REACTOME_NF_KB_ACTIVATION_THROUGH_FADD_RIP_1_PATHWAY_MEDIATED_BY_CASPASE_8_AND_10 Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 IKBKG NF-kappa-B essential modulator [1] -1.66[2] -1.54[3] -3.42[4] -1.54[5] -2.35[6] -1.28[7]
2 FADD FAS-associated death domain protein [8] -0.73[9] -1.47[10] -0.37[11] 1.24[12] -0.54[13] -2.44[14]
3 CASP8 Caspase-8 [15] -0.75[16] -0.21[17] -0.67[18] -0.77[19] -1.11[20] -2.09[21]
4 TRIM4 E3 ubiquitin-protein ligase TRIM4 [22] -1.06[23] -0.89[24] -0.34[25] -2.01[26] -0.99[27] -0.27[28]
5 TRIM25 E3 ubiquitin/ISG15 ligase TRIM25 [29] 1.36[30] 0.98[31] 1.18[32] 0.19[33] 1.25[34] 1.14[35]
6 IFIH1 Interferon-induced helicase C domain-containing protein 1 [36] -2.74[37] -2.68[38] -6.42[39] -1.92[40] -1.28[41] -0.42[42]
7 RIPK1 Receptor-interacting serine/threonine-protein kinase 1 [43] -0.48[44] -0.35[45] -0.30[46] 0.39[47] 0.31[48] 0.81[49]
8 CHUK Inhibitor of nuclear factor kappa-B kinase subunit alpha [50] 0.13[51] 1.33[52] 1.66[53] -0.04[54] 1.18[55] 0.84[56]
9 IKBKB Inhibitor of nuclear factor kappa-B kinase subunit beta [57] -0.25[58] -0.22[59] 0.26[60] -0.43[61] 0.06[62] 0.51[63]
10 DDX58 Probable ATP-dependent RNA helicase DDX58 [64] -1.47[65] -1.51[66] -1.97[67] -1.48[68] -0.51[69] 0.44[70]
11 MAVS Mitochondrial antiviral-signaling protein [71] 3.51[72] 3.09[73] 3.06[74] 3.04[75] 3.04[76] 2.68[77]
12 CASP10 Caspase-10 [78] 0.45[79] 1.71[80] 1.04[81] -0.27[82] 0.19[83] 0.39[84]
13 RNF135 E3 ubiquitin-protein ligase RNF135 [85] -8.08[86] -7.71[87] -6.06[88] -8.17[89] 1.15[90] 0.19[91]
[1]
ref_hepatocyte IKBKG
Mean 22.7
Standard deviation 14
Values 7.4 36 37 24 10
[2]
HepG2 IKBKG
Mean 27.1
Standard deviation 5.7
Values 31 23
[3]
HepG2.C3A IKBKG
Mean 26.7
Standard deviation 4
Values 30 24
[4]
HuH.7 IKBKG
Mean 5.4
Standard deviation 1.3
Values 5.4 4.1 6.7
[5]
SNU475 IKBKG
Mean 23.2
Standard deviation 3.5
Values 21 26
[6]
THLE IKBKG
Mean 11.2
Standard deviation 1
Values 10 12
[7]
liver IKBKG
Mean 21.3
Standard deviation 6.6
Values 20 22 29 13
[8]
ref_hepatocyte FADD
Mean 9.28
Standard deviation 6.6
Values 3.8 12 20 6.3 5.1
[9]
HepG2 FADD
Mean 21.1
Standard deviation 4.6
Values 24 18
[10]
HepG2.C3A FADD
Mean 11.5
Standard deviation 1.6
Values 10 13
[11]
HuH.7 FADD
Mean 18.2
Standard deviation 3.2
Values 16 16 22
[12]
SNU475 FADD
Mean 65.1
Standard deviation 11
Values 73 58
[13]
THLE FADD
Mean 16
Standard deviation 3.5
Values 14 19
[14]
liver FADD
Mean 3.86
Standard deviation 1.3
Values 2.5 4.9 3 5.1
[15]
ref_hepatocyte CASP8
Mean 8.88
Standard deviation 6.8
Values 18 13 8.9 1.9 2.8
[16]
HepG2 CASP8
Mean 19.9
Standard deviation 3.1
Values 22 18
[17]
HepG2.C3A CASP8
Mean 26.3
Standard deviation 13
Values 17 35
[18]
HuH.7 CASP8
Mean 14.2
Standard deviation 3.6
Values 14 11 18
[19]
SNU475 CASP8
Mean 15.4
Standard deviation 0.7
Values 16 15
[20]
THLE CASP8
Mean 10.3
Standard deviation 0.97
Values 9.6 11
[21]
liver CASP8
Mean 4.72
Standard deviation 0.87
Values 3.4 5.2 5.3 5
[22]
ref_hepatocyte TRIM4
Mean 7
Standard deviation 3.2
Values 13 4.2 5.9 5.7 6.7
[23]
HepG2 TRIM4
Mean 12.7
Standard deviation 1.4
Values 12 14
[24]
HepG2.C3A TRIM4
Mean 12.9
Standard deviation 5.9
Values 17 8.8
[25]
HuH.7 TRIM4
Mean 14.1
Standard deviation 1.8
Values 14 16 12
[26]
SNU475 TRIM4
Mean 5.17
Standard deviation 0.5
Values 5.5 4.8
[27]
THLE TRIM4
Mean 8.85
Standard deviation 0.71
Values 8.3 9.4
[28]
liver TRIM4
Mean 13.1
Standard deviation 2.9
Values 17 12 13 10
[29]
ref_hepatocyte TRIM25
Mean 6.54
Standard deviation 4.3
Values 10 11 7.2 2.2 1.9
[30]
HepG2 TRIM25
Mean 63.4
Standard deviation 2.6
Values 65 62
[31]
HepG2.C3A TRIM25
Mean 43.9
Standard deviation 3.5
Values 41 46
[32]
HuH.7 TRIM25
Mean 37.6
Standard deviation 5.8
Values 42 39 31
[33]
SNU475 TRIM25
Mean 22.1
Standard deviation 1.8
Values 23 21
[34]
THLE TRIM25
Mean 39
Standard deviation 5.5
Values 35 43
[35]
liver TRIM25
Mean 32.7
Standard deviation 17
Values 20 44 16 51
[36]
ref_hepatocyte IFIH1
Mean 4.45
Standard deviation 2
Values 7.6 4.6 2.9 2.5 4.6
[37]
HepG2 IFIH1
Mean 2.51
Standard deviation 0.64
Values 2.1 3
[38]
HepG2.C3A IFIH1
Mean 2.38
Standard deviation 0.31
Values 2.6 2.2
[39]
HuH.7 IFIH1
Mean 0.132
Standard deviation 0.058
Values 0.16 0.17 0.066
[40]
SNU475 IFIH1
Mean 3.48
Standard deviation 0.87
Values 4.1 2.9
[41]
THLE IFIH1
Mean 4.58
Standard deviation 1.1
Values 5.3 3.8
[42]
liver IFIH1
Mean 7.55
Standard deviation 1.8
Values 10 7.5 5.9 6.7
[43]
ref_hepatocyte RIPK1
Mean 4.28
Standard deviation 0.89
Values 3.7 4.4 3.1 5.4 4.8
[44]
HepG2 RIPK1
Mean 11.5
Standard deviation 4
Values 8.7 14
[45]
HepG2.C3A RIPK1
Mean 11.5
Standard deviation 0.53
Values 11 12
[46]
HuH.7 RIPK1
Mean 8.85
Standard deviation 0.42
Values 8.4 9.3 8.8
[47]
SNU475 RIPK1
Mean 16.6
Standard deviation 2.9
Values 19 15
[48]
THLE RIPK1
Mean 13.4
Standard deviation 1
Values 13 14
[49]
liver RIPK1
Mean 17
Standard deviation 5.1
Values 12 21 13 22
[50]
ref_hepatocyte CHUK
Mean 3.93
Standard deviation 1.2
Values 4.2 5.7 2.3 3.4 4.1
[51]
HepG2 CHUK
Mean 16.2
Standard deviation 6.4
Values 12 21
[52]
HepG2.C3A CHUK
Mean 33.6
Standard deviation 13
Values 25 43
[53]
HuH.7 CHUK
Mean 31.4
Standard deviation 3.3
Values 34 28 32
[54]
SNU475 CHUK
Mean 11.3
Standard deviation 1.1
Values 11 12
[55]
THLE CHUK
Mean 22.3
Standard deviation 0.15
Values 22 22
[56]
liver CHUK
Mean 16
Standard deviation 3.3
Values 13 21 15 15
[57]
ref_hepatocyte IKBKB
Mean 3.48
Standard deviation 0.8
Values 2.9 4.3 4.2 3.5 2.5
[58]
HepG2 IKBKB
Mean 11
Standard deviation 0.46
Values 11 11
[59]
HepG2.C3A IKBKB
Mean 10.2
Standard deviation 1
Values 11 9.5
[60]
HuH.7 IKBKB
Mean 10.6
Standard deviation 1.9
Values 11 8.4 12
[61]
SNU475 IKBKB
Mean 7.65
Standard deviation 1.8
Values 8.9 6.4
[62]
THLE IKBKB
Mean 9.14
Standard deviation 0.21
Values 9.3 9
[63]
liver IKBKB
Mean 11.2
Standard deviation 0.34
Values 11 11 11 12
[64]
ref_hepatocyte DDX58
Mean 3.45
Standard deviation 3
Values 1.2 7.5 5.8 1.2 1.7
[65]
HepG2 DDX58
Mean 4.68
Standard deviation 1.6
Values 3.5 5.8
[66]
HepG2.C3A DDX58
Mean 4.13
Standard deviation 1.1
Values 3.4 4.9
[67]
HuH.7 DDX58
Mean 2.24
Standard deviation 0.73
Values 1.8 3.1 1.9
[68]
SNU475 DDX58
Mean 3.67
Standard deviation 0.0023
Values 3.7 3.7
[69]
THLE DDX58
Mean 6.07
Standard deviation 0.0034
Values 6.1 6.1
[70]
liver DDX58
Mean 10.6
Standard deviation 2.3
Values 13 12 10 7.7
[71]
ref_hepatocyte MAVS
Mean 2.3
Standard deviation 1.1
Values 4.3 1.9 1.7 1.8 1.9
[72]
HepG2 MAVS
Mean 98.5
Standard deviation 2.4
Values 97 1e+02
[73]
HepG2.C3A MAVS
Mean 66.9
Standard deviation 0.12
Values 67 67
[74]
HuH.7 MAVS
Mean 48.8
Standard deviation 7.5
Values 56 50 41
[75]
SNU475 MAVS
Mean 56.1
Standard deviation 14
Values 66 46
[76]
THLE MAVS
Mean 47.4
Standard deviation 9.4
Values 41 54
[77]
liver MAVS
Mean 33.3
Standard deviation 8
Values 26 34 29 44
[78]
ref_hepatocyte CASP10
Mean 1.74
Standard deviation 0.76
Values 3 1 1.8 1.3 1.6
[79]
HepG2 CASP10
Mean 8.95
Standard deviation 0.044
Values 9 8.9
[80]
HepG2.C3A CASP10
Mean 19.5
Standard deviation 6.6
Values 24 15
[81]
HuH.7 CASP10
Mean 9.07
Standard deviation 0.43
Values 9 9.5 8.7
[82]
SNU475 CASP10
Mean 4.29
Standard deviation 1.6
Values 5.5 3.1
[83]
THLE CASP10
Mean 5
Standard deviation 0.38
Values 5.3 4.7
[84]
liver CASP10
Mean 5.18
Standard deviation 1.9
Values 3.7 7.8 3.9 5.3
[85]
ref_hepatocyte RNF135
Mean 0.925
Standard deviation 0.88
Values 0 1.1 0.45 0.78 2.3
[86]
HepG2 RNF135
Mean 0.0129
Standard deviation 0.0061
Values 0.017 0.0086
[87]
HepG2.C3A RNF135
Mean 0.0151
Standard deviation 0.0062
Values 0.019 0.011
[88]
HuH.7 RNF135
Mean 0.0351
Standard deviation 0.018
Values 0.016 0.051 0.037
[89]
SNU475 RNF135
Mean 0.00949
Standard deviation 0.0063
Values 0.014 0.0051
[90]
THLE RNF135
Mean 5.16
Standard deviation 0.15
Values 5.1 5.3
[91]
liver RNF135
Mean 2.39
Standard deviation 0.75
Values 3.2 1.6 2.8 1.9