REACTOME_NEGATIVE_REGULATORS_OF_DDX58_IFIH1_SIGNALING | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -0.80[2] | -1.09[3] | -1.06[4] | -1.12[5] | -0.84[6] | -0.49[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -0.36[16] | -0.33[17] | -0.69[18] | -0.27[19] | -0.46[20] | -0.04[21] |
4 | PCBP2 | Poly(rC)-binding protein 2 | [22] | 1.69[23] | 1.73[24] | 1.97[25] | 1.52[26] | 1.47[27] | 0.24[28] |
5 | UBE2D3 | Ubiquitin-conjugating enzyme E2 D3 | [29] | 0.57[30] | 0.81[31] | 0.92[32] | 0.92[33] | 1.21[34] | 1.24[35] |
6 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [36] | 2.08[37] | 1.90[38] | 2.82[39] | 1.13[40] | 1.76[41] | 0.73[42] |
7 | ISG15 | Ubiquitin-like protein ISG15 | [43] | -0.76[44] | -0.60[45] | -1.83[46] | -1.64[47] | -2.96[48] | -1.01[49] |
8 | UBE2L6 | Ubiquitin/ISG15-conjugating enzyme E2 L6 | [50] | -0.35[51] | -2.93[52] | -1.39[53] | 0.60[54] | -0.14[55] | 0.70[56] |
9 | TAX1BP1 | Tax1-binding protein 1 | [57] | 1.30[58] | 2.38[59] | 2.45[60] | 2.63[61] | 1.66[62] | 1.94[63] |
10 | PIN1 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | [64] | 0.36[65] | 0.33[66] | 0.46[67] | 0.00[68] | 0.96[69] | 0.03[70] |
11 | UBE2K | Ubiquitin-conjugating enzyme E2 K | [71] | 1.72[72] | 2.12[73] | 2.24[74] | 2.06[75] | 2.36[76] | 1.70[77] |
12 | TNFAIP3 | Tumor necrosis factor alpha-induced protein 3 | [78] | 2.03[79] | 2.64[80] | -0.74[81] | 0.44[82] | 2.23[83] | 0.36[84] |
13 | UBE2D2 | Ubiquitin-conjugating enzyme E2 D2 | [85] | 2.40[86] | 2.36[87] | 1.52[88] | 2.45[89] | 2.47[90] | 1.35[91] |
14 | IRF3 | Interferon regulatory factor 3 | [92] | 1.70[93] | 1.78[94] | 2.39[95] | 2.01[96] | 1.43[97] | 0.20[98] |
15 | ITCH | E3 ubiquitin-protein ligase Itchy homolog | [99] | 2.75[100] | 3.19[101] | 2.33[102] | 3.19[103] | 2.34[104] | 3.55[105] |
16 | OTUD5 | OTU domain-containing protein 5 | [106] | 2.07[107] | 1.60[108] | 2.44[109] | 2.09[110] | 1.86[111] | 0.81[112] |
17 | TRIM4 | E3 ubiquitin-protein ligase TRIM4 | [113] | 1.11[114] | 1.22[115] | 1.28[116] | 0.34[117] | 0.78[118] | 1.79[119] |
18 | TBK1 | Serine/threonine-protein kinase TBK1 | [120] | 0.76[121] | 2.35[122] | 1.38[123] | 2.15[124] | 2.06[125] | 1.86[126] |
19 | TRIM25 | E3 ubiquitin/ISG15 ligase TRIM25 | [127] | 3.53[128] | 3.08[129] | 2.80[130] | 2.54[131] | 3.02[132] | 3.20[133] |
20 | ATG5 | Autophagy protein 5 | [134] | 1.18[135] | 2.12[136] | 1.66[137] | 2.44[138] | 2.01[139] | 2.23[140] |
21 | ATG12 | Ubiquitin-like protein ATG12 | [141] | 1.83[142] | 2.64[143] | 2.45[144] | 3.12[145] | 2.72[146] | 2.82[147] |
22 | IFIH1 | Interferon-induced helicase C domain-containing protein 1 | [148] | -0.57[149] | -0.57[150] | -4.80[151] | 0.43[152] | 0.48[153] | 1.64[154] |
23 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | [155] | 1.30[156] | 1.34[157] | 0.04[158] | 2.60[159] | 3.65[160] | 3.33[161] |
24 | DDX58 | Probable ATP-dependent RNA helicase DDX58 | [162] | 0.69[163] | 0.60[164] | -0.35[165] | 0.87[166] | 1.25[167] | 2.50[168] |
25 | UBA7 | Ubiquitin-like modifier-activating enzyme 7 | [169] | 1.16[170] | 0.81[171] | -4.08[172] | 2.72[173] | 2.10[174] | 2.77[175] |
26 | RNF216 | E3 ubiquitin-protein ligase RNF216 | [176] | 3.51[177] | 3.40[178] | 3.55[179] | 3.55[180] | 3.43[181] | 3.54[182] |
27 | UBE2D1 | Ubiquitin-conjugating enzyme E2 D1 | [183] | 2.19[184] | 2.97[185] | 3.20[186] | 3.18[187] | 2.76[188] | 1.89[189] |
28 | MAVS | Mitochondrial antiviral-signaling protein | [190] | 5.67[191] | 5.20[192] | 4.68[193] | 5.39[194] | 4.80[195] | 4.73[196] |
29 | NLRX1 | NLR family member X1 | [197] | 3.25[198] | 2.52[199] | 1.10[200] | 2.88[201] | 2.01[202] | 2.53[203] |
30 | RNF125 | E3 ubiquitin-protein ligase RNF125 | [204] | -1.07[205] | 0.39[206] | 0.73[207] | 0.40[208] | -0.58[209] | 2.96[210] |
31 | TRAF3 | TNF receptor-associated factor 3 | [211] | 4.29[212] | 3.62[213] | 3.11[214] | 4.49[215] | 4.72[216] | 3.31[217] |
32 | HERC5 | E3 ISG15--protein ligase HERC5 | [218] | -1.58[219] | -4.64[220] | 0.97[221] | 2.41[222] | 1.45[223] | 2.62[224] |
33 | RNF135 | E3 ubiquitin-protein ligase RNF135 | [225] | -5.91[226] | -5.60[227] | -4.44[228] | -5.83[229] | 2.92[230] | 2.25[231] |
34 | IKBKE | Inhibitor of nuclear factor kappa-B kinase subunit epsilon | [232] | 3.12[233] | 2.90[234] | 1.68[235] | 4.22[236] | 3.59[237] | 1.15[238] |
35 | NLRC5 | Protein NLRC5 | [239] | 2.61[240] | 3.04[241] | 1.62[242] | 5.43[243] | 4.76[244] | 4.51[245] |