REACTOME_NETRIN_1_SIGNALING | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | CDC42 | Cell division control protein 42 homolog | [1] | -1.31[2] | -0.63[3] | -1.31[4] | -0.91[5] | -1.80[6] | -2.13[7] |
2 | RAC1 | Ras-related C3 botulinum toxin substrate 1 | [8] | -0.88[9] | -1.24[10] | -0.21[11] | -0.37[12] | -0.55[13] | -1.01[14] |
3 | EZR | Ezrin | [15] | 0.48[16] | -0.92[17] | 0.17[18] | -0.72[19] | 0.36[20] | -0.43[21] |
4 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | [22] | -0.04[23] | 0.36[24] | 0.64[25] | 0.51[26] | 0.98[27] | 1.21[28] |
5 | ABLIM3 | Actin-binding LIM protein 3 | [29] | -2.91[30] | -8.29[31] | -2.83[32] | -2.18[33] | 0.06[34] | 0.92[35] |
6 | NTN4 | Netrin-4 | [36] | -2.50[37] | -1.85[38] | -3.63[39] | -2.12[40] | -1.79[41] | 0.06[42] |
7 | SIAH2 | E3 ubiquitin-protein ligase SIAH2 | [43] | 0.28[44] | -0.56[45] | -1.51[46] | -2.23[47] | -1.95[48] | -0.79[49] |
8 | NCK1 | Cytoplasmic protein NCK1 | [50] | -2.08[51] | -2.01[52] | -1.58[53] | -0.94[54] | -1.00[55] | -0.52[56] |
9 | ABLIM1 | Actin-binding LIM protein 1 | [57] | 1.64[58] | 1.55[59] | 0.65[60] | -0.05[61] | -3.37[62] | 1.30[63] |
10 | PTK2 | Focal adhesion kinase 1 | [64] | 0.25[65] | 0.70[66] | 1.41[67] | 1.57[68] | 0.60[69] | 0.71[70] |
11 | MAPK14 | Mitogen-activated protein kinase 14 | [71] | 0.99[72] | 1.02[73] | 0.93[74] | 1.30[75] | 0.61[76] | 1.24[77] |
12 | WASL | Neural Wiskott-Aldrich syndrome protein | [78] | -0.97[79] | 0.07[80] | 0.80[81] | 0.72[82] | -0.28[83] | 1.08[84] |
13 | PITPNA | Phosphatidylinositol transfer protein alpha isoform | [85] | 0.28[86] | -0.06[87] | 0.82[88] | 0.78[89] | 0.75[90] | -0.01[91] |
14 | SIAH1 | E3 ubiquitin-protein ligase SIAH1 | [92] | -2.30[93] | -1.86[94] | -1.52[95] | -2.48[96] | -2.57[97] | -1.05[98] |
15 | MAPK8 | Mitogen-activated protein kinase 8 | [99] | -1.93[100] | -0.55[101] | -1.36[102] | -1.28[103] | -1.59[104] | -0.56[105] |
16 | MAPK13 | Mitogen-activated protein kinase 13 | [106] | 1.86[107] | 2.23[108] | -0.13[109] | -2.26[110] | -0.91[111] | -1.76[112] |
17 | TRIO | Triple functional domain protein | [113] | 1.51[114] | 1.21[115] | 1.78[116] | 2.23[117] | 2.95[118] | 2.71[119] |
18 | SRC | Proto-oncogene tyrosine-protein kinase Src | [120] | 2.54[121] | 2.49[122] | 1.81[123] | 2.02[124] | 1.03[125] | -0.90[126] |
19 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 3.01[127] | 2.59[128] | 2.25[129] | 2.44[130] | 1.77[131] | 0.29[132] | |
20 | ROBO1 | Roundabout homolog 1 | [133] | 2.28[134] | 2.68[135] | 1.74[136] | 1.13[137] | 1.10[138] | -0.16[139] |
21 | RGMB | RGM domain family member B | [140] | -0.51[141] | -0.93[142] | -0.53[143] | -1.25[144] | -0.15[145] | -0.36[146] |
22 | DOCK1 | Dedicator of cytokinesis protein 1 | [147] | 1.50[148] | 2.00[149] | 2.31[150] | -3.03[151] | 1.61[152] | 2.47[153] |
23 | PAK1 | Serine/threonine-protein kinase PAK 1 | [154] | -0.50[155] | -1.29[156] | 1.44[157] | -2.24[158] | 1.38[159] | 0.22[160] |
24 | FYN | Tyrosine-protein kinase Fyn | [161] | 0.46[162] | -8.18[163] | 0.71[164] | 1.09[165] | 2.45[166] | 0.92[167] |
25 | NEO1 | Neogenin | [168] | 2.17[169] | -1.07[170] | 2.71[171] | 1.27[172] | 3.04[173] | 2.28[174] |
26 | MYO10 | Unconventional myosin-X | [175] | 3.06[176] | 2.47[177] | -3.97[178] | 3.40[179] | 3.90[180] | 3.97[181] |
27 | MAPK12 | Mitogen-activated protein kinase 12 | [182] | 2.34[183] | 1.96[184] | 3.40[185] | 1.11[186] | 2.19[187] | -0.95[188] |
28 | NTN1 | Netrin-1 | [189] | -2.65[190] | -3.36[191] | 0.53[192] | -5.03[193] | -2.91[194] | 3.23[195] |
29 | TRPC1 | Short transient receptor potential channel 1 | [196] | 1.59[197] | 2.88[198] | 3.38[199] | 2.66[200] | 2.52[201] | -0.10[202] |
30 | MAPK11 | Mitogen-activated protein kinase 11 | [203] | -0.66[204] | -0.79[205] | -1.36[206] | -0.02[207] | 1.81[208] | 0.12[209] |
31 | AGAP2 | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 | 2.25[210] | 3.26[211] | 1.24[212] | -3.81[213] | 0.38[214] | 0.94[215] | |
32 | ABLIM2 | Actin-binding LIM protein 2 | [216] | -0.35[217] | -3.39[218] | -0.84[219] | 0.32[220] | 0.01[221] | 2.14[222] |
33 | UNC5B | Netrin receptor UNC5B | [223] | 1.89[224] | -1.50[225] | 1.36[226] | 2.43[227] | 6.57[228] | 3.05[229] |
34 | SLIT2 | Slit homolog 2 protein | [230] | -1.73[231] | -5.70[232] | -0.38[233] | 1.80[234] | 1.10[235] | 2.95[236] |
35 | PRKCQ | Protein kinase C theta type | [237] | 0.42[238] | -3.18[239] | [240] | 1.75[241] | 3.08[242] | 2.04[243] |
36 | TRPC5 | Short transient receptor potential channel 5 | [244] | [245] | [246] | [247] | -3.78[248] | -5.94[249] | 4.47[250] |
37 | UNC5D | Netrin receptor UNC5D | [251] | [252] | [253] | [254] | [255] | -2.91[256] | -3.48[257] |
38 | DSCAML1 | Down syndrome cell adhesion molecule-like protein 1 | [258] | 3.18[259] | 0.61[260] | [261] | -2.50[262] | [263] | 4.47[264] |
39 | UNC5A | Netrin receptor UNC5A | [265] | 0.85[266] | [267] | 1.23[268] | [269] | 0.30[270] | 4.31[271] |
40 | SLIT3 | Slit homolog 3 protein | [272] | 0.87[273] | 2.02[274] | 1.92[275] | 11.27[276] | 9.16[277] | 6.97[278] |
41 | SLIT1 | Slit homolog 1 protein | [279] | 1.30[280] | 3.40[281] | 4.33[282] | 1.45[283] | 1.15[284] | 4.83[285] |
42 | TRPC6 | Short transient receptor potential channel 6 | [286] | -1.40[287] | 0.13[288] | 1.16[289] | 0.48[290] | -1.38[291] | 3.23[292] |
43 | DSCAM | Down syndrome cell adhesion molecule | [293] | [294] | [295] | [296] | [297] | [298] | [299] |
44 | RGMA | Repulsive guidance molecule A | [300] | [301] | [302] | [303] | [304] | [305] | [306] |
45 | TRPC4 | Short transient receptor potential channel 4 | [307] | [308] | [309] | [310] | [311] | [312] | [313] |
46 | HJV | [314] | [315] | [316] | [317] | [318] | [319] | [320] | |
47 | DCC | Netrin receptor DCC | [321] | [322] | [323] | [324] | [325] | [326] | [327] |
48 | TRPC3 | Short transient receptor potential channel 3 | [328] | [329] | [330] | [331] | [332] | [333] | [334] |
49 | TRPC7 | Short transient receptor potential channel 7 | [335] | [336] | [337] | [338] | [339] | [340] | [341] |
50 | UNC5C | Netrin receptor UNC5C | [342] | [343] | [344] | [345] | [346] | [347] | [348] |