REACTOME_NEUROTOXICITY_OF_CLOSTRIDIUM_TOXINS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 VAMP2 Vesicle-associated membrane protein 2 [1] -0.82[2] -1.00[3] -0.82[4] -1.56[5] -2.23[6] -0.58[7]
2 VAMP1 Vesicle-associated membrane protein 1 [8] 0.24[9] 1.01[10] 0.50[11] 0.44[12] 0.84[13] 1.49[14]
3 STX1A Syntaxin-1A [15] 1.46[16] 0.90[17] -0.77[18] 1.50[19] 0.03[20] -1.55[21]
4 STX1B Syntaxin-1B [22] 1.00[23] 2.53[24] -0.84[25] -0.31[26] -0.23[27] 1.03[28]
5 SNAP25 Synaptosomal-associated protein 25 [29] -2.97[30] -3.31[31] 2.19[32] 1.37[33] 2.94[34] 0.65[35]
6 SV2A Synaptic vesicle glycoprotein 2A [36] 4.84[37] 4.50[38] 2.50[39] 1.70[40] 6.05[41] 1.00[42]
7 SV2B Synaptic vesicle glycoprotein 2B [43] 1.23[44] 1.42[45] 1.30[46] 0.22[47] -0.70[48] 1.29[49]
8 SYT1 Synaptotagmin-1 [50] -1.57[51] -2.86[52] 5.60[53] 6.10[54] 1.80[55] 3.83[56]
9 SYT2 Synaptotagmin-2 [57] 0.87[58] 1.69[59] 4.38[60] 4.15[61] -0.41[62] 4.25[63]
10 SV2C Synaptic vesicle glycoprotein 2C [64] [65] [66] [67] [68] [69] [70]
[1]
ref_hepatocyte VAMP2
Mean 7.38
Standard deviation 2
Values 9.9 5.1 8 8.2 5.7
[2]
HepG2 VAMP2
Mean 6.41
Standard deviation 1.5
Values 7.4 5.4
[3]
HepG2.C3A VAMP2
Mean 7.34
Standard deviation 3
Values 9.5 5.2
[4]
HuH.7 VAMP2
Mean 8.97
Standard deviation 0.78
Values 8.3 8.8 9.8
[5]
SNU475 VAMP2
Mean 9.81
Standard deviation 1.6
Values 11 8.7
[6]
THLE VAMP2
Mean 9.61
Standard deviation 0.14
Values 9.5 9.7
[7]
liver VAMP2
Mean 9.18
Standard deviation 10
Values 22 1 11 1.9
[8]
ref_hepatocyte VAMP1
Mean 0.789
Standard deviation 0.34
Values 0.33 0.98 0.97 0.53 1.1
[9]
HepG2 VAMP1
Mean 1.44
Standard deviation 0.77
Values 0.89 2
[10]
HepG2.C3A VAMP1
Mean 3.16
Standard deviation 0.59
Values 2.7 3.6
[11]
HuH.7 VAMP1
Mean 2.39
Standard deviation 0.63
Values 1.9 2.1 3.1
[12]
SNU475 VAMP1
Mean 4.19
Standard deviation 0.18
Values 4.3 4.1
[13]
THLE VAMP1
Mean 8.62
Standard deviation 1.3
Values 9.6 7.7
[14]
liver VAMP1
Mean 4.12
Standard deviation 1.2
Values 5.7 3.3 4.5 3
[15]
ref_hepatocyte STX1A
Mean 0.672
Standard deviation 0.98
Values 0.23 0.39 2.4 0.095 0.24
[16]
HepG2 STX1A
Mean 2.85
Standard deviation 0.85
Values 3.4 2.2
[17]
HepG2.C3A STX1A
Mean 2.48
Standard deviation 0.71
Values 3 2
[18]
HuH.7 STX1A
Mean 0.845
Standard deviation 0.25
Values 0.57 0.91 1.1
[19]
SNU475 STX1A
Mean 7.45
Standard deviation 3.6
Values 4.9 10
[20]
THLE STX1A
Mean 4.19
Standard deviation 1.3
Values 5.1 3.3
[21]
liver STX1A
Mean 0.426
Standard deviation 0.18
Values 0.35 0.31 0.69 0.34
[22]
ref_hepatocyte STX1B
Mean 0.198
Standard deviation 0.14
Values 0.28 0 0.11 0.24 0.37
[23]
HepG2 STX1B
Mean 0.607
Standard deviation 0.42
Values 0.31 0.91
[24]
HepG2.C3A STX1B
Mean 2.27
Standard deviation 0.33
Values 2 2.5
[25]
HuH.7 STX1B
Mean 0.236
Standard deviation 0.063
Values 0.16 0.26 0.28
[26]
SNU475 STX1B
Mean 0.621
Standard deviation 0.27
Values 0.81 0.43
[27]
THLE STX1B
Mean 1.03
Standard deviation 0.077
Values 1.1 0.97
[28]
liver STX1B
Mean 0.753
Standard deviation 0.22
Values 0.45 0.76 0.98 0.83
[29]
ref_hepatocyte SNAP25
Mean 0.146
Standard deviation 0.17
Values 0 0 0.3 0.069 0.36
[30]
HepG2 SNAP25
Mean 0.0286
Standard deviation 0.032
Values 0.0057 0.051
[31]
HepG2.C3A SNAP25
Mean 0.0292
Standard deviation 0.041
Values 0.058 0
[32]
HuH.7 SNAP25
Mean 1.43
Standard deviation 0.14
Values 1.4 1.3 1.6
[33]
SNU475 SNAP25
Mean 1.47
Standard deviation 0.63
Values 1 1.9
[34]
THLE SNAP25
Mean 6.82
Standard deviation 0.47
Values 7.1 6.5
[35]
liver SNAP25
Mean 0.427
Standard deviation 0.11
Values 0.42 0.34 0.36 0.58
[36]
ref_hepatocyte SV2A
Mean 0.0636
Standard deviation 0.049
Values 0.11 0.026 0.13 0.026 0.033
[37]
HepG2 SV2A
Mean 2.79
Standard deviation 2.1
Values 4.3 1.3
[38]
HepG2.C3A SV2A
Mean 2.86
Standard deviation 1.2
Values 3.7 2
[39]
HuH.7 SV2A
Mean 0.771
Standard deviation 0.11
Values 0.74 0.89 0.68
[40]
SNU475 SV2A
Mean 0.807
Standard deviation 0.47
Values 0.48 1.1
[41]
THLE SV2A
Mean 25.7
Standard deviation 0.91
Values 26 25
[42]
liver SV2A
Mean 0.237
Standard deviation 0.076
Values 0.26 0.26 0.13 0.3
[43]
ref_hepatocyte SV2B
Mean 0.0474
Standard deviation 0.041
Values 0.094 0.028 0.016 0.0086 0.089
[44]
HepG2 SV2B
Mean 0.17
Standard deviation 0.038
Values 0.14 0.2
[45]
HepG2.C3A SV2B
Mean 0.252
Standard deviation 0.098
Values 0.32 0.18
[46]
HuH.7 SV2B
Mean 0.25
Standard deviation 0.079
Values 0.24 0.33 0.18
[47]
SNU475 SV2B
Mean 0.215
Standard deviation 0.061
Values 0.17 0.26
[48]
THLE SV2B
Mean 0.177
Standard deviation 0.017
Values 0.19 0.16
[49]
liver SV2B
Mean 0.216
Standard deviation 0.21
Values 0.047 0.53 0.13 0.16
[50]
ref_hepatocyte SYT1
Mean 0.0375
Standard deviation 0.071
Values 0 0 0.16 0 0.024
[51]
HepG2 SYT1
Mean 0.0193
Standard deviation 0.021
Values 0.034 0.0043
[52]
HepG2.C3A SYT1
Mean 0.0102
Standard deviation 0.00071
Values 0.0097 0.011
[53]
HuH.7 SYT1
Mean 3.9
Standard deviation 1.6
Values 3.6 5.6 2.5
[54]
SNU475 SYT1
Mean 10
Standard deviation 0.7
Values 9.5 11
[55]
THLE SYT1
Mean 0.793
Standard deviation 0.075
Values 0.85 0.74
[56]
liver SYT1
Mean 0.992
Standard deviation 0.082
Values 0.94 1.1 0.98 0.94
[57]
ref_hepatocyte SYT2
Mean 0.0289
Standard deviation 0.024
Values 0.014 0.06 0.046 0 0.024
[58]
HepG2 SYT2
Mean 0.0809
Standard deviation 0.023
Values 0.097 0.064
[59]
HepG2.C3A SYT2
Mean 0.184
Standard deviation 0.12
Values 0.27 0.097
[60]
HuH.7 SYT2
Mean 1.29
Standard deviation 0.34
Values 1.7 0.99 1.2
[61]
SNU475 SYT2
Mean 2
Standard deviation 1.1
Values 1.2 2.8
[62]
THLE SYT2
Mean 0.132
Standard deviation 0.089
Values 0.2 0.069
[63]
liver SYT2
Mean 1.02
Standard deviation 0.79
Values 0.38 1.3 0.39 2
[64]
ref_hepatocyte SV2C
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[65]
HepG2 SV2C
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[66]
HepG2.C3A SV2C
Mean 0
Standard deviation 0
Values 0 0
[67]
HuH.7 SV2C
Mean 0.0191
Standard deviation 0.033
Values 0.057 0 0
[68]
SNU475 SV2C
Mean 0
Standard deviation 0
Values 0 0
[69]
THLE SV2C
Mean 0
Standard deviation 0
Values 0 0
[70]
liver SV2C
Mean 0.0418
Standard deviation 0.031
Values 0.071 0.057 0 0.04