REACTOME_NOTCH2_ACTIVATION_AND_TRANSMISSION_OF_SIGNAL_TO_THE_NUCLEUS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 UBB Polyubiquitin-B [1] -0.66[2] -0.68[3] -0.84[4] -0.76[5] -0.52[6] -0.15[7]
2 RPS27A Ubiquitin-40S ribosomal protein S27a [8] [9] [10] [11] [12] [13] [14]
3 UBC Polyubiquitin-C [15] -0.21[16] 0.07[17] -0.47[18] 0.09[19] -0.14[20] 0.30[21]
4 UBA52 Ubiquitin-60S ribosomal protein L40 [22] 2.22[23] 2.31[24] 3.04[25] 1.49[26] 2.09[27] 1.07[28]
5 MDK Midkine [29] 1.89[30] 1.48[31] 1.97[32] -3.50[33] -1.66[34] -3.24[35]
6 APH1A Gamma-secretase subunit APH-1A [36] 1.47[37] 1.93[38] 1.84[39] 1.75[40] 1.43[41] 0.71[42]
7 PSENEN Gamma-secretase subunit PEN-2 [43] -0.53[44] -0.33[45] -0.17[46] 0.13[47] -0.50[48] -0.34[49]
8 NCSTN Nicastrin [50] 2.89[51] 2.22[52] 2.07[53] 3.11[54] 2.77[55] 2.11[56]
9 ADAM10 Disintegrin and metalloproteinase domain-containing protein 10 [57] 2.52[58] 3.18[59] 2.90[60] 3.30[61] 3.49[62] 2.52[63]
10 PSEN1 Presenilin-1 [64] 2.60[65] 2.99[66] 2.26[67] 3.27[68] 2.93[69] 2.72[70]
11 NOTCH2 Neurogenic locus notch homolog protein 2 [71] 1.68[72] -3.88[73] 3.29[74] 5.06[75] 5.63[76] 5.05[77]
12 PSEN2 Presenilin-2 [78] 0.85[79] 0.17[80] -3.95[81] 2.10[82] 0.51[83] 1.63[84]
13 MIB2 E3 ubiquitin-protein ligase MIB2 [85] 2.66[86] 3.28[87] 2.34[88] 2.39[89] 2.47[90] 1.84[91]
14 MIB1 E3 ubiquitin-protein ligase MIB1 [92] 3.04[93] 4.43[94] 4.34[95] 4.94[96] 3.77[97] 4.42[98]
15 JAG1 Protein jagged-1 [99] 6.32[100] 5.08[101] 4.24[102] 3.53[103] 1.96[104] 2.77[105]
16 APH1B Gamma-secretase subunit APH-1B [106] 1.31[107] 2.29[108] 5.11[109] 5.11[110] 3.94[111] 2.95[112]
17 DLL4 Delta-like protein 4 [113] 2.29[114] 3.18[115] 1.64[116] -1.11[117] -0.04[118] 4.92[119]
18 DLL1 Delta-like protein 1 [120] -2.82[121] -1.44[122] -1.68[123] -4.77[124] 2.11[125] 4.23[126]
19 JAG2 Protein jagged-2 [127] 4.99[128] 1.22[129] 4.95[130] 7.87[131] 4.82[132] 3.63[133]
20 NEURL1B E3 ubiquitin-protein ligase NEURL1B [134] 4.64[135] 0.93[136] 2.70[137] 6.90[138] 7.54[139] 8.25[140]
21 CNTN1 Contactin-1 [141] [142] [143] [144] [145] [146] [147]
22 NEURL1 E3 ubiquitin-protein ligase NEURL1 [148] [149] [150] [151] [152] [153] [154]
[1]
ref_hepatocyte UBB
Mean 764
Standard deviation 4.8e+02
Values 3.8e+02 3.5e+02 5.3e+02 1.2e+03 1.3e+03
[2]
HepG2 UBB
Mean 368
Standard deviation 39
Values 4e+02 3.4e+02
[3]
HepG2.C3A UBB
Mean 285
Standard deviation 14
Values 2.8e+02 3e+02
[4]
HuH.7 UBB
Mean 304
Standard deviation 40
Values 2.9e+02 2.7e+02 3.5e+02
[5]
SNU475 UBB
Mean 204
Standard deviation 3.3
Values 2.1e+02 2e+02
[6]
THLE UBB
Mean 315
Standard deviation 34
Values 2.9e+02 3.4e+02
[7]
liver UBB
Mean 296
Standard deviation 1.3e+02
Values 4.3e+02 2.1e+02 3.9e+02 1.5e+02
[8]
ref_hepatocyte RPS27A
Mean 499
Standard deviation 2.2e+02
Values 6.6e+02 6.1e+02 1.7e+02 6.8e+02 3.8e+02
[9]
HepG2 RPS27A
Missing
[10]
HepG2.C3A RPS27A
Missing
[11]
HuH.7 RPS27A
Missing
[12]
SNU475 RPS27A
Missing
[13]
THLE RPS27A
Missing
[14]
liver RPS27A
Missing
[15]
ref_hepatocyte UBC
Mean 480
Standard deviation 2.8e+02
Values 1.8e+02 3.5e+02 9.1e+02 5.8e+02 3.8e+02
[16]
HepG2 UBC
Mean 314
Standard deviation 38
Values 3.4e+02 2.9e+02
[17]
HepG2.C3A UBC
Mean 302
Standard deviation 41
Values 3.3e+02 2.7e+02
[18]
HuH.7 UBC
Mean 246
Standard deviation 64
Values 2.4e+02 3.1e+02 1.9e+02
[19]
SNU475 UBC
Mean 232
Standard deviation 63
Values 2.8e+02 1.9e+02
[20]
THLE UBC
Mean 257
Standard deviation 41
Values 2.3e+02 2.9e+02
[21]
liver UBC
Mean 254
Standard deviation 78
Values 2.2e+02 3.1e+02 3.3e+02 1.6e+02
[22]
ref_hepatocyte UBA52
Mean 57.3
Standard deviation 43
Values 14 23 49 1.2e+02 81
[23]
HepG2 UBA52
Mean 203
Standard deviation 20
Values 2.2e+02 1.9e+02
[24]
HepG2.C3A UBA52
Mean 169
Standard deviation 3.3
Values 1.7e+02 1.7e+02
[25]
HuH.7 UBA52
Mean 334
Standard deviation 46
Values 3.4e+02 2.8e+02 3.7e+02
[26]
SNU475 UBA52
Mean 72.9
Standard deviation 11
Values 65 81
[27]
THLE UBA52
Mean 144
Standard deviation 15
Values 1.3e+02 1.5e+02
[28]
liver UBA52
Mean 51.7
Standard deviation 26
Values 79 32 68 28
[29]
ref_hepatocyte MDK
Mean 50.6
Standard deviation 1.1e+02
Values 2.4e+02 2.1 3.1 5.3 3.5
[30]
HepG2 MDK
Mean 143
Standard deviation 11
Values 1.5e+02 1.4e+02
[31]
HepG2.C3A MDK
Mean 84.5
Standard deviation 16
Values 73 96
[32]
HuH.7 MDK
Mean 141
Standard deviation 61
Values 1.5e+02 74 1.9e+02
[33]
SNU475 MDK
Mean 2.04
Standard deviation 0.054
Values 2.1 2
[34]
THLE MDK
Mean 9.44
Standard deviation 0.24
Values 9.6 9.3
[35]
liver MDK
Mean 2.3
Standard deviation 2.8
Values 6.2 0.2 2.6 0.17
[36]
ref_hepatocyte APH1A
Mean 33
Standard deviation 14
Values 23 24 22 47 49
[37]
HepG2 APH1A
Mean 69.5
Standard deviation 1.3
Values 69 70
[38]
HepG2.C3A APH1A
Mean 75
Standard deviation 1.3
Values 76 74
[39]
HuH.7 APH1A
Mean 83.8
Standard deviation 7.5
Values 79 80 92
[40]
SNU475 APH1A
Mean 50.3
Standard deviation 16
Values 61 39
[41]
THLE APH1A
Mean 52.6
Standard deviation 11
Values 45 60
[42]
liver APH1A
Mean 23.2
Standard deviation 0.44
Values 23 24 23 24
[43]
ref_hepatocyte PSENEN
Mean 26.8
Standard deviation 21
Values 8.7 7.6 23 58 37
[44]
HepG2 PSENEN
Mean 14.1
Standard deviation 1.6
Values 13 15
[45]
HepG2.C3A PSENEN
Mean 12.7
Standard deviation 0.49
Values 12 13
[46]
HuH.7 PSENEN
Mean 16.9
Standard deviation 4
Values 17 13 21
[47]
SNU475 PSENEN
Mean 13.3
Standard deviation 0.61
Values 13 14
[48]
THLE PSENEN
Mean 11.1
Standard deviation 0.49
Values 11 11
[49]
liver PSENEN
Mean 9.09
Standard deviation 9.1
Values 17 1.1 17 1.3
[50]
ref_hepatocyte NCSTN
Mean 16.1
Standard deviation 1.3
Values 18 15 16 16 15
[51]
HepG2 NCSTN
Mean 90.9
Standard deviation 5.4
Values 95 87
[52]
HepG2.C3A NCSTN
Mean 45.1
Standard deviation 8.2
Values 51 39
[53]
HuH.7 NCSTN
Mean 48.2
Standard deviation 2.5
Values 47 46 51
[54]
SNU475 NCSTN
Mean 63.1
Standard deviation 12
Values 72 55
[55]
THLE NCSTN
Mean 65
Standard deviation 14
Values 55 75
[56]
liver NCSTN
Mean 30.1
Standard deviation 12
Values 32 22 46 20
[57]
ref_hepatocyte ADAM10
Mean 8.78
Standard deviation 8.3
Values 21 13 2.8 3.4 3.4
[58]
HepG2 ADAM10
Mean 38.3
Standard deviation 10
Values 31 46
[59]
HepG2.C3A ADAM10
Mean 47.7
Standard deviation 4.9
Values 44 51
[60]
HuH.7 ADAM10
Mean 46.6
Standard deviation 9
Values 51 53 36
[61]
SNU475 ADAM10
Mean 39.1
Standard deviation 5.2
Values 43 35
[62]
THLE ADAM10
Mean 58.2
Standard deviation 3.8
Values 56 61
[63]
liver ADAM10
Mean 21.7
Standard deviation 10
Values 13 34 14 26
[64]
ref_hepatocyte PSEN1
Mean 6.64
Standard deviation 2.1
Values 8.7 7.5 8.3 4.7 4.1
[65]
HepG2 PSEN1
Mean 30.5
Standard deviation 2.4
Values 29 32
[66]
HepG2.C3A PSEN1
Mean 31.6
Standard deviation 3.9
Values 34 29
[67]
HuH.7 PSEN1
Mean 22.5
Standard deviation 3.1
Values 23 25 19
[68]
SNU475 PSEN1
Mean 29.1
Standard deviation 1.1
Values 30 28
[69]
THLE PSEN1
Mean 30
Standard deviation 4
Values 27 33
[70]
liver PSEN1
Mean 18.8
Standard deviation 3
Values 15 22 19 19
[71]
ref_hepatocyte NOTCH2
Mean 5.26
Standard deviation 4
Values 1.6 11 7.1 2.4 3.7
[72]
HepG2 NOTCH2
Mean 12.7
Standard deviation 3.4
Values 15 10
[73]
HepG2.C3A NOTCH2
Mean 0.213
Standard deviation 0.12
Values 0.13 0.3
[74]
HuH.7 NOTCH2
Mean 36.5
Standard deviation 12
Values 44 43 23
[75]
SNU475 NOTCH2
Mean 79.3
Standard deviation 13
Values 88 70
[76]
THLE NOTCH2
Mean 154
Standard deviation 35
Values 1.3e+02 1.8e+02
[77]
liver NOTCH2
Mean 74.9
Standard deviation 42
Values 39 1.2e+02 39 99
[78]
ref_hepatocyte PSEN2
Mean 4.44
Standard deviation 2.5
Values 2.3 4.3 8.7 3.4 3.5
[79]
HepG2 PSEN2
Mean 6.08
Standard deviation 0.97
Values 6.8 5.4
[80]
HepG2.C3A PSEN2
Mean 2.99
Standard deviation 0.53
Values 3.4 2.6
[81]
HuH.7 PSEN2
Mean 0.204
Standard deviation 0.067
Values 0.13 0.22 0.26
[82]
SNU475 PSEN2
Mean 8.62
Standard deviation 2.2
Values 10 7.1
[83]
THLE PSEN2
Mean 3.74
Standard deviation 0.46
Values 3.4 4.1
[84]
liver PSEN2
Mean 5.9
Standard deviation 0.87
Values 7.1 5.8 5.8 5
[85]
ref_hepatocyte MIB2
Mean 3.64
Standard deviation 1.3
Values 4.4 2.1 2.4 4.9 4.4
[86]
HepG2 MIB2
Mean 17.4
Standard deviation 8.3
Values 23 11
[87]
HepG2.C3A MIB2
Mean 21.1
Standard deviation 11
Values 29 13
[88]
HuH.7 MIB2
Mean 13.1
Standard deviation 1.5
Values 11 14 14
[89]
SNU475 MIB2
Mean 8.62
Standard deviation 0.85
Values 9.2 8
[90]
THLE MIB2
Mean 11.9
Standard deviation 2.4
Values 14 10
[91]
liver MIB2
Mean 5.6
Standard deviation 2.5
Values 4.6 6.1 2.9 8.8
[92]
ref_hepatocyte MIB1
Mean 3.05
Standard deviation 2
Values 4.6 5.4 2.9 0.66 1.7
[93]
HepG2 MIB1
Mean 19
Standard deviation 5.8
Values 15 23
[94]
HepG2.C3A MIB1
Mean 39.4
Standard deviation 4.4
Values 36 42
[95]
HuH.7 MIB1
Mean 43.8
Standard deviation 11
Values 46 54 31
[96]
SNU475 MIB1
Mean 42.3
Standard deviation 11
Values 50 35
[97]
THLE MIB1
Mean 24.6
Standard deviation 1.6
Values 26 23
[98]
liver MIB1
Mean 28
Standard deviation 19
Values 13 49 11 39
[99]
ref_hepatocyte JAG1
Mean 2.61
Standard deviation 3.4
Values 8.4 2.4 1.7 0.3 0.21
[100]
HepG2 JAG1
Mean 158
Standard deviation 86
Values 2.2e+02 97
[101]
HepG2.C3A JAG1
Mean 52.9
Standard deviation 7.2
Values 58 48
[102]
HuH.7 JAG1
Mean 35.1
Standard deviation 12
Values 45 21 39
[103]
SNU475 JAG1
Mean 13.7
Standard deviation 0.39
Values 13 14
[104]
THLE JAG1
Mean 6
Standard deviation 0.4
Values 5.7 6.3
[105]
liver JAG1
Mean 7.68
Standard deviation 5.1
Values 4.1 8.6 3.5 15
[106]
ref_hepatocyte APH1B
Mean 0.759
Standard deviation 0.26
Values 0.86 1.2 0.64 0.63 0.5
[107]
HepG2 APH1B
Mean 1.42
Standard deviation 0.39
Values 1.7 1.1
[108]
HepG2.C3A APH1B
Mean 2.22
Standard deviation 0.15
Values 2.3 2.1
[109]
HuH.7 APH1B
Mean 18.6
Standard deviation 5.3
Values 23 13 20
[110]
SNU475 APH1B
Mean 11.9
Standard deviation 2.9
Values 14 9.9
[111]
THLE APH1B
Mean 6.86
Standard deviation 0.17
Values 7 6.7
[112]
liver APH1B
Mean 2.52
Standard deviation 0.52
Values 3 2.6 2.7 1.8
[113]
ref_hepatocyte DLL4
Mean 0.192
Standard deviation 0.12
Values 0.27 0 0.32 0.21 0.16
[114]
HepG2 DLL4
Mean 0.711
Standard deviation 0.21
Values 0.86 0.56
[115]
HepG2.C3A DLL4
Mean 1.04
Standard deviation 0.087
Values 1.1 0.98
[116]
HuH.7 DLL4
Mean 0.424
Standard deviation 0.13
Values 0.45 0.54 0.28
[117]
SNU475 DLL4
Mean 0.0403
Standard deviation 0.05
Values 0.0046 0.076
[118]
THLE DLL4
Mean 0.111
Standard deviation 0.039
Values 0.083 0.14
[119]
liver DLL4
Mean 2.51
Standard deviation 0.68
Values 3.4 2 2 2.7
[120]
ref_hepatocyte DLL1
Mean 0.139
Standard deviation 0.16
Values 0 0 0.22 0.38 0.098
[121]
HepG2 DLL1
Mean 0.015
Standard deviation 0.021
Values 0 0.03
[122]
HepG2.C3A DLL1
Mean 0.0307
Standard deviation 0.0021
Values 0.029 0.032
[123]
HuH.7 DLL1
Mean 0.0308
Standard deviation 0.012
Values 0.016 0.039 0.037
[124]
SNU475 DLL1
Mean 0.00232
Standard deviation 0.0033
Values 0.0046 0
[125]
THLE DLL1
Mean 0.356
Standard deviation 0.16
Values 0.47 0.24
[126]
liver DLL1
Mean 1.13
Standard deviation 0.35
Values 1.6 1.2 0.72 1.1
[127]
ref_hepatocyte JAG2
Mean 0.109
Standard deviation 0.15
Values 0 0.38 0.043 0.086 0.041
[128]
HepG2 JAG2
Mean 2.63
Standard deviation 2.9
Values 4.7 0.56
[129]
HepG2.C3A JAG2
Mean 0.152
Standard deviation 0.18
Values 0.28 0.021
[130]
HuH.7 JAG2
Mean 2.4
Standard deviation 0.54
Values 3 1.9 2.3
[131]
SNU475 JAG2
Mean 11.6
Standard deviation 2.5
Values 13 9.8
[132]
THLE JAG2
Mean 1.82
Standard deviation 0.62
Values 2.3 1.4
[133]
liver JAG2
Mean 0.58
Standard deviation 0.49
Values 0.38 0.59 0.1 1.3
[134]
ref_hepatocyte NEURL1B
Mean 0.0666
Standard deviation 0.09
Values 0 0.036 0 0.22 0.081
[135]
HepG2 NEURL1B
Mean 1.26
Standard deviation 0.81
Values 1.8 0.69
[136]
HepG2.C3A NEURL1B
Mean 0.0759
Standard deviation 0.016
Values 0.087 0.064
[137]
HuH.7 NEURL1B
Mean 0.307
Standard deviation 0.12
Values 0.24 0.24 0.44
[138]
SNU475 NEURL1B
Mean 3.62
Standard deviation 0.98
Values 4.3 2.9
[139]
THLE NEURL1B
Mean 7.33
Standard deviation 1.7
Values 6.1 8.5
[140]
liver NEURL1B
Mean 8.7
Standard deviation 5.1
Values 5.1 13 3.5 13
[141]
ref_hepatocyte CNTN1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[142]
HepG2 CNTN1
Mean 0.0487
Standard deviation 0.004
Values 0.046 0.051
[143]
HepG2.C3A CNTN1
Mean 0.00972
Standard deviation 0.014
Values 0.019 0
[144]
HuH.7 CNTN1
Mean 0.814
Standard deviation 0.38
Values 0.71 1.2 0.5
[145]
SNU475 CNTN1
Mean 4.42
Standard deviation 2.1
Values 5.9 2.9
[146]
THLE CNTN1
Mean 0.0109
Standard deviation 0.0071
Values 0.0059 0.016
[147]
liver CNTN1
Mean 0.621
Standard deviation 0.59
Values 0.071 1.2 1 0.17
[148]
ref_hepatocyte NEURL1
Missing
[149]
HepG2 NEURL1
Missing
[150]
HepG2.C3A NEURL1
Missing
[151]
HuH.7 NEURL1
Missing
[152]
SNU475 NEURL1
Missing
[153]
THLE NEURL1
Missing
[154]
liver NEURL1
Missing