12]
SNU475 STAT1
Mean 216
Standard deviation 1.4e+02
Values 3.2e+02 1.1e+02
[13]
THLE STAT1
Mean 50.3
Standard deviation 2.1
Values 49 52
[14]
liver STAT1
Mean 55.8
Standard deviation 15
Values 49 69 67 38
[15]
ref_hepatocyte HES1
Mean 7.15
Standard deviation 5.3
Values 9.1 1 3.7 15 7
[16]
HepG2 HES1
Mean 11.7
Standard deviation 5.7
Values 16 7.7
[17]
HepG2.C3A HES1
Mean 1.84
Standard deviation 0.56
Values 2.2 1.4
[18]
HuH.7 HES1
Mean 8.41
Standard deviation 1.4
Values 6.9 8.7 9.7
[19]
SNU475 HES1
Mean 5.42
Standard deviation 0.41
Values 5.7 5.1
[20]
THLE HES1
Mean 3.42
Standard deviation 0.023
Values 3.4 3.4
[21]
liver HES1
Mean 3.86
Standard deviation 1.7
Values 6.2 3 4.1 2.2
[22]
ref_hepatocyte WWC1
Mean 6.99
Standard deviation 6.4
Values 2 16 11 3.1 2.8
[23]
HepG2 WWC1
Mean 27.7
Standard deviation 0.17
Values 28 28
[24]
HepG2.C3A WWC1
Mean 14.8
Standard deviation 2.6
Values 17 13
[25]
HuH.7 WWC1
Mean 19.2
Standard deviation 5.7
Values 25 13 19
[26]
SNU475 WWC1
Mean 3.83
Standard deviation 1.1
Values 3 4.6
[27]
THLE WWC1
Mean 16.5
Standard deviation 2.2
Values 15 18
[28]
liver WWC1
Mean 13.7
Standard deviation 8.6
Values 5.4 22 7.2 20
[29]
ref_hepatocyte KAT2A
Mean 4.96
Standard deviation 1.9
Values 2.4 3.8 6.7 6.8 5
[30]
HepG2 KAT2A
Mean 44.7
Standard deviation 6.9
Values 40 50
[31]
HepG2.C3A KAT2A
Mean 36.2
Standard deviation 5
Values 40 33
[32]
HuH.7 KAT2A
Mean 18.7
Standard deviation 8
Values 18 11 27
[33]
SNU475 KAT2A
Mean 19.9
Standard deviation 2.9
Values 18 22
[34]
THLE KAT2A
Mean 20.1
Standard deviation 3.5
Values 23 18
[35]
liver KAT2A
Mean 8.57
Standard deviation 1.6
Values 9.3 6.8 11 7.7
[36]
ref_hepatocyte DLGAP5
Mean 4.52
Standard deviation 5.7
Values 8 13 0.59 0.43 0.7
[37]
HepG2 DLGAP5
Mean 7.14
Standard deviation 3.6
Values 4.6 9.7
[38]
HepG2.C3A DLGAP5
Mean 21.9
Standard deviation 14
Values 12 32
[39]
HuH.7 DLGAP5
Mean 23.9
Standard deviation 9.5
Values 30 13 28
[40]
SNU475 DLGAP5
Mean 23.5
Standard deviation 1
Values 24 23
[41]
THLE DLGAP5
Mean 37
Standard deviation 0.83
Values 36 38
[42]
liver DLGAP5
Mean 0.726
Standard deviation 0.58
Values 0.47 1.2 1.2 0.026
[43]
ref_hepatocyte RBPJ
Mean 3.53
Standard deviation 1.3
Values 5.4 3.5 3.8 2.1 2.8
[44]
HepG2 RBPJ
Mean 19.7
Standard deviation 8.2
Values 14 26
[45]
HepG2.C3A RBPJ
Mean 26.2
Standard deviation 1.4
Values 25 27
[46]
HuH.7 RBPJ
Mean 50.4
Standard deviation 6.7
Values 58 49 45
[47]
SNU475 RBPJ
Mean 26.3
Standard deviation 0.26
Values 26 26
[48]
THLE RBPJ
Mean 28.1
Standard deviation 3.7
Values 26 31
[49]
liver RBPJ
Mean 18.1
Standard deviation 2.4
Values 21 19 17 16
[50]
ref_hepatocyte KAT2B
Mean 3.02
Standard deviation 2.4
Values 0.53 4.6 0.74 3.2 6.1
[51]
HepG2 KAT2B
Mean 1.62
Standard deviation 1.1
Values 0.84 2.4
[52]
HepG2.C3A KAT2B
Mean 0.662
Standard deviation 0.012
Values 0.67 0.65
[53]
HuH.7 KAT2B
Mean 3.28
Standard deviation 0.41
Values 2.8 3.6 3.4
[54]
SNU475 KAT2B
Mean 5.31
Standard deviation 1.3
Values 6.2 4.4
[55]
THLE KAT2B
Mean 7.98
Standard deviation 1.1
Values 7.2 8.8
[56]
liver KAT2B
Mean 14.8
Standard deviation 5
Values 19 17 7.6 16
[57]
ref_hepatocyte EP300
Mean 2.46
Standard deviation 1.2
Values 3 1.8 4.4 1.4 1.8
[58]
HepG2 EP300
Mean 35.9
Standard deviation 5.7
Values 32 40
[59]
HepG2.C3A EP300
Mean 24.1
Standard deviation 1.4
Values 23 25
[60]
HuH.7 EP300
Mean 43
Standard deviation 15
Values 55 48 26
[61]
SNU475 EP300
Mean 26.9
Standard deviation 1.3
Values 28 26
[62]
THLE EP300
Mean 31.2
Standard deviation 11
Values 23 39
[63]
liver EP300
Mean 23.6
Standard deviation 8
Values 20 27 15 33
[64]
ref_hepatocyte MAML1
Mean 2.18
Standard deviation 1.5
Values 4.8 1.9 2.1 1.1 1
[65]
HepG2 MAML1
Mean 20.9
Standard deviation 0.74
Values 20 21
[66]
HepG2.C3A MAML1
Mean 18.1
Standard deviation 1.4
Values 19 17
[67]
HuH.7 MAML1
Mean 25.3
Standard deviation 3.3
Values 29 23 24
[68]
SNU475 MAML1
Mean 19
Standard deviation 0.56
Values 19 19
[69]
THLE MAML1
Mean 23.3
Standard deviation 2.6
Values 21 25
[70]
liver MAML1
Mean 6.56
Standard deviation 1.8
Values 6 5.9 5.1 9.3
[71]
ref_hepatocyte CREBBP
Mean 1.78
Standard deviation 0.69
Values 1.8 0.72 2.6 1.9 1.9
[72]
HepG2 CREBBP
Mean 29.3
Standard deviation 2.8
Values 27 31
[73]
HepG2.C3A CREBBP
Mean 15.2
Standard deviation 1
Values 16 14
[74]
HuH.7 CREBBP
Mean 22.2
Standard deviation 7.2
Values 28 24 14
[75]
SNU475 CREBBP
Mean 22.1
Standard deviation 0.2
Values 22 22
[76]
THLE CREBBP
Mean 24.9
Standard deviation 7.3
Values 20 30
[77]
liver CREBBP
Mean 23.8
Standard deviation 6
Values 30 21 17 28
[78]
ref_hepatocyte PLXND1
Mean 0.852
Standard deviation 0.65
Values 1.9 0.17 0.55 0.79 0.85
[79]
HepG2 PLXND1
Mean 92.8
Standard deviation 34
Values 1.2e+02 69
[80]
HepG2.C3A PLXND1
Mean 35.9
Standard deviation 11
Values 44 28
[81]
HuH.7 PLXND1
Mean 7.66
Standard deviation 2.4
Values 10 5.5 7.3
[82]
SNU475 PLXND1
Mean 109
Standard deviation 50
Values 1.5e+02 74
[83]
THLE PLXND1
Mean 9.41
Standard deviation 0.89
Values 8.8 10
[84]
liver PLXND1
Mean 16.6
Standard deviation 10
Values 7.5 21 9.2 28
[85]
ref_hepatocyte MAMLD1
Mean 0.833
Standard deviation 1.1
Values 0 0.39 2.7 0.16 0.94
[86]
HepG2 MAMLD1
Mean 0.493
Standard deviation 0.22
Values 0.34 0.65
[87]
HepG2.C3A MAMLD1
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[88]
HuH.7 MAMLD1
Mean 0.356
Standard deviation 0.046
Values 0.31 0.35 0.4
[89]
SNU475 MAMLD1
Mean 3.17
Standard deviation 0.79
Values 2.6 3.7
[90]
THLE MAMLD1
Mean 3.14
Standard deviation 0.38
Values 3.4 2.9
[91]
liver MAMLD1
Mean 0.94
Standard deviation 0.39
Values 1.1 0.64 1.4 0.62
[92]
ref_hepatocyte HEY1
Mean 0.786
Standard deviation 0.62
Values 1.6 0.56 1.2 0.43 0.098
[93]
HepG2 HEY1
Mean 5.41
Standard deviation 3.1
Values 7.6 3.2
[94]
HepG2.C3A HEY1
Mean 1.65
Standard deviation 0.44
Values 2 1.3
[95]
HuH.7 HEY1
Mean 1.67
Standard deviation 0.046
Values 1.6 1.7 1.7
[96]
SNU475 HEY1
Mean 1.02
Standard deviation 0.89
Values 0.39 1.7
[97]
THLE HEY1
Mean 0.501
Standard deviation 0.0059
Values 0.5 0.51
[98]
liver HEY1
Mean 1.16
Standard deviation 1.3
Values 3.1 0.3 0.62 0.61
[99]
ref_hepatocyte NOTCH1
Mean 0.644
Standard deviation 0.25
Values 0.33 0.55 0.55 0.91 0.89
[100]
HepG2 NOTCH1
Mean 5.33
Standard deviation 3.7
Values 8 2.7
[101]
HepG2.C3A NOTCH1
Mean 2.12
Standard deviation 0.1
Values 2.1 2.2
[102]
HuH.7 NOTCH1
Mean 5.14
Standard deviation 1.4
Values 5.4 6.4 3.6
[103]
SNU475 NOTCH1
Mean 7.09
Standard deviation 0.64
Values 6.6 7.5
[104]
THLE NOTCH1
Mean 10.2
Standard deviation 2.2
Values 8.6 12
[105]
liver NOTCH1
Mean 22.8
Standard deviation 16
Values 10 31 8.8 41
[106]
ref_hepatocyte HEY2
Mean 0.577
Standard deviation 0.4
Values 0.22 0.17 0.54 1.1 0.85
[107]
HepG2 HEY2
Mean 0.0967
Standard deviation 0.058
Values 0.14 0.056
[108]
HepG2.C3A HEY2
Mean 0.0248
Standard deviation 0.02
Values 0.039 0.011
[109]
HuH.7 HEY2
Mean 0.0222
Standard deviation 0.021
Values 0.041 0.026 0
[110]
SNU475 HEY2
Mean 0.0728
Standard deviation 0.0046
Values 0.07 0.076
[111]
THLE HEY2
Mean 0.0115
Standard deviation 0.0088
Values 0.018 0.0053
[112]
liver HEY2
Mean 1.38
Standard deviation 1.1
Values 2.6 0.27 1.9 0.75
[113]
ref_hepatocyte PBX1
Mean 0.566
Standard deviation 0.5
Values 0 1.3 0.61 0.34 0.54
[114]
HepG2 PBX1
Mean 0.167
Standard deviation 0.042
Values 0.14 0.2
[115]
HepG2.C3A PBX1
Mean 0.0404
Standard deviation 0.012
Values 0.049 0.032
[116]
HuH.7 PBX1
Mean 13.5
Standard deviation 3.6
Values 15 16 9.3
[117]
SNU475 PBX1
Mean 57.2
Standard deviation 7
Values 62 52
[118]
THLE PBX1
Mean 37.8
Standard deviation 14
Values 28 47
[119]
liver PBX1
Mean 3.62
Standard deviation 0.95
Values 4.7 3.4 2.5 3.9
[120]
ref_hepatocyte MAML3
Mean 0.411
Standard deviation 0.24
Values 0 0.58 0.59 0.46 0.43
[121]
HepG2 MAML3
Mean 0.699
Standard deviation 0.024
Values 0.72 0.68
[122]
HepG2.C3A MAML3
Mean 1.04
Standard deviation 0.079
Values 0.98 1.1
[123]
HuH.7 MAML3
Mean 8.13
Standard deviation 2.1
Values 9.1 9.5 5.8
[124]
SNU475 MAML3
Mean 1.99
Standard deviation 0.56
Values 2.4 1.6
[125]
THLE MAML3
Mean 0.858
Standard deviation 0.2
Values 0.72 1
[126]
liver MAML3
Mean 6.6
Standard deviation 2.8
Values 4.4 9.7 4 8.3
[127]
ref_hepatocyte MAML2
Mean 0.226
Standard deviation 0.3
Values 0.69 0 0.36 0 0.089
[128]
HepG2 MAML2
Mean 5.61
Standard deviation 0.32
Values 5.8 5.4
[129]
HepG2.C3A MAML2
Mean 7.69
Standard deviation 1.2
Values 8.6 6.8
[130]
HuH.7 MAML2
Mean 0.0778
Standard deviation 0.056
Values 0.13 0.083 0.019
[131]
SNU475 MAML2
Mean 11.4
Standard deviation 0.01
Values 11 11
[132]
THLE MAML2
Mean 5.83
Standard deviation 0.93
Values 5.2 6.5
[133]
liver MAML2
Mean 1.66
Standard deviation 0.64
Values 1.1 1.9 1.2 2.4
[134]
ref_hepatocyte IKZF1
Mean 0.176
Standard deviation 0.22
Values 0 0 0.15 0.18 0.54
[135]
HepG2 IKZF1
Mean 0.00643
Standard deviation 0.0091
Values 0 0.013
[136]
HepG2.C3A IKZF1
Mean 0
Standard deviation 0
Values 0 0
[137]
HuH.7 IKZF1
Mean 0
Standard deviation 0
Values 0 0 0
[138]
SNU475 IKZF1
Mean 0
Standard deviation 0
Values 0 0
[139]
THLE IKZF1
Mean 0.00592
Standard deviation 0.0084
Values 0.012 0
[140]
liver IKZF1
Mean 2.81
Standard deviation 1.3
Values 2 2.6 2 4.7
[141]
ref_hepatocyte NOTCH3
Mean 0.138
Standard deviation 0.22
Values 0.028 0.028 0.54 0.043 0.057
[142]
HepG2 NOTCH3
Mean 5.12
Standard deviation 6.5
Values 9.7 0.55
[143]
HepG2.C3A NOTCH3
Mean 0.222
Standard deviation 0.057
Values 0.26 0.18
[144]
HuH.7 NOTCH3
Mean 13.3
Standard deviation 4.1
Values 18 9.9 12
[145]
SNU475 NOTCH3
Mean 19.3
Standard deviation 5.2
Values 23 16
[146]
THLE NOTCH3
Mean 4.85
Standard deviation 2.7
Values 6.7 3
[147]
liver NOTCH3
Mean 3.33
Standard deviation 2.3
Values 2 4.1 1.1 6.2
[148]
ref_hepatocyte PTCRA
Mean 0.0986
Standard deviation 0.16
Values 0 0 0 0.38 0.11
[149]
HepG2 PTCRA
Mean 0
Standard deviation 0
Values 0 0
[150]
HepG2.C3A PTCRA
Mean 0.00972
Standard deviation 0.014
Values 0.019 0
[151]
HuH.7 PTCRA
Mean 0
Standard deviation 0
Values 0 0 0
[152]
SNU475 PTCRA
Mean 0.0076
Standard deviation 0.011
Values 0 0.015
[153]
THLE PTCRA
Mean 0
Standard deviation 0
Values 0 0
[154]
liver PTCRA
Mean 0.0624
Standard deviation 0.049
Values 0.047 0.1 0.1 0
[155]
ref_hepatocyte HES5
Mean 0.0207
Standard deviation 0.046
Values 0 0 0 0.1 0
[156]
HepG2 HES5
Mean 0.43
Standard deviation 0.39
Values 0.7 0.15
[157]
HepG2.C3A HES5
Mean 0.0204
Standard deviation 0.0014
Values 0.019 0.021
[158]
HuH.7 HES5
Mean 0
Standard deviation 0
Values 0 0 0
[159]
SNU475 HES5
Mean 0
Standard deviation 0
Values 0 0
[160]
THLE HES5
Mean 0.00828
Standard deviation 0.0033
Values 0.0059 0.011
[161]
liver HES5
Mean 0.0382
Standard deviation 0.05
Values 0.047 0 0 0.11
[162]
ref_hepatocyte HEYL
Mean 0.0138
Standard deviation 0.031
Values 0 0 0 0.069 0
[163]
HepG2 HEYL
Mean 0.144
Standard deviation 0.04
Values 0.17 0.12
[164]
HepG2.C3A HEYL
Mean 0.057
Standard deviation 0.026
Values 0.039 0.075
[165]
HuH.7 HEYL
Mean 0.21
Standard deviation 0.056
Values 0.27 0.2 0.16
[166]
SNU475 HEYL
Mean 1.36
Standard deviation 0.2
Values 1.2 1.5
[167]
THLE HEYL
Mean 0.206
Standard deviation 0.035
Values 0.23 0.18
[168]
liver HEYL
Mean 1.37
Standard deviation 0.88
Values 2.5 0.4 1.2 1.4
[169]
ref_hepatocyte FABP7
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[170]
HepG2 FABP7
Mean 0
Standard deviation 0
Values 0 0
[171]
HepG2.C3A FABP7
Mean 0
Standard deviation 0
Values 0 0
[172]
HuH.7 FABP7
Mean 0.00839
Standard deviation 0.0095
Values 0 0.0064 0.019
[173]
SNU475 FABP7
Mean 0
Standard deviation 0
Values 0 0
[174]
THLE FABP7
Mean 0
Standard deviation 0
Values 0 0
[175]
liver FABP7
Mean 0
Standard deviation 0
Values 0 0 0 0