REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 PDE9A High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [1] -0.30[2] 0.80[3] -0.18[4] -5.97[5] -5.76[6] -3.81[7]
2 KCNMB3 Calcium-activated potassium channel subunit beta-3 [8] -2.10[9] 0.10[10] -0.19[11] -2.14[12] -1.71[13] -3.21[14]
3 KCNMA1 Calcium-activated potassium channel subunit alpha-1 [15] -9.53[16] -9.83[17] -4.43[18] -0.32[19] -1.72[20] -1.52[21]
4 NOS2 Nitric oxide synthase, inducible [22] -1.65[23] [24] -8.21[25] -6.84[26] -6.79[27] -10.32[28]
5 ITPR1 Inositol 1,4,5-trisphosphate receptor type 1 [29] 1.47[30] 1.72[31] 2.19[32] 0.86[33] 2.68[34] 1.64[35]
6 PDE2A cGMP-dependent 3',5'-cyclic phosphodiesterase [36] -0.15[37] -5.98[38] -5.60[39] -5.57[40] -0.31[41] 1.85[42]
7 KCNMB4 Calcium-activated potassium channel subunit beta-4 [43] 0.49[44] 0.85[45] 1.16[46] -0.89[47] -0.84[48] -2.07[49]
8 PDE11A Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [50] 0.47[51] 0.06[52] 0.06[53] 1.06[54] -3.72[55] 1.40[56]
9 PDE5A cGMP-specific 3',5'-cyclic phosphodiesterase [57] -1.78[58] -0.12[59] 1.00[60] 1.95[61] 1.17[62] -0.03[63]
10 NOS3 Nitric oxide synthase, endothelial [64] 3.10[65] 0.57[66] -0.65[67] -1.93[68] 0.35[69] -0.24[70]
11 NOS1 Nitric oxide synthase, brain [71] -3.22[72] -0.89[73] -3.14[74] -2.66[75] -1.82[76] -2.32[77]
12 PDE1B Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B -5.35[78] -5.96[79] [80] -2.81[81] -2.94[82] 0.85[83]
13 KCNMB1 Calcium-activated potassium channel subunit beta-1 [84] [85] [86] [87] -2.47[88] [89] -2.44[90]
14 PRKG1 cGMP-dependent protein kinase 1 [91] -1.83[92] [93] -0.77[94] 1.19[95] 4.05[96] 3.50[97]
15 PDE1A Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [98] -2.03[99] 1.99[100] 4.13[101] 1.54[102] 3.59[103]
16 KCNMB2 Calcium-activated potassium channel subunit beta-2 [104] [105] -0.85[106] -0.35[107] -3.25[108] -3.29[109] -2.00[110]
17 PRKG2 cGMP-dependent protein kinase 2 [111] 1.23[112] [113] [114] 4.80[115] 0.04[116] -0.97[117]
18 GUCY1A2 Guanylate cyclase soluble subunit alpha-2 [118] -0.42[119] 1.04[120] 6.05[121] 8.24[122] 3.73[123] 7.56[124]
19 PDE10A cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [125] -2.37[126] [127] [128] 0.39[129] 7.67[130] 4.52[131]
20 GUCY1A1 [132] [133] [134] [135] [136] [137] [138]
21 GUCY1B1 [139] [140] [141] [142] [143] [144] [145]
22 IRAG1 [146] [147] [148] [149] [150] [151] [152]
[1]
ref_hepatocyte PDE9A
Mean 1.11
Standard deviation 0.46
Values 0.89 0.75 1.7 1.6 0.7
[2]
HepG2 PDE9A
Mean 6.33
Standard deviation 2
Values 7.7 4.9
[3]
HepG2.C3A PDE9A
Mean 9.42
Standard deviation 4.6
Values 13 6.2
[4]
HuH.7 PDE9A
Mean 7.34
Standard deviation 1.1
Values 7.2 6.3 8.5
[5]
SNU475 PDE9A
Mean 0.129
Standard deviation 0.097
Values 0.06 0.2
[6]
THLE PDE9A
Mean 0.087
Standard deviation 0.078
Values 0.14 0.032
[7]
liver PDE9A
Mean 0.908
Standard deviation 0.36
Values 1.3 0.59 0.62 1.1
[8]
ref_hepatocyte KCNMB3
Mean 1.01
Standard deviation 0.91
Values 0.67 0.13 2.5 0.63 1.1
[9]
HepG2 KCNMB3
Mean 1.66
Standard deviation 0.024
Values 1.6 1.7
[10]
HepG2.C3A KCNMB3
Mean 5.29
Standard deviation 3.1
Values 7.5 3.1
[11]
HuH.7 KCNMB3
Mean 6.65
Standard deviation 4.6
Values 3.5 12 4.6
[12]
SNU475 KCNMB3
Mean 1.67
Standard deviation 0.078
Values 1.6 1.7
[13]
THLE KCNMB3
Mean 1.32
Standard deviation 0.44
Values 1.6 1
[14]
liver KCNMB3
Mean 1.26
Standard deviation 0.46
Values 1.1 1.5 0.72 1.7
[15]
ref_hepatocyte KCNMA1
Mean 0.906
Standard deviation 0.66
Values 0 0.7 0.85 1.2 1.8
[16]
HepG2 KCNMA1
Mean 0.0086
Standard deviation 0.012
Values 0.017 0
[17]
HepG2.C3A KCNMA1
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[18]
HuH.7 KCNMA1
Mean 0.313
Standard deviation 0.19
Values 0.42 0.09 0.43
[19]
SNU475 KCNMA1
Mean 5.29
Standard deviation 2.9
Values 7.3 3.3
[20]
THLE KCNMA1
Mean 1.17
Standard deviation 0.89
Values 0.53 1.8
[21]
liver KCNMA1
Mean 3.61
Standard deviation 1.8
Values 3.2 4.5 1.3 5.3
[22]
ref_hepatocyte NOS2
Mean 0.74
Standard deviation 1.6
Values 0 0 3.7 0 0.024
[23]
HepG2 NOS2
Mean 1.66
Standard deviation 0.53
Values 1.3 2
[24]
HepG2.C3A NOS2
Mean 0
Standard deviation 0
Values 0 0
[25]
HuH.7 NOS2
Mean 0.0187
Standard deviation 0.017
Values 0.0082 0.039 0.0094
[26]
SNU475 NOS2
Mean 0.0469
Standard deviation 0.027
Values 0.028 0.066
[27]
THLE NOS2
Mean 0.0284
Standard deviation 0.01
Values 0.035 0.021
[28]
liver NOS2
Mean 0.00662
Standard deviation 0.013
Values 0 0 0 0.026
[29]
ref_hepatocyte ITPR1
Mean 0.398
Standard deviation 0.44
Values 1.2 0.25 0.1 0.2 0.25
[30]
HepG2 ITPR1
Mean 7.73
Standard deviation 1.3
Values 8.7 6.8
[31]
HepG2.C3A ITPR1
Mean 6.36
Standard deviation 0.83
Values 7 5.8
[32]
HuH.7 ITPR1
Mean 13.6
Standard deviation 3.5
Values 15 16 9.6
[33]
SNU475 ITPR1
Mean 5.27
Standard deviation 3.4
Values 2.8 7.7
[34]
THLE ITPR1
Mean 10.8
Standard deviation 2.1
Values 12 9.3
[35]
liver ITPR1
Mean 14.2
Standard deviation 12
Values 4.3 20 3.8 29
[36]
ref_hepatocyte PDE2A
Mean 0.315
Standard deviation 0.3
Values 0 0 0.54 0.41 0.63
[37]
HepG2 PDE2A
Mean 2
Standard deviation 2
Values 3.4 0.6
[38]
HepG2.C3A PDE2A
Mean 0.0243
Standard deviation 0.034
Values 0.049 0
[39]
HuH.7 PDE2A
Mean 0.0485
Standard deviation 0.0085
Values 0.041 0.058 0.047
[40]
SNU475 PDE2A
Mean 0.0483
Standard deviation 0.0038
Values 0.051 0.046
[41]
THLE PDE2A
Mean 1.08
Standard deviation 0.29
Values 1.3 0.87
[42]
liver PDE2A
Mean 13.1
Standard deviation 4.8
Values 6.4 17 13 16
[43]
ref_hepatocyte KCNMB4
Mean 0.29
Standard deviation 0.15
Values 0.51 0.25 0.23 0.12 0.34
[44]
HepG2 KCNMB4
Mean 2.85
Standard deviation 0.22
Values 2.7 3
[45]
HepG2.C3A KCNMB4
Mean 2.54
Standard deviation 0.13
Values 2.4 2.6
[46]
HuH.7 KCNMB4
Mean 4.83
Standard deviation 1.4
Values 5.6 3.2 5.7
[47]
SNU475 KCNMB4
Mean 1.14
Standard deviation 0.076
Values 1.2 1.1
[48]
THLE KCNMB4
Mean 0.685
Standard deviation 0.27
Values 0.88 0.49
[49]
liver KCNMB4
Mean 0.791
Standard deviation 0.31
Values 1 1 0.36 0.77
[50]
ref_hepatocyte PDE11A
Mean 0.283
Standard deviation 0.2
Values 0.12 0.25 0.14 0.61 0.29
[51]
HepG2 PDE11A
Mean 2.75
Standard deviation 1.3
Values 1.8 3.7
[52]
HepG2.C3A PDE11A
Mean 1.44
Standard deviation 0.66
Values 0.97 1.9
[53]
HuH.7 PDE11A
Mean 2.2
Standard deviation 0.53
Values 2.6 2.4 1.6
[54]
SNU475 PDE11A
Mean 4.31
Standard deviation 2.3
Values 5.9 2.7
[55]
THLE PDE11A
Mean 0.0908
Standard deviation 0.031
Values 0.11 0.069
[56]
liver PDE11A
Mean 8.57
Standard deviation 3.9
Values 6.4 13 4.6 9.8
[57]
ref_hepatocyte PDE5A
Mean 0.272
Standard deviation 0.28
Values 0.087 0.77 0.15 0.15 0.2
[58]
HepG2 PDE5A
Mean 0.557
Standard deviation 0.27
Values 0.37 0.75
[59]
HepG2.C3A PDE5A
Mean 1.22
Standard deviation 0.49
Values 0.87 1.6
[60]
HuH.7 PDE5A
Mean 4.06
Standard deviation 1.4
Values 3.4 5.7 3.1
[61]
SNU475 PDE5A
Mean 7.63
Standard deviation 6
Values 12 3.4
[62]
THLE PDE5A
Mean 2.59
Standard deviation 0.16
Values 2.5 2.7
[63]
liver PDE5A
Mean 3.05
Standard deviation 1.4
Values 2.2 4.1 1.6 4.3
[64]
ref_hepatocyte NOS3
Mean 0.251
Standard deviation 0.22
Values 0.58 0.37 0.014 0.12 0.18
[65]
HepG2 NOS3
Mean 15.1
Standard deviation 1.3
Values 14 16
[66]
HepG2.C3A NOS3
Mean 1.81
Standard deviation 0.061
Values 1.8 1.9
[67]
HuH.7 NOS3
Mean 1.2
Standard deviation 0.2
Values 1.4 1 1.2
[68]
SNU475 NOS3
Mean 0.48
Standard deviation 0.28
Values 0.68 0.28
[69]
THLE NOS3
Mean 1.36
Standard deviation 0.21
Values 1.5 1.2
[70]
liver NOS3
Mean 2.44
Standard deviation 1.3
Values 1.5 2.3 1.6 4.3
[71]
ref_hepatocyte NOS1
Mean 0.0628
Standard deviation 0.06
Values 0.16 0.013 0.033 0.086 0.024
[72]
HepG2 NOS1
Mean 0.0472
Standard deviation 0.042
Values 0.017 0.077
[73]
HepG2.C3A NOS1
Mean 0.165
Standard deviation 0.04
Values 0.14 0.19
[74]
HuH.7 NOS1
Mean 0.0531
Standard deviation 0.054
Values 0.0082 0.039 0.11
[75]
SNU475 NOS1
Mean 0.0724
Standard deviation 0.07
Values 0.023 0.12
[76]
THLE NOS1
Mean 0.0754
Standard deviation 0.069
Values 0.12 0.027
[77]
liver NOS1
Mean 0.144
Standard deviation 0.1
Values 0 0.19 0.23 0.16
[78]
ref_hepatocyte PDE1B
Mean 0.0622
Standard deviation 0.087
Values 0 0 0 0.18 0.13
[79]
HepG2 PDE1B
Mean 0.0107
Standard deviation 0.015
Values 0 0.021
[80]
HepG2.C3A PDE1B
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[81]
HuH.7 PDE1B
Mean 0
Standard deviation 0
Values 0 0 0
[82]
SNU475 PDE1B
Mean 0.0648
Standard deviation 0.059
Values 0.023 0.11
[83]
THLE PDE1B
Mean 0.0343
Standard deviation 0.018
Values 0.047 0.021
[84]
liver PDE1B
Mean 1.29
Standard deviation 0.48
Values 0.92 1.7 0.82 1.7
[85]
ref_hepatocyte KCNMB1
Mean 0.059
Standard deviation 0.084
Values 0 0 0 0.18 0.11
[86]
HepG2 KCNMB1
Mean 0
Standard deviation 0
Values 0 0
[87]
HepG2.C3A KCNMB1
Mean 0
Standard deviation 0
Values 0 0
[88]
HuH.7 KCNMB1
Mean 0
Standard deviation 0
Values 0 0 0
[89]
SNU475 KCNMB1
Mean 0.0772
Standard deviation 0.0089
Values 0.083 0.071
[90]
THLE KCNMB1
Mean 0
Standard deviation 0
Values 0 0
[91]
liver KCNMB1
Mean 0.125
Standard deviation 0.065
Values 0.047 0.11 0.21 0.13
[92]
ref_hepatocyte PRKG1
Mean 0.0174
Standard deviation 0.027
Values 0 0 0.062 0 0.024
[93]
HepG2 PRKG1
Mean 0.0343
Standard deviation 0.024
Values 0.017 0.051
[94]
HepG2.C3A PRKG1
Mean 0
Standard deviation 0
Values 0 0
[95]
HuH.7 PRKG1
Mean 0.0764
Standard deviation 0.034
Values 0.057 0.12 0.056
[96]
SNU475 PRKG1
Mean 0.289
Standard deviation 0.11
Values 0.21 0.36
[97]
THLE PRKG1
Mean 1.22
Standard deviation 0.23
Values 1.4 1.1
[98]
liver PRKG1
Mean 2.25
Standard deviation 1
Values 1.3 3.1 1.4 3.2
[99]
ref_hepatocyte PDE1A
Mean 0.0163
Standard deviation 0.036
Values 0 0 0 0 0.081
[100]
HepG2 PDE1A
Mean 0
Standard deviation 0
Values 0 0
[101]
HepG2.C3A PDE1A
Mean 0.0194
Standard deviation 0.027
Values 0.039 0
[102]
HuH.7 PDE1A
Mean 0.483
Standard deviation 0.49
Values 0.13 1 0.27
[103]
SNU475 PDE1A
Mean 2.08
Standard deviation 0.94
Values 2.7 1.4
[104]
THLE PDE1A
Mean 0.2
Standard deviation 0.048
Values 0.17 0.23
[105]
liver PDE1A
Mean 2.24
Standard deviation 1
Values 0.92 2.9 2.1 3.1
[106]
ref_hepatocyte KCNMB2
Mean 0.013
Standard deviation 0.029
Values 0 0 0 0 0.065
[107]
HepG2 KCNMB2
Mean 0
Standard deviation 0
Values 0 0
[108]
HepG2.C3A KCNMB2
Mean 0.035
Standard deviation 0.019
Values 0.049 0.021
[109]
HuH.7 KCNMB2
Mean 0.0763
Standard deviation 0.027
Values 0.09 0.045 0.094
[110]
SNU475 KCNMB2
Mean 0.00992
Standard deviation 0.0075
Values 0.0046 0.015
[111]
THLE KCNMB2
Mean 0.00562
Standard deviation 0.00042
Values 0.0059 0.0053
[112]
liver KCNMB2
Mean 0.0373
Standard deviation 0.031
Values 0 0.071 0.051 0.026
[113]
ref_hepatocyte PRKG2
Mean 0.00924
Standard deviation 0.021
Values 0 0 0.046 0 0
[114]
HepG2 PRKG2
Mean 0.153
Standard deviation 0.12
Values 0.24 0.064
[115]
HepG2.C3A PRKG2
Mean 0
Standard deviation 0
Values 0 0
[116]
HuH.7 PRKG2
Mean 0
Standard deviation 0
Values 0 0 0
[117]
SNU475 PRKG2
Mean 1.87
Standard deviation 0.4
Values 2.2 1.6
[118]
THLE PRKG2
Mean 0.0402
Standard deviation 0.048
Values 0.0059 0.074
[119]
liver PRKG2
Mean 0.054
Standard deviation 0.05
Values 0.024 0.1 0 0.093
[120]
ref_hepatocyte GUCY1A2
Mean 0.00543
Standard deviation 0.012
Values 0 0 0.027 0 0
[121]
HepG2 GUCY1A2
Mean 0.0286
Standard deviation 0.032
Values 0.0057 0.051
[122]
HepG2.C3A GUCY1A2
Mean 0.0545
Standard deviation 0.047
Values 0.087 0.021
[123]
HuH.7 GUCY1A2
Mean 2.69
Standard deviation 2.1
Values 2.3 4.9 0.87
[124]
SNU475 GUCY1A2
Mean 11.9
Standard deviation 0.86
Values 11 13
[125]
THLE GUCY1A2
Mean 0.305
Standard deviation 0.0048
Values 0.3 0.31
[126]
liver GUCY1A2
Mean 11.7
Standard deviation 8.7
Values 4.6 23 4.8 15
[127]
ref_hepatocyte PDE10A
Mean 0.00422
Standard deviation 0.006
Values 0 0.013 0 0 0.0081
[128]
HepG2 PDE10A
Mean 0.00573
Standard deviation 0.0081
Values 0.011 0
[129]
HepG2.C3A PDE10A
Mean 0
Standard deviation 0
Values 0 0
[130]
HuH.7 PDE10A
Mean 0
Standard deviation 0
Values 0 0 0
[131]
SNU475 PDE10A
Mean 0.0403
Standard deviation 0.028
Values 0.06 0.02
[132]
THLE PDE10A
Mean 3.63
Standard deviation 0.96
Values 2.9 4.3
[133]
liver PDE10A
Mean 1.11
Standard deviation 0.82
Values 0.63 1.6 0.23 2
[134]
ref_hepatocyte GUCY1A1
Missing
[135]
HepG2 GUCY1A1
Missing
[136]
HepG2.C3A GUCY1A1
Missing
[137]
HuH.7 GUCY1A1
Missing
[138]
SNU475 GUCY1A1
Missing
[139]
THLE GUCY1A1
Missing
[140]
liver GUCY1A1
Missing
[141]
ref_hepatocyte GUCY1B1
Missing
[142]
HepG2 GUCY1B1
Missing
[143]
HepG2.C3A GUCY1B1
Missing
[144]
HuH.7 GUCY1B1
Missing
[145]
SNU475 GUCY1B1
Missing
[146]
THLE GUCY1B1
Missing
[147]
liver GUCY1B1
Missing
[148]
ref_hepatocyte IRAG1
Missing
[149]
HepG2 IRAG1
Missing
[150]
HepG2.C3A IRAG1
Missing
[151]
HuH.7 IRAG1
Missing
[152]
SNU475 IRAG1
Missing
[153]
THLE IRAG1
Missing
[154]
liver IRAG1
Missing