REACTOME_NEPHRIN_FAMILY_INTERACTIONS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 ACTN4 Alpha-actinin-4 [1] -0.54[2] -0.61[3] -0.79[4] -0.36[5] -0.93[6] -1.62[7]
2 ACTN1 Alpha-actinin-1 [8] -0.54[9] -1.03[10] -2.02[11] 0.07[12] -0.29[13] -1.22[14]
3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 [15] 1.39[16] 1.31[17] 1.39[18] -0.24[19] 0.39[20] 1.70[21]
4 CD2AP CD2-associated protein [22] -2.22[23] -0.55[24] -1.35[25] -0.60[26] -1.60[27] -1.66[28]
5 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 [29] 1.38[30] 1.10[31] 1.45[32] 1.11[33] 1.53[34] 0.69[35]
6 NCK1 Cytoplasmic protein NCK1 [36] -2.96[37] -2.47[38] -2.68[39] -2.21[40] -1.81[41] -1.72[42]
7 WASL Neural Wiskott-Aldrich syndrome protein [43] -1.85[44] -0.38[45] -0.31[46] -0.54[47] -1.10[48] -0.13[49]
8 PIK3R1 Phosphatidylinositol 3-kinase regulatory subunit alpha [50] -1.83[51] -1.33[52] -0.56[53] 0.42[54] 0.21[55] 1.75[56]
9 PIK3R2 Phosphatidylinositol 3-kinase regulatory subunit beta [57] 0.51[58] 1.12[59] 1.41[60] -0.94[61] -0.10[62] -1.55[63]
10 NCK2 Cytoplasmic protein NCK2 [64] -0.57[65] -0.59[66] -2.50[67] -1.97[68] -0.95[69] -2.08[70]
11 IQGAP1 Ras GTPase-activating-like protein IQGAP1 [71] 0.49[72] 0.43[73] 0.51[74] 2.33[75] 2.45[76] 0.77[77]
12 PIK3CB Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform -0.15[78] 0.75[79] 0.58[80] -0.59[81] -0.15[82] -0.10[83]
13 FYN Tyrosine-protein kinase Fyn [84] -0.42[85] -8.63[86] -0.39[87] -0.17[88] 1.64[89] -0.29[90]
14 CASK Peripheral plasma membrane protein CASK [91] 0.44[92] 0.73[93] 1.95[94] 1.27[95] 0.85[96] 0.00[97]
15 PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform -1.74[98] 0.28[99] 0.15[100] -0.52[101] -0.03[102] 0.66[103]
16 MAGI2 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 0.22[104] 1.61[105] -0.48[106] 0.28[107] 0.42[108] 1.23[109]
17 KIRREL2 Kin of IRRE-like protein 2 [110] -1.47[111] -3.96[112] -8.12[113] -2.79[114] -0.87[115] [116]
18 NPHS1 Nephrin [117] 0.30[118] 0.10[119] -0.70[120] -1.01[121] -1.59[122] -2.14[123]
19 ACTN2 Alpha-actinin-2 [124] -1.09[125] -0.50[126] -3.13[127] 0.58[128] 0.59[129] 1.66[130]
20 ACTN3 Alpha-actinin-3 [131] 1.82[132] 2.15[133] 3.04[134] -4.00[135] -2.73[136] [137]
21 KIRREL1 Kin of IRRE-like protein 1 [138] [139] [140] [141] [142] [143] [144]
22 KIRREL3 Kin of IRRE-like protein 3 [145] [146] [147] [148] [149] [150] [151]
23 NPHS2 Podocin [152] [153] [154] [155] [156] [157] [158]
[1]
ref_hepatocyte ACTN4
Mean 57.4
Standard deviation 35
Values 54 80 1e+02 26 23
[2]
HepG2 ACTN4
Mean 224
Standard deviation 35
Values 2.5e+02 2e+02
[3]
HepG2.C3A ACTN4
Mean 145
Standard deviation 8.5
Values 1.5e+02 1.4e+02
[4]
HuH.7 ACTN4
Mean 154
Standard deviation 21
Values 1.8e+02 1.4e+02 1.5e+02
[5]
SNU475 ACTN4
Mean 257
Standard deviation 68
Values 3.1e+02 2.1e+02
[6]
THLE ACTN4
Mean 159
Standard deviation 27
Values 1.4e+02 1.8e+02
[7]
liver ACTN4
Mean 63.3
Standard deviation 12
Values 49 66 60 78
[8]
ref_hepatocyte ACTN1
Mean 41
Standard deviation 28
Values 17 82 59 26 20
[9]
HepG2 ACTN1
Mean 160
Standard deviation 12
Values 1.7e+02 1.5e+02
[10]
HepG2.C3A ACTN1
Mean 77.3
Standard deviation 10
Values 85 70
[11]
HuH.7 ACTN1
Mean 46.8
Standard deviation 15
Values 62 32 46
[12]
SNU475 ACTN1
Mean 246
Standard deviation 54
Values 2.8e+02 2.1e+02
[13]
THLE ACTN1
Mean 177
Standard deviation 43
Values 1.5e+02 2.1e+02
[14]
liver ACTN1
Mean 59.6
Standard deviation 20
Values 44 54 89 51
[15]
ref_hepatocyte SPTBN1
Mean 25.8
Standard deviation 13
Values 32 44 25 14 14
[16]
HepG2 SPTBN1
Mean 385
Standard deviation 14
Values 3.9e+02 3.7e+02
[17]
HepG2.C3A SPTBN1
Mean 248
Standard deviation 46
Values 2.8e+02 2.1e+02
[18]
HuH.7 SPTBN1
Mean 314
Standard deviation 86
Values 3.6e+02 3.7e+02 2.1e+02
[19]
SNU475 SPTBN1
Mean 126
Standard deviation 3.7
Values 1.2e+02 1.3e+02
[20]
THLE SPTBN1
Mean 179
Standard deviation 44
Values 1.5e+02 2.1e+02
[21]
liver SPTBN1
Mean 285
Standard deviation 1.2e+02
Values 2.1e+02 4.4e+02 1.7e+02 3.2e+02
[22]
ref_hepatocyte CD2AP
Mean 14.1
Standard deviation 15
Values 14 39 11 2.2 4.3
[23]
HepG2 CD2AP
Mean 17.2
Standard deviation 4.9
Values 14 21
[24]
HepG2.C3A CD2AP
Mean 37.2
Standard deviation 11
Values 30 45
[25]
HuH.7 CD2AP
Mean 25.7
Standard deviation 4.3
Values 29 28 21
[26]
SNU475 CD2AP
Mean 53.7
Standard deviation 7.2
Values 59 49
[27]
THLE CD2AP
Mean 24.7
Standard deviation 3.4
Values 27 22
[28]
liver CD2AP
Mean 15.1
Standard deviation 3.8
Values 13 19 11 17
[29]
ref_hepatocyte SPTAN1
Mean 12.4
Standard deviation 7.5
Values 14 24 9.8 8.3 5.1
[30]
HepG2 SPTAN1
Mean 184
Standard deviation 2.1
Values 1.8e+02 1.9e+02
[31]
HepG2.C3A SPTAN1
Mean 103
Standard deviation 10
Values 1.1e+02 96
[32]
HuH.7 SPTAN1
Mean 158
Standard deviation 56
Values 2.2e+02 1.2e+02 1.3e+02
[33]
SNU475 SPTAN1
Mean 153
Standard deviation 20
Values 1.7e+02 1.4e+02
[34]
THLE SPTAN1
Mean 189
Standard deviation 65
Values 1.4e+02 2.3e+02
[35]
liver SPTAN1
Mean 67.8
Standard deviation 40
Values 29 1.2e+02 42 84
[36]
ref_hepatocyte NCK1
Mean 11
Standard deviation 7.6
Values 4.9 23 13 6.3 7.3
[37]
HepG2 NCK1
Mean 8.05
Standard deviation 1.5
Values 7 9.1
[38]
HepG2.C3A NCK1
Mean 7.7
Standard deviation 1.8
Values 6.4 9
[39]
HuH.7 NCK1
Mean 7.97
Standard deviation 0.27
Values 7.7 7.9 8.2
[40]
SNU475 NCK1
Mean 13.7
Standard deviation 1.9
Values 15 12
[41]
THLE NCK1
Mean 16.6
Standard deviation 0.3
Values 16 17
[42]
liver NCK1
Mean 11.3
Standard deviation 2.9
Values 15 11 12 7.7
[43]
ref_hepatocyte WASL
Mean 8.59
Standard deviation 2.4
Values 12 10 6.2 6.4 8.7
[44]
HepG2 WASL
Mean 13.6
Standard deviation 3.9
Values 11 16
[45]
HepG2.C3A WASL
Mean 25.4
Standard deviation 2.9
Values 28 23
[46]
HuH.7 WASL
Mean 32.2
Standard deviation 9.3
Values 28 43 25
[47]
SNU475 WASL
Mean 33.9
Standard deviation 2.2
Values 35 32
[48]
THLE WASL
Mean 21.2
Standard deviation 0.65
Values 21 22
[49]
liver WASL
Mean 26.7
Standard deviation 9.5
Values 39 19 30 19
[50]
ref_hepatocyte PIK3R1
Mean 7.45
Standard deviation 3.9
Values 4.1 7.4 4.2 8.1 14
[51]
HepG2 PIK3R1
Mean 11.9
Standard deviation 3
Values 9.8 14
[52]
HepG2.C3A PIK3R1
Mean 11.5
Standard deviation 2.6
Values 9.6 13
[53]
HuH.7 PIK3R1
Mean 23.4
Standard deviation 8.6
Values 23 32 15
[54]
SNU475 PIK3R1
Mean 57.3
Standard deviation 32
Values 80 35
[55]
THLE PIK3R1
Mean 45.5
Standard deviation 1.5
Values 44 47
[56]
liver PIK3R1
Mean 84.8
Standard deviation 47
Values 64 1e+02 32 1.4e+02
[57]
ref_hepatocyte PIK3R2
Mean 5.25
Standard deviation 3.4
Values 11 3.2 3.1 4.9 3.8
[58]
HepG2 PIK3R2
Mean 42.5
Standard deviation 2.8
Values 44 41
[59]
HepG2.C3A PIK3R2
Mean 44.2
Standard deviation 13
Values 53 35
[60]
HuH.7 PIK3R2
Mean 64.7
Standard deviation 10
Values 75 55 64
[61]
SNU475 PIK3R2
Mean 15.7
Standard deviation 3.3
Values 18 13
[62]
THLE PIK3R2
Mean 26
Standard deviation 2.8
Values 24 28
[63]
liver PIK3R2
Mean 6.1
Standard deviation 1.7
Values 7.6 6 3.8 6.9
[64]
ref_hepatocyte NCK2
Mean 4.8
Standard deviation 3.5
Values 9.1 5.5 7 1.3 1
[65]
HepG2 NCK2
Mean 18.4
Standard deviation 3.6
Values 21 16
[66]
HepG2.C3A NCK2
Mean 12.3
Standard deviation 3.8
Values 15 9.6
[67]
HuH.7 NCK2
Mean 3.94
Standard deviation 0.32
Values 3.8 4.3 3.7
[68]
SNU475 NCK2
Mean 7.02
Standard deviation 0.0081
Values 7 7
[69]
THLE NCK2
Mean 13.2
Standard deviation 0.15
Values 13 13
[70]
liver NCK2
Mean 3.85
Standard deviation 2.3
Values 3.3 3.9 1.3 6.9
[71]
ref_hepatocyte IQGAP1
Mean 4.76
Standard deviation 3
Values 8.8 6 5.4 0.97 2.7
[72]
HepG2 IQGAP1
Mean 38
Standard deviation 13
Values 29 47
[73]
HepG2.C3A IQGAP1
Mean 24.7
Standard deviation 3.2
Values 22 27
[74]
HuH.7 IQGAP1
Mean 31.6
Standard deviation 8.7
Values 42 28 26
[75]
SNU475 IQGAP1
Mean 137
Standard deviation 20
Values 1.5e+02 1.2e+02
[76]
THLE IQGAP1
Mean 138
Standard deviation 22
Values 1.2e+02 1.5e+02
[77]
liver IQGAP1
Mean 27.5
Standard deviation 11
Values 17 40 18 35
[78]
ref_hepatocyte PIK3CB
Mean 3.18
Standard deviation 1.5
Values 5.2 4.2 2.6 1.8 2.1
[79]
HepG2 PIK3CB
Mean 16.3
Standard deviation 2.1
Values 15 18
[80]
HepG2.C3A PIK3CB
Mean 20.6
Standard deviation 2.7
Values 23 19
[81]
HuH.7 PIK3CB
Mean 22.1
Standard deviation 2.1
Values 24 23 20
[82]
SNU475 PIK3CB
Mean 12.1
Standard deviation 2.7
Values 14 10
[83]
THLE PIK3CB
Mean 15.1
Standard deviation 0.94
Values 14 16
[84]
liver PIK3CB
Mean 10.1
Standard deviation 3.7
Values 6.4 15 7.9 11
[85]
ref_hepatocyte FYN
Mean 2.1
Standard deviation 2.2
Values 2.2 0.039 0.23 2.6 5.5
[86]
HepG2 FYN
Mean 8.91
Standard deviation 0.7
Values 9.4 8.4
[87]
HepG2.C3A FYN
Mean 0.0204
Standard deviation 0.0014
Values 0.019 0.021
[88]
HuH.7 FYN
Mean 7.43
Standard deviation 2.2
Values 8.9 4.8 8.5
[89]
SNU475 FYN
Mean 10.7
Standard deviation 2.5
Values 12 8.9
[90]
THLE FYN
Mean 34.5
Standard deviation 4.9
Values 38 31
[91]
liver FYN
Mean 5.84
Standard deviation 2.1
Values 8.9 4.4 5.1 5
[92]
ref_hepatocyte CASK
Mean 2.05
Standard deviation 0.81
Values 3 2.8 1.7 1.1 1.6
[93]
HepG2 CASK
Mean 15.8
Standard deviation 1
Values 17 15
[94]
HepG2.C3A CASK
Mean 13.2
Standard deviation 2
Values 15 12
[95]
HuH.7 CASK
Mean 36.8
Standard deviation 5.1
Values 36 42 32
[96]
SNU475 CASK
Mean 28.4
Standard deviation 8.4
Values 34 22
[97]
THLE CASK
Mean 19.6
Standard deviation 2.8
Values 22 18
[98]
liver CASK
Mean 6.96
Standard deviation 3
Values 6.1 8.6 3.2 9.9
[99]
ref_hepatocyte PIK3CA
Mean 1.87
Standard deviation 0.73
Values 2.3 2.6 2.3 1.2 0.94
[100]
HepG2 PIK3CA
Mean 3.17
Standard deviation 1.6
Values 2.1 4.3
[101]
HepG2.C3A PIK3CA
Mean 8.78
Standard deviation 1.1
Values 8 9.6
[102]
HuH.7 PIK3CA
Mean 9.59
Standard deviation 2.4
Values 10 12 7
[103]
SNU475 PIK3CA
Mean 7.49
Standard deviation 0.93
Values 8.1 6.8
[104]
THLE PIK3CA
Mean 9.67
Standard deviation 0.66
Values 10 9.2
[105]
liver PIK3CA
Mean 9.99
Standard deviation 4.7
Values 6.1 15 6 13
[106]
ref_hepatocyte MAGI2
Mean 0.14
Standard deviation 0.14
Values 0 0 0.26 0.15 0.29
[107]
HepG2 MAGI2
Mean 0.928
Standard deviation 0.04
Values 0.9 0.96
[108]
HepG2.C3A MAGI2
Mean 1.65
Standard deviation 0.33
Values 1.9 1.4
[109]
HuH.7 MAGI2
Mean 0.467
Standard deviation 0.22
Values 0.25 0.69 0.46
[110]
SNU475 MAGI2
Mean 0.976
Standard deviation 0.39
Values 1.3 0.7
[111]
THLE MAGI2
Mean 0.99
Standard deviation 0.1
Values 0.92 1.1
[112]
liver MAGI2
Mean 1.12
Standard deviation 0.24
Values 1.3 1.3 0.77 1.1
[113]
ref_hepatocyte KIRREL2
Mean 0.128
Standard deviation 0.15
Values 0.31 0 0.26 0 0.065
[114]
HepG2 KIRREL2
Mean 0.262
Standard deviation 0.079
Values 0.21 0.32
[115]
HepG2.C3A KIRREL2
Mean 0.0317
Standard deviation 0.031
Values 0.0097 0.054
[116]
HuH.7 KIRREL2
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[117]
SNU475 KIRREL2
Mean 0.106
Standard deviation 0.021
Values 0.12 0.091
[118]
THLE KIRREL2
Mean 0.369
Standard deviation 0.27
Values 0.56 0.18
[119]
liver KIRREL2
Mean 0
Standard deviation 0
Values 0 0 0 0
[120]
ref_hepatocyte NPHS1
Mean 0.0793
Standard deviation 0.084
Values 0.21 0 0.098 0.06 0.024
[121]
HepG2 NPHS1
Mean 0.556
Standard deviation 0.16
Values 0.67 0.44
[122]
HepG2.C3A NPHS1
Mean 0.328
Standard deviation 0.1
Values 0.4 0.26
[123]
HuH.7 NPHS1
Mean 0.227
Standard deviation 0.075
Values 0.18 0.31 0.19
[124]
SNU475 NPHS1
Mean 0.226
Standard deviation 0.047
Values 0.26 0.19
[125]
THLE NPHS1
Mean 0.139
Standard deviation 0.029
Values 0.12 0.16
[126]
liver NPHS1
Mean 0.0611
Standard deviation 0.077
Values 0 0.086 0 0.16
[127]
ref_hepatocyte ACTN2
Mean 0.0201
Standard deviation 0.045
Values 0 0 0.1 0 0
[128]
HepG2 ACTN2
Mean 0.0537
Standard deviation 0.021
Values 0.069 0.039
[129]
HepG2.C3A ACTN2
Mean 0.055
Standard deviation 0.032
Values 0.078 0.032
[130]
HuH.7 ACTN2
Mean 0.0107
Standard deviation 0.019
Values 0 0.032 0
[131]
SNU475 ACTN2
Mean 0.173
Standard deviation 0.035
Values 0.15 0.2
[132]
THLE ACTN2
Mean 0.16
Standard deviation 0.075
Values 0.21 0.11
[133]
liver ACTN2
Mean 0.215
Standard deviation 0.35
Values 0.73 0.014 0 0.12
[134]
ref_hepatocyte ACTN3
Mean 0.00707
Standard deviation 0.016
Values 0 0 0.035 0 0
[135]
HepG2 ACTN3
Mean 0.142
Standard deviation 0.054
Values 0.1 0.18
[136]
HepG2.C3A ACTN3
Mean 0.121
Standard deviation 0.035
Values 0.15 0.097
[137]
HuH.7 ACTN3
Mean 0.269
Standard deviation 0.13
Values 0.3 0.13 0.38
[138]
SNU475 ACTN3
Mean 0.00253
Standard deviation 0.0036
Values 0 0.0051
[139]
THLE ACTN3
Mean 0.00562
Standard deviation 0.00042
Values 0.0059 0.0053
[140]
liver ACTN3
Mean 0
Standard deviation 0
Values 0 0 0 0
[141]
ref_hepatocyte KIRREL1
Missing
[142]
HepG2 KIRREL1
Missing
[143]
HepG2.C3A KIRREL1
Missing
[144]
HuH.7 KIRREL1
Missing
[145]
SNU475 KIRREL1
Missing
[146]
THLE KIRREL1
Missing
[147]
liver KIRREL1
Missing
[148]
ref_hepatocyte KIRREL3
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[149]
HepG2 KIRREL3
Mean 0.0336
Standard deviation 0.017
Values 0.046 0.021
[150]
HepG2.C3A KIRREL3
Mean 0.0209
Standard deviation 0.016
Values 0.0097 0.032
[151]
HuH.7 KIRREL3
Mean 0.0103
Standard deviation 0.013
Values 0.025 0.0064 0
[152]
SNU475 KIRREL3
Mean 0.0926
Standard deviation 0.02
Values 0.079 0.11
[153]
THLE KIRREL3
Mean 0.166
Standard deviation 0.051
Values 0.13 0.2
[154]
liver KIRREL3
Mean 0.18
Standard deviation 0.17
Values 0.047 0.37 0.026 0.28
[155]
ref_hepatocyte NPHS2
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[156]
HepG2 NPHS2
Missing
[157]
HepG2.C3A NPHS2
Missing
[158]
HuH.7 NPHS2
Missing
[159]
SNU475 NPHS2
Missing
[160]
THLE NPHS2
Missing
[161]
liver NPHS2
Missing