REACTOME_NEUROTRANSMITTER_CLEARANCE Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 ALDH2 Aldehyde dehydrogenase, mitochondrial [1] -0.15[2] -0.92[3] -0.55[4] -0.46[5] -1.42[6] -0.61[7]
2 SLC22A1 Solute carrier family 22 member 1 [8] -8.11[9] -6.42[10] -8.94[11] -6.32[12] -8.15[13] 1.02[14]
3 COMT Catechol O-methyltransferase [15] 2.12[16] 2.84[17] 0.71[18] 2.24[19] 1.32[20] 0.21[21]
4 MAOA Amine oxidase [flavin-containing] A [22] -0.45[23] 0.46[24] 2.75[25] -0.66[26] 3.55[27] 1.35[28]
5 BCHE Cholinesterase [29] -9.58[30] -8.34[31] -6.75[32] 2.13[33] 2.41[34] 0.19[35]
6 ACHE Acetylcholinesterase [36] 0.66[37] -1.54[38] 1.52[39] -1.17[40] -1.52[41] -4.61[42]
7 LRTOMT Transmembrane O-methyltransferase [43] 2.63[44] 3.20[45] 2.85[46] 4.04[47] 2.78[48] 0.29[49]
8 SLC6A4 Sodium-dependent serotonin transporter [50] 6.48[51] 7.97[52] 9.33[53] 4.46[54] 2.93[55] 0.81[56]
9 SLC22A2 Solute carrier family 22 member 2 [57] [58] 0.15[59] 0.06[60] 3.92[61] 2.25[62] [63]
10 SLC6A3 Sodium-dependent dopamine transporter [64] 3.24[65] 1.25[66] 1.16[67] 4.31[68] 3.77[69] -1.86[70]
11 LRRC51 [71] [72] [73] [74] [75] [76] [77]
[1]
ref_hepatocyte ALDH2
Mean 413
Standard deviation 5.9e+02
Values 20 27 22 6.4e+02 1.4e+03
[2]
HepG2 ALDH2
Mean 122
Standard deviation 2.9
Values 1.2e+02 1.2e+02
[3]
HepG2.C3A ALDH2
Mean 58.8
Standard deviation 8.6
Values 65 53
[4]
HuH.7 ALDH2
Mean 71
Standard deviation 19
Values 81 49 83
[5]
SNU475 ALDH2
Mean 34.9
Standard deviation 8.2
Values 41 29
[6]
THLE ALDH2
Mean 39.5
Standard deviation 1.8
Values 38 41
[7]
liver ALDH2
Mean 429
Standard deviation 2.9e+02
Values 7.1e+02 1.8e+02 6.5e+02 1.8e+02
[8]
ref_hepatocyte SLC22A1
Mean 98.8
Standard deviation 1.2e+02
Values 0 2.5 42 1.9e+02 2.6e+02
[9]
HepG2 SLC22A1
Mean 0.117
Standard deviation 0.052
Values 0.08 0.15
[10]
HepG2.C3A SLC22A1
Mean 0.311
Standard deviation 0.14
Values 0.41 0.21
[11]
HuH.7 SLC22A1
Mean 0.0506
Standard deviation 0.035
Values 0.025 0.09 0.037
[12]
SNU475 SLC22A1
Mean 0.144
Standard deviation 0.039
Values 0.17 0.12
[13]
THLE SLC22A1
Mean 0.0887
Standard deviation 0.05
Values 0.12 0.053
[14]
liver SLC22A1
Mean 317
Standard deviation 1.8e+02
Values 5.4e+02 2.2e+02 3.7e+02 1.4e+02
[15]
ref_hepatocyte COMT
Mean 41.6
Standard deviation 29
Values 24 25 14 61 83
[16]
HepG2 COMT
Mean 59.3
Standard deviation 6.8
Values 64 55
[17]
HepG2.C3A COMT
Mean 80
Standard deviation 0.37
Values 80 80
[18]
HuH.7 COMT
Mean 17.1
Standard deviation 2.6
Values 14 18 19
[19]
SNU475 COMT
Mean 22.9
Standard deviation 4.5
Values 26 20
[20]
THLE COMT
Mean 26.6
Standard deviation 0.81
Values 26 27
[21]
liver COMT
Mean 76.3
Standard deviation 82
Values 1.9e+02 20 71 20
[22]
ref_hepatocyte MAOA
Mean 22.1
Standard deviation 16
Values 3.4 23 8.6 34 41
[23]
HepG2 MAOA
Mean 5.32
Standard deviation 0.22
Values 5.5 5.2
[24]
HepG2.C3A MAOA
Mean 8.16
Standard deviation 2.3
Values 9.8 6.5
[25]
HuH.7 MAOA
Mean 37.5
Standard deviation 10
Values 36 49 28
[26]
SNU475 MAOA
Mean 1.62
Standard deviation 0.75
Values 1.1 2.1
[27]
THLE MAOA
Mean 66.1
Standard deviation 1.4
Values 67 65
[28]
liver MAOA
Mean 88.9
Standard deviation 19
Values 1.1e+02 90 88 65
[29]
ref_hepatocyte BCHE
Mean 11.7
Standard deviation 16
Values 0 5.4 1.6 12 39
[30]
HepG2 BCHE
Mean 0.00501
Standard deviation 0.001
Values 0.0057 0.0043
[31]
HepG2.C3A BCHE
Mean 0.00972
Standard deviation 0.014
Values 0.019 0
[32]
HuH.7 BCHE
Mean 0.0273
Standard deviation 0.032
Values 0.0082 0.064 0.0094
[33]
SNU475 BCHE
Mean 5.94
Standard deviation 0.44
Values 6.3 5.6
[34]
THLE BCHE
Mean 15.9
Standard deviation 2.8
Values 18 14
[35]
liver BCHE
Mean 21.2
Standard deviation 9.3
Values 35 17 17 16
[36]
ref_hepatocyte ACHE
Mean 1.58
Standard deviation 1.8
Values 0.21 2.1 4.5 0.71 0.4
[37]
HepG2 ACHE
Mean 0.818
Standard deviation 0.67
Values 1.3 0.35
[38]
HepG2.C3A ACHE
Mean 0.146
Standard deviation 0.055
Values 0.18 0.11
[39]
HuH.7 ACHE
Mean 1.14
Standard deviation 0.67
Values 0.74 1.9 0.76
[40]
SNU475 ACHE
Mean 0.0812
Standard deviation 0.036
Values 0.11 0.056
[41]
THLE ACHE
Mean 0.14
Standard deviation 0.065
Values 0.095 0.19
[42]
liver ACHE
Mean 0.102
Standard deviation 0.031
Values 0.14 0.1 0.1 0.066
[43]
ref_hepatocyte LRTOMT
Mean 1.37
Standard deviation 1
Values 0.46 0.56 0.83 2.6 2.4
[44]
HepG2 LRTOMT
Mean 2.78
Standard deviation 0.23
Values 2.9 2.6
[45]
HepG2.C3A LRTOMT
Mean 3.39
Standard deviation 0.21
Values 3.2 3.5
[46]
HuH.7 LRTOMT
Mean 2.48
Standard deviation 0.14
Values 2.6 2.4 2.4
[47]
SNU475 LRTOMT
Mean 2.61
Standard deviation 0.57
Values 3 2.2
[48]
THLE LRTOMT
Mean 2.41
Standard deviation 0.67
Values 1.9 2.9
[49]
liver LRTOMT
Mean 2.65
Standard deviation 0.55
Values 1.9 2.9 3.1 2.7
[50]
ref_hepatocyte SLC6A4
Mean 0.119
Standard deviation 0.22
Values 0.52 0.078 0 0 0
[51]
HepG2 SLC6A4
Mean 3.47
Standard deviation 0.68
Values 3.9 3
[52]
HepG2.C3A SLC6A4
Mean 8.01
Standard deviation 2.3
Values 9.7 6.3
[53]
HuH.7 SLC6A4
Mean 19.2
Standard deviation 1.8
Values 20 20 17
[54]
SNU475 SLC6A4
Mean 0.303
Standard deviation 0.056
Values 0.34 0.26
[55]
THLE SLC6A4
Mean 0.232
Standard deviation 0.049
Values 0.27 0.2
[56]
liver SLC6A4
Mean 0.329
Standard deviation 0.31
Values 0.071 0.41 0.1 0.73
[57]
ref_hepatocyte SLC22A2
Mean 0.0163
Standard deviation 0.036
Values 0 0 0.082 0 0
[58]
HepG2 SLC22A2
Mean 0
Standard deviation 0
Values 0 0
[59]
HepG2.C3A SLC22A2
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[60]
HuH.7 SLC22A2
Mean 0.00428
Standard deviation 0.0074
Values 0 0.013 0
[61]
SNU475 SLC22A2
Mean 0.0287
Standard deviation 0.012
Values 0.037 0.02
[62]
THLE SLC22A2
Mean 0.0198
Standard deviation 0.0054
Values 0.024 0.016
[63]
liver SLC22A2
Mean 0
Standard deviation 0
Values 0 0 0 0
[64]
ref_hepatocyte SLC6A3
Mean 0.00761
Standard deviation 0.017
Values 0 0 0.038 0 0
[65]
HepG2 SLC6A3
Mean 0.0236
Standard deviation 0.015
Values 0.034 0.013
[66]
HepG2.C3A SLC6A3
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[67]
HuH.7 SLC6A3
Mean 0.00428
Standard deviation 0.0074
Values 0 0.013 0
[68]
SNU475 SLC6A3
Mean 0.0175
Standard deviation 0.018
Values 0.0046 0.03
[69]
THLE SLC6A3
Mean 0.0266
Standard deviation 0.038
Values 0.053 0
[70]
liver SLC6A3
Mean 0.00331
Standard deviation 0.0066
Values 0 0 0 0.013
[71]
ref_hepatocyte LRRC51
Missing
[72]
HepG2 LRRC51
Missing
[73]
HepG2.C3A LRRC51
Missing
[74]
HuH.7 LRRC51
Missing
[75]
SNU475 LRRC51
Missing
[76]
THLE LRRC51
Missing
[77]
liver LRRC51
Missing