REACTOME_NOTCH3_ACTIVATION_AND_TRANSMISSION_OF_SIGNAL_TO_THE_NUCLEUS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 UBB Polyubiquitin-B [1] -0.71[2] -0.78[3] -0.95[4] -0.92[5] -0.63[6] -0.06[7]
2 RPS27A Ubiquitin-40S ribosomal protein S27a [8] [9] [10] [11] [12] [13] [14]
3 UBC Polyubiquitin-C [15] -0.27[16] -0.03[17] -0.58[18] -0.07[19] -0.25[20] 0.39[21]
4 YBX1 Nuclease-sensitive element-binding protein 1 [22] 0.50[23] 0.48[24] 0.60[25] 0.53[26] 0.73[27] -0.97[28]
5 UBA52 Ubiquitin-60S ribosomal protein L40 [29] 2.17[30] 2.21[31] 2.93[32] 1.33[33] 1.98[34] 1.16[35]
6 APH1A Gamma-secretase subunit APH-1A [36] 1.42[37] 1.83[38] 1.73[39] 1.59[40] 1.33[41] 0.80[42]
7 PSENEN Gamma-secretase subunit PEN-2 [43] -0.58[44] -0.43[45] -0.28[46] -0.03[47] -0.61[48] -0.25[49]
8 NCSTN Nicastrin [50] 2.84[51] 2.13[52] 1.96[53] 2.95[54] 2.66[55] 2.21[56]
9 ADAM10 Disintegrin and metalloproteinase domain-containing protein 10 [57] 2.47[58] 3.09[59] 2.79[60] 3.14[61] 3.38[62] 2.61[63]
10 PSEN1 Presenilin-1 [64] 2.55[65] 2.90[66] 2.14[67] 3.11[68] 2.83[69] 2.81[70]
11 EGFR Epidermal growth factor receptor [71] 0.79[72] 0.55[73] 3.11[74] 2.29[75] 2.75[76] 4.47[77]
12 TACC3 Transforming acidic coiled-coil-containing protein 3 [78] 3.06[79] 3.11[80] 3.95[81] 4.28[82] 4.03[83] 0.07[84]
13 WWP2 NEDD4-like E3 ubiquitin-protein ligase WWP2 [85] 3.23[86] 3.37[87] 2.81[88] 2.60[89] 2.45[90] 2.89[91]
14 PSEN2 Presenilin-2 [92] 0.80[93] 0.08[94] -4.06[95] 1.94[96] 0.41[97] 1.72[98]
15 MIB2 E3 ubiquitin-protein ligase MIB2 [99] 2.60[100] 3.18[101] 2.23[102] 2.23[103] 2.37[104] 1.93[105]
16 MIB1 E3 ubiquitin-protein ligase MIB1 [106] 2.98[107] 4.34[108] 4.23[109] 4.78[110] 3.67[111] 4.51[112]
17 JAG1 Protein jagged-1 [113] 6.26[114] 4.98[115] 4.13[116] 3.37[117] 1.85[118] 2.87[119]
18 APH1B Gamma-secretase subunit APH-1B [120] 1.25[121] 2.19[122] 5.00[123] 4.95[124] 3.83[125] 3.04[126]
19 DLL4 Delta-like protein 4 [127] 2.23[128] 3.08[129] 1.52[130] -1.27[131] -0.14[132] 5.02[133]
20 DLL1 Delta-like protein 1 [134] -2.87[135] -1.54[136] -1.80[137] -4.93[138] 2.01[139] 4.33[140]
21 NOTCH3 Neurogenic locus notch homolog protein 3 [141] 5.55[142] 1.33[143] 6.97[144] 8.11[145] 5.79[146] 5.90[147]
22 JAG2 Protein jagged-2 [148] 4.94[149] 1.12[150] 4.84[151] 7.71[152] 4.72[153] 3.72[154]
23 NEURL1B E3 ubiquitin-protein ligase NEURL1B [155] 4.59[156] 0.83[157] 2.59[158] 6.74[159] 7.43[160] 8.34[161]
24 EGF Pro-epidermal growth factor [162] 3.46[163] 5.38[164] 8.67[165] 10.88[166] 8.14[167] 3.39[168]
25 NEURL1 E3 ubiquitin-protein ligase NEURL1 [169] [170] [171] [172] [173] [174] [175]
[1]
ref_hepatocyte UBB
Mean 764
Standard deviation 4.8e+02
Values 3.8e+02 3.5e+02 5.3e+02 1.2e+03 1.3e+03
[2]
HepG2 UBB
Mean 368
Standard deviation 39
Values 4e+02 3.4e+02
[3]
HepG2.C3A UBB
Mean 285
Standard deviation 14
Values 2.8e+02 3e+02
[4]
HuH.7 UBB
Mean 304
Standard deviation 40
Values 2.9e+02 2.7e+02 3.5e+02
[5]
SNU475 UBB
Mean 204
Standard deviation 3.3
Values 2.1e+02 2e+02
[6]
THLE UBB
Mean 315
Standard deviation 34
Values 2.9e+02 3.4e+02
[7]
liver UBB
Mean 296
Standard deviation 1.3e+02
Values 4.3e+02 2.1e+02 3.9e+02 1.5e+02
[8]
ref_hepatocyte RPS27A
Mean 499
Standard deviation 2.2e+02
Values 6.6e+02 6.1e+02 1.7e+02 6.8e+02 3.8e+02
[9]
HepG2 RPS27A
Missing
[10]
HepG2.C3A RPS27A
Missing
[11]
HuH.7 RPS27A
Missing
[12]
SNU475 RPS27A
Missing
[13]
THLE RPS27A
Missing
[14]
liver RPS27A
Missing
[15]
ref_hepatocyte UBC
Mean 480
Standard deviation 2.8e+02
Values 1.8e+02 3.5e+02 9.1e+02 5.8e+02 3.8e+02
[16]
HepG2 UBC
Mean 314
Standard deviation 38
Values 3.4e+02 2.9e+02
[17]
HepG2.C3A UBC
Mean 302
Standard deviation 41
Values 3.3e+02 2.7e+02
[18]
HuH.7 UBC
Mean 246
Standard deviation 64
Values 2.4e+02 3.1e+02 1.9e+02
[19]
SNU475 UBC
Mean 232
Standard deviation 63
Values 2.8e+02 1.9e+02
[20]
THLE UBC
Mean 257
Standard deviation 41
Values 2.3e+02 2.9e+02
[21]
liver UBC
Mean 254
Standard deviation 78
Values 2.2e+02 3.1e+02 3.3e+02 1.6e+02
[22]
ref_hepatocyte YBX1
Mean 305
Standard deviation 1.8e+02
Values 3.5e+02 5.8e+02 2.6e+02 2e+02 1.3e+02
[23]
HepG2 YBX1
Mean 339
Standard deviation 4.5
Values 3.4e+02 3.4e+02
[24]
HepG2.C3A YBX1
Mean 272
Standard deviation 55
Values 2.3e+02 3.1e+02
[25]
HuH.7 YBX1
Mean 355
Standard deviation 1.1e+02
Values 4.4e+02 2.3e+02 4e+02
[26]
SNU475 YBX1
Mean 223
Standard deviation 22
Values 2.4e+02 2.1e+02
[27]
THLE YBX1
Mean 322
Standard deviation 79
Values 2.7e+02 3.8e+02
[28]
liver YBX1
Mean 62.7
Standard deviation 12
Values 74 64 68 45
[29]
ref_hepatocyte UBA52
Mean 57.3
Standard deviation 43
Values 14 23 49 1.2e+02 81
[30]
HepG2 UBA52
Mean 203
Standard deviation 20
Values 2.2e+02 1.9e+02
[31]
HepG2.C3A UBA52
Mean 169
Standard deviation 3.3
Values 1.7e+02 1.7e+02
[32]
HuH.7 UBA52
Mean 334
Standard deviation 46
Values 3.4e+02 2.8e+02 3.7e+02
[33]
SNU475 UBA52
Mean 72.9
Standard deviation 11
Values 65 81
[34]
THLE UBA52
Mean 144
Standard deviation 15
Values 1.3e+02 1.5e+02
[35]
liver UBA52
Mean 51.7
Standard deviation 26
Values 79 32 68 28
[36]
ref_hepatocyte APH1A
Mean 33
Standard deviation 14
Values 23 24 22 47 49
[37]
HepG2 APH1A
Mean 69.5
Standard deviation 1.3
Values 69 70
[38]
HepG2.C3A APH1A
Mean 75
Standard deviation 1.3
Values 76 74
[39]
HuH.7 APH1A
Mean 83.8
Standard deviation 7.5
Values 79 80 92
[40]
SNU475 APH1A
Mean 50.3
Standard deviation 16
Values 61 39
[41]
THLE APH1A
Mean 52.6
Standard deviation 11
Values 45 60
[42]
liver APH1A
Mean 23.2
Standard deviation 0.44
Values 23 24 23 24
[43]
ref_hepatocyte PSENEN
Mean 26.8
Standard deviation 21
Values 8.7 7.6 23 58 37
[44]
HepG2 PSENEN
Mean 14.1
Standard deviation 1.6
Values 13 15
[45]
HepG2.C3A PSENEN
Mean 12.7
Standard deviation 0.49
Values 12 13
[46]
HuH.7 PSENEN
Mean 16.9
Standard deviation 4
Values 17 13 21
[47]
SNU475 PSENEN
Mean 13.3
Standard deviation 0.61
Values 13 14
[48]
THLE PSENEN
Mean 11.1
Standard deviation 0.49
Values 11 11
[49]
liver PSENEN
Mean 9.09
Standard deviation 9.1
Values 17 1.1 17 1.3
[50]
ref_hepatocyte NCSTN
Mean 16.1
Standard deviation 1.3
Values 18 15 16 16 15
[51]
HepG2 NCSTN
Mean 90.9
Standard deviation 5.4
Values 95 87
[52]
HepG2.C3A NCSTN
Mean 45.1
Standard deviation 8.2
Values 51 39
[53]
HuH.7 NCSTN
Mean 48.2
Standard deviation 2.5
Values 47 46 51
[54]
SNU475 NCSTN
Mean 63.1
Standard deviation 12
Values 72 55
[55]
THLE NCSTN
Mean 65
Standard deviation 14
Values 55 75
[56]
liver NCSTN
Mean 30.1
Standard deviation 12
Values 32 22 46 20
[57]
ref_hepatocyte ADAM10
Mean 8.78
Standard deviation 8.3
Values 21 13 2.8 3.4 3.4
[58]
HepG2 ADAM10
Mean 38.3
Standard deviation 10
Values 31 46
[59]
HepG2.C3A ADAM10
Mean 47.7
Standard deviation 4.9
Values 44 51
[60]
HuH.7 ADAM10
Mean 46.6
Standard deviation 9
Values 51 53 36
[61]
SNU475 ADAM10
Mean 39.1
Standard deviation 5.2
Values 43 35
[62]
THLE ADAM10
Mean 58.2
Standard deviation 3.8
Values 56 61
[63]
liver ADAM10
Mean 21.7
Standard deviation 10
Values 13 34 14 26
[64]
ref_hepatocyte PSEN1
Mean 6.64
Standard deviation 2.1
Values 8.7 7.5 8.3 4.7 4.1
[65]
HepG2 PSEN1
Mean 30.5
Standard deviation 2.4
Values 29 32
[66]
HepG2.C3A PSEN1
Mean 31.6
Standard deviation 3.9
Values 34 29
[67]
HuH.7 PSEN1
Mean 22.5
Standard deviation 3.1
Values 23 25 19
[68]
SNU475 PSEN1
Mean 29.1
Standard deviation 1.1
Values 30 28
[69]
THLE PSEN1
Mean 30
Standard deviation 4
Values 27 33
[70]
liver PSEN1
Mean 18.8
Standard deviation 3
Values 15 22 19 19
[71]
ref_hepatocyte EGFR
Mean 5.53
Standard deviation 4.2
Values 0.94 8.5 11 3.5 3.5
[72]
HepG2 EGFR
Mean 7.53
Standard deviation 0.89
Values 6.9 8.2
[73]
HepG2.C3A EGFR
Mean 5.18
Standard deviation 0.67
Values 5.7 4.7
[74]
HuH.7 EGFR
Mean 36.6
Standard deviation 25
Values 32 63 15
[75]
SNU475 EGFR
Mean 13.7
Standard deviation 0.74
Values 13 14
[76]
THLE EGFR
Mean 23.6
Standard deviation 4.4
Values 20 27
[77]
liver EGFR
Mean 49.4
Standard deviation 14
Values 39 69 47 42
[78]
ref_hepatocyte TACC3
Mean 5.23
Standard deviation 5.7
Values 7.6 14 1.4 1.8 1.2
[79]
HepG2 TACC3
Mean 34.4
Standard deviation 1.7
Values 33 36
[80]
HepG2.C3A TACC3
Mean 28.8
Standard deviation 13
Values 20 38
[81]
HuH.7 TACC3
Mean 62
Standard deviation 35
Values 77 22 88
[82]
SNU475 TACC3
Mean 51.3
Standard deviation 3.7
Values 49 54
[83]
THLE TACC3
Mean 54.2
Standard deviation 18
Values 42 67
[84]
liver TACC3
Mean 2.22
Standard deviation 1
Values 1.5 2.4 3.6 1.4
[85]
ref_hepatocyte WWP2
Mean 4.56
Standard deviation 2
Values 5.7 2.4 7.5 3.6 3.6
[86]
HepG2 WWP2
Mean 33.7
Standard deviation 1.1
Values 35 33
[87]
HepG2.C3A WWP2
Mean 30.1
Standard deviation 2.2
Values 32 29
[88]
HuH.7 WWP2
Mean 24.4
Standard deviation 4
Values 29 23 21
[89]
SNU475 WWP2
Mean 14
Standard deviation 1.8
Values 15 13
[90]
THLE WWP2
Mean 15.8
Standard deviation 2.3
Values 14 17
[91]
liver WWP2
Mean 13.7
Standard deviation 1.8
Values 14 12 16 13
[92]
ref_hepatocyte PSEN2
Mean 4.44
Standard deviation 2.5
Values 2.3 4.3 8.7 3.4 3.5
[93]
HepG2 PSEN2
Mean 6.08
Standard deviation 0.97
Values 6.8 5.4
[94]
HepG2.C3A PSEN2
Mean 2.99
Standard deviation 0.53
Values 3.4 2.6
[95]
HuH.7 PSEN2
Mean 0.204
Standard deviation 0.067
Values 0.13 0.22 0.26
[96]
SNU475 PSEN2
Mean 8.62
Standard deviation 2.2
Values 10 7.1
[97]
THLE PSEN2
Mean 3.74
Standard deviation 0.46
Values 3.4 4.1
[98]
liver PSEN2
Mean 5.9
Standard deviation 0.87
Values 7.1 5.8 5.8 5
[99]
ref_hepatocyte MIB2
Mean 3.64
Standard deviation 1.3
Values 4.4 2.1 2.4 4.9 4.4
[100]
HepG2 MIB2
Mean 17.4
Standard deviation 8.3
Values 23 11
[101]
HepG2.C3A MIB2
Mean 21.1
Standard deviation 11
Values 29 13
[102]
HuH.7 MIB2
Mean 13.1
Standard deviation 1.5
Values 11 14 14
[103]
SNU475 MIB2
Mean 8.62
Standard deviation 0.85
Values 9.2 8
[104]
THLE MIB2
Mean 11.9
Standard deviation 2.4
Values 14 10
[105]
liver MIB2
Mean 5.6
Standard deviation 2.5
Values 4.6 6.1 2.9 8.8
[106]
ref_hepatocyte MIB1
Mean 3.05
Standard deviation 2
Values 4.6 5.4 2.9 0.66 1.7
[107]
HepG2 MIB1
Mean 19
Standard deviation 5.8
Values 15 23
[108]
HepG2.C3A MIB1
Mean 39.4
Standard deviation 4.4
Values 36 42
[109]
HuH.7 MIB1
Mean 43.8
Standard deviation 11
Values 46 54 31
[110]
SNU475 MIB1
Mean 42.3
Standard deviation 11
Values 50 35
[111]
THLE MIB1
Mean 24.6
Standard deviation 1.6
Values 26 23
[112]
liver MIB1
Mean 28
Standard deviation 19
Values 13 49 11 39
[113]
ref_hepatocyte JAG1
Mean 2.61
Standard deviation 3.4
Values 8.4 2.4 1.7 0.3 0.21
[114]
HepG2 JAG1
Mean 158
Standard deviation 86
Values 2.2e+02 97
[115]
HepG2.C3A JAG1
Mean 52.9
Standard deviation 7.2
Values 58 48
[116]
HuH.7 JAG1
Mean 35.1
Standard deviation 12
Values 45 21 39
[117]
SNU475 JAG1
Mean 13.7
Standard deviation 0.39
Values 13 14
[118]
THLE JAG1
Mean 6
Standard deviation 0.4
Values 5.7 6.3
[119]
liver JAG1
Mean 7.68
Standard deviation 5.1
Values 4.1 8.6 3.5 15
[120]
ref_hepatocyte APH1B
Mean 0.759
Standard deviation 0.26
Values 0.86 1.2 0.64 0.63 0.5
[121]
HepG2 APH1B
Mean 1.42
Standard deviation 0.39
Values 1.7 1.1
[122]
HepG2.C3A APH1B
Mean 2.22
Standard deviation 0.15
Values 2.3 2.1
[123]
HuH.7 APH1B
Mean 18.6
Standard deviation 5.3
Values 23 13 20
[124]
SNU475 APH1B
Mean 11.9
Standard deviation 2.9
Values 14 9.9
[125]
THLE APH1B
Mean 6.86
Standard deviation 0.17
Values 7 6.7
[126]
liver APH1B
Mean 2.52
Standard deviation 0.52
Values 3 2.6 2.7 1.8
[127]
ref_hepatocyte DLL4
Mean 0.192
Standard deviation 0.12
Values 0.27 0 0.32 0.21 0.16
[128]
HepG2 DLL4
Mean 0.711
Standard deviation 0.21
Values 0.86 0.56
[129]
HepG2.C3A DLL4
Mean 1.04
Standard deviation 0.087
Values 1.1 0.98
[130]
HuH.7 DLL4
Mean 0.424
Standard deviation 0.13
Values 0.45 0.54 0.28
[131]
SNU475 DLL4
Mean 0.0403
Standard deviation 0.05
Values 0.0046 0.076
[132]
THLE DLL4
Mean 0.111
Standard deviation 0.039
Values 0.083 0.14
[133]
liver DLL4
Mean 2.51
Standard deviation 0.68
Values 3.4 2 2 2.7
[134]
ref_hepatocyte DLL1
Mean 0.139
Standard deviation 0.16
Values 0 0 0.22 0.38 0.098
[135]
HepG2 DLL1
Mean 0.015
Standard deviation 0.021
Values 0 0.03
[136]
HepG2.C3A DLL1
Mean 0.0307
Standard deviation 0.0021
Values 0.029 0.032
[137]
HuH.7 DLL1
Mean 0.0308
Standard deviation 0.012
Values 0.016 0.039 0.037
[138]
SNU475 DLL1
Mean 0.00232
Standard deviation 0.0033
Values 0.0046 0
[139]
THLE DLL1
Mean 0.356
Standard deviation 0.16
Values 0.47 0.24
[140]
liver DLL1
Mean 1.13
Standard deviation 0.35
Values 1.6 1.2 0.72 1.1
[141]
ref_hepatocyte NOTCH3
Mean 0.138
Standard deviation 0.22
Values 0.028 0.028 0.54 0.043 0.057
[142]
HepG2 NOTCH3
Mean 5.12
Standard deviation 6.5
Values 9.7 0.55
[143]
HepG2.C3A NOTCH3
Mean 0.222
Standard deviation 0.057
Values 0.26 0.18
[144]
HuH.7 NOTCH3
Mean 13.3
Standard deviation 4.1
Values 18 9.9 12
[145]
SNU475 NOTCH3
Mean 19.3
Standard deviation 5.2
Values 23 16
[146]
THLE NOTCH3
Mean 4.85
Standard deviation 2.7
Values 6.7 3
[147]
liver NOTCH3
Mean 3.33
Standard deviation 2.3
Values 2 4.1 1.1 6.2
[148]
ref_hepatocyte JAG2
Mean 0.109
Standard deviation 0.15
Values 0 0.38 0.043 0.086 0.041
[149]
HepG2 JAG2
Mean 2.63
Standard deviation 2.9
Values 4.7 0.56
[150]
HepG2.C3A JAG2
Mean 0.152
Standard deviation 0.18
Values 0.28 0.021
[151]
HuH.7 JAG2
Mean 2.4
Standard deviation 0.54
Values 3 1.9 2.3
[152]
SNU475 JAG2
Mean 11.6
Standard deviation 2.5
Values 13 9.8
[153]
THLE JAG2
Mean 1.82
Standard deviation 0.62
Values 2.3 1.4
[154]
liver JAG2
Mean 0.58
Standard deviation 0.49
Values 0.38 0.59 0.1 1.3
[155]
ref_hepatocyte NEURL1B
Mean 0.0666
Standard deviation 0.09
Values 0 0.036 0 0.22 0.081
[156]
HepG2 NEURL1B
Mean 1.26
Standard deviation 0.81
Values 1.8 0.69
[157]
HepG2.C3A NEURL1B
Mean 0.0759
Standard deviation 0.016
Values 0.087 0.064
[158]
HuH.7 NEURL1B
Mean 0.307
Standard deviation 0.12
Values 0.24 0.24 0.44
[159]
SNU475 NEURL1B
Mean 3.62
Standard deviation 0.98
Values 4.3 2.9
[160]
THLE NEURL1B
Mean 7.33
Standard deviation 1.7
Values 6.1 8.5
[161]
liver NEURL1B
Mean 8.7
Standard deviation 5.1
Values 5.1 13 3.5 13
[162]
ref_hepatocyte EGF
Mean 0.00415
Standard deviation 0.0093
Values 0 0.021 0 0 0
[163]
HepG2 EGF
Mean 0.0358
Standard deviation 0.014
Values 0.046 0.026
[164]
HepG2.C3A EGF
Mean 0.11
Standard deviation 0.087
Values 0.049 0.17
[165]
HuH.7 EGF
Mean 1.29
Standard deviation 0.44
Values 0.97 1.8 1.1
[166]
SNU475 EGF
Mean 3.97
Standard deviation 0.5
Values 4.3 3.6
[167]
THLE EGF
Mean 0.743
Standard deviation 0.02
Values 0.76 0.73
[168]
liver EGF
Mean 0.0176
Standard deviation 0.027
Values 0 0.057 0 0.013
[169]
ref_hepatocyte NEURL1
Missing
[170]
HepG2 NEURL1
Missing
[171]
HepG2.C3A NEURL1
Missing
[172]
HuH.7 NEURL1
Missing
[173]
SNU475 NEURL1
Missing
[174]
THLE NEURL1
Missing
[175]
liver NEURL1
Missing